Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis.

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Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat Neurosci (2008) 3.24

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev (2009) 2.96

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci (2011) 2.61

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature (2015) 2.47

Developmental genetics of vertebrate glial-cell specification. Nature (2010) 2.44

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Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat Neurosci (2010) 1.84

Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. Cell (2014) 1.83

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Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66

The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci (2009) 1.60

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning. Nat Neurosci (2016) 1.52

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proc Natl Acad Sci U S A (2010) 1.51

Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development. J Cell Biol (2004) 1.47

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The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation. J Neurosci (2011) 1.35

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Production, characterization, and efficient transfection of highly pure oligodendrocyte precursor cultures from mouse embryonic neural progenitors. Glia (2008) 1.30

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Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. Stem Cells (2007) 1.27

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Astrocytes from the contused spinal cord inhibit oligodendrocyte differentiation of adult oligodendrocyte precursor cells by increasing the expression of bone morphogenetic proteins. J Neurosci (2011) 1.21

Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. J Clin Invest (2008) 1.19

Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system. Neuron (2012) 1.18

Integrin-mediated axoglial interactions initiate myelination in the central nervous system. J Cell Biol (2009) 1.15

Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K. J Cell Biol (2011) 1.14

Glial development: the crossroads of regeneration and repair in the CNS. Neuron (2014) 1.12

Zebrafish myelination: a transparent model for remyelination? Dis Model Mech (2008) 1.12

Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain (2010) 1.12

Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease. Proc Natl Acad Sci U S A (2004) 1.12

The biology of CNS remyelination: the key to therapeutic advances. J Neurol (2008) 1.10

Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies. Curr Neuropharmacol (2010) 1.10

The emerging role of microRNAs in multiple sclerosis. Nat Rev Neurol (2010) 1.08

Platelet-derived growth factor promotes repair of chronically demyelinated white matter. J Neuropathol Exp Neurol (2007) 1.08

Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Ann Neurol (2008) 1.08

Remyelination therapy for multiple sclerosis. Neurotherapeutics (2013) 1.08

Digestion products of the PH20 hyaluronidase inhibit remyelination. Ann Neurol (2013) 1.06

Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. Nat Neurosci (2014) 1.05

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia (2013) 1.05

Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. J Cereb Blood Flow Metab (2009) 1.02

ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev (2010) 1.01

Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes. Glia (2010) 1.01

Focal adhesion kinase (FAK): A regulator of CNS myelination. J Neurosci Res (2009) 1.00

Cortical remyelination: a new target for repair therapies in multiple sclerosis. Ann Neurol (2012) 1.00

Endothelin-1 regulates oligodendrocyte development. J Neurosci (2009) 1.00

High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology. Stem Cell Reports (2013) 0.99

Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls. BMC Psychiatry (2007) 0.98

Astrocyte-derived endothelin-1 inhibits remyelination through notch activation. Neuron (2014) 0.98

Actomyosin contractility controls cell surface area of oligodendrocytes. BMC Cell Biol (2009) 0.97

Retroviral lineage analysis of fibroblast growth factor receptor signaling in FGF2 inhibition of oligodendrocyte progenitor differentiation. Glia (2006) 0.96

Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials. Exp Neurol (2013) 0.96

Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. Glia (2010) 0.96

Progesterone synthesis in the nervous system: implications for myelination and myelin repair. Front Neurosci (2012) 0.95

Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions. J Neurosci (2011) 0.95

Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philos Trans R Soc Lond B Biol Sci (2008) 0.93

The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination. Brain (2013) 0.93

Myelin regeneration in multiple sclerosis: targeting endogenous stem cells. Neurotherapeutics (2011) 0.93

Early distal axonopathy of the visual pathway in experimental diabetes. Am J Pathol (2011) 0.92

Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis. Acta Neuropathol Commun (2014) 0.92

CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Exp Neurol (2006) 0.91

Promoting remyelination in multiple sclerosis-recent advances. Drugs (2013) 0.91

Remyelination after chronic spinal cord injury is associated with proliferation of endogenous adult progenitor cells after systemic administration of guanosine. Purinergic Signal (2008) 0.91

Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system. J Cell Biol (2011) 0.91

Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy. Glia (2013) 0.90

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation. Glia (2014) 0.90

Polydendrocytes in development and myelin repair. Neurosci Bull (2013) 0.90

Cell therapy for multiple sclerosis. Neurotherapeutics (2011) 0.89

Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem (2012) 0.89

The development of hematopoietic and mesenchymal stem cell transplantation as an effective treatment for multiple sclerosis. Am J Stem Cells (2013) 0.89

CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-kappaB (NFkappaB) and activator protein-1 (AP-1). J Neurosci Res (2008) 0.89

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models. Acta Neuropathol (2013) 0.89

Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair. Future Neurol (2008) 0.88

TGFbeta1 stimulates the over-production of white matter astrocytes from precursors of the "brain marrow" in a rodent model of neonatal encephalopathy. PLoS One (2010) 0.88

How big is the myelinating orchestra? Cellular diversity within the oligodendrocyte lineage: facts and hypotheses. Front Cell Neurosci (2014) 0.88

Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron (2015) 0.88

Inhibitors of myelination: ECM changes, CSPGs and PTPs. Exp Neurol (2013) 0.86

Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. J Exp Med (2014) 0.86

Combination of electroacupuncture and grafted mesenchymal stem cells overexpressing TrkC improves remyelination and function in demyelinated spinal cord of rats. Sci Rep (2015) 0.86

Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. J Immunol (2011) 0.86

Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells. Mol Cell Neurosci (2014) 0.86

