Published in Biochemistry on December 24, 2002
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A (2002) 9.55
Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry (2006) 6.54
Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A (2008) 4.84
Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nat Struct Mol Biol (2010) 3.75
Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry (2007) 3.57
Solid-state NMR studies of amyloid fibril structure. Annu Rev Phys Chem (2011) 2.38
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry (2006) 1.88
Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences. Protein Sci (2005) 1.80
Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p. Biochemistry (2005) 1.79
Molecular dynamics simulation of amyloid beta dimer formation. Biophys J (2004) 1.63
Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape. Chem Rev (2010) 1.62
Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A (2009) 1.61
Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.60
Amyloid structure: conformational diversity and consequences. Annu Rev Biochem (2011) 1.57
Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR. J Am Chem Soc (2011) 1.54
The α-helical C-terminal domain of full-length recombinant PrP converts to an in-register parallel β-sheet structure in PrP fibrils: evidence from solid state nuclear magnetic resonance. Biochemistry (2010) 1.53
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation. J Biol Chem (2009) 1.53
Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril. Proc Natl Acad Sci U S A (2016) 1.51
Structure of the 21-30 fragment of amyloid beta-protein. Protein Sci (2006) 1.51
Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils. J Am Chem Soc (2016) 1.49
Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM. Proc Natl Acad Sci U S A (2009) 1.45
Aβ(1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease. Nat Struct Mol Biol (2015) 1.42
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. Br J Pharmacol (2005) 1.32
Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy. Proc Natl Acad Sci U S A (2009) 1.28
High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure . Biochemistry (2010) 1.24
Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions. Biochem J (2007) 1.24
2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure. J Am Chem Soc (2011) 1.20
Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages. Neurobiol Aging (2007) 1.17
Vibrational coupling, isotopic editing, and beta-sheet structure in a membrane-bound polypeptide. J Am Chem Soc (2004) 1.15
Sensitivity enhancement in (13)C solid-state NMR of protein microcrystals by use of paramagnetic metal ions for optimizing (1)H T(1) relaxation. J Magn Reson (2006) 1.12
Fibril structure of human islet amyloid polypeptide. J Biol Chem (2011) 1.12
Structural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth. J Am Chem Soc (2011) 1.10
Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J (2006) 1.09
Differences in β-strand populations of monomeric Aβ40 and Aβ42. Biophys J (2013) 1.08
Dichotomous versus palm-type mechanisms of lateral assembly of amyloid fibrils. Protein Sci (2006) 1.04
Site-specific identification of non-beta-strand conformations in Alzheimer's beta-amyloid fibrils by solid-state NMR. Biophys J (2003) 1.04
Investigating how peptide length and a pathogenic mutation modify the structural ensemble of amyloid beta monomer. Biophys J (2012) 1.02
Structures and free-energy landscapes of the wild type and mutants of the Abeta(21-30) peptide are determined by an interplay between intrapeptide electrostatic and hydrophobic interactions. J Mol Biol (2008) 1.01
Protein thermal aggregation involves distinct regions: sequential events in the heat-induced unfolding and aggregation of hemoglobin. Biophys J (2004) 1.00
Physical and structural basis for polymorphism in amyloid fibrils. Protein Sci (2014) 0.99
Amyloid structure and assembly: insights from scanning transmission electron microscopy. J Struct Biol (2010) 0.98
β-hairpin-mediated nucleation of polyglutamine amyloid formation. J Mol Biol (2013) 0.96
Intrinsic linear heterogeneity of amyloid β protein fibrils revealed by higher resolution mass-per-length determinations. J Biol Chem (2010) 0.96
Amyloid polymorphism: structural basis and neurobiological relevance. Neuron (2015) 0.95
Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange. Biophys J (2009) 0.95
[PSI+] maintenance is dependent on the composition, not primary sequence, of the oligopeptide repeat domain. PLoS One (2011) 0.93
