Published in Exp Cell Res on May 25, 2007
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature (2012) 2.76
Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest (2009) 2.34
Intermediate filaments: primary determinants of cell architecture and plasticity. J Clin Invest (2009) 1.88
Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity. Hepatology (2009) 1.08
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon. Proc Natl Acad Sci U S A (2011) 0.94
Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones. J Cell Sci (2009) 0.89
The molecular basis of human keratin disorders. Hum Genet (2009) 0.88
Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins. J Cell Sci (2012) 0.84
The mechanical behavior of mutant K14-R125P keratin bundles and networks in NEB-1 keratinocytes. PLoS One (2012) 0.80
Distinct Impact of Two Keratin Mutations Causing Epidermolysis Bullosa Simplex on Keratinocyte Adhesion and Stiffness. J Invest Dermatol (2015) 0.77
Intermediate Filaments and Polarization in the Intestinal Epithelium. Cells (2016) 0.77
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature (2011) 11.44
New consensus nomenclature for mammalian keratins. J Cell Biol (2006) 3.27
Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J Biol Chem (2001) 3.10
'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. Curr Opin Cell Biol (2002) 3.00
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet (2008) 3.00
Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer (2012) 2.76
Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat Struct Mol Biol (2009) 2.64
From Mallory to Mallory-Denk bodies: what, how and why? Exp Cell Res (2007) 2.61
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell (2013) 2.38
Panhematin provides a therapeutic benefit in experimental pancreatitis. Gut (2010) 2.23
Comprehensive analysis of keratin gene clusters in humans and rodents. Eur J Cell Biol (2004) 2.20
High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia. Blood (2011) 2.08
CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation. Hepatology (2013) 2.04
Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly). Nat Genet (2002) 1.99
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol (2004) 1.92
Underrepresentation of underrepresented minorities in academic medicine: the need to enhance the pipeline and the pipe. Gastroenterology (2009) 1.91
Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments. Trends Cell Biol (2005) 1.89
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. Nat Cell Biol (2003) 1.84
Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease. Am J Hum Genet (2006) 1.78
Loss of keratin 10 leads to mitogen-activated protein kinase (MAPK) activation, increased keratinocyte turnover, and decreased tumor formation in mice. J Invest Dermatol (2004) 1.78
Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly. EMBO J (2002) 1.73
Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. J Cell Biol (2011) 1.72
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab (2011) 1.68
A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol (2006) 1.68
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS One (2008) 1.67
Vimentin organization modulates the formation of lamellipodia. Mol Biol Cell (2011) 1.60
Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med (2008) 1.59
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. Proc Natl Acad Sci U S A (2009) 1.58
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57
The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Eur J Cell Biol (2006) 1.57
Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma. Gastroenterology (2006) 1.54
Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom. Eur J Cell Biol (2002) 1.50
Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. Eur J Cell Biol (2002) 1.45
Studying simple epithelial keratins in cells and tissues. Methods Cell Biol (2004) 1.43
Keratin 8/18 breakdown and reorganization during apoptosis. Exp Cell Res (2004) 1.42
The biology of desmin filaments: how do mutations affect their structure, assembly, and organisation? J Struct Biol (2004) 1.42
Crystal structure of the human lamin A coil 2B dimer: implications for the head-to-tail association of nuclear lamins. J Mol Biol (2004) 1.42
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol (2007) 1.41
Molecular architecture of intermediate filaments. Bioessays (2003) 1.40
Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions. J Biol Chem (2013) 1.40
Structural basis of dynamic glycine receptor clustering by gephyrin. EMBO J (2004) 1.39
Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment. J Cell Sci (2005) 1.39
Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis. Mol Biol Cell (2003) 1.38
Towards a molecular description of intermediate filament structure and assembly. Exp Cell Res (2007) 1.38
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. J Biol Chem (2005) 1.38
Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology (2007) 1.37
