Published in J Biol Chem on November 26, 2002
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47
Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J (2008) 2.31
Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol (2004) 2.03
TRPC channel activation by extracellular thioredoxin. Nature (2008) 1.97
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (2004) 1.91
TRP channels and lipids: from Drosophila to mammalian physiology. J Physiol (2006) 1.90
Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol (2005) 1.72
Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal (2010) 1.70
Multiple roles of calmodulin and other Ca(2+)-binding proteins in the functional regulation of TRP channels. Pflugers Arch (2005) 1.68
Human TRPC5 channel activated by a multiplicity of signals in a single cell. J Physiol (2004) 1.63
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells. Eur J Neurosci (2006) 1.52
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons. J Neurosci (2009) 1.48
Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife (2016) 1.42
Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS One (2007) 1.41
The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch (2005) 1.40
TRPC3 properties of a native constitutively active Ca2+-permeable cation channel in rabbit ear artery myocytes. J Physiol (2006) 1.36
TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels. J Biol Chem (2009) 1.27
Twenty odd years of stretch-sensitive channels. Pflugers Arch (2006) 1.26
Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels. Pflugers Arch (2008) 1.26
Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate. Cell Calcium (2007) 1.25
Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch (2005) 1.17
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem (2011) 1.16
Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.15
Balancing calcium signals through TRPC5 and TRPC6 in podocytes. J Am Soc Nephrol (2011) 1.11
Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol (2008) 1.10
Receptor-operated cation channels formed by TRPC4 and TRPC5. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.10
In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold? Br J Pharmacol (2013) 1.06
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species. Am J Physiol Renal Physiol (2011) 1.04
Pharmacological profile of store-operated channels in cerebral arteriolar smooth muscle cells. Br J Pharmacol (2003) 1.03
Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli. Kidney Int (2014) 1.03
TRPC channels in smooth muscle cells. Front Biosci (Landmark Ed) (2010) 1.00
Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proc Natl Acad Sci U S A (2012) 1.00
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. J Physiol (2005) 0.99
N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. J Biol Chem (2012) 0.97
TRPC5 channels undergo changes in gating properties during the activation-deactivation cycle. J Cell Physiol (2008) 0.96
Mitochondrial calcium buffering contributes to the maintenance of Basal calcium levels in mouse taste cells. J Neurophysiol (2008) 0.95
Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2. J Biol Chem (2008) 0.95
Regulation of TRPM2 channels in neutrophil granulocytes by ADP-ribose: a promising pharmacological target. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.93
TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild-type and TRPC1-/- mice. FASEB J (2011) 0.93
Cholecystokinin facilitates neuronal excitability in the entorhinal cortex via activation of TRPC-like channels. J Neurophysiol (2011) 0.93
Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+). Biochem Biophys Res Commun (2010) 0.93
Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases. Br J Pharmacol (2010) 0.89
Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A (2012) 0.89
Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats. J Neurochem (2011) 0.87
Homer regulates calcium signalling in growth cone turning. Neural Dev (2009) 0.87
Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels. Antioxid Redox Signal (2011) 0.86
Permeation, regulation and control of expression of TRP channels by trace metal ions. Pflugers Arch (2014) 0.85
Hyperforin activates nonselective cation channels (NSCCs). Br J Pharmacol (2005) 0.84
Muscarinic receptor-activated cationic channels in murine ileal myocytes. Br J Pharmacol (2006) 0.84
Channel regulation by extracellular redox protein. Channels (Austin) (2008) 0.84
Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics. Eur Biophys J (2016) 0.84
Calcium signaling in taste cells: regulation required. Chem Senses (2010) 0.83
Molecular substrates mediating lanthanide-evoked neurotransmitter release in central synapses. J Neurophysiol (2008) 0.83
Conserved gating elements in TRPC4 and TRPC5 channels. J Biol Chem (2013) 0.82
Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflugers Arch (2010) 0.82
Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes. Br J Pharmacol (2010) 0.82
TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nat Commun (2016) 0.81
Extracellular disulfide bridges stabilize TRPC5 dimerization, trafficking, and activity. Pflugers Arch (2014) 0.81
Riluzole activates TRPC5 channels independently of PLC activity. Br J Pharmacol (2014) 0.81
Modulation of TRPC5 cation channels by halothane, chloroform and propofol. Br J Pharmacol (2008) 0.81
G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels. Pflugers Arch (2013) 0.81
Transient receptor potential channel C5 in cancer chemoresistance. Acta Pharmacol Sin (2015) 0.80
