Published in Antiviral Res on January 08, 2010
A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults. PLoS Negl Trop Dis (2010) 1.85
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro. Proc Natl Acad Sci U S A (2012) 1.48
A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis (2012) 1.37
High-content assay to identify inhibitors of dengue virus infection. Assay Drug Dev Technol (2010) 1.33
Inhibition of dengue virus by targeting viral NS4B protein. J Virol (2011) 1.31
Towards a semen proteome of the dengue vector mosquito: protein identification and potential functions. PLoS Negl Trop Dis (2011) 1.29
A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis. J Virol (2011) 1.17
Characterization of dengue virus resistance to brequinar in cell culture. Antimicrob Agents Chemother (2010) 1.13
Inhibition of dengue virus through suppression of host pyrimidine biosynthesis. J Virol (2011) 1.13
Dengue fever: a Wikipedia clinical review. Open Med (2014) 1.10
Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay. Antimicrob Agents Chemother (2010) 1.09
Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Res (2010) 1.09
Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release. Antimicrob Agents Chemother (2010) 1.03
A novel inhibitor of dengue virus replication that targets the capsid protein. Antimicrob Agents Chemother (2012) 1.02
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J Clin Invest (2011) 1.01
Chloroquine use improves dengue-related symptoms. Mem Inst Oswaldo Cruz (2013) 1.01
Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection. Antiviral Res (2011) 0.99
Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence. J Virol (2011) 0.98
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside. Antimicrob Agents Chemother (2010) 0.96
A translation inhibitor that suppresses dengue virus in vitro and in vivo. Antimicrob Agents Chemother (2011) 0.95
The burden of dengue and chikungunya worldwide: implications for the southern United States and California. Ann Glob Health (2015) 0.93
Japanese encephalitis: the virus and vaccines. Hum Vaccin Immunother (2013) 0.93
Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity. Antiviral Res (2014) 0.90
Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives. Bioorg Med Chem (2011) 0.90
Inhibition of dengue virus by an ester prodrug of an adenosine analog. Antimicrob Agents Chemother (2010) 0.89
High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Negl Trop Dis (2013) 0.89
Expression of dengue-3 premembrane and envelope polyprotein in lettuce chloroplasts. Plant Mol Biol (2011) 0.86
Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2. BMC Complement Altern Med (2013) 0.86
Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. J Med Chem (2012) 0.85
Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors. Antimicrob Agents Chemother (2015) 0.85
Characterization of 8-hydroxyquinoline derivatives containing aminobenzothiazole as inhibitors of dengue virus type 2 protease in vitro. Antiviral Res (2012) 0.84
Identification of luteolin as enterovirus 71 and coxsackievirus A16 inhibitors through reporter viruses and cell viability-based screening. Viruses (2014) 0.83
Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase. PLoS One (2015) 0.83
Cissampelos pareira Linn: Natural Source of Potent Antiviral Activity against All Four Dengue Virus Serotypes. PLoS Negl Trop Dis (2015) 0.83
Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling. J Virol (2014) 0.82
The flavivirus protease as a target for drug discovery. Virol Sin (2013) 0.81
Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold. Bioorg Med Chem (2012) 0.81
Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical application. PLoS Negl Trop Dis (2013) 0.81
Identification of three antiviral inhibitors against Japanese encephalitis virus from library of pharmacologically active compounds 1280. PLoS One (2013) 0.81
Discovery of Dengue Virus NS4B Inhibitors. J Virol (2015) 0.81
Allosteric inhibition of the NS2B-NS3 protease from dengue virus. ACS Chem Biol (2013) 0.80
Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections. Antivir Ther (2014) 0.80
Dengue-3 Virus Entry into Vero Cells: Role of Clathrin-Mediated Endocytosis in the Outcome of Infection. PLoS One (2015) 0.80
Bioinformatics prediction of siRNAs as potential antiviral agents against dengue viruses. Bioinformation (2012) 0.79
Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents. Emerg Microbes Infect (2013) 0.79
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways. J Virol (2013) 0.78
Carbohydrate-related inhibitors of dengue virus entry. Viruses (2013) 0.78
