Published in Eur J Cell Biol on January 25, 2010
Genomic and Epigenetic Complexity of the FOXF1 Locus in 16q24.1: Implications for Development and Disease. Curr Genomics (2015) 0.85
Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol (2011) 0.85
Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch. J Biol Chem (2012) 0.83
Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferation. PLoS One (2013) 0.79
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol (2015) 0.78
Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation. Clin Immunol (2015) 0.77
Proteomic Profiling of Hematopoietic Stem/Progenitor Cells after a Whole Body Exposure of CBA/CaJ Mice to Titanium ((48)Ti) Ions. Proteomes (2015) 0.75
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol (2004) 5.44
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A (2005) 3.57
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood (2003) 3.51
New consensus nomenclature for mammalian keratins. J Cell Biol (2006) 3.27
Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J Biol Chem (2001) 3.10
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. EMBO J (2005) 2.95
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell (2006) 2.43
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. EMBO J (2007) 2.39
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell (2004) 2.29
Comprehensive analysis of keratin gene clusters in humans and rodents. Eur J Cell Biol (2004) 2.20
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J Immunol (2004) 2.19
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem (2003) 2.05
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem (2005) 2.03
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. J Cell Biol (2004) 1.90
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Nat Immunol (2006) 1.83
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med (2010) 1.80
Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease. Am J Hum Genet (2006) 1.78
Loss of keratin 10 leads to mitogen-activated protein kinase (MAPK) activation, increased keratinocyte turnover, and decreased tumor formation in mice. J Invest Dermatol (2004) 1.78
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc Natl Acad Sci U S A (2005) 1.69
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem (2009) 1.58
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol Dis (2004) 1.56
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy. FASEB J (2006) 1.53
Limited redundancy of the proprotein convertase furin in mouse liver. J Biol Chem (2004) 1.52
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol Cell Biol (2005) 1.47
CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior. Hum Mol Genet (2003) 1.43
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem (2009) 1.33
Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J Biol Chem (2003) 1.32
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity. Mol Cell Biol (2006) 1.32
LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. Hum Mol Genet (2003) 1.32
Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J (2007) 1.31
Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J Cell Biol (2009) 1.29
Functional complexity of intermediate filament cytoskeletons: from structure to assembly to gene ablation. Int Rev Cytol (2003) 1.28
Hyperproliferation, induction of c-Myc and 14-3-3sigma, but no cell fragility in keratin-10-null mice. J Cell Sci (2002) 1.28
Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia. J Cell Biol (2011) 1.25
Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J Neurosci (2008) 1.24
Keratins significantly contribute to cell stiffness and impact invasive behavior. Proc Natl Acad Sci U S A (2013) 1.23
Spred1 is required for synaptic plasticity and hippocampus-dependent learning. J Neurosci (2008) 1.22
Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. J Cell Sci (2012) 1.18
Type II keratins precede type I keratins during early embryonic development. Eur J Cell Biol (2005) 1.18
Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol (2012) 1.15
Dominant cataract formation in association with a vimentin assembly disrupting mutation. Hum Mol Genet (2009) 1.12
Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17. Curr Alzheimer Res (2008) 1.12
Retracted Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Mol Cell Biol (2005) 1.10
Keratins control intercellular adhesion involving PKC-α-mediated desmoplakin phosphorylation. J Cell Biol (2013) 1.09
Hematopoietic stem cell transplantation for complete IFN-gamma receptor 1 deficiency: a multi-institutional survey. J Pediatr (2004) 1.09
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. Hum Mol Genet (2004) 1.08
Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. Mol Cell Biol (2006) 1.07
