Published in J Biol Chem on January 28, 2010
Many ceramides. J Biol Chem (2011) 2.31
Mammalian ceramide synthases. IUBMB Life (2010) 1.94
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev (2011) 1.93
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Proc Natl Acad Sci U S A (2010) 1.68
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60
Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J (2012) 1.57
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol (2010) 1.53
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem (2010) 1.41
Sphingolipids containing very-long-chain fatty acids define a secretory pathway for specific polar plasma membrane protein targeting in Arabidopsis. Plant Cell (2011) 1.23
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res (2010) 1.23
Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy. Ann Clin Transl Neurol (2014) 1.11
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. J Biol Chem (2013) 1.11
Sphingolipids and plant defense/disease: the "death" connection and beyond. Front Plant Sci (2012) 1.05
Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochim Biophys Acta (2013) 1.04
Distribution and functions of sterols and sphingolipids. Cold Spring Harb Perspect Biol (2011) 1.02
Modulation of ceramide synthase activity via dimerization. J Biol Chem (2012) 1.02
Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels. J Biol Chem (2011) 0.99
Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes. J Lipid Res (2012) 0.97
Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. PLoS One (2013) 0.97
Metabolism of very long-chain Fatty acids: genes and pathophysiology. Biomol Ther (Seoul) (2014) 0.96
It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. Neurochem Res (2012) 0.94
Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes. J Biol Chem (2012) 0.93
Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction. J Biol Chem (2012) 0.93
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO Mol Med (2014) 0.92
Construction of conditional acid ceramidase knockout mice and in vivo effects on oocyte development and fertility. Cell Physiol Biochem (2012) 0.90
Autophagy regulates sphingolipid levels in the liver. J Lipid Res (2014) 0.90
Genetic loci associated with circulating levels of very long-chain saturated fatty acids. J Lipid Res (2014) 0.89
The twists and turns of sphingolipid pathway in glucose regulation. Biochimie (2010) 0.87
Ceramide in stem cell differentiation and embryo development: novel functions of a topological cell-signaling lipid and the concept of ceramide compartments. J Lipids (2010) 0.86
Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/- mice fed on a high-fat diet. Biosci Rep (2012) 0.85
Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid. J Lipid Res (2014) 0.85
Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization. J Biol Chem (2013) 0.84
Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization. Cell Death Dis (2013) 0.84
Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities. J Biol Chem (2013) 0.84
Developing therapeutic approaches for metachromatic leukodystrophy. Drug Des Devel Ther (2013) 0.83
Self-segregation of myelin membrane lipids in model membranes. Biophys J (2011) 0.83
Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules (2014) 0.83
Human genetic disorders of sphingolipid biosynthesis. J Inherit Metab Dis (2014) 0.81
Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis. PLoS One (2015) 0.81
Ceramides: a potential therapeutic target in pulmonary emphysema. Respir Res (2013) 0.80
Glucosylceramide transferase activity is critical for encystation and viable cyst production by an intestinal protozoan, Giardia lamblia. J Biol Chem (2013) 0.80
Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length. Biochim Biophys Acta (2014) 0.79
Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via KC a 1.1 upregulation. Aging Cell (2015) 0.77
KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress. Aging Cell (2016) 0.76
Sphingolipids and mitochondrial apoptosis. J Bioenerg Biomembr (2016) 0.76
Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. J Biol Chem (2015) 0.76
Metabolic Conversion of Ceramides in HeLa Cells - A Cholesteryl Phosphocholine Delivery Approach. PLoS One (2015) 0.76
Quantified CSF antibody reactivity against myelin in multiple sclerosis. Ann Clin Transl Neurol (2015) 0.75
Dietary Very Long Chain Saturated Fatty Acids and Metabolic Factors: Findings from the Korea National Health and Nutrition Examination Survey 2013. Clin Nutr Res (2015) 0.75
LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity. Curr Mol Med (2016) 0.75
Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J Biol Chem (2016) 0.75
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest (2017) 0.75
Role of Intracellular Lipid Logistics in the Preferential Usage of Very Long Chain-Ceramides in Glucosylceramide. Int J Mol Sci (2016) 0.75
Pharmacogenetics of resistance to Cisplatin and other anticancer drugs and the role of sphingolipid metabolism. Methods Mol Biol (2013) 0.75
Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis. J Cell Sci (2017) 0.75
Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell Mol Life Sci (2017) 0.75
Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol (2008) 12.34
Mechanisms of endocytosis. Annu Rev Biochem (2009) 10.07
Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol (2003) 9.29
A comprehensive classification system for lipids. J Lipid Res (2005) 6.52
Nanotubular highways for intercellular organelle transport. Science (2004) 6.04
Molecular machinery for non-vesicular trafficking of ceramide. Nature (2003) 5.19
A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay. Anal Biochem (1988) 4.76
The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci U S A (2006) 4.15
Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods (2005) 3.42
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem (1991) 3.20
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature (2007) 3.13
The complex life of simple sphingolipids. EMBO Rep (2004) 3.10
When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. J Biol Chem (2006) 3.09
Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. J Biol Chem (1990) 2.72
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J (2005) 2.62
Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails. J Cell Biol (1999) 2.55
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J Biol Chem (2007) 2.50
How curved membranes recruit amphipathic helices and protein anchoring motifs. Nat Chem Biol (2009) 2.38
Sorting of lipids and proteins in membrane curvature gradients. Biophys J (2009) 2.21
Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol (2000) 2.13
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem (2003) 2.06
Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res (2008) 2.03
Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver. Biochem J (1991) 1.80
Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature (2005) 1.76
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem (2009) 1.58
Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry. J Lipid Res (2008) 1.57
An investigation of the substrate specificity of protein phosphatase 2C using synthetic peptide substrates; comparison with protein phosphatase 2A. Biochim Biophys Acta (1990) 1.56
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J (2008) 1.56
LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. Biochem J (2006) 1.54
Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Sci STKE (2001) 1.53
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem (2004) 1.52
Rapid semi-micro procedure for estimating free and total cholesterol. Clin Chem (1959) 1.46
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. Biochem J (1993) 1.43
Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. Biochem J (2009) 1.29
Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett (2007) 1.29
(Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology. Trends Biochem Sci (2007) 1.26
Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins. J Lipid Res (2007) 1.18
Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cells. Methods Enzymol (1993) 1.11
Membrane domain formation, interdigitation, and morphological alterations induced by the very long chain asymmetric C24:1 ceramide. Biophys J (2008) 1.07
Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations. Biophys J (2009) 1.04
Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide. J Biochem (1999) 0.99
Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ-specific differences in toxin accumulation and sphingoid base metabolism. Toxicol Sci (2006) 0.98
Thermotropic behavior and lateral distribution of very long chain sphingolipids. Biochim Biophys Acta (2009) 0.89
Analysis of glucocerebrosidase activity using N-(1-[14C]hexanoyl)-D-erythroglucosylsphingosine demonstrates a correlation between levels of residual enzyme activity and the type of Gaucher disease. Biochem J (1994) 0.88
Moisture content in Dall's porpoise (Phocoenoides dalli) tissues: a reference base for conversion factors between dry and wet weight trace element concentrations in cetaceans. Environ Pollut (2003) 0.83
Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice. J Toxicol Environ Health A (2006) 0.81
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science (2008) 9.42
A comprehensive classification system for lipids. J Lipid Res (2005) 6.52
LMSD: LIPID MAPS structure database. Nucleic Acids Res (2006) 6.21
Sphingomyelin/phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts. Biophys J (2003) 4.48
Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res (2010) 4.14
Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta (2006) 3.10
When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. J Biol Chem (2006) 3.09
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem (2005) 2.64
Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers. J Lipid Res (2008) 2.62
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J Biol Chem (2007) 2.50
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell (2012) 2.38
High cholesterol level is essential for myelin membrane growth. Nat Neurosci (2005) 2.34
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nat Genet (2007) 2.30
