The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change.

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Published in Biochemistry on March 02, 2010

Authors

Alexander V Matveev1, J Browning Fitzgerald, Jianhua Xu, Anna P Malykhina, Karla K Rodgers, Xi-Qin Ding

Author Affiliations

1: Department of Cell Biology, University ofOklahoma Health Sciences Center, 940 Stanton L. Young Boulevard, Oklahoma City, Oklahoma 73104, USA.

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