Published in Int J Mol Sci on November 20, 2009
The genome of Theobroma cacao. Nat Genet (2010) 3.47
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Cocoa polyphenols and inflammatory markers of cardiovascular disease. Nutrients (2014) 1.12
Cocoa polyphenols and their potential benefits for human health. Oxid Med Cell Longev (2012) 0.94
Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. Int J Mol Sci (2010) 0.93
Cocoa Consumption Alters the Global DNA Methylation of Peripheral Leukocytes in Humans with Cardiovascular Disease Risk Factors: A Randomized Controlled Trial. PLoS One (2013) 0.84
The Possible Role of Flavonoids in the Prevention of Diabetic Complications. Nutrients (2016) 0.81
Database survey of anti-inflammatory plants in South America: a review. Int J Mol Sci (2011) 0.79
Epicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiation. PLoS One (2014) 0.78
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Epigenetic associations in relation to cardiovascular prevention and therapeutics. Clin Epigenetics (2016) 0.77
Cocoa polyphenols and fiber modify colonic gene expression in rats. Eur J Nutr (2016) 0.76
Cocoa and Dark Chocolate Polyphenols: From Biology to Clinical Applications. Front Immunol (2017) 0.76
Chocolate: (un)healthy source of polyphenols? Genes Nutr (2010) 0.75
Cluster analysis of polyphenol intake in a French middle-aged population (aged 35-64 years). J Nutr Sci (2016) 0.75
NMR protocol for determination of oxidation susceptibility of serum lipids and application of the protocol to a chocolate study. Metabolomics (2011) 0.75
Polyphenols from Root, Tubercles and Grains Cropped in Brazil: Chemical and Nutritional Characterization and Their Effects on Human Health and Diseases. Nutrients (2017) 0.75
The Cardiovascular Effects of Cocoa Polyphenols-An Overview. Diseases (2016) 0.75
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet (1993) 6.53
The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med (2001) 6.37
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr (2008) 3.84
Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr (2005) 3.66
Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension (2005) 3.26
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A (2006) 3.03
Antioxidants in chocolate. Lancet (1996) 3.02
Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr (2007) 2.88
Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep (2009) 2.79
Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA (2007) 2.70
Plasma antioxidants from chocolate. Nature (2003) 2.69
Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens (2003) 2.54
Cocoa and cardiovascular health. Circulation (2009) 2.29
Inhibition of LDL oxidation by cocoa. Lancet (1996) 2.16
Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol (2008) 2.12
Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am J Clin Nutr (2001) 2.10
Chocolate and blood pressure in elderly individuals with isolated systolic hypertension. JAMA (2003) 1.92
Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study. Arch Intern Med (2006) 1.86
Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status. J Nutr (2000) 1.83
Dark chocolate improves coronary vasomotion and reduces platelet reactivity. Circulation (2007) 1.83
Aging and vascular responses to flavanol-rich cocoa. J Hypertens (2006) 1.77
Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr (2008) 1.71
Cocoa and chocolate flavonoids: implications for cardiovascular health. J Am Diet Assoc (2003) 1.70
Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr (2007) 1.66
Vascular effects of cocoa rich in flavan-3-ols. JAMA (2003) 1.63
Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. Cardiovasc Res (2008) 1.44
Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am J Clin Nutr (2008) 1.44
Cocoa inhibits platelet activation and function. Am J Clin Nutr (2000) 1.42
Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. J Am Coll Cardiol (2005) 1.36
Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radic Biol Med (2004) 1.36
Cocoa and health: a decade of research. Br J Nutr (2007) 1.30
Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am J Clin Nutr (2003) 1.25
Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr (2002) 1.24
Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography/mass spectrometry. J Agric Food Chem (1999) 1.24
Comparison of the antioxidant activity of commonly consumed polyphenolic beverages (coffee, cocoa, and tea) prepared per cup serving. J Agric Food Chem (2001) 1.23
Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study. Clin Sci (Lond) (2006) 1.22
Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr (2000) 1.19
Flavonoids, vascular function and cardiovascular protection. Curr Pharm Des (2009) 1.16
Dark chocolate improves endothelial and platelet function. Heart (2006) 1.15
Chocolate consumption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program. J Intern Med (2009) 1.14
Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo. Arch Biochem Biophys (2008) 1.11
Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects. Int J Obes (Lond) (2008) 1.08
Salt and high blood pressure. Clin Sci (Lond) (2009) 1.08
Chocolate consumption and platelet function. JAMA (2002) 1.06
Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. Am J Clin Nutr (2007) 1.05
Cocoa: antioxidant and immunomodulator. Br J Nutr (2009) 1.04
Plasma kinetics in man of epicatechin from black chocolate. Eur J Clin Nutr (1999) 1.04
Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans. J Nutr (2002) 0.99
Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women. J Cardiovasc Pharmacol (2006) 0.99
Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J (2003) 0.98
Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week. J Cardiovasc Pharmacol (2007) 0.97
Sulfation of genistein alters its antioxidant properties and its effect on platelet aggregation and monocyte and endothelial function. Biochim Biophys Acta (2004) 0.97
A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage. J Nutr (2000) 0.97
Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-kappaB-dependent gene expression in RAW 264.7 macrophages. FEBS Lett (2000) 0.96
Effect of dark chocolate on arterial function in healthy individuals. Am J Hypertens (2005) 0.96
Flavonoids from Theobroma cacao down-regulate inflammatory mediators. J Agric Food Chem (2005) 0.96
Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects. Phytochemistry (2002) 0.95
Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers. Free Radic Res (2000) 0.94
Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process. J Agric Food Chem (2008) 0.94
Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers. Free Radic Res (2001) 0.94
Influence of oligomer chain length on the antioxidant activity of procyanidins. Biochem Biophys Res Commun (2000) 0.94
Modulation of TNF-alpha secretion in peripheral blood mononuclear cells by cocoa flavanols and procyanidins. Dev Immunol (2002) 0.93
Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in humans. Free Radic Biol Med (2004) 0.93
Effect of circulating forms of soy isoflavones on the oxidation of low density lipoprotein. Free Radic Res (2004) 0.91
Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase. Biol Chem (2001) 0.91
Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells. Exp Biol Med (Maywood) (2007) 0.91
Chocolate, lifestyle, and health. Crit Rev Food Sci Nutr (2009) 0.90
Cocoa, chocolate, and cardiovascular disease. J Cardiovasc Pharmacol (2009) 0.90
Food effects on the absorption and pharmacokinetics of cocoa flavanols. Life Sci (2003) 0.90
Cocoa procyanidins and human cytokine transcription and secretion. J Nutr (2000) 0.89
Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase. J Nutr (2002) 0.89
Phenol antioxidant quantity and quality in foods: cocoa, dark chocolate, and milk chocolate. J Agric Food Chem (1999) 0.88
Chocolate is a powerful ex vivo and in vivo antioxidant, an antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American Diets. J Agric Food Chem (2006) 0.88
Dark chocolate inhibits platelet aggregation in healthy volunteers. Platelets (2003) 0.88
Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats. J Agric Food Chem (2008) 0.88
Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am J Clin Nutr (2009) 0.87
Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. Am J Clin Nutr (2001) 0.87
Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits. J Atheroscler Thromb (2005) 0.86
Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins. FEBS Lett (2003) 0.86
Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. Exp Biol Med (Maywood) (2002) 0.85
Cocoa, diabetes, and hypertension: should we eat more chocolate? Am J Clin Nutr (2005) 0.85
Effect of Theobroma cacao flavonoids on immune activation of a lymphoid cell line. Br J Nutr (2005) 0.84
The effect of cocoa procyanidins on the transcription and secretion of interleukin 1 beta in peripheral blood mononuclear cells. Life Sci (2000) 0.84
Milk does not affect the bioavailability of cocoa powder flavonoid in healthy human. Ann Nutr Metab (2007) 0.84
Inhibitory effects of cocoa flavanols and procyanidin oligomers on free radical-induced erythrocyte hemolysis. Exp Biol Med (Maywood) (2002) 0.83
(+)-Catechin is more bioavailable than (-)-catechin: relevance to the bioavailability of catechin from cocoa. Free Radic Res (2006) 0.83
The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function. Thromb Res (2002) 0.83
Cocoa and wine polyphenols modulate platelet activation and function. J Nutr (2000) 0.82
Flavanol-rich cocoa: a cardioprotective nutraceutical. Cardiol Rev (2008) 0.82
Effect of cocoa flavanols and their related oligomers on the secretion of interleukin-5 in peripheral blood mononuclear cells. J Med Food (2002) 0.80
Assessing bioflavonoids as regulators of NF-kappa B activity and inflammatory gene expression in mammalian cells. Methods Enzymol (2001) 0.80
Cocoa powder enhances the level of antioxidative activity in rat plasma. Br J Nutr (2000) 0.80
Cacao procyanidins reduce plasma cholesterol and increase fecal steroid excretion in rats fed a high-cholesterol diet. Biofactors (2008) 0.80
Nitric oxide formation in macrophages detected by spin trapping with iron-dithiocarbamate complex: effect of purified flavonoids and plant extracts. Methods Enzymol (2001) 0.79
Chronic consumption of a flavanol- and procyanindin-rich diet is associated with reduced levels of 8-hydroxy-2'-deoxyguanosine in rat testes. J Nutr Biochem (2003) 0.79
Cocoa procyanidin chain length does not determine ability to protect LDL from oxidation when monomer units are controlled. J Nutr Biochem (2002) 0.79
Is it the dark in dark chocolate? Circulation (2007) 0.79
Plasma antioxidants: health benefits of eating chocolate? Nature (2003) 0.78
Mediterranean diet, cocoa and cardiovascular disease: a sweeter life, a longer life, or both? J Hypertens (2003) 0.76
Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions. J Interferon Cytokine Res (2005) 1.65
Curcumin--from molecule to biological function. Angew Chem Int Ed Engl (2012) 1.55
Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression. Biochem Biophys Res Commun (2007) 1.09
Effect of quercetin on inflammatory gene expression in mice liver in vivo - role of redox factor 1, miRNA-122 and miRNA-125b. Pharmacol Res (2012) 1.01
Effect of dietary genistein on Phase II and antioxidant enzymes in rat liver. Cancer Genomics Proteomics (2009) 1.00
Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155. J Nutr Biochem (2010) 0.99
APOE ε4 is associated with higher vitamin D levels in targeted replacement mice and humans. FASEB J (2011) 0.94
Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts. Pharmacol Res (2010) 0.93
A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Res (2012) 0.91
Gene expression and physiological changes of different populations of the long-lived bivalve Arctica islandica under low oxygen conditions. PLoS One (2012) 0.89
Betanin--a food colorant with biological activity. Mol Nutr Food Res (2014) 0.88
Gene-regulatory activity of alpha-tocopherol. Molecules (2010) 0.87
Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res (2013) 0.84
Stress resistance and longevity are not directly linked to levels of enzymatic antioxidants in the ponerine ant Harpegnathos saltator. PLoS One (2011) 0.82
Effect of dietary quercetin on brain quercetin levels and the expression of antioxidant and Alzheimer's disease relevant genes in mice. Pharmacol Res (2009) 0.82
Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype-studies in targeted gene replacement mice. J Mol Med (Berl) (2011) 0.80
Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice. IUBMB Life (2011) 0.79
Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice. Genes Nutr (2012) 0.77