Published in Science on March 22, 1991
Studies on anticancer activities of antimicrobial peptides. Biochim Biophys Acta (2007) 3.24
Plant defensins: novel antimicrobial peptides as components of the host defense system. Plant Physiol (1995) 3.03
Enteric defensins: antibiotic peptide components of intestinal host defense. J Cell Biol (1992) 3.03
FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc Natl Acad Sci U S A (1995) 2.89
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science (2012) 2.44
Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores. Protein Sci (1994) 2.43
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci U S A (2003) 2.32
Susceptibility of Chlamydia trachomatis to protegrins and defensins. Infect Immun (1996) 2.16
Epithelial antibiotic induced in states of disease. Proc Natl Acad Sci U S A (1997) 2.11
Multidimensional signatures in antimicrobial peptides. Proc Natl Acad Sci U S A (2004) 2.00
Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect Immun (1994) 1.93
Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR. Proc Natl Acad Sci U S A (2006) 1.87
Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect Immun (1994) 1.78
Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci (2006) 1.68
Antimicrobial characterization of human beta-defensin 3 derivatives. Antimicrob Agents Chemother (2003) 1.63
The roles of antimicrobial peptides in innate host defense. Curr Pharm Des (2009) 1.58
Innate immune response of oral and foreskin keratinocytes: utilization of different signaling pathways by various bacterial species. Infect Immun (2004) 1.55
Antimicrobial defensin peptides of the human ocular surface. Br J Ophthalmol (1999) 1.44
Defensins promote fusion and lysis of negatively charged membranes. Protein Sci (1993) 1.43
Novel antimicrobial peptides derived from human immunodeficiency virus type 1 and other lentivirus transmembrane proteins. Antimicrob Agents Chemother (1997) 1.35
Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization. PLoS Pathog (2010) 1.34
Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1-3) in colon cancer serum and tumours: a biomarker study. BMC Cancer (2005) 1.30
Titration calorimetric studies to elucidate the specificity of the interactions of polymyxin B with lipopolysaccharides and lipid A. Biochem J (1996) 1.27
Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II. FEBS Lett (2010) 1.26
Through the looking glass, mechanistic insights from enantiomeric human defensins. J Biol Chem (2009) 1.25
Antiviral mechanisms of human defensins. J Mol Biol (2013) 1.22
Antimicrobial peptides in human skin disease. Eur J Dermatol (2007) 1.17
Paneth cell α-defensins in enteric innate immunity. Cell Mol Life Sci (2011) 1.16
Released ATP is an extracellular cytotoxic mediator in salivary histatin 5-induced killing of Candida albicans. Infect Immun (2000) 1.16
Macrocyclic beta-sheet peptides that mimic protein quaternary structure through intermolecular beta-sheet interactions. J Am Chem Soc (2007) 1.14
Structure and dynamics of cationic membrane peptides and proteins: insights from solid-state NMR. Protein Sci (2011) 1.13
Trp-26 imparts functional versatility to human alpha-defensin HNP1. J Biol Chem (2010) 1.12
Phosphoinositide-mediated oligomerization of a defensin induces cell lysis. Elife (2014) 1.11
Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. Infect Immun (1991) 1.11
Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences on tumor cell proliferation. Am J Pathol (2002) 1.10
Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proc Natl Acad Sci U S A (1997) 1.08
Primary and secondary structure of the pore-forming peptide of pathogenic Entamoeba histolytica. EMBO J (1992) 1.04
Ponticulin is an atypical membrane protein. J Cell Biol (1994) 1.04
Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun (2005) 1.03
Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface. J Biol Chem (2012) 1.03
Large-scale synthesis and functional elements for the antimicrobial activity of defensins. Biochem J (2000) 1.03
Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide. J Biol Chem (2012) 1.03
Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines. Antimicrob Agents Chemother (2005) 1.02
The complexity of selection at the major primate beta-defensin locus. BMC Evol Biol (2005) 1.02
The membrane-bound structure and topology of a human α-defensin indicate a dimer pore mechanism for membrane disruption. Biochemistry (2010) 1.01
Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol (2005) 1.01
Beta edge strands in protein structure prediction and aggregation. Protein Sci (2003) 0.98
Structure-function relationships in novel peptide dodecamerswith broad-spectrum bactericidal and endotoxin-neutralizing activities. Biochem J (2000) 0.96
Dimerization of plant defensin NaD1 enhances its antifungal activity. J Biol Chem (2012) 0.96
Identification of an anti-mycobacterial domain in NK-lysin and granulysin. Biochem J (1999) 0.96
NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5. Biochemistry (2012) 0.94
A protein important for antimicrobial peptide resistance, YdeI/OmdA, is in the periplasm and interacts with OmpD/NmpC. J Bacteriol (2009) 0.92
Effects of arginine density on the membrane-bound structure of a cationic antimicrobial peptide from solid-state NMR. Biochim Biophys Acta (2008) 0.91
Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proc Natl Acad Sci U S A (2013) 0.91
The use of antimicrobial peptides in ophthalmology: an experimental study in corneal preservation and the management of bacterial keratitis. Trans Am Ophthalmol Soc (2002) 0.90
Classification of protein disulphide-bridge topologies. J Comput Aided Mol Des (2001) 0.90
Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR. J Mol Biol (2010) 0.90
Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity. Antimicrob Agents Chemother (2008) 0.89
Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP. Blood (2016) 0.88
Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 function. PLoS One (2013) 0.87
An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5. PLoS One (2013) 0.87
Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1. J Biol Chem (2012) 0.87
Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with Fic fold. PLoS One (2013) 0.87
3D (13)C-(13)C-(13)C correlation NMR for de novo distance determination of solid proteins and application to a human alpha-defensin. J Magn Reson (2009) 0.86
X-ray crystallographic structure of an artificial beta-sheet dimer. J Am Chem Soc (2010) 0.85
Rapid construction of adenoviral vectors by lambda phage genetics. J Virol (2002) 0.85
Peptides and Peptidomimetics for Antimicrobial Drug Design. Pharmaceuticals (Basel) (2015) 0.85
The defensin receptor: a possible mechanism responsible for reduced excitability of the neuronal sensory membrane. Dokl Biol Sci (2001) 0.84
Visualizing attack of Escherichia coli by the antimicrobial peptide human defensin 5. Biochemistry (2015) 0.84
Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. J Am Chem Soc (2014) 0.83
Pro-inflammatory and pro-apoptotic properties of Human Defensin 5. Biochem Biophys Res Commun (2013) 0.83
Inhibition of HIV-1 infection by human α-defensin-5, a natural antimicrobial peptide expressed in the genital and intestinal mucosae. PLoS One (2012) 0.82
Molecular evolution of the primate α-/θ-defensin multigene family. PLoS One (2014) 0.82
Molecular basis for self-assembly of a human host-defense peptide that entraps bacterial pathogens. J Am Chem Soc (2014) 0.82
Arginine-specific mono ADP-ribosylation in vitro of antimicrobial peptides by ADP-ribosylating toxins. PLoS One (2012) 0.80
Modelling study of dimerization in mammalian defensins. BMC Bioinformatics (2006) 0.79
Amyloid formation: functional friend or fearful foe? J Intern Med (2016) 0.78
Polarisation of major histocompatibility complex II host genotype with pathogenesis of European Brown Hare syndrome virus. PLoS One (2013) 0.78
Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque. J Biol Chem (2008) 0.78
High-resolution NMR structure of the antimicrobial peptide protegrin-2 in the presence of DPC micelles. J Biomol NMR (2014) 0.77
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients. BMC Cancer (2010) 0.76
Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing. PLoS One (2017) 0.75
Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut. Crit Rev Biochem Mol Biol (2016) 0.75
Human β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity. PLoS One (2015) 0.75
In the Wnt of Paneth Cells: Immune-Epithelial Crosstalk in Small Intestinal Crohn's Disease. Front Immunol (2017) 0.75
Oligomerization of the antimicrobial peptide Protegrin-5 in a membrane-mimicking environment. Structural studies by high-resolution NMR spectroscopy. Eur Biophys J (2016) 0.75
Profile analysis: detection of distantly related proteins. Proc Natl Acad Sci U S A (1987) 29.26
Assigning protein functions by comparative genome analysis: protein phylogenetic profiles. Proc Natl Acad Sci U S A (1999) 22.80
