Published in Nat Chem Biol on January 17, 2010
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell (2012) 2.36
HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition. EMBO J (2012) 2.24
Stem cell metabolism in tissue development and aging. Development (2013) 2.01
Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility. Oncogene (2010) 1.41
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition. Nat Cell Biol (2015) 1.16
Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells. Oncotarget (2015) 1.06
Metabolic regulation of stem cell function. J Intern Med (2014) 0.97
Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells. J Cardiovasc Transl Res (2012) 0.93
Stem cells: Metabolism regulates differentiation. Nat Chem Biol (2010) 0.90
5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation. Stem Cells (2012) 0.90
Energy metabolism in the acquisition and maintenance of stemness. Semin Cell Dev Biol (2016) 0.90
A major fraction of glycosphingolipids in model and cellular cholesterol-containing membranes is undetectable by their binding proteins. J Biol Chem (2010) 0.90
Changes in acetyl CoA levels during the early embryonic development of Xenopus laevis. PLoS One (2014) 0.82
SEEDSTICK is a master regulator of development and metabolism in the Arabidopsis seed coat. PLoS Genet (2014) 0.81
AMP-activated Protein Kinase Stimulates Warburg-like Glycolysis and Activation of Satellite Cells during Muscle Regeneration. J Biol Chem (2015) 0.80
Induction of tumor stem cell differentiation--novel strategy to overcome therapy resistance in gastric cancer. Langenbecks Arch Surg (2013) 0.79
Metabolic remodeling in early development and cardiomyocyte maturation. Semin Cell Dev Biol (2016) 0.78
Metabolic determinants of embryonic development and stem cell fate. Reprod Fertil Dev (2014) 0.78
Expressed sequence tags for bovine muscle satellite cells, myotube formed-cells and adipocyte-like cells. PLoS One (2013) 0.78
Molecular mechanism of extrinsic factors affecting anti-aging of stem cells. World J Stem Cells (2015) 0.77
Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation. J Biol Chem (2016) 0.77
FIH-1/c-kit signaling: a novel contributor to corneal epithelial glycogen metabolism. Invest Ophthalmol Vis Sci (2013) 0.77
Mitochondria in pluripotent stem cells: stemness regulators and disease targets. Curr Opin Genet Dev (2016) 0.75
A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development (2016) 0.75
A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC). Elife (2017) 0.75
Metabolic remodeling during the loss and acquisition of pluripotency. Development (2017) 0.75
Generation of red blood cells in vitro: monitoring the process for improved efficiency. Cytotherapy (2013) 0.75
Metabolism and Skeletal Muscle Homeostasis in Lung Disease. Am J Respir Cell Mol Biol (2017) 0.75
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91
ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell (2005) 7.65
A myogenic cell line with altered serum requirements for differentiation. Differentiation (1977) 5.30
Rhabdomyosarcoma: an overview. Oncologist (1999) 2.68
Expression profiling and identification of novel genes involved in myogenic differentiation. FASEB J (2003) 2.30
NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J (2003) 2.24
Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev Biol (2004) 1.82
Molecular framework underlying pluripotency. Cell Cycle (2008) 1.42
Minireview: hexose-6-phosphate dehydrogenase and redox control of 11{beta}-hydroxysteroid dehydrogenase type 1 activity. Endocrinology (2005) 1.35
ATP-citrate lyase deficiency in the mouse. J Biol Chem (2003) 1.35
Endoplasmic reticulum stress increases myofiber formation in vitro. FASEB J (2007) 1.18
Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. J Biol Chem (2008) 1.18
Modulation of DNA polymerases alpha, delta and epsilon by lactate dehydrogenase and 3-phosphoglycerate kinase. Biochim Biophys Acta (1998) 1.14
Modeling DNA sequence-based cis-regulatory gene networks. Dev Biol (2002) 1.03
Biochemistry. A glucose-to-gene link. Science (2009) 1.01
Microsomal hexose-6-phosphate and 6-phosphogluconate dehydrogenases in extrahepatic tissues: human placenta and pig kidney cortex. Biochem Int (1990) 0.82
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Genomic maps and comparative analysis of histone modifications in human and mouse. Cell (2005) 18.96
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell (2005) 7.20
Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature (2011) 7.03
Single-nucleosome mapping of histone modifications in S. cerevisiae. PLoS Biol (2005) 6.37
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78
Reconstituting organ-level lung functions on a chip. Science (2010) 5.75
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A (2003) 5.56
Global nucleosome occupancy in yeast. Genome Biol (2004) 5.49
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol (2009) 5.41
ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Res (2007) 5.10
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science (2013) 4.39
A planning strategy for diversity-oriented synthesis. Angew Chem Int Ed Engl (2004) 4.21
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J (2006) 4.06
Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett (2005) 3.90
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A (2005) 3.86
Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chem Biol (2002) 3.66
Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol (2006) 3.63
