Published in Curr Opin Microbiol on January 14, 2010
Evolution of two-component signal transduction systems. Annu Rev Microbiol (2012) 2.24
Diversity of structure and function of response regulator output domains. Curr Opin Microbiol (2010) 2.17
Global regulation by the seven-component Pi signaling system. Curr Opin Microbiol (2010) 2.07
Regulation of response regulator autophosphorylation through interdomain contacts. J Biol Chem (2010) 1.85
Receiver domain structure and function in response regulator proteins. Curr Opin Microbiol (2010) 1.77
A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence. Nucleic Acids Res (2012) 1.70
Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris. Proc Natl Acad Sci U S A (2010) 1.48
The aspartate-less receiver (ALR) domains: distribution, structure and function. PLoS Pathog (2015) 1.43
Sensing the messenger: the diverse ways that bacteria signal through c-di-GMP. Protein Sci (2012) 1.38
Structural basis of response regulator dephosphorylation by Rap phosphatases. PLoS Biol (2011) 1.35
Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. Mol Cell (2012) 1.25
Inactivation of a novel response regulator is necessary for biofilm formation and host colonization by Vibrio fischeri. Mol Microbiol (2011) 1.11
CheV: CheW-like coupling proteins at the core of the chemotaxis signaling network. Trends Microbiol (2010) 1.09
A structural model of anti-anti-σ inhibition by a two-component receiver domain: the PhyR stress response regulator. Mol Microbiol (2010) 1.06
Involvement of WalK (VicK) phosphatase activity in setting WalR (VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells. Mol Microbiol (2012) 1.03
Anti-adaptors provide multiple modes for regulation of the RssB adaptor protein. Genes Dev (2013) 0.99
Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator. Chem Biol Drug Des (2012) 0.98
Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation. Proc Natl Acad Sci U S A (2013) 0.98
Mechanistic insights into c-di-GMP-dependent control of the biofilm regulator FleQ from Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2015) 0.94
Regulation of virulence by the RevR response regulator in Clostridium perfringens. Infect Immun (2011) 0.93
Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger cyclic di-GMP. J Biol Chem (2014) 0.92
C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG. PLoS One (2013) 0.90
Phosphorylation of PhoP protein plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis. J Biol Chem (2011) 0.90
A Phosphosignaling Adaptor Primes the AAA+ Protease ClpXP to Drive Cell Cycle-Regulated Proteolysis. Mol Cell (2015) 0.89
An asymmetric heterodomain interface stabilizes a response regulator-DNA complex. Nat Commun (2014) 0.89
Identification of the amino acids essential for LytSR-mediated signal transduction in Staphylococcus aureus and their roles in biofilm-specific gene expression. Mol Microbiol (2015) 0.88
Molecular Mechanisms of Two-Component Signal Transduction. J Mol Biol (2016) 0.87
Phosphorylated CpxR restricts production of the RovA global regulator in Yersinia pseudotuberculosis. PLoS One (2011) 0.86
A link between dimerization and autophosphorylation of the response regulator PhoB. J Biol Chem (2013) 0.86
Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast. Mol Biol Cell (2013) 0.83
Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation. MBio (2014) 0.83
The sensory histidine kinases TorS and EvgS tend to form clusters in Escherichia coli cells. PLoS One (2013) 0.83
Autophosphorylation activity of a soluble hexameric histidine kinase correlates with the shift in protein conformational equilibrium. Chem Biol (2013) 0.82
An orphan chemotaxis sensor regulates virulence and antibiotic tolerance in the human pathogen Pseudomonas aeruginosa. PLoS One (2012) 0.82
Temporal hierarchy of gene expression mediated by transcription factor binding affinity and activation dynamics. MBio (2015) 0.82
Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens. Virulence (2014) 0.81
The atypical two-component sensor kinase Lpl0330 from Legionella pneumophila controls the bifunctional diguanylate cyclase-phosphodiesterase Lpl0329 to modulate bis-(3'-5')-cyclic dimeric GMP synthesis. J Biol Chem (2011) 0.81
Structure-function studies of DNA binding domain of response regulator KdpE reveals equal affinity interactions at DNA half-sites. PLoS One (2012) 0.81
Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae. Nucleic Acids Res (2014) 0.81
