1
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SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function.
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Cell
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2008
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5.02
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2
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Stable isotope labeling by amino acids in cell culture (SILAC) and proteome quantitation of mouse embryonic stem cells to a depth of 5,111 proteins.
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Mol Cell Proteomics
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2007
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3.60
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3
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Kindlin-2 controls bidirectional signaling of integrins.
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Genes Dev
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2008
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3.15
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4
|
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.
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Nat Med
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2009
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2.51
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5
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Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.
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J Exp Med
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2007
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2.43
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6
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Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy.
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Nat Genet
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2005
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2.38
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7
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The Kindlins: subcellular localization and expression during murine development.
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Exp Cell Res
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2006
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2.36
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8
|
LAD-1/variant syndrome is caused by mutations in FERMT3.
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Blood
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2008
|
2.22
|
9
|
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.
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Blood
|
2010
|
2.04
|
10
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The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.
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J Cell Biol
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2007
|
1.81
|
11
|
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction.
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PLoS Genet
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2008
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1.78
|
12
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Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD/PKHD1).
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J Am Soc Nephrol
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2003
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1.70
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13
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Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.
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Blood
|
2012
|
1.64
|
14
|
Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration.
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Cancer Res
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2005
|
1.49
|
15
|
Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene.
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J Am Soc Nephrol
|
2002
|
1.41
|
16
|
Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.
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J Neurosci
|
2005
|
1.40
|
17
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PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD).
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Hum Mutat
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2004
|
1.40
|
18
|
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage.
|
J Cell Sci
|
2005
|
1.34
|
19
|
Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.
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J Neurosci
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2005
|
1.33
|
20
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Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption.
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J Cell Biol
|
2011
|
1.32
|
21
|
Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development.
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Dev Dyn
|
2008
|
1.30
|
22
|
The molecular basis of leukocyte recruitment and its deficiencies.
|
Mol Immunol
|
2012
|
1.30
|
23
|
The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation.
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Mol Cell Biol
|
2010
|
1.23
|
24
|
The mechanism of kindlin-mediated activation of integrin αIIbβ3.
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Curr Biol
|
2013
|
1.22
|
25
|
Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions.
|
Blood
|
2009
|
1.21
|
26
|
Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice.
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J Biol Chem
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2007
|
1.19
|
27
|
Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice.
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J Clin Invest
|
2006
|
1.19
|
28
|
PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions.
|
Exp Cell Res
|
2003
|
1.16
|
29
|
RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo.
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Blood
|
2010
|
1.14
|
30
|
Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I.
|
EMBO J
|
2011
|
1.11
|
31
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CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules.
|
Blood
|
2011
|
1.10
|
32
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Consequences of loss of PINCH2 expression in mice.
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J Cell Sci
|
2005
|
1.08
|
33
|
PKHD1 mutations in families requesting prenatal diagnosis for autosomal recessive polycystic kidney disease (ARPKD).
|
Hum Mutat
|
2004
|
1.06
|
34
|
Novel highly sensitive IL-10-beta-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo.
|
J Immunol
|
2011
|
1.03
|
35
|
The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis.
|
Mol Cell Biol
|
2009
|
1.03
|
36
|
Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
|
Mol Cell Neurosci
|
2007
|
1.03
|
37
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Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues.
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J Bone Miner Res
|
2013
|
1.02
|
38
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Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability.
|
Biochim Biophys Acta
|
2007
|
1.01
|
39
|
GLUT1 messenger RNA and protein induction relates to the malignant transformation of cervical cancer.
|
Am J Clin Pathol
|
2003
|
0.98
|
40
|
Identification and embryonic expression of a new AP-2 transcription factor, AP-2 epsilon.
|
Dev Dyn
|
2004
|
0.98
|
41
|
Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation.
|
J Immunol
|
2011
|
0.97
|
42
|
LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys.
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J Am Soc Nephrol
|
2013
|
0.97
|
43
|
Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes.
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J Biol Chem
|
2003
|
0.95
|
44
|
Comparative expression analysis of the murine palladin isoforms.
|
Dev Dyn
|
2008
|
0.94
|
45
|
GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer.
|
Oncology
|
2004
|
0.94
|
46
|
Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues.
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Lab Invest
|
2005
|
0.93
|
47
|
Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa.
|
Mol Membr Biol
|
2008
|
0.90
|
48
|
Biological role of prolyl 3-hydroxylation in type IV collagen.
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Proc Natl Acad Sci U S A
|
2013
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0.88
|
49
|
A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning.
|
PLoS One
|
2011
|
0.88
|
50
|
Two biochemically distinct and tissue-specific twinfilin isoforms are generated from the mouse Twf2 gene by alternative promoter usage.
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Biochem J
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2009
|
0.88
|
51
|
The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin.
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PLoS One
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2010
|
0.87
|
52
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The cartilage-specific transcription factor Sox9 regulates AP-2epsilon expression in chondrocytes.
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FEBS J
|
2009
|
0.86
|
53
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The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis.
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Blood
|
2013
|
0.86
|
54
|
The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.
|
Hum Mol Genet
|
2012
|
0.85
|
55
|
Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1.
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Biochem Biophys Res Commun
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2006
|
0.85
|
56
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Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.
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Proc Natl Acad Sci U S A
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2013
|
0.85
|
57
|
Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.
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Biochem Biophys Res Commun
|
2010
|
0.82
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58
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β1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse.
|
Blood
|
2013
|
0.81
|
59
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Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure.
|
BMC Dev Biol
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2008
|
0.81
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60
|
Enhanced selection for homologous-recombinant embryonic stem cell clones by Cre recombinase-mediated deletion of the positive selection marker.
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Transgenic Res
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2011
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0.80
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61
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The small RNA expression profile of the developing murine urinary and reproductive systems.
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FEBS Lett
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2010
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0.80
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62
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Bral2 is indispensable for the proper localization of brevican and the structural integrity of the perineuronal net in the brainstem and cerebellum.
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J Comp Neurol
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2012
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0.79
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63
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Validation of a luminescence immunoassay for the detection of PrP(Sc) in brain homogenate.
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J Virol Methods
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2002
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0.78
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64
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Cloning, expression and characterization of the murine orthologue of SBF2, the gene mutated in Charcot-Marie-Tooth disease type 4B2.
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Gene Expr Patterns
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2006
|
0.78
|
65
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The murine latent transforming growth factor-beta binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22.
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Gene
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2003
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0.77
|
66
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Twinfilin-2a is dispensable for mouse development.
|
PLoS One
|
2011
|
0.77
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67
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AP-2δ is a crucial transcriptional regulator of the posterior midbrain.
|
PLoS One
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2011
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0.77
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68
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Diagnosis, pathogenesis, and treatment prospects in cystic kidney disease.
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Mol Diagn Ther
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2006
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0.77
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69
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MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.
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J Clin Invest
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2016
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0.75
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70
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Leukocyte adhesion deficiency-III: when leukocytes cannot stop.
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Pediatr Res
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2010
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0.75
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