Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMID 10753869)

Published in J Biol Chem on April 14, 2000

Authors

D Sakkab1, M Lewitzky, G Posern, U Schaeper, M Sachs, W Birchmeier, S M Feller

Author Affiliations

1: Laboratory of Molecular Oncology, MSZ-Institut für Medizinische Strahlenkunde und Zellforschung, Universität Würzburg, D-97078 Würzburg, Germany.

Articles citing this

MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol (2010) 5.44

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol (2000) 2.48

Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol (2000) 1.97

An overview of the c-MET signaling pathway. Ther Adv Med Oncol (2011) 1.95

Control of cell adhesion dynamics by Rap1 signaling. Curr Opin Cell Biol (2009) 1.68

Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun Signal (2009) 1.59

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Mol Biol Cell (2002) 1.34

Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood (2005) 1.33

MET as a target for treatment of chest tumors. Lung Cancer (2008) 1.29

Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Mol Cell Biol (2009) 1.23

Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. J Biol Chem (2003) 1.20

Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wiley Interdiscip Rev Syst Biol Med (2011) 1.10

Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1. Proteomics (2009) 1.07

E-cadherin dis-engagement activates the Rap1 GTPase. J Cell Biochem (2008) 1.05

Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis. Mol Biol Cell (2002) 1.04

Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton. BMC Cell Biol (2004) 0.95

Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth. Oncogene (2013) 0.91

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program. Mol Biol Cell (2003) 0.90

The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J Pharmacol Exp Ther (2010) 0.84

Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells. J Cell Biochem (2010) 0.83

Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology. Am J Blood Res (2011) 0.82

Self-organization and regulation of intrinsically disordered proteins with folded N-termini. PLoS Biol (2011) 0.82

Amniotic fluid-borne hepatocyte growth factor protects rat pups against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol (2014) 0.79

The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain. Mol Psychiatry (2016) 0.79

Gab adapter proteins as therapeutic targets for hematologic disease. Adv Hematol (2011) 0.78

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. Mol Cell Proteomics (2014) 0.77

What's in a loop? Cell Commun Signal (2012) 0.76

Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Anxiety Increases After Zinc Therapy. Nutr Metab Insights (2010) 0.76

Analysis of progress and challenges for various patterns of c-MET-targeted molecular imaging: a systematic review. EJNMMI Res (2017) 0.75

c-Met expression and activity in urogenital cancers - novel aspects of signal transduction and medical implications. Cell Commun Signal (2017) 0.75

Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor. Biochem J (2016) 0.75

Articles by these authors

Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 15.88

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol (1991) 8.60

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell (2001) 8.41

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science (1998) 8.27

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol (1989) 6.31

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol (1993) 5.86

Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol (2000) 4.36

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol (1994) 4.34

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol (1990) 4.05

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell (1994) 3.86

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. J Cell Biol (1985) 3.77

Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction. N Engl J Med (1992) 3.64

New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev (2001) 3.63

Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol (1988) 3.57

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature (1996) 3.00

Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol (1993) 2.84

In vivo distribution and turnover of fluorescently labeled actin microinjected into human fibroblasts. Proc Natl Acad Sci U S A (1979) 2.71

Microinjection of fluorescently labeled proteins into living cells with emphasis on cytoskeletal proteins. Int Rev Cytol (1982) 2.70

E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res (1991) 2.67

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J (1992) 2.65

A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J (1993) 2.58

Cell-cell interaction and polarity of epithelial cells: specific perturbation using a monoclonal antibody. Cell (1983) 2.56

E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res (1993) 2.55

Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature (1995) 2.54

On the mechanism of ATP-induced shape changes in human erythrocyte membranes. II. The role of ATP. J Cell Biol (1977) 2.54

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J Cell Biol (1993) 2.53

Inhibitory action of transforming growth factor beta on endothelial cells. Proc Natl Acad Sci U S A (1987) 2.50