AccR is a master regulator involved in carbon catabolite repression of the anaerobic catabolism of aromatic compounds in Azoarcus sp. CIB. J Biol Chem (2013) 0.81
The dimeric form of the unphosphorylated response regulator BaeR. Protein Sci (2013) 0.80
Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network. Proc Natl Acad Sci U S A (2013) 0.79
Ligand-induced folding of a two-component signaling receiver domain. Biochemistry (2015) 0.79
NMR assignments for the Sinorhizobium meliloti response regulator Sma0114. Biomol NMR Assign (2010) 0.78
DNA-affinity-purified chip (DAP-chip) method to determine gene targets for bacterial two component regulatory systems. J Vis Exp (2014) 0.78
Interactions of the CpxA sensor kinase and cognate CpxR response regulator from Yersinia pseudotuberculosis. BMC Res Notes (2012) 0.78
Expression, purification, crystallization and preliminary X-ray analysis of the receiver domain of Staphylococcus aureus LytR protein. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.77
Interaction of the RcsB Response Regulator with Auxiliary Transcription Regulators in Escherichia coli. J Biol Chem (2015) 0.77
Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element. Nucleic Acids Res (2014) 0.77
Determinants of interaction specificity of the Bacillus subtilis GlcT antitermination protein: functionality and phosphorylation specificity depend on the arrangement of the regulatory domains. J Biol Chem (2012) 0.76
Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris. Acta Crystallogr F Struct Biol Commun (2015) 0.76
Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. PLoS Biol (2016) 0.76
Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action. Elife (2016) 0.75
Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites. J Biomed Sci (2017) 0.75
Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction. J Bacteriol (2016) 0.75
The YsrS Paralog DygS Has the Capacity To Activate Expression of the Yersinia enterocolitica Ysa Type III Secretion System. J Bacteriol (2016) 0.75
The Response Regulator YycF Inhibits Expression of the Fatty Acid Biosynthesis Repressor FabT in Streptococcus pneumoniae. Front Microbiol (2016) 0.75
Anti-adaptors use distinct modes of binding to inhibit the RssB-dependent turnover of RpoS (σ(S)) by ClpXP. Front Mol Biosci (2015) 0.75
Signaling mechanism by the Staphylococcus aureus two-component system LytSR: role of acetyl phosphate in bypassing the cell membrane electrical potential sensor LytS. F1000Res (2015) 0.75
Role of the Transporter-Like Sensor Kinase CbrA in Histidine Uptake and Signal Transduction. J Bacteriol (2015) 0.75
Conformational Dynamics of Response Regulator RegX3 from Mycobacterium tuberculosis. PLoS One (2015) 0.75
The Escherichia coli NarL receiver domain regulates transcription through promoter specific functions. BMC Microbiol (2015) 0.75
The histidine residue of QseC is required for canonical signaling between QseB and PmrB in uropathogenic Escherichia coli. J Bacteriol (2017) 0.75
Use of a Phosphorylation Site Mutant to Identify Distinct Modes of Gene Repression by the Control of Virulence Regulator (CovR) in Streptococcus pyogenes. J Bacteriol (2017) 0.75
The Legionella pneumophila incomplete phosphotransferase system (PTS) is required for optimal intracellular growth and maximal expression of PmrA regulated effectors. Infect Immun (2017) 0.75
Structural and mechanistic determinants of c-di-GMP signalling. Nat Rev Microbiol (2009) 3.39
Structure of the Escherichia coli response regulator NarL. Biochemistry (1996) 3.19
Phosphorylation-independent regulation of the diguanylate cyclase WspR. PLoS Biol (2008) 2.99
Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition. Structure (2007) 2.93
Nucleotide sequence of the phoR gene, a regulatory gene for the phosphate regulon of Escherichia coli. J Mol Biol (1986) 2.65
Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains. Genes Dev (2003) 2.50
Mechanism of activation for transcription factor PhoB suggested by different modes of dimerization in the inactive and active states. Structure (2005) 2.39
Conformational changes induced by phosphorylation of the FixJ receiver domain. Structure (1999) 2.22
Diversity of structure and function of response regulator output domains. Curr Opin Microbiol (2010) 2.17
Dimerization allows DNA target site recognition by the NarL response regulator. Nat Struct Biol (2002) 2.05
Crystal structure of an activated response regulator bound to its target. Nat Struct Biol (2001) 1.95