High resolution structural characterization of Aβ42 amyloid fibrils by magic angle spinning NMR. J Am Chem Soc (2015) 0.93
Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: application to Abeta(1-40) fibrillogenesis. Biotechnol Bioeng (2008) 0.90
Characterization of amyloid structures at the molecular level by solid state nuclear magnetic resonance spectroscopy. Methods Enzymol (2006) 0.89
Band-selective 13C homonuclear 3D spectroscopy for solid proteins at high field with rotor-synchronized soft pulses. J Biomol NMR (2006) 0.89
Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics. Chem Rev (2015) 0.88
Molecular structures of quiescently grown and brain-derived polymorphic fibrils of the Alzheimer amyloid abeta9-40 peptide: a comparison to agitated fibrils. PLoS Comput Biol (2010) 0.88
Dynamics of metastable β-hairpin structures in the folding nucleus of amyloid β-protein. J Phys Chem B (2012) 0.87
Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM. J Struct Biol (2012) 0.86
Computational study of the binding of CuII to Alzheimer's amyloid-beta peptide: do Abeta42 and Abeta40 bind copper in identical fashion? J Biol Inorg Chem (2008) 0.85
Systematic examination of polymorphism in amyloid fibrils by molecular-dynamics simulation. Biophys J (2011) 0.85
Computational selection of inhibitors of Abeta aggregation and neuronal toxicity. Bioorg Med Chem (2009) 0.85
Urea modulation of beta-amyloid fibril growth: experimental studies and kinetic models. Protein Sci (2004) 0.84
Unique example of amyloid aggregates stabilized by main chain H-bond instead of the steric zipper: molecular dynamics study of the amyloidogenic segment of amylin wild-type and mutants. J Mol Model (2011) 0.83
Modulation of aggregate size- and shape-distributions of the amyloid-beta peptide by a designed beta-sheet breaker. Eur Biophys J (2009) 0.83
Structural basis of infectious and non-infectious amyloids. Curr Alzheimer Res (2008) 0.83
Solid-state NMR as a probe of amyloid structure. Protein Pept Lett (2006) 0.81
Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study. J Am Chem Soc (2016) 0.81
Flexibility and Solvation of Amyloid-β Hydrophobic Core. J Biol Chem (2016) 0.81
Context dependence of protein misfolding and structural strains in neurodegenerative diseases. Biopolymers (2013) 0.80
Targeted conformational search with map-restrained self-guided Langevin dynamics: application to flexible fitting into electron microscopic density maps. J Struct Biol (2013) 0.80
N-terminal engineering of amyloid-β-binding Affibody molecules yields improved chemical synthesis and higher binding affinity. Protein Sci (2010) 0.80
A new structural model of Alzheimer's Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modeling. J Struct Biol (2016) 0.80
Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation. J Mol Biol (2012) 0.79
Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils. ACS Chem Neurosci (2013) 0.78
Use of a combination of the RDC method and NOESY NMR spectroscopy to determine the structure of Alzheimer's amyloid Aβ10-35 peptide in solution and in SDS micelles. Eur Biophys J (2013) 0.77
The formation of fibrils by intertwining of filaments: model and application to amyloid Abeta protein. Biophys J (2006) 0.76
Characterization of an antibody scFv that recognizes fibrillar insulin and beta-amyloid using atomic force microscopy. Nanomedicine (2008) 0.75
Size distribution of amyloid nanofibrils. Biophys J (2011) 0.75
Signature of an aggregation-prone conformation of tau. Sci Rep (2017) 0.75
Molecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic Resonance. Cold Spring Harb Perspect Med (2016) 0.75
Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin (2017) 0.75
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A (2002) 9.55
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83
Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry (2006) 6.54
Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A (2008) 4.84
Molecular structure of β-amyloid fibrils in Alzheimer's disease brain tissue. Cell (2013) 4.02
Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry (2007) 3.57
Protein oxidation implicated as the primary determinant of bacterial radioresistance. PLoS Biol (2007) 3.22
Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure. Proc Natl Acad Sci U S A (2006) 2.88
Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance. Biophys J (2002) 2.78
Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano (2009) 2.39
Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A (2010) 2.33
Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure. Proc Natl Acad Sci U S A (2009) 2.15