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep (2016) 0.86

Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. Glia (2007) 0.85

Distinctive properties of human adult brain-derived myelin progenitor cells. Am J Pathol (2004) 0.85

Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination. Brain (2015) 0.85

Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol (2012) 0.85

Olig1 function is required for oligodendrocyte differentiation in the mouse brain. J Neurosci (2015) 0.85

Harnessing the integrated stress response for the treatment of multiple sclerosis. Lancet Neurol (2016) 0.84

Experimental and therapeutic opportunities for stem cells in multiple sclerosis. Int J Mol Sci (2012) 0.84

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain (2015) 0.83

Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. PLoS One (2012) 0.83

Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis. Neuropharmacology (2015) 0.83

Tcf7l2 is tightly controlled during myelin formation. Cell Mol Neurobiol (2011) 0.82

Growth factor regulation of remyelination: behind the growing interest in endogenous cell repair of the CNS. Future Neurol (2007) 0.82

Apoptosis of Oligodendrocytes during Early Development Delays Myelination and Impairs Subsequent Responses to Demyelination. J Neurosci (2015) 0.82

Accelerated repair of demyelinated CNS lesions in the absence of non-muscle myosin IIB. Glia (2014) 0.82

Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain. J Neurosci (2009) 0.82

Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci (2006) 3.85

Axon-glial signaling and the glial support of axon function. Annu Rev Neurosci (2008) 3.82

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol (2006) 2.93

Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropathol Exp Neurol (2003) 2.85

Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement. Arch Neurol (2005) 2.55

Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med (2005) 2.46

Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology (2007) 2.10

Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients. Ann Neurol (2011) 1.98

Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors. Neuron (2003) 1.95

Imaging correlates of decreased axonal Na+/K+ ATPase in chronic multiple sclerosis lesions. Ann Neurol (2008) 1.80

Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. J Neuropathol Exp Neurol (2002) 1.70

Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis. Brain (2011) 1.63

The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci (2009) 1.60

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J (2008) 1.60

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Prog Neurobiol (2010) 1.54

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46

Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. J Neurosci (2012) 1.46

Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Ann Neurol (2007) 1.31

Evolution of a neuroprotective function of central nervous system myelin. J Cell Biol (2006) 1.25

Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination. J Biol Chem (2011) 1.25

Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier. J Neurosci (2011) 1.23

NG2-positive cells generate A2B5-positive oligodendrocyte precursor cells. Glia (2007) 1.21

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis. Brain Res Mol Brain Res (2003) 1.18

N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve. Ann Neurol (2002) 1.17

Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells. Nat Neurosci (2013) 1.16

Structure and stability of internodal myelin in mouse models of hereditary neuropathy. J Neuropathol Exp Neurol (2005) 1.16

Axonal degeneration and progressive neurologic disability in multiple sclerosis. Neurotox Res (2003) 1.14

Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors. Ann Neurol (2009) 1.14

Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors. Ann Neurol (2009) 1.12

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol (2013) 1.11

The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease. Neuromolecular Med (2004) 1.10

Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. J Neurosci (2010) 1.10

Neurogenesis in the chronic lesions of multiple sclerosis. Brain (2008) 1.10

Relating interactions between neurofilaments to the structure of axonal neurofilament distributions through polymer brush models. Biophys J (2002) 1.08

The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2. Glia (2002) 1.07

Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis. Arch Neurol (2009) 1.07

Clinically feasible MTR is sensitive to cortical demyelination in MS. Neurology (2012) 1.07

EMMPRIN: a novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci (2011) 1.06

Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients. Prostaglandins Leukot Essent Fatty Acids (2005) 1.04

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Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Lab Invest (2003) 1.03

Cortical remyelination: a new target for repair therapies in multiple sclerosis. Ann Neurol (2012) 1.00

Preconditioning paradigms and pathways in the brain. Cleve Clin J Med (2008) 0.99

Sodium channel expression within chronic multiple sclerosis plaques. J Neuropathol Exp Neurol (2007) 0.99

Expression of protein 4.1G in Schwann cells of the peripheral nervous system. J Neurosci Res (2006) 0.98

Gray-matter injury in multiple sclerosis. N Engl J Med (2009) 0.97

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Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J Neuroimmunol (2006) 0.96

Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients. Brain (2007) 0.96

VCAM-1-positive microglia target oligodendrocytes at the border of multiple sclerosis lesions. J Neuropathol Exp Neurol (2002) 0.96

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Increased citrullinated glial fibrillary acidic protein in secondary progressive multiple sclerosis. J Comp Neurol (2004) 0.94

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ADAM-10 and ADAM-17 in the inflamed human CNS. Glia (2003) 0.92

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Activated microglia enhance neurogenesis via trypsinogen secretion. Proc Natl Acad Sci U S A (2013) 0.88

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Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease. J Alzheimers Dis (2006) 0.85

Role of long-range repulsive forces in organizing axonal neurofilament distributions: evidence from mice deficient in myelin-associated glycoprotein. J Neurosci Res (2002) 0.85

Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis. J Clin Immunol (2005) 0.85

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P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. J Neurosci (2008) 0.82

Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain. J Neurosci (2009) 0.82

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Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice. J Neurosci Res (2002) 0.80

Oligodendrocyte precursor hypercellularity and abnormal retina development in mice overexpressing PDGF-B in myelinating tracts. Glia (2003) 0.79

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Decrease in levels of the evolutionarily conserved microRNA miR-124 affects oligodendrocyte numbers in Zebrafish, Danio rerio. Invert Neurosci (2015) 0.77

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