The activation of PhoB by acetylphosphate. Mol Microbiol (1996) 1.85
Tandem binding of six OmpR proteins to the ompF upstream regulatory sequence of Escherichia coli. J Biol Chem (1995) 1.85
Receiver domain structure and function in response regulator proteins. Curr Opin Microbiol (2010) 1.77
Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. J Biol Chem (2007) 1.77
Structural analysis and solution studies of the activated regulatory domain of the response regulator ArcA: a symmetric dimer mediated by the alpha4-beta5-alpha5 face. J Mol Biol (2005) 1.76
The structural basis for regulated assembly and function of the transcriptional activator NtrC. Genes Dev (2006) 1.74
Structural analysis of the domain interface in DrrB, a response regulator of the OmpR/PhoB subfamily. J Bacteriol (2003) 1.71
Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima. Structure (2002) 1.68
AlgR-binding sites within the algD promoter make up a set of inverted repeats separated by a large intervening segment of DNA. J Bacteriol (1992) 1.56
A common dimerization interface in bacterial response regulators KdpE and TorR. Protein Sci (2005) 1.42
Negative regulation of AAA + ATPase assembly by two component receiver domains: a transcription activation mechanism that is conserved in mesophilic and extremely hyperthermophilic bacteria. J Mol Biol (2005) 1.39
Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states. J Bacteriol (2004) 1.36
The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis. J Biol Chem (2006) 1.34
Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex. EMBO J (1999) 1.32
Crystal structures of the receiver domain of the response regulator PhoP from Escherichia coli in the absence and presence of the phosphoryl analog beryllofluoride. J Bacteriol (2007) 1.32
Determinants for the activation and autoinhibition of the diguanylate cyclase response regulator WspR. J Mol Biol (2009) 1.31
Structure of an atypical orphan response regulator protein supports a new phosphorylation-independent regulatory mechanism. J Biol Chem (2007) 1.30
Dimer formation and transcription activation in the sporulation response regulator Spo0A. J Mol Biol (2002) 1.27
Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation. Biochemistry (2007) 1.27
Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. J Mol Biol (2005) 1.26
Phosphorylation-induced dimerization of the FixJ receiver domain. Mol Microbiol (1999) 1.26
System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids. Mol Microbiol (2008) 1.23
Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation. J Mol Biol (2008) 1.22
Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation. J Mol Biol (2008) 1.20
Two-component signaling in the AAA + ATPase DctD: binding Mg2+ and BeF3- selects between alternate dimeric states of the receiver domain. FASEB J (2002) 1.17
Dimer form of phosphorylated Spo0A, a transcriptional regulator, stimulates the spo0F transcription at the initiation of sporulation in Bacillus subtilis. J Mol Biol (1995) 1.10
An active-like structure in the unphosphorylated StyR response regulator suggests a phosphorylation- dependent allosteric activation mechanism. Structure (2005) 1.08
Structural analysis of the DNA-binding domain of the Erwinia amylovora RcsB protein and its interaction with the RcsAB box. J Biol Chem (2003) 1.07
Phosphorylation-induced signal propagation in the response regulator ntrC. J Bacteriol (2000) 1.06
Structural and functional analysis of the C-terminal DNA binding domain of the Salmonella typhimurium SPI-2 response regulator SsrB. J Biol Chem (2009) 1.05
Domain swapping in the sporulation response regulator Spo0A. J Mol Biol (2000) 1.03
Crystal structure of a cyanobacterial phytochrome response regulator. Protein Sci (2002) 0.98
Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators. Biophys J (2004) 0.95
The structure of a full-length response regulator from Mycobacterium tuberculosis in a stabilized three-dimensional domain-swapped, activated state. J Biol Chem (2007) 0.88
The HupR receiver domain crystal structure in its nonphospho and inhibitory phospho states. J Mol Biol (2008) 0.84
Mutational scanning and affinity cleavage analysis of UhpA-binding sites in the Escherichia coli uhpT promoter. J Bacteriol (2002) 0.84
SAS solution structures of the apo and Mg2+/BeF3(-)-bound receiver domain of DctD from Sinorhizobium meliloti. Biochemistry (2005) 0.82