Towards the optimal screening collection: a synthesis strategy. Angew Chem Int Ed Engl (2008) 3.53
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell (2003) 3.47
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J (2002) 3.45
A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature (2009) 3.44
Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science (2012) 3.33
Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation (2008) 3.33
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell (2009) 3.31
Mechanical control of tissue and organ development. Development (2010) 3.18
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci U S A (2005) 3.18
A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol (2009) 3.15
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci (2006) 2.98
Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc Natl Acad Sci U S A (2009) 2.94
Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics (2003) 2.92
Large-scale chemical dissection of mitochondrial function. Nat Biotechnol (2008) 2.91
From 3D cell culture to organs-on-chips. Trends Cell Biol (2011) 2.83
Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun (2003) 2.71
Non-genetic heterogeneity--a mutation-independent driving force for the somatic evolution of tumours. Nat Rev Genet (2009) 2.69
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol (2006) 2.62
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol (2004) 2.57
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med (2012) 2.52
From knowing to controlling: a path from genomics to drugs using small molecule probes. Science (2003) 2.48
Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest (2008) 2.46
Micropatterning tractional forces in living cells. Cell Motil Cytoskeleton (2002) 2.45
High-betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol (2005) 2.44
Cell tension, matrix mechanics, and cancer development. Cancer Cell (2005) 2.42
Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE (2002) 2.36
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip (2012) 2.36
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature (2002) 2.34
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell (2013) 2.30
Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell (2003) 2.29
Development and validation of a T7 based linear amplification for genomic DNA. BMC Genomics (2003) 2.23
Nanomagnetic actuation of receptor-mediated signal transduction. Nat Nanotechnol (2007) 2.22
A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol (2009) 2.21
Microengineered physiological biomimicry: organs-on-chips. Lab Chip (2012) 2.21
Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet (2007) 2.18
Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J Cell Biol (2002) 2.14
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci U S A (2002) 2.14
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn (2005) 2.13
Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors. Angew Chem Int Ed Engl (2007) 2.11
Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. Am J Physiol Cell Physiol (2003) 2.09
Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. Neonatology (2013) 2.06
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat Struct Mol Biol (2010) 2.04
Perturbational profiling of nanomaterial biologic activity. Proc Natl Acad Sci U S A (2008) 2.04
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles. Proc Natl Acad Sci U S A (2010) 2.01
Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem (2004) 1.98
Combined microfluidic-micromagnetic separation of living cells in continuous flow. Biomed Microdevices (2006) 1.96
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol (2006) 1.95
Self-assembly of three-dimensional prestressed tensegrity structures from DNA. Nat Nanotechnol (2010) 1.95
Micromagnetic-microfluidic blood cleansing device. Lab Chip (2009) 1.95
Revealing complex traits with small molecules and naturally recombinant yeast strains. Chem Biol (2006) 1.87
SIR1, an upstream component in auxin signaling identified by chemical genetics. Science (2003) 1.87
Generating diverse skeletons of small molecules combinatorially. Science (2003) 1.87
Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins. J Cell Biol (2004) 1.86
Geometric determinants of directional cell motility revealed using microcontact printing. Langmuir (2003) 1.85
Direct control of mitochondrial function by mTOR. Proc Natl Acad Sci U S A (2009) 1.85
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res (2009) 1.84
Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell (2011) 1.82
Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem (2007) 1.81
Organic chemistry: Molecular diversity by design. Nature (2009) 1.81
Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg (2004) 1.81
PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition. Proc Natl Acad Sci U S A (2008) 1.80
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene (2005) 1.79
TBP dynamics in living human cells: constitutive association of TBP with mitotic chromosomes. Mol Biol Cell (2002) 1.78
Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci (2012) 1.76
The potential landscape of genetic circuits imposes the arrow of time in stem cell differentiation. Biophys J (2010) 1.76
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci U S A (2004) 1.75
Selective chemical treatment of cellular microdomains using multiple laminar streams. Chem Biol (2003) 1.74
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest (2011) 1.74
Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent. J Cell Sci (2006) 1.72