Organization of the core structure of the postsynaptic density. Proc Natl Acad Sci U S A (2008) 2.06
Molecular dynamics simulations of Alzheimer's beta-amyloid protofilaments. J Mol Biol (2005) 1.99
Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide. Biophys J (2006) 1.84
Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure. Proc Natl Acad Sci U S A (2008) 1.80
Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p. Biochemistry (2005) 1.79
Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid. Biochemistry (2005) 1.78
Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance. Biochemistry (2007) 1.73
Oligomeric structure of the human immunodeficiency virus type 1 envelope protein on the virion surface. J Virol (2002) 1.69
Mass of the postsynaptic density and enumeration of three key molecules. Proc Natl Acad Sci U S A (2005) 1.67
Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.60
Biomolecular solid state NMR with magic-angle spinning at 25K. J Magn Reson (2008) 1.60
Probing site-specific conformational distributions in protein folding with solid-state NMR. Proc Natl Acad Sci U S A (2005) 1.57
Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells. J Transl Med (2008) 1.54
Low-temperature dynamic nuclear polarization at 9.4 T with a 30 mW microwave source. J Magn Reson (2010) 1.49
Sensitivity enhancement in structural measurements by solid state NMR through pulsed spin locking. J Magn Reson (2002) 1.45
Measurement of sample temperatures under magic-angle spinning from the chemical shift and spin-lattice relaxation rate of 79Br in KBr powder. J Magn Reson (2008) 1.44
Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel. Biophys J (2004) 1.41
PSD-95 is required to sustain the molecular organization of the postsynaptic density. J Neurosci (2011) 1.33
Nanoscale 3D cellular imaging by axial scanning transmission electron tomography. Nat Methods (2009) 1.32
Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure. Biochemistry (2008) 1.32
Two prion variants of Sup35p have in-register parallel beta-sheet structures, independent of hydration. Biochemistry (2009) 1.30
The functional curli amyloid is not based on in-register parallel beta-sheet structure. J Biol Chem (2009) 1.30
Solid-state NMR yields structural constraints on the V3 loop from HIV-1 Gp120 bound to the 447-52D antibody Fv fragment. J Am Chem Soc (2004) 1.30
Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy. Proc Natl Acad Sci U S A (2009) 1.28
Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proc Natl Acad Sci U S A (2006) 1.18
Detection of a transient intermediate in a rapid protein folding process by solid-state nuclear magnetic resonance. J Am Chem Soc (2010) 1.15
Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: the importance of level crossings. J Chem Phys (2012) 1.13
Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors. J Transl Med (2009) 1.11
Structural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth. J Am Chem Soc (2011) 1.10
Polymorph-specific kinetics and thermodynamics of β-amyloid fibril growth. J Am Chem Soc (2013) 1.09
Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J (2006) 1.09
Frequency-selective homonuclear dipolar recoupling in solid state NMR. J Chem Phys (2006) 1.09
Structure and dynamics of the HIV-1 Vpu transmembrane domain revealed by solid-state NMR with magic-angle spinning. Biochemistry (2006) 1.08
Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance. J Mol Biol (2009) 1.06
The Japanese mutant Aβ (ΔE22-Aβ(1-39)) forms fibrils instantaneously, with low-thioflavin T fluorescence: seeding of wild-type Aβ(1-40) into atypical fibrils by ΔE22-Aβ(1-39). Biochemistry (2011) 1.05
Site-specific identification of non-beta-strand conformations in Alzheimer's beta-amyloid fibrils by solid-state NMR. Biophys J (2003) 1.04
Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond) (2010) 1.04
The core of Ure2p prion fibrils is formed by the N-terminal segment in a parallel cross-β structure: evidence from solid-state NMR. J Mol Biol (2011) 1.03
Promoting trimerization of soluble human immunodeficiency virus type 1 (HIV-1) Env through the use of HIV-1/simian immunodeficiency virus chimeras. J Virol (2004) 1.03
Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein. Biophys J (2011) 1.02
Segmental polymorphism in a functional amyloid. Biophys J (2011) 1.01
Structural and dynamical characterization of tubular HIV-1 capsid protein assemblies by solid state nuclear magnetic resonance and electron microscopy. Protein Sci (2010) 1.01