A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture. Virol J (2015) 0.78
An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. Antiviral Res (2016) 0.78
Designing cyclopentapeptide inhibitor as potential antiviral drug for dengue virus ns5 methyltransferase. Bioinformation (2012) 0.78
Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing. J Virol (2013) 0.78
Structural basis of Zika virus helicase in recognizing its substrates. Protein Cell (2016) 0.77
Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses. Antiviral Res (2016) 0.77
A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease. Antimicrob Agents Chemother (2013) 0.77
Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells. Acta Pharmacol Sin (2015) 0.77
Immunosuppressive effects and mechanisms of leflunomide in dengue virus infection of human dendritic cells. J Clin Immunol (2011) 0.76
Membrane interacting regions of Dengue virus NS2A protein. J Phys Chem B (2014) 0.75
Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase. Antimicrob Agents Chemother (2015) 0.75
Human heme oxygenase 1 is a potential host cell factor against dengue virus replication. Sci Rep (2016) 0.75
Dengue-specific subviral nanoparticles: design, creation and characterization. J Nanobiotechnology (2013) 0.75
Dengue virus: A global human threat: Review of literature. J Int Soc Prev Community Dent (2016) 0.75
A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein. J Virol (2016) 0.75
High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. Antiviral Res (2016) 0.75
Inhibitors compounds of the flavivirus replication process. Virol J (2017) 0.75
Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation. Drug Target Insights (2017) 0.75
Antiviral activity of an N-allyl acridone against dengue virus. J Biomed Sci (2015) 0.75
Asunaprevir Evokes Hepatocytes Innate Immunity to Restrict the Replication of Hepatitis C and Dengue Virus. Front Microbiol (2017) 0.75
A Molecular Approach Designed to Limit the Replication of Mature DENV2 in Host Cells. Viral Immunol (2015) 0.75
Computational predictions suggest that structural similarity in viral polymerases may lead to comparable allosteric binding sites. Virus Res (2016) 0.75
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Proc Natl Acad Sci U S A (2016) 0.75
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell (2008) 4.88
A 12-month phase 3 study of pasireotide in Cushing's disease. N Engl J Med (2012) 3.85
2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature (2010) 3.49
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. J Virol (2010) 3.10
Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins. J Virol (2005) 3.08
West Nile virus 5'-cap structure is formed by sequential guanine N-7 and ribose 2'-O methylations by nonstructural protein 5. J Virol (2006) 3.07
Structure and function of flavivirus NS5 methyltransferase. J Virol (2007) 2.93
A highly structured, nuclease-resistant, noncoding RNA produced by flaviviruses is required for pathogenicity. Cell Host Microbe (2008) 2.93
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature (2005) 2.87
Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol (2007) 2.65
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nat Struct Mol Biol (2006) 2.55
NS5 of dengue virus mediates STAT2 binding and degradation. J Virol (2009) 2.42
The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway. J Virol (2004) 2.37
West Nile virus. Lancet Neurol (2007) 2.26
An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A (2009) 2.20
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO J (2008) 1.99
The structural basis for serotype-specific neutralization of dengue virus by a human antibody. Sci Transl Med (2012) 1.95
Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Negl Trop Dis (2007) 1.86
Ten years of dengue drug discovery: progress and prospects. Antiviral Res (2013) 1.84
Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol (2005) 1.75
High-throughput assays using a luciferase-expressing replicon, virus-like particles, and full-length virus for West Nile virus drug discovery. Antimicrob Agents Chemother (2005) 1.73
A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell (2004) 1.73
The West Nile virus mutant spectrum is host-dependant and a determinant of mortality in mice. Virology (2006) 1.72
Triaryl pyrazoline compound inhibits flavivirus RNA replication. Antimicrob Agents Chemother (2006) 1.72
Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries. J Biol Chem (2005) 1.70
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. J Clin Microbiol (2003) 1.65
Cholesterol biosynthesis modulation regulates dengue viral replication. Virology (2009) 1.64
