Published in EMBO J on February 03, 2005
The many faces and functions of β-catenin. EMBO J (2012) 3.85
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A (2005) 3.57
The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol (2010) 3.32
Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol (2010) 3.02
Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule. Am J Pathol (2007) 2.78
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Semin Cancer Biol (2010) 2.75
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell (2006) 2.43
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J (2010) 2.35
Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci (2008) 2.29
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev (2011) 2.06
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci (2010) 1.85
Anchoring junctions as drug targets: role in contraceptive development. Pharmacol Rev (2008) 1.76
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin. Circ Res (2008) 1.66
Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2. PLoS Biol (2014) 1.57
Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis. Semin Cell Dev Biol (2007) 1.50
Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity. PLoS One (2008) 1.49
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol Cell Biol (2005) 1.47
Klotho is a substrate for alpha-, beta- and gamma-secretase. FEBS Lett (2009) 1.45
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J Biol Chem (2007) 1.44
Extracellular cleavage of cadherin-11 by ADAM metalloproteases is essential for Xenopus cranial neural crest cell migration. Mol Biol Cell (2008) 1.38
The way Wnt works: components and mechanism. Growth Factors (2012) 1.37
ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration. J Neurosci (2009) 1.36
Derivation and characterization of hepatic progenitor cells from human embryonic stem cells. PLoS One (2009) 1.33
Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage. J Cell Sci (2007) 1.33
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem (2009) 1.33
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity. Mol Cell Biol (2006) 1.32
Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J (2007) 1.31
Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. Dev Cell (2012) 1.23
Evolution: structural and functional diversity of cadherin at the adherens junction. J Cell Biol (2011) 1.22
N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation. Neuron (2007) 1.21
Proteolytic processing of delta-like 1 by ADAM proteases. J Biol Chem (2006) 1.21
Soluble cadherins as cancer biomarkers. Clin Exp Metastasis (2007) 1.20
Low cholesterol triggers membrane microdomain-dependent CD44 shedding and suppresses tumor cell migration. J Biol Chem (2010) 1.19
Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation. Am J Physiol Heart Circ Physiol (2010) 1.15
Secretome signature of invasive glioblastoma multiforme. J Proteome Res (2011) 1.13
Retracted Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Mol Cell Biol (2005) 1.10
Probing cellular microenvironments and tissue remodeling by atomic force microscopy. Pflugers Arch (2007) 1.10
Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling. Subcell Biochem (2012) 1.10
Molecular and cellular mechanisms of ectodomain shedding. Anat Rec (Hoboken) (2010) 1.08
Synaptic autoregulation by metalloproteases and γ-secretase. J Neurosci (2011) 1.08
EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2. Mol Biol Cell (2008) 1.07
To adhere or not to adhere: the role of Cadherins in neural crest development. Cell Adh Migr (2008) 1.06
The dynamic role of beta-catenin in synaptic plasticity. Neuropharmacology (2011) 1.04
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10. PLoS Biol (2009) 1.03
ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling. Cardiovasc Res (2010) 1.03
Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J Biol Chem (2008) 1.03
ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer. Oncotarget (2014) 1.02
Combinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processing. Mol Cell Biol (2007) 1.01
Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. Dev Biol (2008) 1.01
Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
Proteases and sFlt-1 release in the human placenta. Placenta (2010) 1.00
Soluble N-cadherin fragment promotes angiogenesis. Clin Exp Metastasis (2006) 0.99
Epithelial to mesenchymal transition: new and old insights from the classical neural crest model. Semin Cancer Biol (2012) 0.98
Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration. Dev Cell (2011) 0.97
A role for WNT/β-catenin signaling in the neural mechanisms of behavior. J Neuroimmune Pharmacol (2012) 0.97
Cancer cells cut homophilic cell adhesion molecules and run. Cancer Res (2010) 0.96
Xenopus ADAM19 is involved in neural, neural crest and muscle development. Mech Dev (2008) 0.96
Leukocyte cell surface proteinases: regulation of expression, functions, and mechanisms of surface localization. Int J Biochem Cell Biol (2008) 0.96
An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin. Nat Neurosci (2012) 0.94
Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways. Proc Natl Acad Sci U S A (2013) 0.94
A systemic network for Chlamydia pneumoniae entry into human cells. J Bacteriol (2010) 0.93
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). J Biol Chem (2010) 0.92
ADAM function in embryogenesis. Semin Cell Dev Biol (2008) 0.92
Cellular mechanisms of γ-secretase substrate selection, processing and toxicity. Prog Neurobiol (2012) 0.92
Conservation and divergence of ADAM family proteins in the Xenopus genome. BMC Evol Biol (2010) 0.91
δ-Catenin promotes E-cadherin processing and activates β-catenin-mediated signaling: implications on human prostate cancer progression. Biochim Biophys Acta (2012) 0.91
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase. PLoS One (2011) 0.91
Posttranslational regulation of Fas ligand function. Cell Commun Signal (2008) 0.90
Nuclear signaling from cadherin adhesion complexes. Curr Top Dev Biol (2015) 0.90
Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers. Wiley Interdiscip Rev Syst Biol Med (2011) 0.90
Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest. Mol Biol Cell (2013) 0.90
MT5-MMP, ADAM-10, and N-cadherin act in concert to facilitate synapse reorganization after traumatic brain injury. J Neurotrauma (2012) 0.90
Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection. Cell Microbiol (2012) 0.90
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice. BMC Genomics (2009) 0.88
Targeting self-renewal pathways in myeloid malignancies. Cell Commun Signal (2013) 0.87
Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS One (2008) 0.87
Life after proteolysis: Exploring the signaling capabilities of classical cadherin cleavage fragments. Commun Integr Biol (2009) 0.87
Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation. J Biol Chem (2012) 0.87
Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest. Cell Adh Migr (2010) 0.87
ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis. Dev Biol (2012) 0.87
Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease. Neurobiol Aging (2013) 0.86
N-cadherin prodomain cleavage regulates synapse formation in vivo. Dev Neurobiol (2009) 0.85
TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS. J Biol Chem (2015) 0.84
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin. Exp Brain Res (2011) 0.84
Tumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in glioma. PLoS One (2013) 0.84
A functional role for ADAM10 in human immunodeficiency virus type-1 replication. Retrovirology (2011) 0.84
Proteolytic remodeling of the synaptic cell adhesion molecules (CAMs) by metzincins in synaptic plasticity. Neurochem Res (2012) 0.84
Dynamic self-guiding analysis of Alzheimer's disease. Oncotarget (2015) 0.84
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife (2016) 0.83
miR379-410 cluster miRNAs regulate neurogenesis and neuronal migration by fine-tuning N-cadherin. EMBO J (2014) 0.82
ADAM10 negatively regulates neuronal differentiation during spinal cord development. PLoS One (2014) 0.81
Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes. Eur J Hum Genet (2013) 0.81
Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10. Proc Natl Acad Sci U S A (2014) 0.81
Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia. J Biol Chem (2011) 0.80
Should I stay or should I go? Shedding of RPTPs in cancer cells switches signals from stabilizing cell-cell adhesion to driving cell migration. Cell Adh Migr (2011) 0.80
Activity dependent CAM cleavage and neurotransmission. Front Cell Neurosci (2015) 0.80
Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. BMC Cell Biol (2011) 0.80
Cadherins as regulators of neuronal polarity. Cell Adh Migr (2014) 0.80
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling. Oncotarget (2015) 0.80
ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion. Cell Death Differ (2015) 0.79
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34
Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell (1996) 14.75
Cadherin cell adhesion receptors as a morphogenetic regulator. Science (1991) 13.78
Convergence of Wnt, beta-catenin, and cadherin pathways. Science (2004) 13.13
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A (1999) 10.75
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat Neurosci (2000) 6.10
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol (2004) 5.44
The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev (2003) 4.47
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A (1999) 4.35
Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol (2000) 4.33
Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol (1997) 4.29
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet (2002) 4.19
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell (2003) 3.96
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J (2002) 3.87
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A (1999) 3.85
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood (2003) 3.51
Developmental defects in mouse embryos lacking N-cadherin. Dev Biol (1997) 3.39
Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr Biol (1997) 3.16
Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. Proc Natl Acad Sci U S A (1994) 2.95
Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus. J Cell Biol (1996) 2.86
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci (1999) 2.82
Uncoupling cadherin-based adhesion from wingless signalling in Drosophila. Nature (1996) 2.76
Membrane protein secretases. Biochem J (1997) 2.70
Inhibition of beta-catenin-mediated transactivation by cadherin derivatives. Proc Natl Acad Sci U S A (1998) 2.55
N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res (2001) 2.47
Neural crest emigration from the neural tube depends on regulated cadherin expression. Development (1998) 2.17
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem (2003) 1.99
Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth. J Cell Biol (1990) 1.82
Remarkable roles of proteolysis on and beyond the cell surface. Curr Opin Cell Biol (2000) 1.67
Fos family members induce cell cycle entry by activating cyclin D1. Mol Cell Biol (1998) 1.61
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. FASEB J (2002) 1.58
Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol (2003) 1.57
Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life. Mol Cell Biol (2002) 1.56
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts. Oncogene (1999) 1.55
Cadherins mediate intercellular mechanical signaling in fibroblasts by activation of stretch-sensitive calcium-permeable channels. J Biol Chem (2001) 1.31
MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function. J Biol Chem (2001) 1.23
Purification and characterization of NCAD90, a soluble endogenous form of N-cadherin, which is generated by proteolysis during retinal development and retains adhesive and neurite-promoting function. J Neurosci Res (1993) 1.22
