PubRank

Robert Tycko

Author PubWeight™ 116.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A 2002 9.55
2 Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science 2005 8.86
3 Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 2012 6.83
4 Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry 2006 6.54
5 Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A 2008 4.84
6 Molecular structure of β-amyloid fibrils in Alzheimer's disease brain tissue. Cell 2013 4.02
7 Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry 2007 3.57
8 Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure. Proc Natl Acad Sci U S A 2006 2.88
9 Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance. Biophys J 2002 2.78
10 Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. Biochemistry 2002 2.37
11 Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure. Proc Natl Acad Sci U S A 2009 2.15
12 Molecular dynamics simulations of Alzheimer's beta-amyloid protofilaments. J Mol Biol 2005 1.99
13 Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide. Biophys J 2006 1.84
14 Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure. Proc Natl Acad Sci U S A 2008 1.80
15 Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p. Biochemistry 2005 1.79
16 Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid. Biochemistry 2005 1.78
17 Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance. Biochemistry 2007 1.73
18 Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc Natl Acad Sci U S A 2012 1.60
19 Biomolecular solid state NMR with magic-angle spinning at 25K. J Magn Reson 2008 1.60
20 Probing site-specific conformational distributions in protein folding with solid-state NMR. Proc Natl Acad Sci U S A 2005 1.57
21 Low-temperature dynamic nuclear polarization at 9.4 T with a 30 mW microwave source. J Magn Reson 2010 1.49
22 Sensitivity enhancement in structural measurements by solid state NMR through pulsed spin locking. J Magn Reson 2002 1.45
23 Measurement of sample temperatures under magic-angle spinning from the chemical shift and spin-lattice relaxation rate of 79Br in KBr powder. J Magn Reson 2008 1.44
24 Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel. Biophys J 2004 1.41
25 Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure. Biochemistry 2008 1.32
26 Two prion variants of Sup35p have in-register parallel beta-sheet structures, independent of hydration. Biochemistry 2009 1.30
27 The functional curli amyloid is not based on in-register parallel beta-sheet structure. J Biol Chem 2009 1.30
28 Solid-state NMR yields structural constraints on the V3 loop from HIV-1 Gp120 bound to the 447-52D antibody Fv fragment. J Am Chem Soc 2004 1.30
29 Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy. Proc Natl Acad Sci U S A 2009 1.28
30 Detection of a transient intermediate in a rapid protein folding process by solid-state nuclear magnetic resonance. J Am Chem Soc 2010 1.15
31 Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: the importance of level crossings. J Chem Phys 2012 1.13
32 Structural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth. J Am Chem Soc 2011 1.10
33 Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J 2006 1.09
34 Polymorph-specific kinetics and thermodynamics of β-amyloid fibril growth. J Am Chem Soc 2013 1.09
35 Frequency-selective homonuclear dipolar recoupling in solid state NMR. J Chem Phys 2006 1.09
36 Structure and dynamics of the HIV-1 Vpu transmembrane domain revealed by solid-state NMR with magic-angle spinning. Biochemistry 2006 1.08
37 Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance. J Mol Biol 2009 1.06
38 The Japanese mutant Aβ (ΔE22-Aβ(1-39)) forms fibrils instantaneously, with low-thioflavin T fluorescence: seeding of wild-type Aβ(1-40) into atypical fibrils by ΔE22-Aβ(1-39). Biochemistry 2011 1.05
39 Site-specific identification of non-beta-strand conformations in Alzheimer's beta-amyloid fibrils by solid-state NMR. Biophys J 2003 1.04
40 The core of Ure2p prion fibrils is formed by the N-terminal segment in a parallel cross-β structure: evidence from solid-state NMR. J Mol Biol 2011 1.03
41 Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein. Biophys J 2011 1.02
42 Structural and dynamical characterization of tubular HIV-1 capsid protein assemblies by solid state nuclear magnetic resonance and electron microscopy. Protein Sci 2010 1.01
43 Segmental polymorphism in a functional amyloid. Biophys J 2011 1.01
44 Simulated self-assembly of the HIV-1 capsid: protein shape and native contacts are sufficient for two-dimensional lattice formation. Biophys J 2011 0.98
45 Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR. Protein Expr Purif 2005 0.98
46 Dynamic nuclear polarization-enhanced ¹H-¹³C double resonance NMR in static samples below 20 K. J Magn Reson 2012 0.98
47 Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers. Protein Sci 2010 0.97
48 A general Monte Carlo/simulated annealing algorithm for resonance assignment in NMR of uniformly labeled biopolymers. J Biomol NMR 2011 0.97
49 Restraints on backbone conformations in solid state NMR studies of uniformly labeled proteins from quantitative amide 15N-15N and carbonyl 13C-13C dipolar recoupling data. J Magn Reson 2012 0.96
50 Fiber diffraction data indicate a hollow core for the Alzheimer's aβ 3-fold symmetric fibril. J Mol Biol 2012 0.96
51 Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH. J Biol Chem 2010 0.95
52 Solid state nuclear magnetic resonance with magic-angle spinning and dynamic nuclear polarization below 25 K. J Magn Reson 2012 0.94
53 Constraints on protein structure in HIV-1 Rev and Rev-RNA supramolecular assemblies from two-dimensional solid state nuclear magnetic resonance. Biochemistry 2007 0.94
54 Absolute structural constraints on amyloid fibrils from solid-state NMR spectroscopy of partially oriented samples. J Am Chem Soc 2004 0.91
55 What can solid state NMR contribute to our understanding of protein folding? Biophys Chem 2010 0.91
56 An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design. J Biol Chem 2010 0.91
57 Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization. Phys Chem Chem Phys 2010 0.90
58 Experimentally derived structural constraints for amyloid fibrils of wild-type transthyretin. Biophys J 2011 0.89
59 Solid-state NMR spectroscopy method for determination of the backbone torsion angle psi in peptides with isolated uniformly labeled residues. J Am Chem Soc 2003 0.86
60 Rotational resonance in uniformly 13C-labeled solids: effects on high-resolution magic-angle spinning NMR spectra and applications in structural studies of biomolecular systems. J Magn Reson 2004 0.85
61 Zero-quantum frequency-selective recoupling of homonuclear dipole-dipole interactions in solid state nuclear magnetic resonance. J Chem Phys 2009 0.84
62 Dynamic nuclear polarization-enhanced 13C NMR spectroscopy of static biological solids. J Magn Reson 2013 0.83
63 Broadband rotational resonance in solid state NMR spectroscopy. J Chem Phys 2004 0.78
64 Conformational constraints in solid-state NMR of uniformly labeled polypeptides from double single-quantum-filtered rotational echo double resonance. Magn Reson Chem 2007 0.78
65 NMR studies of peptide T, an inhibitor of HIV infectivity, in an aqueous environment. J Pept Sci 2004 0.76
66 Techniques: NMR on a chip. Nature 2005 0.75
67 Zero-quantum stochastic dipolar recoupling in solid state nuclear magnetic resonance. J Chem Phys 2012 0.75
68 A "special perspectives" issue: recent achievements and new directions in biomolecular solid state NMR. J Magn Reson 2015 0.75
69 Encapsulation and NMR on an aggregating peptide before fibrillogenesis. J Am Chem Soc 2006 0.75