Published in J Clin Invest on June 15, 1997
The role of gut hormones in glucose homeostasis. J Clin Invest (2007) 3.36
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proc Natl Acad Sci U S A (2003) 2.35
Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest (1998) 1.51
Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp Neurol (2006) 1.40
Clinical review: The extrapancreatic effects of glucagon-like peptide-1 and related peptides. J Clin Endocrinol Metab (2009) 1.38
The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes. Diabetologia (2011) 1.26
Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins. Endocr Rev (2008) 1.18
Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol (2008) 1.13
Therapy in the early stage: incretins. Diabetes Care (2011) 1.08
Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets. Diabetologia (2011) 1.05
Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms. Front Endocrinol (Lausanne) (2014) 0.99
The central GLP-1: implications for food and drug reward. Front Neurosci (2013) 0.96
Bidirectional metabolic regulation of neurocognitive function. Neurobiol Learn Mem (2011) 0.95
The impact of dietary energy intake on cognitive aging. Front Aging Neurosci (2010) 0.94
Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist. PLoS One (2010) 0.93
Liraglutide increases FGF-21 activity and insulin sensitivity in high fat diet and adiponectin knockdown induced insulin resistance. PLoS One (2012) 0.93
Therapeutic Approaches for Preserving or Restoring Pancreatic β-Cell Function and Mass. Diabetes Metab J (2014) 0.89
Exendin-4 improves blood glucose control in both young and aging normal non-diabetic mice, possible contribution of beta cell independent effects. PLoS One (2011) 0.89
Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury. Alzheimers Dement (2014) 0.88
Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2. Br J Pharmacol (2000) 0.86
Diminished mTOR signaling: a common mode of action for endocrine longevity factors. Springerplus (2014) 0.84
Tolerance, fermentation, and cytokine expression in healthy aged male C57BL/6J mice fed resistant starch. Mol Nutr Food Res (2011) 0.84
The L-Cell in Nutritional Sensing and the Regulation of Appetite. Front Nutr (2015) 0.81
Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. Mol Cell Endocrinol (2015) 0.80
We are ageing. Biomed Res Int (2014) 0.79
Dietary resistant starch improves selected brain and behavioral functions in adult and aged rodents. Mol Nutr Food Res (2013) 0.78
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry (1974) 19.75
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest (1993) 5.06
Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med (1992) 4.37
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia (1993) 3.63
Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes (1990) 2.97
Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A (1987) 2.79
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature (1993) 2.52
Banting lecture 1990. Beta-cells in type II diabetes mellitus. Diabetes (1991) 2.45
Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects. Diabetes Care (1992) 2.21
Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol (1996) 2.14
Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells. Science (1991) 1.99
Family of glucose-transporter genes. Implications for glucose homeostasis and diabetes. Diabetes (1990) 1.77
Glucagon-like peptide-1 is a physiological incretin in rat. J Clin Invest (1995) 1.66
The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul Pept (1994) 1.46
Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology (1992) 1.42
Natural history of beta-cell dysfunction in NIDDM. Diabetes Care (1990) 1.34
The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment. J Clin Invest (1992) 1.28
Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia (1992) 1.19
Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia (1991) 1.07
Glucokinase: structural analysis of a protein involved in susceptibility to diabetes. J Biol Chem (1994) 1.07
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. J Biol Chem (1994) 1.00
Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate. Mol Endocrinol (1996) 0.99
Glucagon-like peptide-I and the control of insulin secretion in the normal state and in NIDDM. Diabetes (1993) 0.98
Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes. J Biol Chem (1994) 0.97
Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats. Am J Physiol (1995) 0.95
Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells. Endocrinology (1995) 0.94
Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1 (7-37). J Clin Invest (1996) 0.92
Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action. Endocrinology (1994) 0.87