The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol (2009) 2.22
Lipid rafts have different sizes depending on membrane composition: a time-resolved fluorescence resonance energy transfer study. J Mol Biol (2005) 2.17
A mouse macrophage lipidome. J Biol Chem (2010) 2.14
Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. J Clin Invest (2006) 2.08
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem (2003) 2.06
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem (2010) 2.05
Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res (2008) 2.03
Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J Immunol (2007) 1.99
Mammalian ceramide synthases. IUBMB Life (2010) 1.94
The structures of COPI-coated vesicles reveal alternate coatomer conformations and interactions. Science (2012) 1.90
Common and uncommon pathogenic cascades in lysosomal storage diseases. J Biol Chem (2010) 1.85
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnol J (2007) 1.82
The membrane domains occupied by glycosylphosphatidylinositol-anchored prion protein and Thy-1 differ in lipid composition. J Biol Chem (2003) 1.73
X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease. EMBO Rep (2003) 1.70
Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease. Anal Chem (2008) 1.69
CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J Cell Biol (2002) 1.69
The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay. Curr Biol (2012) 1.65
Gaucher disease: pathological mechanisms and modern management. Br J Haematol (2005) 1.65
Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: "inside-out" sphingolipidomics. Methods Enzymol (2007) 1.63
Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc Natl Acad Sci U S A (2008) 1.63
Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry. J Lipid Res (2008) 1.57
The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation. Mol Cell Biol (2002) 1.54
Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border. Environ Health Perspect (2006) 1.47
Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res (2010) 1.46
CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metab (2014) 1.46
Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature (2012) 1.42
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem (2010) 1.41
N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. Mol Cancer Ther (2008) 1.37
COPI budding within the Golgi stack. Cold Spring Harb Perspect Biol (2011) 1.33
Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods. Biochim Biophys Acta (2003) 1.32
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. J Biol Chem (2009) 1.32
Ceramide-domain formation and collapse in lipid rafts: membrane reorganization by an apoptotic lipid. Biophys J (2006) 1.32
Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum Mol Genet (2003) 1.32
Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem (2003) 1.32
Role of helix 0 of the N-BAR domain in membrane curvature generation. Biophys J (2008) 1.31
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem (2005) 1.31
Ceramide synthases: roles in cell physiology and signaling. Adv Exp Med Biol (2010) 1.30
Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. Proc Natl Acad Sci U S A (2007) 1.29
Phase diagrams of lipid mixtures relevant to the study of membrane rafts. Biochim Biophys Acta (2008) 1.29
Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. J Biol Chem (2010) 1.29
Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett (2007) 1.29
A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J (2010) 1.26
Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J Biol Chem (2001) 1.26
Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy. Biol Chem (2008) 1.25
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. Mol Cancer Res (2007) 1.25
Characterization of gene-activated human acid-beta-glucosidase: crystal structure, glycan composition, and internalization into macrophages. Glycobiology (2009) 1.25
The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases. Neuromolecular Med (2010) 1.25
Ceramide-platform formation and -induced biophysical changes in a fluid phospholipid membrane. Mol Membr Biol (2006) 1.23
Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond. Mov Disord (2011) 1.22
Nonequilibrium phenomena in the phase separation of a two-component lipid bilayer. Biophys J (2002) 1.22
Enhanced calcium release in the acute neuronopathic form of Gaucher disease. Neurobiol Dis (2005) 1.20
Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry. Mol Cancer (2010) 1.19
A global circadian repressor controls antiphasic expression of metabolic genes in Neurospora. Mol Cell (2011) 1.19
Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease. J Lipid Res (2008) 1.19
Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. J Biol Chem (2003) 1.18
Membrane lipid domains and rafts: current applications of fluorescence lifetime spectroscopy and imaging. Chem Phys Lipids (2008) 1.18
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. J Biol Chem (2005) 1.18
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. Mol Cell Biol (2007) 1.17