The myofibroblast: a key cell for wound healing and fibrocontractive diseases. Prog Clin Biol Res (1981) 1.20
Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N-cadherin and the fibroblast growth factor receptor co-cluster in cells. J Neurochem (2001) 1.19
Cadherin sequences that inhibit beta-catenin signaling: a study in yeast and mammalian cells. Mol Biol Cell (2001) 1.13
Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo. Dev Biol (1990) 1.12
Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS. Mol Cell Neurosci (2000) 1.02
The N-cadherin/catenin complex in colon fibroblasts and myofibroblasts. Cell Adhes Commun (1999) 0.86
Cell aggregation assays. Methods Mol Med (2001) 0.86
Dynamic aspects of cadherin-mediated adhesion in synapse development and plasticity. Biol Cell (2002) 0.83
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol (2004) 5.44
Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci (2004) 5.19
Control of peripheral nerve myelination by the beta-secretase BACE1. Science (2006) 4.55
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet (2002) 4.19
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A (2005) 3.57
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood (2003) 3.51
LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Cell (2007) 3.49
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol (2003) 3.26
LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J (2007) 2.97
Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta (2008) 2.60
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A (2003) 2.53
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha. Mol Biol Cell (2009) 2.46
Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol (2010) 2.45
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell (2006) 2.43
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. EMBO J (2007) 2.39
The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions. Semin Cell Dev Biol (2008) 2.31
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell (2004) 2.29
Insights into sick sinus syndrome from an inducible mouse model. Cardiovasc Res (2010) 2.27
Role of LAMP-2 in lysosome biogenesis and autophagy. Mol Biol Cell (2002) 2.25
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J Immunol (2004) 2.19
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem (2005) 2.15
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (2012) 2.14
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J (2007) 2.13
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing. Ann Neurol (2011) 2.11
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem (2003) 2.05
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem (2005) 2.03
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine. J Neurosci (2005) 2.00
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem (2003) 1.99
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J (2006) 1.92
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. J Cell Biol (2004) 1.90
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci (2010) 1.85
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Nat Immunol (2006) 1.83
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell (2011) 1.82
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol (2012) 1.81
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med (2010) 1.80
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest (2013) 1.77
Cathepsin D deficiency is associated with a human neurodegenerative disorder. Am J Hum Genet (2006) 1.76
Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination. Development (2006) 1.72
Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis. Am J Hum Genet (2008) 1.69
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc Natl Acad Sci U S A (2005) 1.69
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J Clin Invest (2007) 1.68
Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. J Immunol (2013) 1.67
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin. Circ Res (2008) 1.66
Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity. J Biol Chem (2008) 1.65
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol (2004) 1.65
Activity-dependent proteolytic cleavage of neuroligin-1. Neuron (2012) 1.64
Tumor-associated MICA is shed by ADAM proteases. Cancer Res (2008) 1.64
Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem (2003) 1.63
In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood (2011) 1.63
CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood (2011) 1.62
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Mol Brain (2009) 1.62
Lysosomal myopathies: an excessive build-up in autophagosomes is too much to handle. Neuromuscul Disord (2008) 1.61
The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer. Semin Cell Dev Biol (2008) 1.60
A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology. J Cell Sci (2002) 1.59
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem (2009) 1.58
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol Dis (2004) 1.56
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy. FASEB J (2006) 1.53
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J Neurosci (2007) 1.52
Limited redundancy of the proprotein convertase furin in mouse liver. J Biol Chem (2004) 1.52
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site. J Cell Sci (2010) 1.49
Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study. Hum Mol Genet (2004) 1.49
Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury. Circ Res (2007) 1.49
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol Cell Biol (2005) 1.47
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. J Biol Chem (2007) 1.46
Klotho is a substrate for alpha-, beta- and gamma-secretase. FEBS Lett (2009) 1.45
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J Biol Chem (2007) 1.44
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol (2013) 1.43
CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior. Hum Mol Genet (2003) 1.43
Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase. Hum Mol Genet (2009) 1.40