Published in JAMA on August 27, 2003
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol (2004) 5.29
Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr (2010) 3.19
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A (2006) 3.03
Chocolate consumption is inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr (2010) 2.40
Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal (2012) 1.96
Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients (2010) 1.66
Dose-dependent increases in flow-mediated dilation following acute cocoa ingestion in healthy older adults. J Appl Physiol (1985) (2011) 1.47
Chocolate and prevention of cardiovascular disease: a systematic review. Nutr Metab (Lond) (2006) 1.40
Short- and long-term effects of (-)-epicatechin on myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2008) 1.34
Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr (2007) 1.30
Cocoa polyphenols and inflammatory markers of cardiovascular disease. Nutrients (2014) 1.12
Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion. J Am Coll Cardiol (2010) 1.09
Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev (2012) 1.08
Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians. Ther Adv Chronic Dis (2012) 1.07
Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr Dis Treat (2008) 1.03
The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. Br J Clin Pharmacol (2013) 1.02
Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. Am J Clin Nutr (2008) 1.01
Flavonoids: antioxidants against atherosclerosis. Nutrients (2010) 1.01
Does flavanol intake influence mortality from nitric oxide-dependent processes? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama. Int J Med Sci (2007) 0.98
Polyphenols from cocoa and vascular health-a critical review. Int J Mol Sci (2009) 0.97
Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study. Clin Nutr (2010) 0.92
Cocoa, chocolate, and cardiovascular disease. J Cardiovasc Pharmacol (2009) 0.90
Effects of flavonoid-containing beverages and EGCG on endothelial function. J Am Coll Nutr (2007) 0.89
Dietary antiaging phytochemicals and mechanisms associated with prolonged survival. J Nutr Biochem (2014) 0.88
Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin. Eur J Nutr (2006) 0.87
Consumption of high-polyphenol dark chocolate improves endothelial function in individuals with stage 1 hypertension and excess body weight. Int J Hypertens (2012) 0.86
Direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells. Eur J Nutr (2011) 0.85
Review: The potential of the common bean (Phaseolus vulgaris) as a vehicle for iron biofortification. Nutrients (2015) 0.84
Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster. J Nutr (2011) 0.84
Short term effects of cocoa consumption on blood pressure. West Indian Med J (2013) 0.83
Impact of fermentation, drying, roasting and Dutch processing on flavan-3-ol stereochemistry in cacao beans and cocoa ingredients. Chem Cent J (2011) 0.83
Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Age (Dordr) (2015) 0.81
Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double-Blind, Randomized, Placebo-Controlled Trial. Clin J Am Soc Nephrol (2015) 0.80
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? Oxid Med Cell Longev (2016) 0.80
Flavanol-rich cocoa ameliorates lipemia-induced endothelial dysfunction. Heart Vessels (2010) 0.79
Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. Br J Nutr (2015) 0.79
Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference. Adv Nutr (2012) 0.78
Procyanidins in Theobroma cacao Reduce Plasma Cholesterol Levels in High Cholesterol-Fed Rats. J Clin Biochem Nutr (2009) 0.78
Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme. Arch Biochem Biophys (2015) 0.77
Immunomodulatory properties of cacao extracts - potential consequences for medical applications. Front Pharmacol (2013) 0.77
Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice. J Agric Food Chem (2013) 0.77
High-cocoa polyphenol-rich chocolate improves blood pressure in patients with diabetes and hypertension. ARYA Atheroscler (2015) 0.76
The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial. Psychopharmacology (Berl) (2015) 0.76
Redox pioneer: professor Helmut Sies. Antioxid Redox Signal (2014) 0.76
Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Nutr (2016) 0.76
Cocoa and Dark Chocolate Polyphenols: From Biology to Clinical Applications. Front Immunol (2017) 0.76
Dietary factors in rheumatic autoimmune diseases: a recipe for therapy? Nat Rev Rheumatol (2017) 0.75
Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet. Food Nutr Res (2016) 0.75
High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials. Nutr Healthy Aging (2016) 0.75
German-Japanese relationships in biochemistry: a personal perspective. Nagoya J Med Sci (2016) 0.75
Dark chocolate supplementation reduces the oxygen cost of moderate intensity cycling. J Int Soc Sports Nutr (2015) 0.75
Chocolate, Air Pollution and Children's Neuroprotection: What Cognition Tools should be at Hand to Evaluate Interventions? Front Pharmacol (2016) 0.75
The Oxygen Paradox, oxidative stress, and ageing. Arch Biochem Biophys (2016) 0.75
Habitual cocoa intake reduces arterial stiffness in postmenopausal women regardless of intake frequency: a randomized parallel-group study. Clin Interv Aging (2016) 0.75
Beneficial effects of dark chocolate on exercise capacity in sedentary subjects: underlying mechanisms. A double blind, randomized, placebo controlled trial. Food Funct (2016) 0.75
Polyphenols from Root, Tubercles and Grains Cropped in Brazil: Chemical and Nutritional Characterization and Their Effects on Human Health and Diseases. Nutrients (2017) 0.75
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 4.62
Concern Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Eur Heart J (2009) 3.14
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A (2006) 3.03
The emerging biology of the nitrite anion. Nat Chem Biol (2005) 2.88
Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol (2005) 2.86
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med (2003) 2.83
Vitamins E and C are safe across a broad range of intakes. Am J Clin Nutr (2005) 2.72
Impact of left ventricular lead position in cardiac resynchronization therapy on left ventricular remodelling. A circumferential strain analysis based on 2D echocardiography. Eur Heart J (2007) 2.59
Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo. FASEB J (2002) 2.46