Biological insights from structures of two-component proteins. Annu Rev Microbiol (2009) 4.47
Molecular information processing: lessons from bacterial chemotaxis. J Biol Chem (2002) 2.72
Bacterial response regulators: versatile regulatory strategies from common domains. Trends Biochem Sci (2007) 2.45
Mechanism of activation for transcription factor PhoB suggested by different modes of dimerization in the inactive and active states. Structure (2005) 2.39
Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease. Proc Natl Acad Sci U S A (2003) 2.21
Regulation of response regulator autophosphorylation through interdomain contacts. J Biol Chem (2010) 1.85
Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease. J Biol Chem (2007) 1.83
Structural analysis and solution studies of the activated regulatory domain of the response regulator ArcA: a symmetric dimer mediated by the alpha4-beta5-alpha5 face. J Mol Biol (2005) 1.76
Universally applicable methods for monitoring response regulator aspartate phosphorylation both in vitro and in vivo using Phos-tag-based reagents. Anal Biochem (2008) 1.76
Structural analysis of the domain interface in DrrB, a response regulator of the OmpR/PhoB subfamily. J Bacteriol (2003) 1.71
Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima. Structure (2002) 1.68
Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding. Structure (2008) 1.50
A common dimerization interface in bacterial response regulators KdpE and TorR. Protein Sci (2005) 1.42
Domain arrangement of Der, a switch protein containing two GTPase domains. Structure (2002) 1.39
NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols. J Biol Chem (2006) 1.32
Crystal structures of the receiver domain of the response regulator PhoP from Escherichia coli in the absence and presence of the phosphoryl analog beryllofluoride. J Bacteriol (2007) 1.32
Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation. Biochemistry (2007) 1.27
System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids. Mol Microbiol (2008) 1.23
Crystal structures of beryllium fluoride-free and beryllium fluoride-bound CheY in complex with the conserved C-terminal peptide of CheZ reveal dual binding modes specific to CheY conformation. J Mol Biol (2006) 1.14
Probing kinase and phosphatase activities of two-component systems in vivo with concentration-dependent phosphorylation profiling. Proc Natl Acad Sci U S A (2012) 1.14
Probing the roles of the two different dimers mediated by the receiver domain of the response regulator PhoB. J Mol Biol (2009) 1.08
Bright lights, abundant operons--fluorescence and genomic technologies advance studies of bacterial locomotion and signal transduction: review of the BLAST meeting, Cuernavaca, Mexico, 14 to 19 January 2001. J Bacteriol (2002) 1.07
Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator. Chem Biol Drug Des (2012) 0.98
Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation. Proc Natl Acad Sci U S A (2013) 0.98
Kinetic basis for the stimulatory effect of phosphorylation on the methylesterase activity of CheB. Biochemistry (2002) 0.94
Crystal structure and autoactivation pathway of the precursor form of human tripeptidyl-peptidase 1, the enzyme deficient in late infantile ceroid lipofuscinosis. J Biol Chem (2008) 0.94
Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption? Biochem J (2007) 0.92
Identification of methylation sites in Thermotoga maritima chemotaxis receptors. J Bacteriol (2006) 0.92
Discrimination between different methylation states of chemotaxis receptor Tar by receptor methyltransferase CheR. Biochemistry (2004) 0.91
Evolutionary tuning of protein expression levels of a positively autoregulated two-component system. PLoS Genet (2013) 0.90
Comprehensive analysis of OmpR phosphorylation, dimerization, and DNA binding supports a canonical model for activation. J Mol Biol (2013) 0.90
Loss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathway. PLoS One (2011) 0.88
Interaction of CheY with the C-terminal peptide of CheZ. J Bacteriol (2007) 0.85
Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding. Biochemistry (2012) 0.85
Characterization of the Thermotoga maritima chemotaxis methylation system that lacks pentapeptide-dependent methyltransferase CheR:MCP tethering. Mol Microbiol (2006) 0.82
Transmembrane signaling by asymmetry. Nat Struct Mol Biol (2006) 0.79
Catalytically incompetent by design. Structure (2009) 0.78
Diguanylate cyclase activation: it takes two. Structure (2007) 0.78