Published in J Am Chem Soc on February 17, 2010
Choosing an effective protein bioconjugation strategy. Nat Chem Biol (2011) 1.82
Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis. Chem Commun (Camb) (2011) 1.38
RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res (2012) 1.36
In situ maleimide bridging of disulfides and a new approach to protein PEGylation. Bioconjug Chem (2011) 1.33
Tunable degradation of maleimide-thiol adducts in reducing environments. Bioconjug Chem (2011) 1.18
Bromopyridazinedione-mediated protein and peptide bioconjugation. Chem Commun (Camb) (2011) 1.15
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Bromomaleimide-linked bioconjugates are cleavable in mammalian cells. Chembiochem (2011) 1.09
Degradable conjugates from oxanorbornadiene reagents. J Am Chem Soc (2012) 1.03
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Bioconjugation of green fluorescent protein via an unexpectedly stable cyclic sulfonium intermediate. Chembiochem (2012) 0.85
Reversible protein affinity-labelling using bromomaleimide-based reagents. Org Biomol Chem (2013) 0.83
N-terminal modification of proteins with o-aminophenols. J Am Chem Soc (2014) 0.82
Controlling topological entanglement in engineered protein hydrogels with a variety of thiol coupling chemistries. Front Chem (2014) 0.79
Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification. PLoS One (2014) 0.79
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A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification. Chem Sci (2013) 0.78
Homogeneous bispecifics by disulfide bridging. Bioconjug Chem (2014) 0.78
Synthesis and antibacterial evaluation of some teicoplanin pseudoaglycon derivatives containing alkyl- and arylthiosubstituted maleimides. J Antibiot (Tokyo) (2015) 0.78
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Reduction-responsive dithiomaleimide-based nanomedicine with high drug loading and FRET-indicated drug release. Chem Commun (Camb) (2015) 0.75
Cys34-PEGylated Human Serum Albumin for Drug Binding and Delivery. Bioconjug Chem (2015) 0.75
Oxidation Protection in Metal-Binding Peptide Motif and Its Application to Antibody for Site-Selective Conjugation. PLoS One (2016) 0.75
Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge. ACS Med Chem Lett (2017) 0.75
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Site-specific PEGylation of native disulfide bonds in therapeutic proteins. Nat Chem Biol (2006) 1.34
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Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase. Biochemistry (1990) 1.23
Synthesis and characterization of novel thiol-reactive poly(ethylene glycol) cross-linkers for extracellular-matrix-mimetic biomaterials. Biomacromolecules (2007) 1.22
Disulfide bridge based PEGylation of proteins. Adv Drug Deliv Rev (2007) 1.19
Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge. Bioconjug Chem (2007) 1.16
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Somatostatin analog octreotide LAR in gastro-entero-pancreatic tumors. Expert Rev Anticancer Ther (2009) 1.02
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The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform. Chem Biol (2007) 3.36
Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Mol Microbiol (2002) 3.26
Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability. Bioconjug Chem (2006) 2.87
Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell (2008) 2.69
Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport. Bioconjug Chem (2004) 2.66
The structural biology of type IV secretion systems. Nat Rev Microbiol (2009) 2.54
Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation. Cell (2002) 2.54
Structure of a type IV secretion system core complex. Science (2009) 2.36
Structure and mechanism of DNA polymerases. Adv Protein Chem (2005) 2.36
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Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy. J Med Chem (2005) 2.32
Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm Res (2002) 2.30
VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion. EMBO J (2003) 2.23
Structure of the outer membrane complex of a type IV secretion system. Nature (2009) 2.17
PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality. Biomacromolecules (2006) 2.17
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Synthesis and functional evaluation of DNA-assembled polyamidoamine dendrimer clusters for cancer cell-specific targeting. Chem Biol (2005) 2.05
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Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex. Adv Drug Deliv Rev (2005) 1.97
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Fiber assembly by the chaperone-usher pathway. Biochim Biophys Acta (2004) 1.89
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc Natl Acad Sci U S A (2006) 1.87
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Targeting and inhibition of cell growth by an engineered dendritic nanodevice. J Med Chem (2005) 1.80
Dendritic polymer macromolecular carriers for drug delivery. Curr Opin Chem Biol (2002) 1.77
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Unveiling molecular scaffolds of the type IV secretion system. J Bacteriol (2004) 1.74
Protein-protein interaction through beta-strand addition. Trends Biochem Sci (2006) 1.69
Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature (2011) 1.67
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Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter. EMBO J (2006) 1.64
Lipid bilayer disruption by polycationic polymers: the roles of size and chemical functional group. Langmuir (2005) 1.56
Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter. EMBO J (2004) 1.53
Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria. EMBO J (2008) 1.48
Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome. Mol Cell (2008) 1.46
Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and imaging. Small (2007) 1.45
Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers. Chem Phys Lipids (2004) 1.42
Molecular recognition by SH2 domains. Adv Protein Chem (2002) 1.40
Bromomaleimides: new reagents for the selective and reversible modification of cysteine. Chem Commun (Camb) (2009) 1.40
Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101. Proc Natl Acad Sci U S A (2003) 1.39
Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori. Proc Natl Acad Sci U S A (2005) 1.39
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Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives. Chem Biol (2010) 1.38
Pre-event smallpox vaccination and postevent exposure and disease: a report of the Joint Task Force on Smallpox Vaccination for Allergists. Ann Allergy Asthma Immunol (2005) 1.38
The 2B domain of the Escherichia coli Rep protein is not required for DNA helicase activity. Proc Natl Acad Sci U S A (2002) 1.37
HER2 specific tumor targeting with dendrimer conjugated anti-HER2 mAb. Bioconjug Chem (2006) 1.36
In situ maleimide bridging of disulfides and a new approach to protein PEGylation. Bioconjug Chem (2011) 1.33
The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA. Protein Sci (2004) 1.31
Dendrimer-epidermal growth factor conjugate displays superagonist activity. Biomacromolecules (2008) 1.31
A quantitative assessment of nanoparticle-ligand distributions: implications for targeted drug and imaging delivery in dendrimer conjugates. ACS Nano (2010) 1.29
Structural biology of bacterial pathogenesis. Curr Opin Struct Biol (2004) 1.28
Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement. Int J Nanomedicine (2008) 1.28
Mucosal immunization with a novel nanoemulsion-based recombinant anthrax protective antigen vaccine protects against Bacillus anthracis spore challenge. Infect Immun (2007) 1.27
Cationic nanoparticles induce nanoscale disruption in living cell plasma membranes. J Phys Chem B (2009) 1.27
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems? Trends Microbiol (2008) 1.27
A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact. J Mol Biol (2006) 1.26
Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapy. Bioconjug Chem (2004) 1.24
Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. J Med Chem (2010) 1.22
Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic Acid-conjugated dendrimers. ACS Nano (2008) 1.22
Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis. Mol Microbiol (2008) 1.21
The role of apoptosis in thyroid autoimmunity. Thyroid (2007) 1.20
Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine. PLoS One (2008) 1.20
Biochemical characterization of protein complexes from the Helicobacter pylori protein interaction map: strategies for complex formation and evidence for novel interactions within type IV secretion systems. Mol Cell Proteomics (2004) 1.20
Synthesis, characterization, and intracellular uptake of carboxyl-terminated poly(amidoamine) dendrimer-stabilized iron oxide nanoparticles. Phys Chem Chem Phys (2007) 1.20
Molecular mechanism of P pilus termination in uropathogenic Escherichia coli. EMBO Rep (2006) 1.18
Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates. AIDS Res Hum Retroviruses (2008) 1.18
Chaperone-usher pathways: diversity and pilus assembly mechanism. Philos Trans R Soc Lond B Biol Sci (2012) 1.18
Development of immune response that protects mice from viral pneumonitis after a single intranasal immunization with influenza A virus and nanoemulsion. Vaccine (2003) 1.17
Real-time biomolecular binding detection using a sensitive photonic crystal biosensor. Anal Chem (2010) 1.17
Architecture of the Helicobacter pylori Cag-type IV secretion system. FEBS J (2011) 1.16
Bromopyridazinedione-mediated protein and peptide bioconjugation. Chem Commun (Camb) (2011) 1.15
Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry. Proc Natl Acad Sci U S A (2008) 1.14
NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system. Proc Natl Acad Sci U S A (2007) 1.14
Current dendrimer applications in cancer diagnosis and therapy. Curr Top Med Chem (2008) 1.14
Sensitive molecular binding assay using a photonic crystal structure in total internal reflection. Opt Express (2008) 1.14
Silver/dendrimer nanocomposites as biomarkers: fabrication, characterization, in vitro toxicity, and intracellular detection. Nano Lett (2005) 1.13
Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding. J Am Chem Soc (2002) 1.13
In vitro targeting of synthesized antibody-conjugated dendrimer nanoparticles. Biomacromolecules (2004) 1.13
Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system. Proc Natl Acad Sci U S A (2012) 1.12
Wiki and other ways to share learning online. Nature (2006) 1.12
Two-photon fluorescence correlation spectroscopy through a dual-clad optical fiber. Opt Express (2008) 1.12
A pre-equilibrium before nucleotide binding limits fingers subdomain closure by Klentaq1. J Biol Chem (2007) 1.12
Structural and energetic basis of folded-protein transport by the FimD usher. Nature (2013) 1.11
Isolation and characterization of dendrimers with precise numbers of functional groups. Chemistry (2010) 1.11
Crystal structure of the P pilus rod subunit PapA. PLoS Pathog (2007) 1.11
Two-step and one-step secretion mechanisms in Gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis. Biochem J (2010) 1.11
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem (2004) 1.10
Bromomaleimide-linked bioconjugates are cleavable in mammalian cells. Chembiochem (2011) 1.09