Defensins.

Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci U S A (1991) 3.98

Intracellular survival of Burkholderia pseudomallei. Infect Immun (1996) 3.56

Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding. Antimicrob Agents Chemother (2007) 3.54

Enteric defensins: antibiotic peptide components of intestinal host defense. J Cell Biol (1992) 3.03

Partial characterization and staphylocidal activity of thrombin-induced platelet microbicidal protein. Infect Immun (1992) 2.53

Cryptdins: antimicrobial defensins of the murine small intestine. Infect Immun (1992) 2.39

Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect Immun (1993) 2.37

Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action. J Clin Invest (1998) 2.29

Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc Natl Acad Sci U S A (1993) 2.22

Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium. EMBO J (1993) 2.03

Mouse neutrophils lack defensins. Infect Immun (1992) 2.01

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol (1998) 1.98

Functional interrelationships between cell membrane and cell wall in antimicrobial peptide-mediated killing of Staphylococcus aureus. Antimicrob Agents Chemother (2005) 1.91

Staphylococcus aureus susceptibility to thrombin-induced platelet microbicidal protein is independent of platelet adherence and aggregation in vitro. Infect Immun (1992) 1.84

Thrombin-induced rabbit platelet microbicidal protein is fungicidal in vitro. Antimicrob Agents Chemother (1993) 1.80

Staphylocidal action of thrombin-induced platelet microbicidal protein is not solely dependent on transmembrane potential. Infect Immun (1996) 1.79

In vitro antibacterial activities of platelet microbicidal protein and neutrophil defensin against Staphylococcus aureus are influenced by antibiotics differing in mechanism of action. Antimicrob Agents Chemother (1999) 1.77

In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity. Infect Immun (2000) 1.73

Common mechanistic action of bacteriocins from lactic Acid bacteria. Appl Environ Microbiol (1993) 1.53

Antifungal peptides: novel therapeutic compounds against emerging pathogens. Antimicrob Agents Chemother (1999) 1.48

Defensins promote fusion and lysis of negatively charged membranes. Protein Sci (1993) 1.43

Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. Proc Natl Acad Sci U S A (2005) 1.38

In vitro activity of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis. Infect Immun (1996) 1.37

A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media. Infect Immun (2005) 1.37

Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare. Infect Immun (1992) 1.32

Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica. Proc Natl Acad Sci U S A (1996) 1.30

Through the looking glass, mechanistic insights from enantiomeric human defensins. J Biol Chem (2009) 1.25

The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides. Infect Immun (2011) 1.25

Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation. J Clin Invest (1998) 1.25

Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathways. Antimicrob Agents Chemother (2000) 1.16

Evaluation of susceptibility of gram-positive and -negative bacteria to human defensins by using radial diffusion assay. Antimicrob Agents Chemother (1996) 1.11

Mechanisms of antibacterial action of tachyplesins and polyphemusins, a group of antimicrobial peptides isolated from horseshoe crab hemocytes. Antimicrob Agents Chemother (1992) 1.10

Human neutrophil-mediated fungistasis against Histoplasma capsulatum. Localization of fungistatic activity to the azurophil granules. J Clin Invest (1993) 1.09

Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proc Natl Acad Sci U S A (1997) 1.08

Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance? Int J Mol Sci (2009) 1.08

Polymorphic expression of defensins in neutrophils from outbred rats. Infect Immun (1990) 1.08

Acquired immunity in experimental murine aspergillosis is mediated by macrophages. Infect Immun (1993) 1.07

Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum. Infect Immun (2000) 1.02

Phenotypic and genotypic characterization of daptomycin-resistant methicillin-resistant Staphylococcus aureus strains: relative roles of mprF and dlt operons. PLoS One (2014) 1.00

Peptide-based Antifungal Therapies against Emerging Infections. Drugs Future (2010) 0.97

Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils. Infect Immun (2005) 0.95

Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. BMC Genomics (2009) 0.93

The use of antimicrobial peptides in ophthalmology: an experimental study in corneal preservation and the management of bacterial keratitis. Trans Am Ophthalmol Soc (2002) 0.90

Influence of platelets and platelet microbicidal protein susceptibility on the fate of Staphylococcus aureus in an in vitro model of infective endocarditis. Infect Immun (2000) 0.89

