Molecular mechanisms of chronic kidney transplant rejection via large-scale proteogenomic analysis of tissue biopsies.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMC 2834542)

Published in J Am Soc Nephrol on January 21, 2010

Authors

Aleksey Nakorchevsky1, Johannes A Hewel, Sunil M Kurian, Tony S Mondala, Daniel Campbell, Steve R Head, Christopher L Marsh, John R Yates, Daniel R Salomon

Author Affiliations

1: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

Associated clinical trials:

Immunosuppression Management in Renal Transplant Recipients With Transplant Excellence Based on TruGraf Test | NCT04670926

Articles citing this

Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int (2011) 2.50

Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients. Hepatology (2012) 1.56

Renal interstitial fibrosis: mechanisms and evaluation. Curr Opin Nephrol Hypertens (2012) 1.46

Cellular senescence limits regenerative capacity and allograft survival. J Am Soc Nephrol (2012) 1.11

Molecular diagnostics in transplantation. Nat Rev Nephrol (2010) 1.01

A rapid noninvasive assay for the detection of renal transplant injury. Transplantation (2013) 0.93

Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol (2013) 0.91

Molecules Great and Small: The Complement System. Clin J Am Soc Nephrol (2015) 0.91

Complement as a multifaceted modulator of kidney transplant injury. J Clin Invest (2014) 0.89

Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli. Mod Pathol (2012) 0.86

Proteomics and metabolomics in renal transplantation-quo vadis? Transpl Int (2012) 0.85

Profiling the proteome in renal transplantation. Proteomics Clin Appl (2011) 0.85

Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling. Am J Transplant (2013) 0.84

Advances of genomic science and systems biology in renal transplantation: a review. Semin Immunopathol (2011) 0.83

Immunologic monitoring in transplantation revisited. Curr Opin Organ Transplant (2012) 0.81

Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection. Proteomics (2016) 0.79

Effects of complement activation on allograft injury. Curr Opin Organ Transplant (2015) 0.79

Mass spectrometry in chronic kidney disease research. Adv Chronic Kidney Dis (2010) 0.79

Recent advances in biomarker discovery in solid organ transplant by proteomics. Expert Rev Proteomics (2011) 0.78

Genomic meta-analysis of growth factor and integrin pathways in chronic kidney transplant injury. BMC Genomics (2013) 0.77

The Use of Genomics and Pathway Analysis in Our Understanding and Prediction of Clinical Renal Transplant Injury. Transplantation (2016) 0.77

Proteomics for rejection diagnosis in renal transplant patients: Where are we now? World J Transplant (2016) 0.76

Advances in diagnostics for transplant rejection. Expert Rev Mol Diagn (2016) 0.75

Transplant genetics and genomics. Nat Rev Genet (2017) 0.75

Significance of urinary proteome pattern in renal allograft recipients. J Transplant (2014) 0.75

High-Throughput Proteomic Approaches to the Elucidation of Potential Biomarkers of Chronic Allograft Injury (CAI). Proteomes (2013) 0.75

Biomarkers in renal transplantation: An updated review. World J Transplant (2017) 0.75

Articles cited by this

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics (2003) 82.89

DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics. J Proteome Res (2003) 12.31

Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol (2006) 10.14

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67

The Banff 97 working classification of renal allograft pathology. Kidney Int (1999) 9.02

The natural history of chronic allograft nephropathy. N Engl J Med (2003) 8.70

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet (2000) 7.39

An automated multidimensional protein identification technology for shotgun proteomics. Anal Chem (2001) 6.90

Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant (2007) 5.39

Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol (2007) 4.31

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet (2002) 4.22

Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant (2004) 4.04

Successful homotransplantation of the human kidney between identical twins. J Am Med Assoc (1956) 3.94

Multiple reaction monitoring-based, multiplexed, absolute quantitation of 45 proteins in human plasma. Mol Cell Proteomics (2009) 3.65

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest (2000) 3.58

Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med (2002) 3.39

Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol (2006) 3.31

International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int (1993) 3.11

Direct analysis and identification of proteins in mixtures by LC/MS/MS and database searching at the low-femtomole level. Anal Chem (1997) 3.09

Antibody-mediated renal allograft rejection: diagnosis and pathogenesis. J Am Soc Nephrol (2007) 2.64

Code developments to improve the efficiency of automated MS/MS spectra interpretation. J Proteome Res (2003) 2.53

Immunosuppressive treatment protects against angiotensin II-induced renal damage. Am J Pathol (2002) 2.50

Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. J Clin Invest (2005) 2.39

Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant (2004) 2.35

De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years. Am J Transplant (2004) 2.17

Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene (1999) 1.91

Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc Natl Acad Sci U S A (2006) 1.87

C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy. J Am Soc Nephrol (2009) 1.85

Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs. Transplantation (2007) 1.80

Overexpression of myofibrillogenesis regulator-1 aggravates cardiac hypertrophy induced by angiotensin II in mice. Hypertension (2007) 1.79

Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. J Cell Biol (2001) 1.73

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest (2003) 1.73

Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis. J Clin Invest (1988) 1.60

Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol (2002) 1.52

Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res (2006) 1.40

Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis. J Exp Med (1997) 1.38

Kidney allograft fibrosis and atrophy early after living donor transplantation. Am J Transplant (2005) 1.37

Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes. J Clin Invest (2004) 1.31

A protective role for kidney apolipoprotein E. Regulation of mesangial cell proliferation and matrix expansion. J Biol Chem (2001) 1.23

Protocol biopsies in renal transplantation: prognostic value of structural monitoring. Kidney Int (2007) 1.17

Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action. FASEB J (2001) 1.16

Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells. J Biol Chem (2003) 1.14

Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice. J Immunol (2006) 1.12

Distinct role of the N-terminal tail of the Na,K-ATPase catalytic subunit as a signal transducer. J Biol Chem (2006) 1.11

Chronic allograft nephropathy. Curr Opin Nephrol Hypertens (2005) 1.09

Depletion of clusterin in renal diseases causing nephrotic syndrome. Kidney Int (2002) 1.04

Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis. Kidney Int (2000) 1.03

Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways. Am J Pathol (2003) 1.03

Cyclosporin A protects against angiotensin II-induced end-organ damage in double transgenic rats harboring human renin and angiotensinogen genes. Hypertension (2000) 1.02

Chronic allograft nephropathy. N Engl J Med (2003) 0.99

P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damage. Hypertension (2002) 0.97

Complement and renal transplantation: from donor to recipient. Transplantation (2008) 0.97

p38 mitogen-activated protein kinase inhibition ameliorates angiotensin II-induced target organ damage. Hypertension (2007) 0.97

Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. J Biol Chem (2002) 0.95

Pharmacological targeting of C5a receptors during organ preservation improves kidney graft survival. Clin Exp Immunol (2008) 0.95

Renin expression at sites of repair in the infarcted rat heart. J Mol Cell Cardiol (2001) 0.91

Chronic allograft nephropathy: what have we learned from protocol biopsies? Transplantation (2008) 0.88

Chronic allograft nephropathy: expression and localization of PAI-1 and PPAR-gamma. Nephrol Dial Transplant (2005) 0.86

Cellular function prediction and biological pathway discovery in Arabidopsis thaliana using microarray data. Conf Proc IEEE Eng Med Biol Soc (2004) 0.85

Blockade of the renin-angiotensin system increases graft survival in patients with chronic allograft nephropathy. Nephrol Dial Transplant (2004) 0.85

Type IV collagen and laminin regulate glomerular mesangial cell susceptibility to apoptosis via beta(1) integrin-mediated survival signals. Am J Pathol (1999) 0.83

Expression of CD59, a human complement system regulatory protein, in extraembryonic membranes. Int Arch Allergy Immunol (1993) 0.83

Articles by these authors

A model for random sampling and estimation of relative protein abundance in shotgun proteomics. Anal Chem (2004) 19.20

Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54

DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics. J Proteome Res (2003) 12.31

A proteomic view of the Plasmodium falciparum life cycle. Nature (2002) 10.65

The minimum information about a proteomics experiment (MIAPE). Nat Biotechnol (2007) 10.24

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92

A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (2002) 7.49

The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol (2006) 6.85

A method for the comprehensive proteomic analysis of membrane proteins. Nat Biotechnol (2003) 6.32

A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science (2005) 5.99

Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell (2002) 5.91

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev (2004) 5.23

Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature (2005) 5.15

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell (2009) 5.05

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell (2006) 5.01

Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science (2004) 4.97

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91

The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol (2006) 4.89

MS1, MS2, and SQT-three unified, compact, and easily parsed file formats for the storage of shotgun proteomic spectra and identifications. Rapid Commun Mass Spectrom (2004) 4.76

Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra. Nat Methods (2004) 4.62

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol (2011) 4.59

Assigning function to yeast proteins by integration of technologies. Mol Cell (2003) 4.58

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57

Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature (2008) 4.52

Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell (2006) 4.50

Global analysis of protein palmitoylation in yeast. Cell (2006) 4.43

PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30

The biological impact of mass-spectrometry-based proteomics. Nature (2007) 4.24

Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell (2007) 4.22

Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell (2009) 4.22

Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21

Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Dev Cell (2007) 4.17

The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II. J Biol Chem (2003) 4.13