A small-molecule dengue virus entry inhibitor. Antimicrob Agents Chemother (2009) 1.59
Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. J Med Chem (2003) 1.57
West Nile virus infection of Drosophila melanogaster induces a protective RNAi response. Virology (2008) 1.56
Interaction between the cellular protein eEF1A and the 3'-terminal stem-loop of West Nile virus genomic RNA facilitates viral minus-strand RNA synthesis. J Virol (2007) 1.56
RNA structures required for production of subgenomic flavivirus RNA. J Virol (2010) 1.52
Distinct RNA elements confer specificity to flavivirus RNA cap methylation events. J Virol (2007) 1.48
Oxidation of 7,8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo. Biochemistry (2002) 1.48
Role of the mutant spectrum in adaptation and replication of West Nile virus. J Gen Virol (2007) 1.46
Tetracycline-inducible packaging cell line for production of flavivirus replicon particles. J Virol (2004) 1.44
West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism. J Virol (2008) 1.44
Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever. Rev Med Virol (2006) 1.44
CD8⁺ cytotoxic T cell and FOXP3⁺ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes. Breast Cancer Res Treat (2011) 1.43
The flavivirus-conserved penta-nucleotide in the 3' stem-loop of the West Nile virus genome requires a specific sequence and structure for RNA synthesis, but not for viral translation. Virology (2005) 1.43
Dengue virus serotype infection specifies the activation of the unfolded protein response. Virol J (2007) 1.41
Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target. Antiviral Res (2008) 1.41
A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice. PLoS Negl Trop Dis (2010) 1.40
Small molecule inhibitors that selectively block dengue virus methyltransferase. J Biol Chem (2010) 1.40
Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol (2005) 1.39
Effect of continuous ozone injection on performance and biomass accumulation of biofilters treating gaseous toluene. Appl Microbiol Biotechnol (2014) 1.39
A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis. Virology (2006) 1.38
Effect of continuous ozone injection on performance and biomass accumulation of biofilters treating gaseous toluene. Appl Microbiol Biotechnol (2014) 1.38
West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions. Virology (2008) 1.37
Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. J Gen Virol (2006) 1.36
Structure and function of the 3' terminal six nucleotides of the west nile virus genome in viral replication. J Virol (2004) 1.33
Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication. J Virol (2004) 1.32
2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. PLoS Pathog (2012) 1.32
Inhibition of dengue virus by targeting viral NS4B protein. J Virol (2011) 1.31
Flavivirus methyltransferase: a novel antiviral target. Antiviral Res (2008) 1.31
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead. Bioorg Med Chem Lett (2005) 1.30
Finding new medicines for flaviviral targets. Novartis Found Symp (2006) 1.29
Keratinocytes are cell targets of West Nile virus in vivo. J Virol (2011) 1.29
Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching. Virology (2008) 1.29
Functional analysis of two cavities in flavivirus NS5 polymerase. J Biol Chem (2011) 1.28
Targeted exome sequencing identified novel USH2A mutations in Usher syndrome families. PLoS One (2013) 1.28
Inhibition of dengue virus polymerase by blocking of the RNA tunnel. J Virol (2010) 1.28
Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing. Antiviral Res (2007) 1.27
Potential high-throughput assay for screening inhibitors of West Nile virus replication. J Virol (2003) 1.25
Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism. J Neurochem (2011) 1.24
The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic. EMBO J (2003) 1.22
Reduction of Akt2 inhibits migration and invasion of glioma cells. Int J Cancer (2009) 1.22
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors. Bioorg Med Chem Lett (2005) 1.22
Biochemical and genetic characterization of dengue virus methyltransferase. Virology (2010) 1.21
Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein. Virology (2008) 1.20
Development and characterization of a stable luciferase dengue virus for high-throughput screening. Antiviral Res (2011) 1.20
Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes. Virology (2010) 1.20
Identification of compounds with anti-West Nile Virus activity. J Med Chem (2006) 1.19
Exclusion of West Nile virus superinfection through RNA replication. J Virol (2009) 1.19