Published in Obes Facts on April 09, 2009
Structure and physiological actions of ghrelin. Scientifica (Cairo) (2013) 1.06
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors. J Biol Chem (2011) 1.01
Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem (2012) 0.97
Neural melanocortin receptors in obesity and related metabolic disorders. Biochim Biophys Acta (2013) 0.96
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nat Commun (2013) 0.90
Mathematical models for quantitative assessment of bioluminescence resonance energy transfer: application to seven transmembrane receptors oligomerization. Front Endocrinol (Lausanne) (2012) 0.89
Evolution of BRET Biosensors from Live Cell to Tissue-Scale In vivo Imaging. Front Endocrinol (Lausanne) (2013) 0.87
Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward. Front Neurosci (2013) 0.87
G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity. PLoS One (2013) 0.81
Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3). eNeuro (2015) 0.80
Biological Significance of GPCR Heteromerization in the Neuro-Endocrine System. Front Endocrinol (Lausanne) (2011) 0.78
Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling. Front Endocrinol (Lausanne) (2016) 0.75
Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83. PLoS One (2016) 0.75
Clarifying the Ghrelin System's Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand. Int J Mol Sci (2017) 0.75
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A (2002) 3.88
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J Exp Med (2010) 3.43
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet (2004) 2.98
Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes. Am J Hum Genet (2010) 2.98
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61
A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev (2006) 2.57
Childhood obesity. J Clin Endocrinol Metab (2004) 2.29
Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells. Immunity (2009) 2.17
Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet (2004) 2.17
Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency. J Clin Invest (2002) 2.09
Reversible photobleaching of enhanced green fluorescent proteins. Biochemistry (2005) 2.05
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. J Cell Biol (2002) 2.03
Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci (2005) 1.93
Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J Biol Chem (2002) 1.91
Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany. J Clin Endocrinol Metab (2006) 1.80
Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab (2003) 1.72
Mutations in TITF-1 are associated with benign hereditary chorea. Hum Mol Genet (2002) 1.69
Mutant G-protein-coupled receptors as a cause of human diseases. Pharmacol Ther (2004) 1.69
Differences in taste sensitivity between obese and non-obese children and adolescents. Arch Dis Child (2012) 1.65
Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem (2005) 1.61
Identification of PENDRIN (SLC26A4) mutations in patients with congenital hypothyroidism and "apparent" thyroid dysgenesis. J Clin Endocrinol Metab (2013) 1.61
Treating patients not numbers: the benefit and burden of lowering TSH newborn screening cut-offs. Arch Dis Child (2010) 1.53
Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study. Eur J Endocrinol (2010) 1.48
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun (2012) 1.48
TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. Cell Calcium (2003) 1.47
A role for beta-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab (2006) 1.46
Gender identity disorders in childhood and adolescence: currently debated concepts and treatment strategies. Dtsch Arztebl Int (2008) 1.43
Intraoperative lung edema monitoring by microwave reflectometry. Interact Cardiovasc Thorac Surg (2010) 1.39
Administration of perflutren contrast agents during transthoracic echocardiography is not associated with a significant increase in acute mortality risk. Cardiology (2012) 1.38
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J Biol Chem (2004) 1.33
Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP. J Biol Chem (2008) 1.29
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. J Biol Chem (2006) 1.28
TRPV1 acts as proton channel to induce acidification in nociceptive neurons. J Biol Chem (2004) 1.28
Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups. Eur J Endocrinol (2004) 1.28
European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. J Clin Endocrinol Metab (2014) 1.26
Screening for mutations in transcription factors in a Czech cohort of 170 patients with congenital and early-onset hypothyroidism: identification of a novel PAX8 mutation in dominantly inherited early-onset non-autoimmune hypothyroidism. Eur J Endocrinol (2007) 1.26
Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers. J Biol Chem (2004) 1.26
The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency. Eur J Endocrinol (2009) 1.23
Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish. J Comp Neurol (2004) 1.22
Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Mol Cell Endocrinol (2006) 1.22
Potentiation of TRPC5 by protons. J Biol Chem (2007) 1.22
Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival. J Physiol (2011) 1.22
Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. FEBS Lett (2003) 1.21
Ca2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells. J Cell Biol (2002) 1.19
Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8. Eur J Endocrinol (2005) 1.19
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet (2009) 1.18
Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency. Hum Mutat (2008) 1.18
TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine. J Biol Chem (2007) 1.15
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. J Cell Sci (2009) 1.14
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proc Natl Acad Sci U S A (2009) 1.13
HESX1 mutations are an uncommon cause of septooptic dysplasia and hypopituitarism. J Clin Endocrinol Metab (2006) 1.12
Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology (2005) 1.11
Receptor-operated cation channels formed by TRPC4 and TRPC5. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.10
The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J (2006) 1.09
Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells. FASEB J (2006) 1.09
Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity (Silver Spring) (2008) 1.07
An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity. PLoS Genet (2012) 1.07
FRET-based analysis of TRPC subunit stoichiometry. Cell Calcium (2003) 1.06
Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus. PLoS One (2010) 1.04
Protein-protein recognition and interaction hot spots in an antigen-antibody complex: free energy decomposition identifies "efficient amino acids". Proteins (2007) 1.03
Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. Hum Mol Genet (2008) 1.03
PKCalpha: a versatile key for decoding the cellular calcium toolkit. J Cell Biol (2006) 1.01
The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho. J Cell Sci (2003) 1.01
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors. J Biol Chem (2011) 1.01
Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma. J Biol Chem (2004) 1.00
Theoretical evaluation of pK(a) in phosphoranes: implications for phosphate ester hydrolysis. J Am Chem Soc (2002) 1.00
Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans? Brain Res (2009) 0.99
Fatal neonatal respiratory failure in an infant with congenital hypothyroidism due to haploinsufficiency of the NKX2-1 gene: alteration of pulmonary surfactant homeostasis. Arch Dis Child Fetal Neonatal Ed (2010) 0.99
Distinct brain networks in recognition memory share a defined region in the precuneus. Eur J Neurosci (2009) 0.99
Arteries define the position of the thyroid gland during its developmental relocalisation. Development (2006) 0.98
Novel insights on thyroid-stimulating hormone receptor signal transduction. Endocr Rev (2013) 0.97
Fluorescence resonance energy transfer analysis reveals the existence of endothelin-A and endothelin-B receptor homodimers. J Cardiovasc Pharmacol (2004) 0.97
Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes (2013) 0.97
Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction. Cell Calcium (2012) 0.97
Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C. Mol Pain (2007) 0.97
Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication. Oncotarget (2014) 0.96
European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. Horm Res Paediatr (2014) 0.95
Detection and treatment of congenital hypothyroidism. Nat Rev Endocrinol (2011) 0.95
Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. PLoS Pathog (2009) 0.95
Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress. Cell Calcium (2008) 0.95
Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology (2007) 0.94
Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent. J Mol Endocrinol (2009) 0.93
Septo-optic dysplasia associated with a new mitochondrial cytochrome b mutation. Ann Neurol (2002) 0.93