Published in Nat Chem Biol on February 01, 2010
DNA as a versatile chemical component for catalysis, encoding, and stereocontrol. Angew Chem Int Ed Engl (2010) 1.51
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science (1991) 12.17
SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands. Biomol Eng (2007) 3.82
Stability of peptide nucleic acids in human serum and cellular extracts. Biochem Pharmacol (1994) 2.60
The chemical biology of aptamers. Angew Chem Int Ed Engl (2009) 2.09
Critical review of the role of HTS in drug discovery. Drug Discov Today (2006) 1.58
Chemical evolution as a tool for molecular discovery. Annu Rev Biochem (2007) 1.29
An in vitro translation, selection and amplification system for peptide nucleic acids. Nat Chem Biol (2009) 1.02
Peptide nucleic acids and the origin of life. Chem Biodivers (2007) 0.96
Treating age-related macular degeneration - interaction of VEGF-antagonists with their target. Mini Rev Med Chem (2009) 0.92
From fragment screening to potent binders: strategies for fragment-to-lead evolution. Mini Rev Med Chem (2009) 0.89
Peptide nucleic acids with a structurally biased backbone: effects of conformational constraints and stereochemistry. Curr Top Med Chem (2007) 0.89
Non-natural nucleic acids for synthetic biology. Curr Opin Chem Biol (2009) 0.86
Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions. J Am Chem Soc (2006) 1.31
Gamma-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display. Angew Chem Int Ed Engl (2007) 1.24
Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds. Nat Commun (2012) 1.06
Colorimetric detection of anthrax DNA with a Peptide nucleic acid sandwich-hybridization assay. J Am Chem Soc (2007) 1.04
(S,S)-trans-cyclopentane-constrained peptide nucleic acids. a general backbone modification that improves binding affinity and sequence specificity. J Am Chem Soc (2004) 1.03
Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution. Org Lett (2007) 1.00
Synthesis of gamma-substituted peptide nucleic acids: a new place to attach fluorophores without affecting DNA binding. Org Lett (2005) 0.98
Click dimers to target HIV TAR RNA conformation. Biochemistry (2012) 0.97
Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol (2010) 0.96
N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53. Bioorg Med Chem (2009) 0.95
Advantages of peptide nucleic acids as diagnostic platforms for detection of nucleic acids in resource-limited settings. J Infect Dis (2010) 0.94
Synthesis and anticancer activities of 6-amino amonafide derivatives. Anticancer Drugs (2008) 0.94
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). Biochemistry (2011) 0.89
Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs. Nucleic Acids Res (2009) 0.89
Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer. Neoplasia (2011) 0.88
PNA-DNA duplexes, triplexes, and quadruplexes are stabilized with trans-cyclopentane units. J Am Chem Soc (2006) 0.87
Enhanced oligonucleotide binding to self-assembled nanofibers. Bioconjug Chem (2005) 0.86
Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates. Bioorg Med Chem Lett (2013) 0.85
Targeting DNA G-quadruplex structures with peptide nucleic acids. Curr Pharm Des (2012) 0.84
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication. Bioorg Med Chem Lett (2009) 0.84
Nonionic side chains modulate the affinity and specificity of binding between functionalized polyamines and structured RNA. J Am Chem Soc (2004) 0.84
A small molecular scaffold for selective inhibition of Wip1 phosphatase. ChemMedChem (2008) 0.81
Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity. Org Lett (2004) 0.81
Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region. Nucleic Acids Res (2011) 0.81
A new family of small molecules to probe the reactivation of mutant p53. J Am Chem Soc (2005) 0.80
Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding. Bioorg Med Chem Lett (2010) 0.80
Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects. J Am Chem Soc (2014) 0.79
A cyclopentane conformational restraint for a peptide nucleic acid: design, asymmetric synthesis, and improved binding affinity to DNA and RNA. Org Lett (2003) 0.78
Cyclopentane-peptide nucleic acids for qualitative, quantitative, and repetitive detection of nucleic acids. Anal Chem (2012) 0.78
Aziridination of aliphatic alkenes catalyzed by N-heterocyclic carbene copper complexes. Org Lett (2008) 0.78
Cyclopentane peptide nucleic acids. Methods Mol Biol (2014) 0.77
PPG peptide nucleic acids that promote DNA guanine quadruplexes. Chembiochem (2014) 0.77
An efficient synthesis of a probe for protein function: 2,3-diaminopropionic acid with orthogonal protecting groups. Org Lett (2004) 0.77
Inhibition of multidrug resistance by SV40 pseudovirion delivery of an antigene peptide nucleic acid (PNA) in cultured cells. PLoS One (2011) 0.76
Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. Bioorg Med Chem (2012) 0.76
Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA. J Nucleic Acids (2012) 0.75
A one-pot preparation of N-2-mercaptobenzoyl-amino amides. Tetrahedron Lett (2011) 0.75
Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x(L). Bioorg Med Chem Lett (2009) 0.75
G-quadruplex formation between G-rich PNA and homologous sequences in oligonucleotides and supercoiled plasmid DNA. Nucleic Acid Ther (2015) 0.75
Mimicking nature: from fundamentals to applications. Curr Opin Chem Biol (2009) 0.75
Peptide nucleic acid microarrays made with (S,S)-trans-cyclopentane-constrained peptide nucleic acids. Methods Enzymol (2006) 0.75
Practical synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate and resolution of enantiomers. J Org Chem (2006) 0.75
Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection. Chem Commun (Camb) (2005) 0.75