Detecting protein function and protein-protein interactions from genome sequences. Science (1999) 18.69
A method to identify protein sequences that fold into a known three-dimensional structure. Science (1991) 14.08
Analysis of membrane and surface protein sequences with the hydrophobic moment plot. J Mol Biol (1984) 13.69
Assessment of protein models with three-dimensional profiles. Nature (1992) 12.64
Solvation energy in protein folding and binding. Nature (1986) 10.94
DIP: the database of interacting proteins. Nucleic Acids Res (2000) 10.06
A combined algorithm for genome-wide prediction of protein function. Nature (1999) 9.99
Profile analysis. Methods Enzymol (1990) 9.40
Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest (1985) 8.63
Three-dimensional structure of membrane and surface proteins. Annu Rev Biochem (1984) 7.38
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol (2000) 6.62
The hydrophobic moment detects periodicity in protein hydrophobicity. Proc Natl Acad Sci U S A (1984) 6.36
Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes. Infect Immun (1984) 5.30
Protein interaction databases. Curr Opin Biotechnol (2001) 5.22
Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest (1989) 5.21
Mining literature for protein-protein interactions. Bioinformatics (2001) 5.18
Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus Revascularization Treatment Investigators. N Engl J Med (1999) 5.09
The helical hydrophobic moment: a measure of the amphiphilicity of a helix. Nature (1982) 5.01
3D domain swapping: a mechanism for oligomer assembly. Protein Sci (1995) 4.96
Ferricytochrome c. I. General features of the horse and bonito proteins at 2.8 A resolution. J Biol Chem (1971) 4.75
Analysis of air contrast barium enema, computed tomographic colonography, and colonoscopy: prospective comparison. Lancet (2005) 4.65
Domain swapping: entangling alliances between proteins. Proc Natl Acad Sci U S A (1994) 4.20
A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science (1999) 3.90
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A (1990) 3.90
The crystal structure of diphtheria toxin. Nature (1992) 3.80
Correlation of sequence hydrophobicities measures similarity in three-dimensional protein structure. J Mol Biol (1983) 3.78
Primary structures of three human neutrophil defensins. J Clin Invest (1985) 3.70
Profile scanning for three-dimensional structural patterns in protein sequences. Comput Appl Biosci (1988) 3.66
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J Biol Chem (1985) 3.58
DIP: The Database of Interacting Proteins: 2001 update. Nucleic Acids Res (2001) 3.38
The structure of melittin. II. Interpretation of the structure. J Biol Chem (1982) 3.22
Atomic solvation parameters applied to molecular dynamics of proteins in solution. Protein Sci (1992) 3.05
Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J Biol Chem (1983) 3.00
Direct inactivation of viruses by human granulocyte defensins. J Virol (1986) 3.00
Defensins. Eur J Haematol (1990) 2.88
Novel subunit-subunit interactions in the structure of glutamine synthetase. Nature (1986) 2.87
Alternative therapies used by women with breast cancer in four ethnic populations. J Natl Cancer Inst (2000) 2.87
Finding families for genomic ORFans. Bioinformatics (1999) 2.76
AIDS serology testing in low- and high-risk groups. JAMA (1985) 2.74
Hydrophobic organization of membrane proteins. Science (1989) 2.74
Sequence-structure analysis of FAD-containing proteins. Protein Sci (2001) 2.73
A census of protein repeats. J Mol Biol (1999) 2.70
Protein fold recognition using sequence-derived predictions. Protein Sci (1996) 2.70
Randomized trial comparing traditional Chinese medical acupuncture, therapeutic massage, and self-care education for chronic low back pain. Arch Intern Med (2001) 2.67
A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Cell (1992) 2.58
Where metal ions bind in proteins. Proc Natl Acad Sci U S A (1990) 2.56
Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus). Proc Natl Acad Sci U S A (2000) 2.55
Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest (1989) 2.50
The structure of melittin in the form I crystals and its implication for melittin's lytic and surface activities. Biophys J (1982) 2.50
Defensins: endogenous antibiotic peptides of animal cells. Cell (1991) 2.45
Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores. Protein Sci (1994) 2.43