The role of canonical transient receptor potential channels in seizure and excitotoxicity. Cells (2014) 0.80
Natural and synthetic flavonoid modulation of TRPC5 channels. Br J Pharmacol (2016) 0.78
Plasma membrane mechanical stress activates TRPC5 channels. PLoS One (2015) 0.78
GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels. Cell Calcium (2011) 0.78
Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes. J Am Soc Nephrol (2016) 0.78
Mechanisms and roles of muscarinic activation in guinea-pig adrenal medullary cells. Am J Physiol Cell Physiol (2012) 0.77
Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease. Brain (2015) 0.76
Canonical transient receptor potential 4 and its small molecule modulators. Sci China Life Sci (2014) 0.75
Redox Regulation of Transient Receptor Potential Channels in the Endothelium. Microcirculation (2016) 0.75
Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment. Annu Rev Chem Biomol Eng (2016) 0.75
Determining the functional role of TRPC channels in primary cells. Pflugers Arch (2005) 0.75
20-Hydroxyeicosatetraenoic Acid (20-HETE) Modulates Canonical Transient Receptor Potential-6 (TRPC6) Channels in Podocytes. Front Physiol (2016) 0.75
Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol. Proc Natl Acad Sci U S A (2016) 0.75
Molecular Determinants of the Sensitivity to Gq/11-phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel. J Biol Chem (2016) 0.75
Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A (2002) 3.88
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J Exp Med (2010) 3.43
Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes. Am J Hum Genet (2010) 2.98
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61
A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev (2006) 2.57
Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells. Immunity (2009) 2.17
Reversible photobleaching of enhanced green fluorescent proteins. Biochemistry (2005) 2.05
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. J Cell Biol (2002) 2.03
Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci (2005) 1.93
TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. Am J Physiol Cell Physiol (2002) 1.90
Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem (2005) 1.61
Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem (2003) 1.60
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun (2012) 1.48
TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. Cell Calcium (2003) 1.47
Intraoperative lung edema monitoring by microwave reflectometry. Interact Cardiovasc Thorac Surg (2010) 1.39
Administration of perflutren contrast agents during transthoracic echocardiography is not associated with a significant increase in acute mortality risk. Cardiology (2012) 1.38
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J Biol Chem (2004) 1.33
Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons. Mol Cell Biol (2011) 1.33
Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP. J Biol Chem (2008) 1.29
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. J Biol Chem (2006) 1.28
TRPV1 acts as proton channel to induce acidification in nociceptive neurons. J Biol Chem (2004) 1.28
Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers. J Biol Chem (2004) 1.26
Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish. J Comp Neurol (2004) 1.22
Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Mol Cell Endocrinol (2006) 1.22
Potentiation of TRPC5 by protons. J Biol Chem (2007) 1.22
Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival. J Physiol (2011) 1.22
Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. FEBS Lett (2003) 1.21
Ca2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells. J Cell Biol (2002) 1.19
TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine. J Biol Chem (2007) 1.15
Positive selection in East Asians for an EDAR allele that enhances NF-kappaB activation. PLoS One (2008) 1.14
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. J Cell Sci (2009) 1.14
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proc Natl Acad Sci U S A (2009) 1.13
Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology (2005) 1.11
Receptor-operated cation channels formed by TRPC4 and TRPC5. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.10
The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J (2006) 1.09
Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells. FASEB J (2006) 1.09
FRET-based analysis of TRPC subunit stoichiometry. Cell Calcium (2003) 1.06
Functional differences between TRPC4 splice variants. J Biol Chem (2001) 1.05
Protein-protein recognition and interaction hot spots in an antigen-antibody complex: free energy decomposition identifies "efficient amino acids". Proteins (2007) 1.03
PKCalpha: a versatile key for decoding the cellular calcium toolkit. J Cell Biol (2006) 1.01
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors. J Biol Chem (2011) 1.01
The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho. J Cell Sci (2003) 1.01
Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma. J Biol Chem (2004) 1.00
Theoretical evaluation of pK(a) in phosphoranes: implications for phosphate ester hydrolysis. J Am Chem Soc (2002) 1.00
Distinct brain networks in recognition memory share a defined region in the precuneus. Eur J Neurosci (2009) 0.99
Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4. PLoS One (2010) 0.98
Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C. Mol Pain (2007) 0.97
Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction. Cell Calcium (2012) 0.97
Fluorescence resonance energy transfer analysis reveals the existence of endothelin-A and endothelin-B receptor homodimers. J Cardiovasc Pharmacol (2004) 0.97
Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication. Oncotarget (2014) 0.96
Parallel selection on TRPV6 in human populations. PLoS One (2008) 0.95
Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. PLoS Pathog (2009) 0.95
Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress. Cell Calcium (2008) 0.95
Spino-dendritic cross-talk in rodent Purkinje neurons mediated by endogenous Ca2+-binding proteins. J Physiol (2007) 0.94
Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. Mol Pharmacol (2013) 0.92
P2X7 receptors at adult neural progenitor cells of the mouse subventricular zone. Neuropharmacology (2013) 0.92
V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis. Am J Physiol Renal Physiol (2008) 0.91
Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. J Biol Chem (2011) 0.90
Comparative analysis of procoagulatory activity of haemodialysis, haemofiltration and haemodiafiltration with a polysulfone membrane (APS) and with different modes of enoxaparin anticoagulation. Nephrol Dial Transplant (2004) 0.90
Heterodimerization of hypothalamic G-protein-coupled receptors involved in weight regulation. Obes Facts (2009) 0.88
The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity. J Biol Chem (2008) 0.87
Proline-rich sequence recognition: I. Marking GYF and WW domain assembly sites in early spliceosomal complexes. Mol Cell Proteomics (2009) 0.87
Real-time analysis of phospholipase C activity during different patterns of receptor-induced Ca2+ responses in HEK293 cells. Cell Calcium (2004) 0.85
MC4R oligomerizes independently of extracellular cysteine residues. Peptides (2005) 0.85
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers. EMBO Mol Med (2012) 0.84
Cross-inhibition between native and recombinant TRPV1 and P2X(3) receptors. Pain (2009) 0.84
A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4R. Obes Facts (2008) 0.83
Celsior versus custodiol: early postischemic recovery after cardioplegia and ischemia at 5 degrees C. Ann Thorac Surg (2002) 0.83
Structure activity relationship by NMR and by computer: a comparative study. J Am Chem Soc (2002) 0.82
Requirement of an intermediate gene expression for biphasic ERK1/2 activation in thrombin-stimulated vascular smooth muscle cells. J Biol Chem (2008) 0.82
A triglyceride/high-density lipoprotein ratio > or = 3.5 is associated with an increased burden of coronary artery disease on cardiac catheterization. J Cardiometab Syndr (2006) 0.82
Riluzole activates TRPC5 channels independently of PLC activity. Br J Pharmacol (2014) 0.81
Luciferase activity under direct ligand-dependent control of a muscarinic acetylcholine receptor. BMC Biotechnol (2009) 0.81
Cellular copper import by nanocarrier systems, intracellular availability, and effects on amyloid beta peptide secretion. Biochemistry (2009) 0.80
Relative strength of relationships of nasal congestion and ocular symptoms with sleep, mood and productivity. Curr Med Res Opin (2009) 0.80
TRPA1 is functionally expressed in melanoma cells but is not critical for impaired proliferation caused by allyl isothiocyanate or cinnamaldehyde. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.79
Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat. J Comp Neurol (2009) 0.79
Inflammatory cytokines increase extracellular procathepsin D in permanent and primary endothelial cell cultures. Eur J Cell Biol (2008) 0.79
Convolution-based one and two component FRAP analysis: theory and application. Eur Biophys J (2009) 0.79
Surface expression of gpA33 is dependent on culture density and cell-cycle phase and is regulated by intracellular traffic rather than gene transcription. Cancer Biother Radiopharm (2008) 0.78
Biliary-type cytokeratin pattern in a canine isolated perfused liver transplantation model. J Surg Res (2007) 0.78
Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling. Mol Membr Biol (2009) 0.78
LI-cadherin cis-dimerizes in the plasma membrane Ca(2+) independently and forms highly dynamic trans-contacts. Cell Mol Life Sci (2012) 0.77
Hemoglobin Bohr effects: atomic origin of the histidine residue contributions. Biochemistry (2013) 0.77
HaCaT keratinocytes exhibit a cholesterol and plasma membrane viscosity gradient during directed migration. Exp Cell Res (2012) 0.77
Apomorphine is a bimodal modulator of TRPA1 channels. Mol Pharmacol (2012) 0.77
Natural compounds with P2X7 receptor-modulating properties. Purinergic Signal (2013) 0.77
Localization of the human female breast in primary somatosensory cortex. Exp Brain Res (2005) 0.76
Primidone inhibits TRPM3 and attenuates thermal nociception in vivo. Pain (2017) 0.75
The role of opioid analgesics in rheumatoid disease in the elderly population. Drugs Aging (2003) 0.75
Belief in a just world is associated with activity in insula and somatosensory cortices as a response to the perception of norm violations. Soc Neurosci (2014) 0.75
Towards an integrated device that utilizes adherent cells in a micro-free-flow electrophoresis chip to achieve separation and biosensing. Anal Bioanal Chem (2013) 0.75
A ZnO nanowire bio-hybrid solar cell. Nanotechnology (2016) 0.75
Endocytosis and intracellular trafficking of fatty acid esters of phenylaminopropanediol, the putative etiologic agents of the toxic oil syndrome (TOS). Toxicol Lett (2005) 0.75