Lithium modifies brain arachidonic and docosahexaenoic metabolism in rat lipopolysaccharide model of neuroinflammation.

PubWeight™: 0.99‹?› | Rank: Top 15%

🔗 View Article (PMC 2853431)

Published in J Lipid Res on December 29, 2009

Authors

Mireille Basselin1, Hyung-Wook Kim, Mei Chen, Kaizong Ma, Stanley I Rapoport, Robert C Murphy, Santiago E Farias

Author Affiliations

1: Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. mirvasln@mail.nih.gov

Associated clinical trials:

Dietary Intervention for Bipolar Disorder | NCT02272010

Articles citing this

Bipolar disorder and mechanisms of action of mood stabilizers. Brain Res Rev (2009) 1.31

14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds. J Biol Chem (2010) 1.08

Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex. J Neurochem (2013) 0.93

Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. Transl Psychiatry (2011) 0.93

Effects of lithium on inflammation. ACS Chem Neurosci (2014) 0.89

Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? Expert Rev Neurother (2012) 0.89

Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain. Biochim Biophys Acta (2010) 0.89

Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. Biochim Biophys Acta (2010) 0.88

Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder? Neural Plast (2015) 0.88

Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. Brain Res Bull (2011) 0.86

Retracted Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. Neurochem Res (2010) 0.86

Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. Am J Pathol (2011) 0.85

Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability. J Neurochem (2012) 0.83

Lithium and the other mood stabilizers effective in bipolar disorder target the rat brain arachidonic acid cascade. ACS Chem Neurosci (2014) 0.83

Retracted Dose-dependent changes in neuroinflammatory and arachidonic acid cascade markers with synaptic marker loss in rat lipopolysaccharide infusion model of neuroinflammation. BMC Neurosci (2012) 0.80

Improving lithium therapeutics by crystal engineering of novel ionic cocrystals. Mol Pharm (2013) 0.79

Mood stabilizing drugs regulate transcription of immune, neuronal and metabolic pathway genes in Drosophila. Psychopharmacology (Berl) (2016) 0.79

Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder. Biochim Biophys Acta (2013) 0.78

Knocking out the dopamine reuptake transporter (DAT) does not change the baseline brain arachidonic acid signal in the mouse. Int J Neurosci (2012) 0.77

Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability. Neuroscience (2012) 0.77

Gabapentin's minimal action on markers of rat brain arachidonic acid metabolism agrees with its inefficacy against bipolar disorder. Prostaglandins Leukot Essent Fatty Acids (2012) 0.77

Neuropathological responses to chronic NMDA in rats are worsened by dietary n-3 PUFA deprivation but are not ameliorated by fish oil supplementation. PLoS One (2014) 0.76

Dietary Linoleic Acid Lowering Reduces Lipopolysaccharide-Induced Increase in Brain Arachidonic Acid Metabolism. Mol Neurobiol (2016) 0.76

Chronic lithium feeding reduces upregulated brain arachidonic acid metabolism in HIV-1 transgenic rat. J Neuroimmune Pharmacol (2012) 0.75

Articles cited by this

A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem (1957) 173.99

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med (2002) 7.99

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol (2007) 5.83

Lithium delays progression of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2008) 5.37

Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem (2003) 4.58

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem (1993) 4.05

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem (2003) 3.80

Lithium salts in the treatment of psychotic excitement. Med J Aust (1949) 3.73

Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res (2008) 3.46

Bipolar disorder. N Engl J Med (2004) 2.75

Inflammation and immune regulation by 12/15-lipoxygenases. Prog Lipid Res (2006) 2.48

Role of inflammation in neurodegenerative diseases. Curr Opin Neurol (2005) 2.12

Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. Brain Res Rev (2006) 1.96

Electrospray ionization and tandem mass spectrometry of eicosanoids. Anal Biochem (2005) 1.84

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry (2009) 1.64

Is aspirin useful in patients on lithium? A pharmacoepidemiological study related to bipolar disorder. Prostaglandins Leukot Essent Fatty Acids (2009) 1.54

A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res Brain Res Rev (1993) 1.51

Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. FASEB J (2006) 1.50

Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. Br J Pharmacol (2003) 1.50

Lithium neuroprotection: molecular mechanisms and clinical implications. Expert Rev Mol Med (2004) 1.44

Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. Am J Clin Nutr (2000) 1.43

A paradigm for gene regulation: inflammation, NF-kappaB and PPAR. Adv Exp Med Biol (2003) 1.39

Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. Prostaglandins Other Lipid Mediat (2005) 1.36

Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. J Neurochem (2004) 1.33

Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET. J Nucl Med (2008) 1.32

Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression. J Biol Chem (1991) 1.32

Bipolar disorder and mechanisms of action of mood stabilizers. Brain Res Rev (2009) 1.31

Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain. Neurochem Res (2005) 1.19

Formation of eicosanoids, E2/D2 isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain. J Lipid Res (2008) 1.16

Lithium improves HIV-associated neurocognitive impairment. AIDS (2006) 1.16

Group-specific assays that distinguish between the four major types of mammalian phospholipase A2. Anal Biochem (1999) 1.15

Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Mol Psychiatry (2009) 1.14

Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation. J Neurochem (2007) 1.13

Relation between free fatty acid and acyl-CoA concentrations in rat brain following decapitation. Neurochem Res (1997) 1.10

Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates. FASEB J (2009) 1.08

Lithium decreases turnover of arachidonate in several brain phospholipids. Neurosci Lett (1996) 1.06

Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease. J Alzheimers Dis (2009) 1.06

Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain. Mol Psychiatry (2002) 1.05

Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization. J Neurochem (2007) 1.05

Brain inflammatory response induced by intracerebroventricular infusion of lipopolysaccharide: an immunohistochemical study. Brain Res (1998) 1.05

In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism. J Pediatr (2003) 1.04

Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease. Adv Drug Deliv Rev (2002) 1.03

Search for a common mechanism of mood stabilizers. Biochem Pharmacol (2003) 1.02

Arachidonate release and eicosanoid generation by group IIE phospholipase A(2). Biochem Biophys Res Commun (2002) 1.00

Distribution of calcium-independent phospholipase A2 (iPLA 2) in monkey brain. J Neurocytol (2006) 0.98

Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6). J Biol Chem (2009) 0.96

Lipoxygenation of docosahexaenoic acid by the rat pineal body. J Neurochem (1994) 0.95

Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment. Neurochem Res (1999) 0.95

85 kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain. Neuroreport (1999) 0.95

Activation of a 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes by the anti-inflammatory agent ibuprofen. J Biol Chem (1984) 0.94

A small-gauge cannula device for continuous infusion of exogenous agents into the brain. Exp Neurol (1987) 0.90

Brain fixation for analysis of brain lipid-mediators of signal transduction and brain eicosanoids requires head-focused microwave irradiation: an historical perspective. Prostaglandins Other Lipid Mediat (2009) 0.89

IL-1beta and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1. Am J Physiol Regul Integr Comp Physiol (2006) 0.88

Chronic intracerebroventricular infusion of lipopolysaccharide: effects of ibuprofen treatment and behavioural and histopathological correlates. Behav Pharmacol (2005) 0.86

Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid. Lipids (2005) 0.85

EFFECTS OF BACTERIAL ENDOTOXIN ON WATER INTAKE, FOOD INTAKE, AND BODY TEMPERATURE IN THE ALBINO RAT. J Exp Med (1963) 0.85

The effects of valproate on the arachidonic acid metabolism of rat brain microvessels and of platelets. Eur J Pharmacol (2000) 0.82

The effect of chronic lithium on arachidonic acid release and metabolism in rat brain does not involve secretory phospholipase A2 or lipoxygenase/cytochrome P450 pathways. Brain Res Bull (2004) 0.82

Frequency of bipolar spectrum in 111 private practice depression outpatients. Eur Arch Psychiatry Clin Neurosci (2003) 0.81

Rat brain docosahexaenoic acid metabolism is not altered by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. Neurochem Int (2009) 0.80

Brain infusion of lipopolysaccharide increases uterine growth as a function of estrogen replacement regimen: suppression of uterine estrogen receptor-alpha by constant, but not pulsed, estrogen replacement. Endocrinology (2006) 0.80

5-Hydroxyeicosatetraenoic acid and human parturition. Prostaglandins (1996) 0.79

Articles by these authors

Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol (2010) 13.03

A comprehensive classification system for lipids. J Lipid Res (2005) 6.52

LMSD: LIPID MAPS structure database. Nucleic Acids Res (2006) 6.21

The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A (2003) 5.83

Electrospray mass spectrometry of phospholipids. Mass Spectrom Rev (2003) 4.18

Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res (2010) 4.14

Update of the LIPID MAPS comprehensive classification system for lipids. J Lipid Res (2008) 4.01

A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med (2011) 3.60

Sublimation as a method of matrix application for mass spectrometric imaging. J Am Soc Mass Spectrom (2007) 3.46

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood (2010) 3.35

Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies. Am J Psychiatry (2002) 3.20

Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res (2006) 2.85

Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. N Engl J Med (2010) 2.82

Para-inflammation in the aging retina. Prog Retin Eye Res (2009) 2.71

TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Cell (2009) 2.58

A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: final overall survival results and safety update. Eur J Cancer (2013) 2.51

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell (2012) 2.38

Cell population tracking and lineage construction with spatiotemporal context. Med Image Anal (2008) 2.26

Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell (2006) 2.26

Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J (2007) 2.20

A mouse macrophage lipidome. J Biol Chem (2010) 2.14

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med (2009) 2.12

Correcting motion artifacts in retinal spectral domain optical coherence tomography via image registration. Med Image Comput Comput Assist Interv (2009) 2.06

Improved tandem affinity purification tag and methods for isolation of protein heterocomplexes from plants. Plant J (2004) 1.99

Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis. Vaccine (2006) 1.97

Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood (2004) 1.95

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell (2007) 1.93

Electrospray ionization tandem mass spectrometry of glycerophosphoethanolamine plasmalogen phospholipids. J Am Soc Mass Spectrom (2004) 1.92

Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition (2010) 1.89

Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing. Mol Cell Biol (2008) 1.88

Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest (2010) 1.85

Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci U S A (2011) 1.85

Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med (2003) 1.85

Direct qualitative analysis of triacylglycerols by electrospray mass spectrometry using a linear ion trap. J Am Soc Mass Spectrom (2005) 1.78

Intravenously injected recombinant human type VII collagen homes to skin wounds and restores skin integrity of dystrophic epidermolysis bullosa. J Invest Dermatol (2013) 1.72

Automated mitosis detection of stem cell populations in phase-contrast microscopy images. IEEE Trans Med Imaging (2011) 1.71

Ligand-receptor binding revealed by the TNF family member TALL-1. Nature (2003) 1.70

Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency. Biol Psychiatry (2013) 1.67

TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection. Int Immunol (2003) 1.62

Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa. Nat Med (2004) 1.62

A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp Eye Res (2008) 1.61

Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry. J Lipid Res (2005) 1.61

Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation (2013) 1.60

Specificity of acyl-homoserine lactone synthases examined by mass spectrometry. J Bacteriol (2006) 1.57

Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression. J Invest Dermatol (2007) 1.57

Working towards an exegesis for lipids in biology. Nat Chem Biol (2009) 1.57

Is aspirin useful in patients on lithium? A pharmacoepidemiological study related to bipolar disorder. Prostaglandins Leukot Essent Fatty Acids (2009) 1.54

Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure. J Lipid Res (2007) 1.54

Amine-modified random primers to label probes for DNA microarrays. Nat Biotechnol (2002) 1.54

One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats. J Lipid Res (2005) 1.54

Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa. Mol Ther (2008) 1.54

Update on positron emission tomography for imaging of prostate cancer. Int J Urol (2013) 1.53

Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. J Lipid Res (2007) 1.48

Age-related cortical grey matter reductions in non-demented Down's syndrome adults determined by MRI with voxel-based morphometry. Brain (2004) 1.45

Progression of corpus callosum atrophy in Alzheimer disease. Arch Neurol (2002) 1.44

High prevalence of hepatitis B virus infection in multiple myeloma. Leuk Lymphoma (2011) 1.43

Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. J Neurochem (2004) 1.42

Protein-protein interactions of tandem affinity purification-tagged protein kinases in rice. Plant J (2006) 1.42

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest (2010) 1.42

Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol Rev (2006) 1.42

Blood pressure and early clinical outcome among acute ischemic stroke patients. Can J Neurol Sci (2011) 1.41

Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing. Mol Ther (2007) 1.41

Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231. Arch Neurol (2002) 1.41

Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: the role of P-type ATPases in transport and a broad specificity acyltransferase in acylation. J Biol Chem (2007) 1.39

A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol (2006) 1.38

Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A (2010) 1.37

Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone. J Invest Dermatol (2003) 1.37

Separation of cellular nonpolar neutral lipids by normal-phase chromatography and analysis by electrospray ionization mass spectrometry. J Lipid Res (2008) 1.37

Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. J Biol Chem (2010) 1.36

Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo. Mol Ther (2004) 1.36

Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol Aging (2002) 1.35

Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients. Neurobiol Dis (2009) 1.35

Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. J Biol Chem (2008) 1.33

Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. J Neurochem (2004) 1.33

Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET. J Nucl Med (2008) 1.32

Bipolar disorder and mechanisms of action of mood stabilizers. Brain Res Rev (2009) 1.31

Turnover of resident retinal microglia in the normal adult mouse. Glia (2007) 1.31

Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1. Arthritis Rheum (2010) 1.31

A novel class of microbial phosphocholine-specific phospholipases C. Mol Microbiol (2002) 1.30

Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair. J Mol Biol (2012) 1.30

Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB. Mol Biol Cell (2003) 1.29

MALDI imaging of lipid biochemistry in tissues by mass spectrometry. Chem Rev (2011) 1.29

Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. Biochim Biophys Acta (2006) 1.28

Qualitative analysis and quantitative assessment of changes in neutral glycerol lipid molecular species within cells. Methods Enzymol (2007) 1.28

Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition. J Mol Cell Cardiol (2009) 1.28

A rice kinase-protein interaction map. Plant Physiol (2008) 1.28

Regional network of magnetic resonance imaging gray matter volume in healthy aging. Neuroreport (2006) 1.27

Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats. Neuropsychopharmacology (2005) 1.26

Brain incorporation of 11C-arachidonic acid, blood volume, and blood flow in healthy aging: a study with partial-volume correction. J Nucl Med (2004) 1.25

Age-related networks of regional covariance in MRI gray matter: reproducible multivariate patterns in healthy aging. Neuroimage (2009) 1.23

Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. J Lipid Res (2007) 1.23

alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J Neurochem (2005) 1.23

Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation. J Neurochem (2011) 1.22

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation. Proc Natl Acad Sci U S A (2009) 1.20