Molecular investigation of age-related changes in mouse endocrine pancreas. J Gerontol A Biol Sci Med Sci (1996) 0.86
GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Mol Cell Endocrinol (1996) 0.84
The effect of age and glucose concentration on insulin secretion by the isolated perfused rat pancreas. Endocrinology (1985) 0.82
Defects of insulin's signal transduction in old rat livers. Endocrinology (1992) 0.82
Effects of aging on insulin synthesis and secretion. Differential effects on preproinsulin messenger RNA levels, proinsulin biosynthesis, and secretion of newly made and preformed insulin in the rat. J Clin Invest (1988) 0.81
Glucose-stimulated insulin release by individual pancreatic beta cells: potentiation by glyburide. Proc Soc Exp Biol Med (1991) 0.78
Age-related impairment in the short term regulation of insulin biosynthesis by glucose in rat pancreatic islets. Endocrinology (1988) 0.78
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ Res (2001) 2.56
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes (2000) 2.50
Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci U S A (1991) 2.10
Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol (1993) 2.06
Prevention of the glucose intolerance of thiazide diuretics by maintenance of body potassium. Diabetes (1983) 1.89
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology (2000) 1.81
Impact of age on weight goals. Ann Intern Med (1985) 1.73
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond) (2010) 1.61
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem (2001) 1.58
An epidemiological test of the hyperinsulinemia-hypertension hypothesis. J Clin Endocrinol Metab (1993) 1.56
Severe deficiency of cystic fibrosis transmembrane conductance regulator messenger RNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis. J Clin Invest (1991) 1.56
Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology (2000) 1.56
Events surrounding the early development of Euglena chloroplasts: cellular origins of chloroplast enzymes in euglena. J Gen Microbiol (1974) 1.48
Modulation of CCAAT/enhancer-binding protein-alpha gene expression by metabolic signals in rodent adipocytes. Endocrinology (1999) 1.39
Computer analysis of holographic systems by means of vector ray tracing. Appl Opt (1981) 1.38
Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. J Clin Invest (2000) 1.34
Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia (1999) 1.34
Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture. Gastroenterology (1996) 1.32
Studies in the distribution of body fat: I. Effects of age, sex, and obesity. J Gerontol (1989) 1.32
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci U S A (2001) 1.32
Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes (1999) 1.31
Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes (1998) 1.30
In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact (2005) 1.24
Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity. N Engl J Med (1982) 1.24
Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. Int J Obes Relat Metab Disord (2003) 1.24
Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes (2001) 1.23
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab (1993) 1.22
Oral glucose augmentation of insulin secretion. Interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels. J Clin Invest (1978) 1.22
Hormonal control of substrate cycling in humans. J Clin Invest (1988) 1.22
Studies in the distribution of body fat. II. Longitudinal effects of change in weight. Int J Obes (1989) 1.18
Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology (2001) 1.12
Does waist circumference add to the predictive power of the body mass index for coronary risk? Obes Res (2001) 1.12
Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium. Am J Physiol (1987) 1.11
Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene). Diabetes (2000) 1.09
Protein discharge from immature secretory granules displays both regulated and constitutive characteristics. J Biol Chem (1991) 1.08
A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase. Curr Med Res Opin (2001) 1.08
Why so few drugs for Alzheimer's disease? Are methods failing drugs? Curr Alzheimer Res (2010) 1.08
GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. Am J Physiol (1998) 1.08
Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues. Hum Mol Genet (1995) 1.08
The effect of age on insulin resistance and secretion: a review. Semin Nephrol (1996) 1.05
Peripheral chemo-cytokine profiles in Alzheimer's and Parkinson's diseases. Mini Rev Med Chem (2009) 1.03
Effect of insulin infusions on the glucose kinetics in alloxan-steptozotocin diabetic dogs. Diabetologia (1974) 1.02
Resistive training increases fat-free mass and maintains RMR despite weight loss in postmenopausal women. J Appl Physiol (1985) (1995) 1.02