Use of complementary medicine by adult patients participating in cancer clinical trials. Oncol Nurs Forum (2000) 2.41
Structure, function, and membrane integration of defensins. Curr Opin Struct Biol (1995) 2.40
Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Science (1997) 2.38
Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages. Infect Immun (1983) 2.33
Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes. J Virol (1985) 2.31
Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium. Infect Immun (1990) 2.25
Localizing proteins in the cell from their phylogenetic profiles. Proc Natl Acad Sci U S A (2000) 2.24
Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest (1988) 2.18
Three-dimensional cluster analysis identifies interfaces and functional residue clusters in proteins. J Mol Biol (2001) 2.17
Oligomer formation by 3D domain swapping: a model for protein assembly and misassembly. Adv Protein Chem (1997) 2.17
Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin. Infect Immun (1987) 2.16
A domain-swapped RNase A dimer with implications for amyloid formation. Nat Struct Biol (2001) 2.15
Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science (1993) 2.09
B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells. Proc Natl Acad Sci U S A (1988) 2.05
Activity of rabbit leukocyte peptides against Candida albicans. Infect Immun (1985) 2.05
The structure of melittin. I. Structure determination and partial refinement. J Biol Chem (1982) 2.04
Transproteomic evidence of a loop-deletion mechanism for enhancing protein thermostability. J Mol Biol (1999) 2.03
Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J (1996) 2.03
In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood (1986) 2.01
Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone. Diabetes Obes Metab (2014) 1.99
The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol (1998) 1.98
Purification and in vitro activities of rabbit platelet microbicidal proteins. Infect Immun (1997) 1.96
Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression profiles. Nat Genet (2001) 1.93
Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect Immun (1994) 1.93
Neutrophils and host defense. Ann Intern Med (1988) 1.92
Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity. Infect Immun (1985) 1.89
Secondary structure-based profiles: use of structure-conserving scoring tables in searching protein sequence databases for structural similarities. Proteins (1991) 1.88
Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci (1994) 1.88
Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes. Chem Biol (1996) 1.87
Reconstruction of glutamine synthetase using computer averaging. Ultramicroscopy (1978) 1.85
In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages. J Infect Dis (1986) 1.84
An evolutionary approach to folding small alpha-helical proteins that uses sequence information and an empirical guiding fitness function. Proc Natl Acad Sci U S A (1994) 1.83
Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide. Biochemistry (1996) 1.81
Assigning folds to the proteins encoded by the genome of Mycoplasma genitalium. Proc Natl Acad Sci U S A (1997) 1.81
Refined atomic model of glutamine synthetase at 3.5 A resolution. J Biol Chem (1989) 1.81
Interactions of melittin, a preprotein model, with detergents. Biochemistry (1979) 1.80
Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect Immun (1994) 1.78
Combination therapy with an ACE inhibitor and an angiotensin receptor blocker for diabetic nephropathy: a meta-analysis. Diabet Med (2007) 1.77
Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol (2000) 1.76
Sizing membrane pores in lipid vesicles by leakage of co-encapsulated markers: pore formation by melittin. Biophys J (1997) 1.76
Assessing the performance of fold recognition methods by means of a comprehensive benchmark. Pac Symp Biocomput (1996) 1.75
Patient experience and preferences toward colon cancer screening: a comparison of virtual colonoscopy and conventional colonoscopy. Gastrointest Endosc (2001) 1.75
A 3D-1D substitution matrix for protein fold recognition that includes predicted secondary structure of the sequence. J Mol Biol (1997) 1.72
Bilayer interactions of indolicidin, a small antimicrobial peptide rich in tryptophan, proline, and basic amino acids. Biophys J (1997) 1.68
Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains. Cell (1981) 1.65
Refined structure of monomeric diphtheria toxin at 2.3 A resolution. Protein Sci (1994) 1.64