Published in J Biol Chem on January 08, 2008
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci (2009) 1.65
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A (2010) 1.47
Physiological functions of APP family proteins. Cold Spring Harb Perspect Med (2012) 1.44
Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers. J Biol Chem (2009) 1.25
Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif. J Biol Chem (2010) 1.21
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J (2011) 1.10
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation. Nat Commun (2012) 1.07
Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc Natl Acad Sci U S A (2010) 1.06
Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease. J Neurosci (2012) 0.90
Homodimerization of amyloid precursor protein at the plasma membrane: a homoFRET study by time-resolved fluorescence anisotropy imaging. PLoS One (2012) 0.90
What is the role of amyloid precursor protein dimerization? Cell Adh Migr (2010) 0.90
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases. J Biol Chem (2010) 0.88
The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). J Biol Chem (2011) 0.87
Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. Am J Neurodegener Dis (2012) 0.87
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cell Mol Life Sci (2011) 0.86
Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease. Neurobiol Aging (2013) 0.86
N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production. J Neurochem (2011) 0.86
Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology. Front Aging Neurosci (2014) 0.85
Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. J Biol Chem (2011) 0.85
Structural aspects and physiological consequences of APP/APLP trans-dimerization. Exp Brain Res (2011) 0.84
An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry (2009) 0.84
Application of consensus scoring and principal component analysis for virtual screening against β-secretase (BACE-1). PLoS One (2012) 0.84
Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development. PLoS One (2012) 0.82
Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One (2012) 0.81
Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization. J Biol Chem (2015) 0.81
Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides. J Alzheimers Dis (2011) 0.81
The beta amyloid peptide can act as a modular aggregation domain. Neurobiol Dis (2008) 0.80
Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants. Am J Neurodegener Dis (2013) 0.78
Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing. FEBS Open Bio (2015) 0.78
Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ. Biochemistry (2016) 0.77
Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes. Acta Crystallogr D Biol Crystallogr (2015) 0.76
Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease. J Neurosci Res (2016) 0.76
APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci (2017) 0.75
Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments. Front Mol Neurosci (2017) 0.75
Palmitoylated APP Forms Dimers, Cleaved by BACE1. PLoS One (2016) 0.75
LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Front Mol Neurosci (2017) 0.75
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A (2002) 3.88
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell (2003) 3.47
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J Exp Med (2010) 3.43
Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes. Am J Hum Genet (2010) 2.98
De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy. Proc Natl Acad Sci U S A (2002) 2.66
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61
A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev (2006) 2.57
The signal flow and motor response controling chemotaxis of sea urchin sperm. Nat Cell Biol (2003) 2.24
Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells. Immunity (2009) 2.17
Reversible photobleaching of enhanced green fluorescent proteins. Biochemistry (2005) 2.05
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. J Cell Biol (2002) 2.03
Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci (2005) 1.93
Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J Biol Chem (2002) 1.91
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc Natl Acad Sci U S A (2004) 1.83
Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell (2013) 1.83
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J (2011) 1.80
Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences. Nat Protoc (2007) 1.73
The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol (2010) 1.71
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade. J Neurochem (2004) 1.68
Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem (2005) 1.61
Ultrahigh resolution in proton solid-state NMR spectroscopy at high levels of deuteration. Angew Chem Int Ed Engl (2006) 1.58
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol (2004) 1.56
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol (2011) 1.54
Two-dimensional proteome reference map of Prototheca zopfii revealed reduced metabolism and enhanced signal transduction as adaptation to an infectious life style. Proteomics (2013) 1.54
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. J Am Soc Nephrol (2006) 1.50
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun (2012) 1.48
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A (2010) 1.47
TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. Cell Calcium (2003) 1.47
WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Sci (2003) 1.46
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice. Proc Natl Acad Sci U S A (2003) 1.46
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43
Intraoperative lung edema monitoring by microwave reflectometry. Interact Cardiovasc Thorac Surg (2010) 1.39
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem (2004) 1.39
Administration of perflutren contrast agents during transthoracic echocardiography is not associated with a significant increase in acute mortality risk. Cardiology (2012) 1.38
Solid-state NMR of proteins sedimented by ultracentrifugation. Proc Natl Acad Sci U S A (2011) 1.38
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem (2003) 1.38
Proton-detected solid-state NMR spectroscopy of fibrillar and membrane proteins. Angew Chem Int Ed Engl (2011) 1.36
Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity. J Neurosci (2009) 1.34
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J Biol Chem (2004) 1.33
Characterization of chemical exchange between soluble and aggregated states of beta-amyloid by solution-state NMR upon variation of salt conditions. Biochemistry (2005) 1.32
Synthesis of biologically active peptide nucleic acid-peptide conjugates by sortase-mediated ligation. J Org Chem (2007) 1.32
A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Mol Cell Biol (2006) 1.30
Determination of multiple torsion-angle constraints in U-(13)C,(15)N-labeled peptides: 3D (1)H-(15)N-(13)C-(1)H dipolar chemical shift NMR spectroscopy in rotating solids. J Am Chem Soc (2002) 1.30
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev (2013) 1.29
Structure calculation from unambiguous long-range amide and methyl 1H-1H distance restraints for a microcrystalline protein with MAS solid-state NMR spectroscopy. J Am Chem Soc (2011) 1.29
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. J Biol Chem (2006) 1.28
Characterization of membrane proteins in isolated native cellular membranes by dynamic nuclear polarization solid-state NMR spectroscopy without purification and reconstitution. Angew Chem Int Ed Engl (2011) 1.28
TRPV1 acts as proton channel to induce acidification in nociceptive neurons. J Biol Chem (2004) 1.28
Large protein complexes with extreme rotational correlation times investigated in solution by magic-angle-spinning NMR spectroscopy. J Am Chem Soc (2009) 1.28
G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. J Biol Chem (2008) 1.28
Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers. J Biol Chem (2004) 1.26
Ca2+ spikes in the flagellum control chemotactic behavior of sperm. EMBO J (2005) 1.25
Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish. J Comp Neurol (2004) 1.22
Direct binding of INHAT to H3 tails disrupted by modifications. J Biol Chem (2004) 1.22
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. J Biol Chem (2010) 1.22
Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Mol Cell Endocrinol (2006) 1.22
Sensitivity enhancement using paramagnetic relaxation in MAS solid-state NMR of perdeuterated proteins. J Magn Reson (2007) 1.22
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J Neural Transm (Vienna) (2009) 1.22
Potentiation of TRPC5 by protons. J Biol Chem (2007) 1.22
Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival. J Physiol (2011) 1.22
Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. FEBS Lett (2003) 1.21
Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif. J Biol Chem (2010) 1.21
Ca2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells. J Cell Biol (2002) 1.19
Dependence of ORC silencing function on NatA-mediated Nalpha acetylation in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.19
Characterization of new members of the group 3 outer membrane protein family of Brucella spp. Infect Immun (2003) 1.19
Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev (2012) 1.19
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem (2010) 1.18
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease. Acta Neuropathol (2006) 1.16
Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers. J Mol Biol (2012) 1.16
Wavelength-selective photoactivatable protecting groups for thiols. J Am Chem Soc (2009) 1.15
TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine. J Biol Chem (2007) 1.15
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. J Cell Sci (2009) 1.14
Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. Nucleic Acids Res (2006) 1.14
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. J Lipid Res (2002) 1.13
Protein side-chain dynamics as observed by solution- and solid-state NMR spectroscopy: a similarity revealed. J Am Chem Soc (2008) 1.13
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proc Natl Acad Sci U S A (2009) 1.13
1H detection in MAS solid-state NMR spectroscopy of biomacromolecules employing pulsed field gradients for residual solvent suppression. J Am Chem Soc (2003) 1.12
Immobilization reduces the activity of surface-bound cationic antimicrobial peptides with no influence upon the activity spectrum. Antimicrob Agents Chemother (2008) 1.12
Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology (2005) 1.11
The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide. J Biol Chem (2006) 1.11
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice. Brain Pathol (2002) 1.11