Published in J Pharmacol Exp Ther on January 19, 2010
The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases. Pflugers Arch (2012) 1.15
HGF-MET cascade, a key target for inhibiting cancer metastasis: the impact of NK4 discovery on cancer biology and therapeutics. Int J Mol Sci (2013) 0.92
A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases. Front Endocrinol (Lausanne) (2013) 0.91
Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers. Br J Pharmacol (2011) 0.84
Importance of the brain Angiotensin system in Parkinson's disease. Parkinsons Dis (2012) 0.81
Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther (2012) 0.80
The Hepatocyte Growth Factor/c-Met Antagonist, Divalinal-Angiotensin IV, Blocks the Acquisition of Methamphetamine Dependent Conditioned Place Preference in Rats. Brain Sci (2012) 0.80
Discovery of inhibitors of insulin-regulated aminopeptidase as cognitive enhancers. Int J Hypertens (2012) 0.78
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther (2014) 0.76
Central administration of angiotensin IV rapidly enhances novel object recognition among mice. Neuropharmacology (2013) 0.76
Analogs of the hepatocyte growth factor and macrophage-stimulating protein hinge regions act as Met and Ron dual inhibitors in pancreatic cancer cells. Anticancer Drugs (2016) 0.75
Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov (2008) 4.76
c-Met: structure, functions and potential for therapeutic inhibition. Cancer Metastasis Rev (2003) 2.81
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell (2004) 2.61
HGF/SF-met signaling in the control of branching morphogenesis and invasion. J Cell Biochem (2003) 2.08
Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci U S A (2006) 1.85
Cancer therapy: can the challenge be MET? Trends Mol Med (2005) 1.81
Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction. Hypertension (2006) 1.54
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis. Adv Cancer Res (2008) 1.54
Showering c-MET-dependent cancers with drugs. Curr Opin Genet Dev (2008) 1.52
Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. J Biol Chem (2001) 1.50
HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. Cancer Res (2000) 1.47
Silencing the MET oncogene leads to regression of experimental tumors and metastases. Oncogene (2007) 1.42
HGF: a multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol (1999) 1.41
The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network. Cancer Res (2000) 1.23
Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells. Int J Oncol (2001) 1.23
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J Biol Chem (2000) 1.22
Identification and change in the receptor for hepatocyte growth factor in rat liver after partial hepatectomy or induced hepatitis. Biochem Biophys Res Commun (1991) 1.20
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding. Nat Struct Biol (1999) 1.14
Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS). Oncogene (2006) 1.09
Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP). J Neurochem (2003) 1.07
A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met. J Biol Chem (2008) 1.06
Discovery of a distinct binding site for angiotensin II (3-8), a putative angiotensin IV receptor. Regul Pept (1992) 1.03
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. Proc Natl Acad Sci U S A (2007) 1.03
Contributions of the brain angiotensin IV-AT4 receptor subtype system to spatial learning. J Neurosci (1999) 1.02
Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist. J Mol Biol (2008) 0.98
Mutational analysis of the active site of human insulin-regulated aminopeptidase. Eur J Biochem (2001) 0.98
Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets. Prog Neurobiol (2007) 0.94
Angiotensin IV activates the nuclear transcription factor-kappaB and related proinflammatory genes in vascular smooth muscle cells. Circ Res (2005) 0.94
Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation. Am J Physiol Lung Cell Mol Physiol (2002) 0.90
Angiotensin IV AT4-receptor system in the rat kidney. Am J Physiol (1998) 0.88
Chronic angiotensin IV treatment reverses endothelial dysfunction in ApoE-deficient mice. Cardiovasc Res (2007) 0.88
The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Brain Res (2001) 0.88
Angiostatin selectively inhibits signaling by hepatocyte growth factor in endothelial and smooth muscle cells. Blood (2002) 0.88
An alternatively spliced form of Met receptor is tumorigenic. Exp Mol Med (2006) 0.86
Angiotensin II- and IV-induced changes in cerebral blood flow. Roles of AT1, AT2, and AT4 receptor subtypes. Regul Pept (1997) 0.84
Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells. Am J Physiol Renal Physiol (2001) 0.84