Chloride transport in functionally active phagosomes isolated from Human neutrophils. Free Radic Biol Med (2012) 0.89

Site-specific mutation of the sensor kinase GraS in Staphylococcus aureus alters the adaptive response to distinct cationic antimicrobial peptides. Infect Immun (2014) 0.88

Staphylococcus aureus, Platelets, and the Heart. Curr Infect Dis Rep (2000) 0.87

Fungicidal properties of defensin NP-1 and activity against Cryptococcus neoformans in vitro. Antimicrob Agents Chemother (1993) 0.87

The role of inflammation in the genesis of the cystic component of craniopharyngiomas. Childs Nerv Syst (2010) 0.86

Diversity in penaeidin antimicrobial peptide form and function. Dev Comp Immunol (2007) 0.86

Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in Staphylococcus aureus. Antimicrob Agents Chemother (2013) 0.85

Functional chemotactic factor CP-10 and MRP-14 are abundant in murine abscesses. Infect Immun (1996) 0.84

Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus). Reprod Biol Endocrinol (2006) 0.84

Bactericidal activity of synthetic peptides based on the structure of the 55-kilodalton bactericidal protein from human neutrophils. Infect Immun (1994) 0.83

Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide. Biochem J (1999) 0.83

Neutrophil-derived Oxidants and Proteinases as Immunomodulatory Mediators in Inflammation. Mediators Inflamm (1994) 0.82

Modification of β-Defensin-2 by Dicarbonyls Methylglyoxal and Glyoxal Inhibits Antibacterial and Chemotactic Function In Vitro. PLoS One (2015) 0.81

Human beta-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium. Infect Immun (1999) 0.79

Combined systems approaches reveal highly plastic responses to antimicrobial peptide challenge in Escherichia coli. PLoS Pathog (2014) 0.79

Biomaterials selectively modulate interactions between human blood-derived polymorphonuclear leukocytes and monocytes. Am J Pathol (2013) 0.78

Structure-antimicrobial activity relationship between pleurocidin and its enantiomer. Exp Mol Med (2008) 0.78

Human α-defensin expression is not dependent on CCAAT/enhancer binding protein-ε in a murine model. PLoS One (2014) 0.76

Lipopolysaccharide induces SBD-1 expression via the P38 MAPK signaling pathway in ovine oviduct epithelial cells. Lipids Health Dis (2016) 0.76

Defensins: ancient but potentially dangerous weapons in the armoury. Thorax (1992) 0.75

Interaction of Candida albicans with human leukocytes and serum. J Bacteriol (1969) 9.19

Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest (1985) 8.63

Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. J Clin Invest (1969) 7.61

Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol (2000) 6.62

Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes. Infect Immun (1984) 5.30

Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest (1989) 5.21

Severe candidal infections: clinical perspective, immune defense mechanisms, and current concepts of therapy. Ann Intern Med (1978) 4.15

Phagocytosis by human monocytes. Blood (1968) 3.96

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science (1999) 3.90

Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A (1990) 3.90

Primary structures of three human neutrophil defensins. J Clin Invest (1985) 3.70

Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J Biol Chem (1985) 3.58

Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob Agents Chemother (1998) 3.45

Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett (1996) 3.39

Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins. FEBS Lett (1993) 3.30

Antifungal effects of peroxidase systems. J Bacteriol (1969) 3.24

Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism. Infect Immun (1980) 3.13

Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family. Proc Natl Acad Sci U S A (1998) 3.02

Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J Biol Chem (1983) 3.00

Direct inactivation of viruses by human granulocyte defensins. J Virol (1986) 3.00

Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science (1991) 2.71

Nonoxidative fungicidal mechanisms of mammalian granulocytes: demonstration of components with candidacidal activity in human, rabbit, and guinea pig leukocytes. Infect Immun (1975) 2.68

NADPH oxidase deficiency in X-linked chronic granulomatous disease. J Clin Invest (1975) 2.62

Defensins. Curr Opin Immunol (1994) 2.55

Defensins. Pharmacol Ther (1995) 2.52

Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest (1989) 2.50

Defensins: endogenous antibiotic peptides of animal cells. Cell (1991) 2.45

Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores. Protein Sci (1994) 2.43

