Published in Science on March 08, 1991
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AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J (1998) 2.45
Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest (1992) 2.37
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat Med (2011) 1.99
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Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates. Proc Natl Acad Sci U S A (1993) 1.52
Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. J Clin Invest (1992) 1.50
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. Proc Natl Acad Sci U S A (1993) 1.40
Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus. Proc Natl Acad Sci U S A (1992) 1.40
Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport. EMBO J (1993) 1.34
The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment. J Clin Invest (1992) 1.28
Heterogeneous expression of glucokinase among pancreatic beta cells. Proc Natl Acad Sci U S A (1992) 1.27
Expression of yeast hexokinase in pancreatic beta cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes. Proc Natl Acad Sci U S A (1992) 1.23
Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats. J Clin Invest (1997) 1.20
Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol (2005) 1.18
[Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis. Proc Natl Acad Sci U S A (1992) 1.01
Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc Natl Acad Sci U S A (2009) 0.98
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Regulation of glucose transport in the NIH 3T3 L1 preadipocyte cell line by TCDD. Environ Health Perspect (1994) 0.91
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A (1998) 0.90
Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells. Biochem J (1991) 0.89
Photolabelling of the liver-type glucose-transporter isoform GLUT2 with an azitrifluoroethylbenzoyl-substituted bis-D-mannose. Biochem J (1992) 0.89
Diabetes mellitus related bone metabolism and periodontal disease. Int J Oral Sci (2015) 0.88
Cellular and molecular biology of the beta cell. Diabetologia (1992) 0.86
GLUT-2 function in glucose-unresponsive beta cells of dexamethasone-induced diabetes in rats. J Clin Invest (1993) 0.85
Metabolic signals trigger glucose-induced inactivation of maltose permease in Saccharomyces. J Bacteriol (2000) 0.84
GLUT2 surface expression and intracellular transport via the constitutive pathway in pancreatic beta cells and insulinoma: evidence for a block in trans-Golgi network exit by brefeldin A. J Cell Biol (1993) 0.84
Stevioside Counteracts Beta-Cell Lipotoxicity without Affecting Acetyl CoA Carboxylase. Rev Diabet Stud (2007) 0.81
Oscillatory glucose flux in INS 1 pancreatic β cells: a self-referencing microbiosensor study. Anal Biochem (2010) 0.81
Insulin secretion, insulin content and glucose phosphorylation in RINm5F insulinoma cells after transfection with human GLUT2 glucose-transporter cDNA. Biochem J (1993) 0.81
Glucose diffusion in pancreatic islets of Langerhans. Biophys J (1998) 0.81
Electrochemical glucose biosensor of platinum nanospheres connected by carbon nanotubes. J Diabetes Sci Technol (2010) 0.80
NADPH oxidase-dependent production of reactive oxygen species induces endoplasmatic reticulum stress in neutrophil-like HL60 cells. PLoS One (2015) 0.80
The beta cell in NIDDM: giving light to the blind. Diabetologia (1994) 0.78
In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents. J Clin Invest (1994) 0.77
Regulated membrane transport of free fatty acids in adipocytes: role in obesity and non-insulin dependent diabetes mellitus. Trans Am Clin Climatol Assoc (1997) 0.77
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Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J Clin Invest (1994) 0.75
Hypoxia-induced increases in glucose uptake do not cause oxidative injury or advanced glycation end-product (AGE) formation in vascular endothelial cells. Physiol Rep (2015) 0.75
Can technological solutions for diabetes replace islet cell function? Organogenesis (2011) 0.75
WTC rat has unique characteristics such as resistant to streptozotocin. Biochem Biophys Rep (2016) 0.75