Structure-function analyses of brain angiotensin control of pressor action in rats. Am J Physiol (1989) 0.84
Characterization and signaling of the AT(4) receptor in human proximal tubule epithelial (HK-2) cells. J Am Soc Nephrol (2001) 0.83
AT4 receptor activation increases intracellular calcium influx and induces a non-N-methyl-D-aspartate dependent form of long-term potentiation. Neuroscience (2005) 0.81
Hepatocyte growth factor/c-met signaling in regulating urokinase plasminogen activator in human stomach cancer: A potential therapeutic target for human stomach cancer. Korean J Intern Med (2006) 0.78
International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev (2000) 6.30
Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium. Neuron (1992) 2.74
The WHO programme for the evaluation and testing of new insecticides. Bull World Health Organ (1971) 2.53
Mitochondrial DNA analyses and the origin and relative age of parthenogenetic lizards (genus Cnemidophorus). Science (1979) 2.48
Evaluation and long-term treatment of aberrant behavior displayed by young children with disabilities. J Dev Behav Pediatr (1998) 2.37
Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels. J Biol Chem (1991) 2.18
Length variation and heteroplasmy are frequent in mitochondrial DNA from parthenogenetic and bisexual lizards (genus Cnemidophorus). Genetics (1985) 2.07
A multicentre comparative trial of talampicillin and ampicillin in general practice. Br J Clin Pract (1975) 1.92
Attenuated GLP-1 secretion in obesity: cause or consequence? Gut (1996) 1.55
Endocrinological and metabolic effects of alcohol. Proc R Soc Med (1977) 1.47
Involvement of nicotinic receptors in alcohol self-administration. Alcohol Clin Exp Res (2000) 1.43
Station and cervical dilation at epidural placement in predicting cesarean risk. Obstet Gynecol (1999) 1.42
Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats. Brain Res (1996) 1.39
Direct interaction between amino- and carboxyl-terminal domains of cyclic nucleotide-gated channels. Neuron (1997) 1.33
Altered ligand specificity by protonation in the ligand binding domain of cyclic nucleotide-gated channels. Biochemistry (1996) 1.27
Denervation of the primary olfactory pathway in mice. V. Long-term effect of intranasal ZnSO4 irrigation on behavior, biochemistry and morphology. Brain Res (1978) 1.26
Immunocytochemistry of the olfactory marker protein. J Histochem Cytochem (1977) 1.22
Evaluating the effects of functional communication training in the presence and absence of establishing operations. J Appl Behav Anal (2000) 1.07
Changing concepts of vector control in malaria eradication. Annu Rev Entomol (1972) 1.05
An amino acid mutation in a potassium channel that prevents inhibition by protein kinase C. Science (1992) 1.04
Discovery of a distinct binding site for angiotensin II (3-8), a putative angiotensin IV receptor. Regul Pept (1992) 1.03
Brain angiotensin receptor subtypes in the control of physiological and behavioral responses. Neurosci Biobehav Rev (1994) 1.03
Contributions of the brain angiotensin IV-AT4 receptor subtype system to spatial learning. J Neurosci (1999) 1.02
Proposed update of angiotensin receptor nomenclature. Hypertension (1995) 1.01
Regulatory role of brain angiotensins in the control of physiological and behavioral responses. Brain Res Brain Res Rev (1993) 0.99
Conditions that affect sleep alter the expression of molecules associated with synaptic plasticity. Am J Physiol Regul Integr Comp Physiol (2001) 0.98
Important role for angiotensin III and IV in the brain renin-angiotensin system. Brain Res Brain Res Rev (1997) 0.97
Second survey of insecticid-resistance in body-lice, 1958-63. Bull World Health Organ (1965) 0.96
Role of glycerol 3-phosphate dehydrogenase in glyceride metabolism. Effect of diet on enzyme activities in chicken liver. Biochem J (1975) 0.96
ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler Thromb Vasc Biol (2000) 0.96
Pneumatic applanation tonometer. Trans Am Acad Ophthalmol Otolaryngol (1966) 0.95
Acoustic and vestibular defects in lightning survivors. Laryngoscope (1974) 0.95
Spot indole test: evaluation of four reagents. J Clin Microbiol (1982) 0.94
Hypothalamic angiotensin release in response to AII or glutamic acid stimulation of the SFO in rats. Brain Res Bull (1993) 0.93
The laser Doppler: a non-invasive measure of cochlear blood flow. Acta Otolaryngol (1985) 0.93
Worldwide studies on aircraft disinsection at "blocks away". Bull World Health Organ (1972) 0.92
Regulation by second messengers of the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes. J Physiol (1992) 0.92
Brain angiotensin receptor subtypes AT1, AT2, and AT4 and their functions. Regul Pept (1995) 0.91