Postoperative care and follow-up after coronary stenting. Dtsch Arztebl Int (2013) 2.32
Red blood cells express a functional endothelial nitric oxide synthase. Blood (2005) 2.30
Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29
Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2008) 2.17
Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15
Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol (2008) 2.12
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat Med (2004) 2.09
Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood (2005) 2.08
Safety and efficacy of deep sedation as compared to general anaesthesia in percutaneous mitral valve repair using the MitraClip system. Catheter Cardiovasc Interv (2014) 2.05
Phosphate incorporation during glycogen synthesis and Lafora disease. Cell Metab (2011) 2.03
Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Am J Respir Crit Care Med (2008) 2.03
Meta-analysis of impact of different types and doses of statins on new-onset diabetes mellitus. Am J Cardiol (2013) 2.00
The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established. J Nutr (2011) 1.99
Plasma nitroso compounds are decreased in patients with endothelial dysfunction. J Am Coll Cardiol (2006) 1.91
Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular function. J Am Coll Cardiol (2010) 1.89
Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med (2005) 1.85
Coronary microembolization: from bedside to bench and back to bedside. Circulation (2009) 1.85
Sulfur and selenium: the role of oxidation state in protein structure and function. Angew Chem Int Ed Engl (2003) 1.77
Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function. Circ Res (2007) 1.76
Antioxidant activity of carotenoids. Mol Aspects Med (2003) 1.72
Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radic Biol Med (2002) 1.71
Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc Res (2004) 1.69
Impact of the metabolic syndrome on angiographic and clinical events after coronary intervention using bare-metal or sirolimus-eluting stents. Am J Cardiol (2007) 1.62
Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification. Thromb Haemost (2009) 1.58
Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia. Cardiovasc Res (2007) 1.58
Decreased plasminogen activator inhibitor and tissue metalloproteinase inhibitor expression may promote increased metalloproteinase activity with increasing duration of human atrial fibrillation. J Cardiovasc Electrophysiol (2007) 1.57
Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events. Ann N Y Acad Sci (2002) 1.56
Sirolimus-eluting stent treatment at high-volume centers confers lower mortality at 6-month follow-up: results from the prospective multicenter German Cypher Registry. Circulation (2009) 1.54
Left ventricular remodeling impairs coronary flow reserve in hypertensive patients. J Hypertens (2002) 1.53
Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta (2004) 1.50
Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning. Circ Res (2014) 1.49
Improved endothelial function and decreased levels of endothelium-derived microparticles after transcatheter aortic valve implantation. EuroIntervention (2015) 1.45
Influence of percutaneous mitral valve repair using the MitraClip® system on renal function in patients with severe mitral regurgitation. Catheter Cardiovasc Interv (2014) 1.45
Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta (2009) 1.44
Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action. Biochem Pharmacol (2003) 1.44
Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis. J Am Coll Cardiol (2008) 1.43
Evidence for in vivo transport of bioactive nitric oxide in human plasma. J Clin Invest (2002) 1.42
Comparative efficacy and safety of anticoagulant strategies for acute coronary syndromes. Comprehensive network meta-analysis of 42 randomised trials involving 117,353 patients. Thromb Haemost (2015) 1.40
Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch Biochem Biophys (2007) 1.40
Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation. Circulation (2012) 1.40
How do dietary flavanols improve vascular function? A position paper. Arch Biochem Biophys (2008) 1.39
The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions. Free Radic Biol Med (2006) 1.38
Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species. J Cell Sci (2006) 1.36
Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. J Am Coll Cardiol (2005) 1.36
Myocardial deformation imaging based on ultrasonic pixel tracking to identify reversible myocardial dysfunction. J Am Coll Cardiol (2008) 1.32
Cocoa polyphenols and inflammatory mediators. Am J Clin Nutr (2005) 1.31
NO adducts in mammalian red blood cells: too much or too little? Nat Med (2003) 1.30
Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema. Int J Vitam Nutr Res (2005) 1.26
Real-time three-dimensional transoesophageal echocardiography for guidance of non-coronary interventions in the catheter laboratory. Eur J Echocardiogr (2009) 1.25
Advanced speckle tracking echocardiography allowing a three-myocardial layer-specific analysis of deformation parameters. Eur J Echocardiogr (2008) 1.24
Peritoneal dialysis relieves clinical symptoms and is well tolerated in patients with refractory heart failure and chronic kidney disease. Eur J Heart Fail (2012) 1.20
Selenium, oxidative stress, and health aspects. Mol Aspects Med (2005) 1.18
Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues. Free Radic Biol Med (2004) 1.15
Griess method for nitrite measurement of aqueous and protein-containing samples. Methods Enzymol (2002) 1.15
Flavanols and cardiovascular disease prevention. Eur Heart J (2010) 1.15
Prevention of dipyrone (metamizole) induced inhibition of aspirin antiplatelet effects. Thromb Haemost (2015) 1.14
(-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase. Biochem Biophys Res Commun (2007) 1.14
Gene expression analysis of human red blood cells. Int J Med Sci (2009) 1.13
Augmentation of left ventricular contractility by cardiac sympathetic neural stimulation. Circulation (2010) 1.12
Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr (2013) 1.12
Incidence and predictors of target vessel revascularization and clinical event rates of the sirolimus-eluting coronary stent (results from the prospective multicenter German Cypher Stent Registry). Am J Cardiol (2005) 1.11
Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood. Circ Res (2002) 1.11