Crystallization of antimicrobial pores in membranes: magainin and protegrin. Biophys J (2000) 2.41

Structure, function, and membrane integration of defensins. Curr Opin Struct Biol (1995) 2.40

Cryptdins: antimicrobial defensins of the murine small intestine. Infect Immun (1992) 2.39

Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. J Clin Invest (1971) 2.35

Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages. Infect Immun (1983) 2.33

Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes. J Virol (1985) 2.31

The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms. J Clin Invest (1975) 2.26

Functional aspects of a second mechanism of candidacidal activity by human neutrophils. J Clin Invest (1972) 2.25

Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium. Infect Immun (1990) 2.25

Defensins and other endogenous peptide antibiotics of vertebrates. J Leukoc Biol (1995) 2.25

Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun (2000) 2.24

Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest (1988) 2.18

Susceptibility of Chlamydia trachomatis to protegrins and defensins. Infect Immun (1996) 2.16

Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin. Infect Immun (1987) 2.16

Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase. J Clin Invest (1973) 2.16

Assessment of chlorination by human neutrophils. Nature (1983) 2.12

Activity of rabbit leukocyte peptides against Candida albicans. Infect Immun (1985) 2.05

Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J (1996) 2.03

Development of amphotericin B-resistant Candida tropicalis in a patient with defective leukocyte function. Am J Med Sci (1979) 2.02

Mouse neutrophils lack defensins. Infect Immun (1992) 2.01

In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood (1986) 2.01

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol (1998) 1.98

Purification and in vitro activities of rabbit platelet microbicidal proteins. Infect Immun (1997) 1.96

Antimicrobial peptides of vertebrates. Curr Opin Immunol (1998) 1.94

Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect Immun (1994) 1.93

Neutrophils and host defense. Ann Intern Med (1988) 1.92

Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity. Infect Immun (1985) 1.89

Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol (1994) 1.88

Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes. Chem Biol (1996) 1.87

In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages. J Infect Dis (1986) 1.84

Designer assays for antimicrobial peptides. Disputing the "one-size-fits-all" theory. Methods Mol Biol (1997) 1.79

Fungicidal activity of rabbit alveolar and peritoneal macrophages against Candida albicans. Infect Immun (1980) 1.79

Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect Immun (1994) 1.78

Rubidium release: a rapid and sensitive assay for amphotericin B. J Infect Dis (1976) 1.76

Sizing membrane pores in lipid vesicles by leakage of co-encapsulated markers: pore formation by melittin. Biophys J (1997) 1.76

Bactericidal properties of murine intestinal phospholipase A2. J Clin Invest (1995) 1.75

Phagolysosomal pH of human neutrophils. Blood (1984) 1.75

Effects of pH and salinity on the antimicrobial properties of clavanins. Infect Immun (1997) 1.75

Bilayer interactions of indolicidin, a small antimicrobial peptide rich in tryptophan, proline, and basic amino acids. Biophys J (1997) 1.68

Susceptibility of Neisseria gonorrhoeae to protegrins. Infect Immun (1996) 1.65

Membrane thinning effect of the beta-sheet antimicrobial protegrin. Biochemistry (2000) 1.64

Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity. J Immunol (1988) 1.64

Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. J Clin Invest (1988) 1.63

Structure and diversity of the murine cryptdin gene family. Genomics (1994) 1.62

Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes. Infect Immun (1981) 1.61

Fungicidal properties of a chymotrypsin-like cationic protein from human neutrophils: adsorption to Candida parapsilosis. Infect Immun (1977) 1.61

Isolation and characterization of human defensin cDNA clones. Proc Natl Acad Sci U S A (1988) 1.61

Defensin-rich dense granules of human neutrophils. Blood (1987) 1.59

Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes. Lab Invest (1977) 1.57

Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology (1994) 1.53

Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant. Infect Immun (1981) 1.52

Antimicrobial proteins of murine macrophages. Infect Immun (1993) 1.50

Antimicrobial activity of phagocyte granule proteins. Semin Respir Infect (1986) 1.49

Purification and antimicrobial properties of three defensins from rat neutrophils. Infect Immun (1989) 1.46