A delayed rectifier potassium current in Xenopus oocytes. Biophys J (1990) 1.02
Reversal of abnormal glucose metabolism in chronic pancreatitis by administration of pancreatic polypeptide. Am J Surg (1986) 1.01
The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Diabetes (1984) 0.99
Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells. Mol Cell Biol (1999) 0.98
Studies on chloroplast development and replication in Euglena. II. Identification of two different deoxyribonucleases. Arch Biochem Biophys (1970) 0.98
Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease. J Med Chem (1999) 0.98
Glucagon-like peptide-1. Recent Prog Horm Res (2001) 0.98
A cross-sectional study on body composition and energy expenditure in women athletes during aging. Am J Physiol (1996) 0.98
Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology (1999) 0.98
Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans. Drug Metab Dispos (2000) 0.97
Capillary gas chromatography combined with ion trap detection for quantitative profiling of polyols in cerebrospinal fluid and plasma. Anal Biochem (1995) 0.96
Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia. J Clin Endocrinol Metab (1998) 0.96
Glucose and lactate kinetics after endotoxin administration in dogs. Am J Physiol (1977) 0.96
Role of cytokines in the gene expression of amyloid beta-protein precursor: identification of a 5'-UTR-binding nuclear factor and its implications in Alzheimer's disease. J Alzheimers Dis (2003) 0.96
Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia. Surgery (1996) 0.96
Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats. Am J Physiol (1995) 0.95
Insulin response during the oral glucose tolerance test: the role of age, sex, body fat and the pattern of fat distribution. Aging (Milano) (1996) 0.94
Effect of acarbose on insulin sensitivity in elderly patients with diabetes. Diabetes Care (2000) 0.94
Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells. Endocrinology (1995) 0.94
Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. J Mol Endocrinol (2002) 0.94
Resistive training increases insulin action in postmenopausal women. J Gerontol A Biol Sci Med Sci (1996) 0.94
Effect of aging on the cardiothoracic ratio of men. J Am Geriatr Soc (1982) 0.94
Reversal of abnormal glucose production after pancreatic resection by pancreatic polypeptide administration in man. Surgery (1988) 0.93
Effect of aging on the relationship between multiple risk factors and waist circumference. J Am Geriatr Soc (2000) 0.93
The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women. J Clin Endocrinol Metab (1996) 0.93
Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action. Endocrinology (1994) 0.93
Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Endocrinology (2001) 0.92
Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Curr Pharm Des (2004) 0.91
Cerebrovascular Biology and the various neural barriers: challenges and future directions. Neurosurgery (1999) 0.91
The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta Neurol Scand Suppl (2000) 0.90
Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem (1996) 0.90
Pancreatic alpha- and beta-cell responses to GIP infusion in normal man. Am J Physiol (1979) 0.90
Optimizing drug delivery to brain tumors. Cancer Treat Rev (1987) 0.90
Pancreatic polypeptide administration improves abnormal glucose metabolism in patients with chronic pancreatitis. J Clin Endocrinol Metab (1996) 0.90
Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrier. Cancer Res (1992) 0.89
Resistive training maintains bone mineral density in postmenopausal women. Calcif Tissue Int (1998) 0.89
Effect of aging and diabetes on the enteroinsular axis. J Gerontol A Biol Sci Med Sci (2001) 0.89
Autoantibodies to insulin do appear in non-diabetic patients with autoimmune disorders: comparison with anti-immunoglobulin antibodies and other autoimmune phenomena. Acta Endocrinol (Copenh) (1990) 0.88
Polyol profiles in Down syndrome. myo-Inositol, specifically, is elevated in the cerebrospinal fluid. J Clin Invest (1995) 0.88
Changes in plasma leptin and insulin action with resistive training in postmenopausal women. Int J Obes Relat Metab Disord (2000) 0.88
Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase. Exp Clin Psychopharmacol (1998) 0.88
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action. J Med Chem (2001) 0.88
The pituitary-adrenal glucocorticoid response is altered by gender and disease. J Gerontol (1993) 0.88
Rodent models of memory dysfunction in Alzheimer's disease and normal aging: moving beyond the cholinergic hypothesis. Life Sci (1994) 0.88
Cloning and characterization of maxi K+ channel alpha-subunit in rabbit kidney. Am J Physiol (1997) 0.87