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol (2000) 2.48

Stress fiber sarcomeres of fibroblasts are contractile. Cell (1980) 2.45

E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 2.35

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol (1996) 2.27

Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol (2000) 1.97

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift. J Cell Biol (1995) 1.92

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells. J Cell Biol (1995) 1.91

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J Cell Biol (1995) 1.91

Transforming growth factor-beta inhibits endothelial cell proliferation. Biochem Biophys Res Commun (1986) 1.86

Epithelial-mesenchymal transitions in cancer progression. Acta Anat (Basel) (1996) 1.84

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. J Biol Chem (1994) 1.81

Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure (1995) 1.76

The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element. Proc Natl Acad Sci U S A (1991) 1.74

New surface component of fibroblast's focal contacts identified by a monoclonal antibody. Cell (1982) 1.73

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci U S A (1992) 1.70

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development (2001) 1.69

Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. Nat Struct Biol (2000) 1.67

Molecular aspects of mesenchymal-epithelial interactions. Annu Rev Cell Biol (1993) 1.63

Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice. Int J Cancer (1991) 1.61

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene (1995) 1.61

Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. Cancer Res (2001) 1.60

Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. Oncogene (2006) 1.59

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Gastroenterology (2000) 1.57

Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis. J Cell Biol (1998) 1.56

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility. Oncogene (1999) 1.55

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol (2001) 1.52

Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection. Curr Opin Cell Biol (1994) 1.48

Corrugated attachment membrane in WI-38 fibroblasts: alternating fibronectin fibers and actin-containing focal contacts. Proc Natl Acad Sci U S A (1980) 1.43

Prognostic value of E-cadherin expression in 413 gastric carcinomas. Int J Cancer (1996) 1.40

Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene (1998) 1.38

Tuning spin-orbit coupling and superconductivity at the SrTiO{3}/LaAlO{3} interface: a magnetotransport study. Phys Rev Lett (2010) 1.36

The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif. Oncogene (2001) 1.34

Mechanisms identified in the transcriptional control of epithelial gene expression. J Biol Chem (1996) 1.29

The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras. J Biol Chem (1994) 1.27

Cytoplasmic aspartate aminotransferase: syncatalytic sulfhydryl group modification. J Biol Chem (1973) 1.22

Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins. EMBO J (1995) 1.19

Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes. J Biol Chem (2000) 1.18

Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. J Cell Biol (1996) 1.16

Sex differences in baseline neuropsychological function and concussion symptoms of collegiate athletes. Br J Sports Med (2006) 1.16

Cell adhesion in invasion and metastasis. Semin Cell Biol (1992) 1.15

Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A (1995) 1.13

Expression of E-cadherin and catenins in invasive mammary carcinomas. Anticancer Res (1997) 1.10

Molecular characteristics of HGF-SF and its role in cell motility and invasion. EXS (1993) 1.10

Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo. Curr Biol (1998) 1.10

Control of cell locomotion: perturbation with an antibody directed against specific glycoproteins. Cell (1985) 1.09

Physiological signals and oncogenesis mediated through Crk family adapter proteins. J Cell Physiol (1998) 1.08

Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: implications for cell adhesion and signaling. Eur J Cancer (1999) 1.07

Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas. Cancer Res (1994) 1.06

Serum and urine markers of bone metabolism during the year after hip fracture. J Am Geriatr Soc (2001) 1.05

Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo. J Biol Chem (1996) 1.02

Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G. Oncogene (1998) 1.02

Intracellular and extracellular components involved in the formation of ventral surfaces of fibroblasts. Cold Spring Harb Symp Quant Biol (1982) 1.02

Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer. Clin Exp Metastasis (1994) 1.02

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. Mol Cell Biol (1999) 1.01

Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development. Genomics (1994) 1.01

Clinical significance of E-cadherin as a prognostic marker in thyroid carcinomas. J Clin Endocrinol Metab (1995) 1.00