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. J Biol Chem (2009) 1.06
Mechanisms of fibroblast cell therapy for dystrophic epidermolysis bullosa: high stability of collagen VII favors long-term skin integrity. Mol Ther (2009) 1.03
Keratins as the main component for the mechanical integrity of keratinocytes. Proc Natl Acad Sci U S A (2013) 1.03
Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model. Lab Invest (2012) 1.02
Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy. Hum Mol Genet (2011) 1.00
Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis. Eur J Cell Biol (2005) 0.98
Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS. J Invest Dermatol (2007) 0.98
Presenilins in memory, Alzheimer's disease, and therapy. Neuron (2004) 0.98
A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice. Exp Cell Res (2007) 0.96
Keratin transgenic and knockout mice: functional analysis and validation of disease-causing mutations. Methods Mol Biol (2007) 0.94
Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes. J Biol Chem (2012) 0.93
Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration. J Neurosci (2008) 0.92
Defolliculated (dfl): a dominant mouse mutation leading to poor sebaceous gland differentiation and total elimination of pelage follicles. J Invest Dermatol (2002) 0.91
Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex. Hum Mutat (2009) 0.89
Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones. J Cell Sci (2009) 0.89
(Make) stick and cut loose--disintegrin metalloproteases in development and disease. Birth Defects Res C Embryo Today (2006) 0.89
Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. PLoS Genet (2011) 0.89
Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem (2011) 0.88
Identification of a keratin-associated protein with a putative role in vesicle transport. Eur J Cell Biol (2007) 0.88
A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice. J Cell Sci (2008) 0.88
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation. Eur J Cell Biol (2004) 0.88
Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin, THL) in the stomach and small intestine. Clin Nutr (2002) 0.87
Denaturing temperature selection may underestimate keratin mutation detection by DHPLC. Hum Mutat (2006) 0.86
The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation. Hum Mutat (2010) 0.86
Keratin 5 knockout mice reveal plasticity of keratin expression in the corneal epithelium. Eur J Cell Biol (2006) 0.85
The pH dependency of the binding of drugs to plasma proteins in man. Ther Drug Monit (2005) 0.85
Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol (2011) 0.85
Gene therapy: prospects for glycolipid storage diseases. Philos Trans R Soc Lond B Biol Sci (2003) 0.84
Keratin 8 modulation of desmoplakin deposition at desmosomes in hepatocytes. Exp Cell Res (2006) 0.84
BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease. Neurodegener Dis (2004) 0.84
Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch. J Biol Chem (2012) 0.83
A fast and robust quantitative time-lapse assay for cell migration. Exp Cell Res (2005) 0.82
Peroxisomal multifunctional protein-2 deficiency causes motor deficits and glial lesions in the adult central nervous system. Am J Pathol (2006) 0.81
Hepatoma-derived growth factor (HDGF) is dispensable for normal mouse development. Dev Dyn (2008) 0.81
Rescue of keratin 18/19 doubly deficient mice using aggregation with tetraploid embryos. Eur J Cell Biol (2005) 0.81
Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. PLoS One (2013) 0.81
Involvement of the ubiquitin-proteasome system in the stabilization of cell-cell contacts in human keratinocytes. Exp Dermatol (2012) 0.80
Vinblastine and doxorubicin administration to pregnant mice affects brain development and behaviour in the offspring. Neurotoxicology (2009) 0.80
A keaper and a striker maintain epidermal homeostasis. Nat Genet (2003) 0.80
Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development. Dev Dyn (2005) 0.80
Targeting the palm: a leap forward toward treatment of keratin disorders. J Invest Dermatol (2012) 0.79
Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis. Pigment Cell Melanoma Res (2014) 0.79
Cell-type-specific expression pattern of ceramide synthase 2 protein in mouse tissues. Histochem Cell Biol (2013) 0.79
Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice. Eur J Neurosci (2004) 0.78
Ectopic expression of desmin in the epidermis of transgenic mice permits development of a normal epidermis. Differentiation (2002) 0.78
Exposure to retinyl esters, retinol, and retinoic acids in non-pregnant women following increasing single and repeated oral doses of vitamin A. Ann Nutr Metab (2005) 0.77
Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2. Biochim Biophys Acta (2012) 0.76