Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch.

PubWeight™: 1.72‹?› | Rank: Top 3%

🔗 View Article (PMID 17526488)

Published in J Biol Chem on May 25, 2007

Authors

Daniel Panne1, Sarah M McWhirter, Tom Maniatis, Stephen C Harrison

Author Affiliations

1: Department of Biological Chemistry and Molecular Pharmacology, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Articles citing this

MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell (2011) 5.91

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal (2012) 3.59

Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol Cell (2009) 2.27

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation. Proc Natl Acad Sci U S A (2012) 1.40

Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response. PLoS Pathog (2016) 1.39

YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation. Nat Immunol (2017) 1.39

Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling. J Biol Chem (2008) 1.36

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation. Nat Struct Mol Biol (2013) 1.33

The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation. J Virol (2008) 1.24

Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol (2008) 1.19

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response. Cell Res (2011) 1.18

Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol (2008) 1.17

Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling. J Virol (2009) 1.08

Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7. Mol Cell Biol (2009) 1.03

Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3. J Mol Biol (2008) 1.00

Structural insights into interferon regulatory factor activation. Cell Signal (2009) 0.98

Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε. PLoS One (2012) 0.95

Activation of interferon regulatory factor 5 by site specific phosphorylation. PLoS One (2012) 0.94

Differential modification of interferon regulatory factor 3 following virus particle entry. J Virol (2009) 0.94

Interferon-regulatory factors determine macrophage phenotype polarization. Mediators Inflamm (2013) 0.93

Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes. Proc Natl Acad Sci U S A (2013) 0.92

The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin. J Immunol (2012) 0.91

Identification of caspase-mediated decay of interferon regulatory factor-3, exploited by a Kaposi sarcoma-associated herpesvirus immunoregulatory protein. J Biol Chem (2009) 0.91

Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation. J Biol Chem (2014) 0.90

Interferon regulatory factor 6 differentially regulates Toll-like receptor 2-dependent chemokine gene expression in epithelial cells. J Biol Chem (2014) 0.90

The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3. PLoS One (2011) 0.89

Different strains of Theiler's murine encephalomyelitis virus antagonize different sites in the type I interferon pathway. J Virol (2010) 0.87

Histone acetyltransferases as regulators of nonhistone proteins: the role of interferon regulatory factor acetylation on gene transcription. J Biomed Biotechnol (2010) 0.83

Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins. G3 (Bethesda) (2012) 0.83

The role of response elements organization in transcription factor selectivity: the IFN-β enhanceosome example. PLoS Comput Biol (2011) 0.82

Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery. J Virol (2012) 0.82

Dengue virus subverts the interferon induction pathway via NS2B/3 protease-IκB kinase epsilon interaction. Clin Vaccine Immunol (2013) 0.81

The IKK Kinases: Operators of Antiviral Signaling. Viruses (2010) 0.80

TLR4-mediated blunting of inflammatory responses to eccentric exercise in young women. Mediators Inflamm (2014) 0.79

Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3). J Biol Chem (2010) 0.79

The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases. Br J Pharmacol (2015) 0.78

A proteomics perspective on viral DNA sensors in host defense and viral immune evasion mechanisms. J Mol Biol (2015) 0.77

Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1). J Biol Chem (2013) 0.77

Two new monoclonal antibodies for biochemical and flow cytometric analyses of human interferon regulatory factor-3 activation, turnover, and depletion. Methods (2012) 0.77

Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc Natl Acad Sci U S A (2016) 0.76

cFLIPL Interrupts IRF3-CBP-DNA Interactions To Inhibit IRF3-Driven Transcription. J Immunol (2016) 0.75

Downregulation of c-Myc is involved in TLR3-mediated tumor death of neuroblastoma xenografts. Lab Invest (2016) 0.75

Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. J Virol (2016) 0.75

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β. Biochem J (2017) 0.75

ArfGAP domain containing protein 2 (ADAP2) integrates upstream and downstream modules of RIG-I signaling, and facilitates Type I interferon production. Mol Cell Biol (2016) 0.75

CXCL10 is produced in hepatitis A virus-infected cells in an IRF3-dependent but IFN-independent manner. Sci Rep (2017) 0.75

Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins. mSphere (2017) 0.75

Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate. J Dent Res (2017) 0.75

Articles by these authors

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67

X-ray structure of a protein-conducting channel. Nature (2003) 9.20

Structure of an unliganded simian immunodeficiency virus gp120 core. Nature (2005) 8.30

The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell (2007) 7.99

Structure of the dengue virus envelope protein after membrane fusion. Nature (2004) 7.97

A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc Natl Acad Sci U S A (2003) 7.76

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci (2007) 6.08

Crystal structure of glycoprotein B from herpes simplex virus 1. Science (2006) 5.57

Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature (2005) 5.44

Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proc Natl Acad Sci U S A (2008) 5.33

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science (2005) 4.97

The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol (2005) 4.81

The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat Struct Mol Biol (2006) 4.62

Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature (2004) 4.48

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci U S A (2003) 4.33

An atomic model of the interferon-beta enhanceosome. Cell (2007) 4.22

Structure and function of an essential component of the outer membrane protein assembly machine. Science (2007) 3.85

B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol (2012) 3.69

Structure of the human transferrin receptor-transferrin complex. Cell (2004) 3.64

Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J Virol (2005) 3.58

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc Natl Acad Sci U S A (2011) 3.51

Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature (2012) 3.37

XMAP215 is a processive microtubule polymerase. Cell (2008) 3.33

Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci U S A (2009) 3.19

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science (2007) 3.16

Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A (2004) 3.10

Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A (2005) 3.01

Beam-induced motion of vitrified specimen on holey carbon film. J Struct Biol (2012) 2.84

Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure (2012) 2.80

Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing. Mol Cell (2002) 2.78

RNA synthesis in a cage--structural studies of reovirus polymerase lambda3. Cell (2002) 2.74

Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A (2009) 2.65

Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature (2012) 2.52

Subunit interactions in bovine papillomavirus. Proc Natl Acad Sci U S A (2010) 2.51

Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Curr Opin Struct Biol (2011) 2.47

Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proc Natl Acad Sci U S A (2003) 2.42

The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. EMBO J (2002) 2.41

Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J Biol Chem (2003) 2.38

SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem (2005) 2.36

Single-particle kinetics of influenza virus membrane fusion. Proc Natl Acad Sci U S A (2008) 2.32

Multilevel regulation of gene expression by microRNAs. Science (2008) 2.28

Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A (2004) 2.28

Atomic model of the papillomavirus capsid. EMBO J (2002) 2.27

Structure of the reovirus membrane-penetration protein, Mu1, in a complex with is protector protein, Sigma3. Cell (2002) 2.24

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells. Nat Methods (2013) 2.22

Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol (2006) 2.17

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14

Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure (2008) 2.13

Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure (2005) 2.13

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. J Neurosci (2013) 2.08

Structural rearrangements in the membrane penetration protein of a non-enveloped virus. Nature (2004) 2.05

How does radiation damage in protein crystals depend on X-ray dose? Structure (2003) 2.01

Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J (2004) 2.01

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell (2002) 2.00

Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature (2011) 1.93

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep (2013) 1.92

Recognition of the centromere-specific histone Cse4 by the chaperone Scm3. Proc Natl Acad Sci U S A (2011) 1.87

Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proc Natl Acad Sci U S A (2005) 1.83

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion. Proc Natl Acad Sci U S A (2006) 1.83

Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature (2004) 1.81

Atomic model of an infectious rotavirus particle. EMBO J (2010) 1.79

Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure (2006) 1.76

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc Natl Acad Sci U S A (2002) 1.75

Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. Mol Cell (2005) 1.72

Induction of type I interferons by bacteria. Cell Microbiol (2010) 1.70

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A (2012) 1.70

Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila. PLoS Pathog (2009) 1.66

Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science (2009) 1.66

X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution. J Mol Biol (2010) 1.61

Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction. J Mol Biol (2007) 1.60

Stu2p binds tubulin and undergoes an open-to-closed conformational change. J Cell Biol (2006) 1.57

Identification of long-range regulatory elements in the protocadherin-alpha gene cluster. Proc Natl Acad Sci U S A (2006) 1.55

Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding. Structure (2007) 1.54

Connecting mitochondria and innate immunity. Cell (2005) 1.54

Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution. Structure (2005) 1.53

FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Rep (2012) 1.50

The active conformation of the PAK1 kinase domain. Structure (2005) 1.50

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A (2013) 1.49

The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell (2010) 1.48

Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell (2003) 1.48

CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Dev Cell (2010) 1.47

Stochastic expression of the interferon-β gene. PLoS Biol (2012) 1.47

Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol (2010) 1.46

Restraining the conformation of HIV-1 gp120 by removing a flexible loop. EMBO J (2006) 1.41

Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol (2014) 1.41

CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice. Proc Natl Acad Sci U S A (2012) 1.39

Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol (2005) 1.38

Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.35

Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLoS Pathog (2010) 1.35

Protein arms in the kinetochore-microtubule interface of the yeast DASH complex. Mol Biol Cell (2007) 1.35

Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain. J Virol (2006) 1.34

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A (2009) 1.33

Clustered protocadherins. Development (2013) 1.32

The role of ubiquitination in Drosophila innate immunity. J Biol Chem (2005) 1.32

Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. Elife (2013) 1.31

Peptides released from reovirus outer capsid form membrane pores that recruit virus particles. EMBO J (2008) 1.30