Simulated self-assembly of the HIV-1 capsid: protein shape and native contacts are sufficient for two-dimensional lattice formation. Biophys J (2011) 0.98
Dynamic nuclear polarization-enhanced ¹H-¹³C double resonance NMR in static samples below 20 K. J Magn Reson (2012) 0.98
Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR. Protein Expr Purif (2005) 0.98
Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers. Protein Sci (2010) 0.97
A general Monte Carlo/simulated annealing algorithm for resonance assignment in NMR of uniformly labeled biopolymers. J Biomol NMR (2011) 0.97
Fiber diffraction data indicate a hollow core for the Alzheimer's aβ 3-fold symmetric fibril. J Mol Biol (2012) 0.96
Restraints on backbone conformations in solid state NMR studies of uniformly labeled proteins from quantitative amide 15N-15N and carbonyl 13C-13C dipolar recoupling data. J Magn Reson (2012) 0.96
Quantitative STEM mass measurement of biological macromolecules in a 300 kV TEM. J Microsc (2007) 0.96
Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH. J Biol Chem (2010) 0.95
Solid state nuclear magnetic resonance with magic-angle spinning and dynamic nuclear polarization below 25 K. J Magn Reson (2012) 0.94
Constraints on protein structure in HIV-1 Rev and Rev-RNA supramolecular assemblies from two-dimensional solid state nuclear magnetic resonance. Biochemistry (2007) 0.94
Dual-axis electron tomography of biological specimens: Extending the limits of specimen thickness with bright-field STEM imaging. J Struct Biol (2010) 0.92
Absolute structural constraints on amyloid fibrils from solid-state NMR spectroscopy of partially oriented samples. J Am Chem Soc (2004) 0.91
What can solid state NMR contribute to our understanding of protein folding? Biophys Chem (2010) 0.91
An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design. J Biol Chem (2010) 0.91
Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization. Phys Chem Chem Phys (2010) 0.90
Experimentally derived structural constraints for amyloid fibrils of wild-type transthyretin. Biophys J (2011) 0.89
RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose. J Endocrinol (2007) 0.89
Effect of the charge state (z = -1, 0, +1) on the nuclear magnetic resonance of monodisperse Au25[S(CH2)2Ph]18(z) clusters. Anal Chem (2011) 0.88
Structure of the cytoskeleton of Spiroplasma melliferum BC3 and its interactions with the cell membrane. J Mol Biol (2008) 0.87
Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM. J Struct Biol (2012) 0.86
Evaluation of bioreactor-cultivated bone by magnetic resonance microscopy and FTIR microspectroscopy. Bone (2006) 0.86
Solid-state NMR spectroscopy method for determination of the backbone torsion angle psi in peptides with isolated uniformly labeled residues. J Am Chem Soc (2003) 0.86
Influence of melanosome dynamics on melanoma drug sensitivity. J Natl Cancer Inst (2009) 0.86
Rotational resonance in uniformly 13C-labeled solids: effects on high-resolution magic-angle spinning NMR spectra and applications in structural studies of biomolecular systems. J Magn Reson (2004) 0.85
Combining portable Raman probes with nanotubes for theranostic applications. Theranostics (2011) 0.85
Zero-quantum frequency-selective recoupling of homonuclear dipole-dipole interactions in solid state nuclear magnetic resonance. J Chem Phys (2009) 0.84
Development and application of STEM for the biological sciences. Ultramicroscopy (2012) 0.84
Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance. ACS Nano (2014) 0.84
Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes. Nanomedicine (Lond) (2009) 0.83
Dynamic nuclear polarization-enhanced 13C NMR spectroscopy of static biological solids. J Magn Reson (2013) 0.83
Nuclear mapping of nanodrug delivery systems in dynamic cellular environments. ACS Nano (2012) 0.81
Cryo-electron tomography of the magnetotactic vibrio Magnetovibrio blakemorei: insights into the biomineralization of prismatic magnetosomes. J Struct Biol (2012) 0.81
Synthesis, characterization, and direct intracellular imaging of ultrasmall and uniform glutathione-coated gold nanoparticles. Small (2012) 0.81
Direct visualization of CaMKII at postsynaptic densities by electron microscopy tomography. J Comp Neurol (2012) 0.81
Elemental mapping by electron energy loss spectroscopy in biology. Methods Mol Biol (2013) 0.80
Organization of designed nanofibrils assembled from alpha-helical peptides as determined by electron microscopy. J Pept Sci (2004) 0.78
Broadband rotational resonance in solid state NMR spectroscopy. J Chem Phys (2004) 0.78