Identification of an AII(3-8) [AIV] binding site in guinea pig hippocampus. Brain Res (1992) 0.91
A role for the angiotensin AT4 receptor subtype in overcoming scopolamine-induced spatial memory deficits. Regul Pept (2001) 0.91
Tachyphylaxis of dipsogenic activity to intracerebroventricular administration of angiotensins. Brain Res (1988) 0.91
Attenuation of scopolamine-induced spatial learning impairments by an angiotensin IV analog. Regul Pept (1998) 0.90
Cerebrospinal fluid otorrhea. Laryngoscope (1980) 0.90
Abnormal hypothalamic-pituitary-gonadal function in chronic alcoholics. Br J Addict Alcohol Other Drugs (1976) 0.90
Meal frequency; does it determine postprandial lipaemia? Eur J Clin Nutr (1996) 0.90
Aminopeptidase-induced elevations and reductions in blood pressure in the spontaneously hypertensive rat. J Hypertens (1990) 0.89
Autoradiographic identification of kidney angiotensin IV binding sites and angiotensin IV-induced renal cortical blood flow changes in rats. Peptides (1998) 0.89
Angiotensin-sensitive neurons in the rat paraventricular nucleus: relative potencies of angiotensin II and angiotensin III. Brain Res (1987) 0.89
The action of porcine glucagon on the motility of the canine duodenum and jejunum. Br J Pharmacol (1982) 0.89
Angiotensin IV AT4-receptor system in the rat kidney. Am J Physiol (1998) 0.88
The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Brain Res (2001) 0.88
Radiolabeling of Angiotensin peptides. Methods Mol Med (2001) 0.88
Pressor action and dipsogenicity induced by angiotensin II and III in rats. Am J Physiol (1985) 0.88
The crystal structure of the DNA-binding drug berenil: molecular modelling studies of berenil-DNA complexes. Nucleic Acids Res (1987) 0.87
Trial of a new broad-spectrum penicillin (amoxycillin) in general practice. Practitioner (1972) 0.87
Calpain II in human lens. Invest Ophthalmol Vis Sci (1989) 0.87
The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochem Biophys Res Commun (1994) 0.86
Cochlear blood flow autoregulation in Wistar-Kyoto rats. Hear Res (1989) 0.86
The effect of various drugs on canine ureteric peristalsis. Urol Res (1986) 0.86
Effects of LY231617 and angiotensin IV on ischemia-induced deficits in circular water maze and passive avoidance performance in rats. Brain Res (1996) 0.86
Clinical trial of ototopical ofloxacin for treatment of chronic suppurative otitis media. Clin Ther (1998) 0.86
Localization of angiotensinogen in multiple cell types of rat brain. Brain Res (1987) 0.86
Interpreting the fetal heart rate tracing. Effect of knowledge of neonatal outcome. J Reprod Med (1998) 0.85
Ortho-isopropoxphenyl methylcarbamate (OMS-33) as a residual spray for control of anopheline mosquitos. With special reference to its evaluation in the WHO programme for evaluating and testing new insecticides. Bull World Health Organ (1969) 0.85
Elucidation of a specific binding site for angiotensin II(3-8), angiotensin IV, in mammalian heart membranes. J Pharmacol Exp Ther (1993) 0.85
Heightened blood pressure and drinking responsiveness to intracerebroventricularly applied angiotensins in the spontaneously hypertensive rat. Brain Res (1987) 0.85
Postprandial lipid and hormone responses to meals of varying fat contents: modulatory role of lipoprotein lipase? Eur J Clin Nutr (1995) 0.85
The angiotensin IV system: functional implications. Front Neuroendocrinol (1995) 0.85
Metabolism of angiotensins II and III by membrane-bound peptidases from rat brain. J Pharmacol Exp Ther (1988) 0.85
Elevations in plasma angiotensin II with prolonged ethanol treatment in rats. Pharmacol Biochem Behav (1986) 0.85
Recovery of olfactory function after bilateral bulbectomy. Science (1982) 0.84
Angiotensin IV enhances LTP in rat dentate gyrus in vivo. Peptides (2001) 0.84
Angiotensin II(3-8) (ANG IV) hippocampal binding: potential role in the facilitation of memory. Brain Res Bull (1993) 0.84
Angiotensin II- and IV-induced changes in cerebral blood flow. Roles of AT1, AT2, and AT4 receptor subtypes. Regul Pept (1997) 0.84
Characterization of the binding properties and physiological action of divalinal-angiotensin IV, a putative AT4 receptor antagonist. Regul Pept (1996) 0.84
Structure-function analyses of brain angiotensin control of pressor action in rats. Am J Physiol (1989) 0.84
AT4 receptor structure-binding relationship: N-terminal-modified angiotensin IV analogues. Peptides (1994) 0.84
Elevated salt appetite and brain binding of angiotensin II in mineralocorticoid-treated rats. Brain Res (1988) 0.83
A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat. Peptides (2001) 0.83
Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs. Br J Pharmacol (2013) 0.83
The distribution of angiotensin II binding sites in rodent brain. Brain Res (1981) 0.83