Probability-based validation of protein identifications using a modified SEQUEST algorithm. Anal Chem (2002) 3.86

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science (2008) 3.77

Recommendations from the 2008 International Summit on Proteomics Data Release and Sharing Policy: the Amsterdam principles. J Proteome Res (2009) 3.77

Shotgun identification of protein modifications from protein complexes and lens tissue. Proc Natl Acad Sci U S A (2002) 3.70

Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science (2003) 3.64

Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res (2004) 3.63

Large-scale database searching using tandem mass spectra: looking up the answer in the back of the book. Nat Methods (2004) 3.62

A systematic approach to modeling, capturing, and disseminating proteomics experimental data. Nat Biotechnol (2003) 3.57

Molecular architecture of the human pre-mRNA 3' processing complex. Mol Cell (2009) 3.52

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science (2007) 3.46

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell (2010) 3.44

Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell (2009) 3.43

A quantitative analysis software tool for mass spectrometry-based proteomics. Nat Methods (2008) 3.35

A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J Cell Biol (2005) 3.18

Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell (2008) 3.11

Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A (2007) 3.08

Arginylation of beta-actin regulates actin cytoskeleton and cell motility. Science (2006) 3.05

A streamlined platform for high-content functional proteomics of primary human specimens. Nat Methods (2005) 3.00

Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture. Nat Biotechnol (2004) 2.98

Analysis of quantitative proteomic data generated via multidimensional protein identification technology. Anal Chem (2002) 2.94

Architecture of the budding yeast kinetochore reveals a conserved molecular core. J Cell Biol (2003) 2.92

A hypergeometric probability model for protein identification and validation using tandem mass spectral data and protein sequence databases. Anal Chem (2003) 2.91

Mass spectrometry in high-throughput proteomics: ready for the big time. Nat Methods (2010) 2.91

A correlation algorithm for the automated quantitative analysis of shotgun proteomics data. Anal Chem (2003) 2.89

Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Curr Biol (2005) 2.86

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76

GutenTag: high-throughput sequence tagging via an empirically derived fragmentation model. Anal Chem (2003) 2.74

Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2003) 2.73

Automatic quality assessment of peptide tandem mass spectra. Bioinformatics (2004) 2.70

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70

Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity. Dev Cell (2005) 2.65

The application of mass spectrometry to membrane proteomics. Nat Biotechnol (2003) 2.61

Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem (2004) 2.60

LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation. Neuron (2009) 2.60

Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol (2004) 2.55

Code developments to improve the efficiency of automated MS/MS spectra interpretation. J Proteome Res (2003) 2.53

The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res (2008) 2.53

RNA-dependent cysteine biosynthesis in archaea. Science (2005) 2.50

Digestion and depletion of abundant proteins improves proteomic coverage. Nat Methods (2012) 2.48

Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription. J Biol Chem (2003) 2.48

Replication-independent histone deposition by the HIR complex and Asf1. Curr Biol (2005) 2.40

Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal Chem (2004) 2.40

Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc Natl Acad Sci U S A (2003) 2.38

Validation of tandem mass spectrometry database search results using DTASelect. Curr Protoc Bioinformatics (2007) 2.37

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (2009) 2.37

ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol (2005) 2.36

Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant (2004) 2.35

Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nat Struct Biol (2003) 2.32

Mass spectrometry for proteomics. Curr Opin Chem Biol (2008) 2.31

Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain. Nat Cell Biol (2004) 2.30

A hormone-dependent module regulating energy balance. Cell (2011) 2.30

PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J (2009) 2.29

Molecular analysis of kinetochore architecture in fission yeast. EMBO J (2005) 2.29

Proteomic survey of metabolic pathways in rice. Proc Natl Acad Sci U S A (2002) 2.27

Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell (2002) 2.23

Statistical characterization of ion trap tandem mass spectra from doubly charged tryptic peptides. Anal Chem (2003) 2.20

One-step affinity purification of the yeast ribosome and its associated proteins and mRNAs. RNA (2002) 2.19

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med (2011) 2.17

De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years. Am J Transplant (2004) 2.17

Adaptation of energy metabolism in breast cancer brain metastases. Cancer Res (2007) 2.17

The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Dev Cell (2009) 2.14

PatternLab for proteomics: a tool for differential shotgun proteomics. BMC Bioinformatics (2008) 2.13

TFG-1 function in protein secretion and oncogenesis. Nat Cell Biol (2011) 2.13

Protein analysis by shotgun/bottom-up proteomics. Chem Rev (2013) 2.13