Towards an integrated understanding of the structure and mechanics of the cell nucleus. Bioessays (2008) 1.35
Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization. J Cell Sci (2007) 1.34
Molecular and biophysical characterization of assembly-starter units of human vimentin. J Mol Biol (2004) 1.33
Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression. Proc Natl Acad Sci U S A (2002) 1.32
Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. J Clin Invest (2005) 1.31
Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages. Proc Natl Acad Sci U S A (2005) 1.30
Origins of elasticity in intermediate filament networks. Phys Rev Lett (2010) 1.30
Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J Cell Biol (2009) 1.29
Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. Mol Biol Cell (2003) 1.29
Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation. Hepatology (2008) 1.29
Functional complexity of intermediate filament cytoskeletons: from structure to assembly to gene ablation. Int Rev Cytol (2003) 1.28
Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Gastroenterology (2010) 1.28
Tensile properties of single desmin intermediate filaments. Biophys J (2008) 1.28
Hyperproliferation, induction of c-Myc and 14-3-3sigma, but no cell fragility in keratin-10-null mice. J Cell Sci (2002) 1.28
The LINC-less granulocyte nucleus. Eur J Cell Biol (2008) 1.26
The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei. Development (2008) 1.26
A quantitative kinetic model for the in vitro assembly of intermediate filaments from tetrameric vimentin. J Biol Chem (2007) 1.25
Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. J Biol Chem (2002) 1.25
Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia. J Cell Biol (2011) 1.25
The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk. Eur J Cell Biol (2006) 1.25
Keratins as susceptibility genes for end-stage liver disease. Gastroenterology (2005) 1.24
Conspicuous involvement of desmin tail mutations in diverse cardiac and skeletal myopathies. Hum Mutat (2007) 1.24
Keratins significantly contribute to cell stiffness and impact invasive behavior. Proc Natl Acad Sci U S A (2013) 1.23
The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. J Biol Chem (2002) 1.23
Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomaly. Hum Mol Genet (2003) 1.22
Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling. Dev Cell (2011) 1.21
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology (2003) 1.21
Intranuclear membrane structure formations by CaaX-containing nuclear proteins. J Cell Sci (2004) 1.20
Acknowledging joint first authors of published work: the time has come. Gastroenterology (2012) 1.19
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Hepatology (2004) 1.19
Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. J Cell Sci (2012) 1.18
Type II keratins precede type I keratins during early embryonic development. Eur J Cell Biol (2005) 1.18
Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol (2004) 1.18
dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development (2006) 1.18
Cytoskeletal keratin glycosylation protects epithelial tissue from injury. Nat Cell Biol (2010) 1.18
Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling. Hum Mol Genet (2013) 1.17
Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins. Proc Natl Acad Sci U S A (2007) 1.17
The nuclear lamina. Both a structural framework and a platform for genome organization. FEBS J (2007) 1.17
Divalent cations crosslink vimentin intermediate filament tail domains to regulate network mechanics. J Mol Biol (2010) 1.17
Desminopathies: pathology and mechanisms. Acta Neuropathol (2012) 1.17
The dynamic properties of intermediate filaments during organelle transport. J Cell Sci (2009) 1.17
The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. Mol Cell Biol (2002) 1.15
Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol (2012) 1.15
The nanomechanical properties of rat fibroblasts are modulated by interfering with the vimentin intermediate filament system. J Struct Biol (2011) 1.14
Epidermolysis bullosa simplex-type mutations alter the dynamics of the keratin cytoskeleton and reveal a contribution of actin to the transport of keratin subunits. Mol Biol Cell (2003) 1.14
Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Hepatology (2006) 1.14
Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. Gastroenterology (2010) 1.14
Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas. Eur J Cell Biol (2003) 1.13
Monitoring intermediate filament assembly by small-angle x-ray scattering reveals the molecular architecture of assembly intermediates. Proc Natl Acad Sci U S A (2006) 1.13
Dominant cataract formation in association with a vimentin assembly disrupting mutation. Hum Mol Genet (2009) 1.12
Vimentin coil 1A-A molecular switch involved in the initiation of filament elongation. J Mol Biol (2009) 1.10
Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization. J Virol (2004) 1.10