Published in Exp Cell Res on June 29, 2006
Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol (2008) 2.88
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med (2009) 2.85
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat Med (2009) 2.51
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med (2009) 2.31
Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem (2009) 2.27
Kindlins: essential regulators of integrin signalling and cell-matrix adhesion. EMBO Rep (2008) 2.10
Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol (2011) 1.94
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet (2008) 1.78
Regulation of integrin activity and signalling. Biochim Biophys Acta (2009) 1.51
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol (2012) 1.48
Kindlins in FERM adhesion. Blood (2010) 1.48
Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol (2011) 1.46
Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells. J Exp Med (2015) 1.42
The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell. J Biol Chem (2010) 1.37
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol (2011) 1.32
Kindling the flame of integrin activation and function with kindlins. Curr Opin Hematol (2009) 1.30
Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. J Invest Dermatol (2008) 1.29
Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci (2011) 1.27
The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J Mol Biol (2009) 1.25
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation. Nat Med (2014) 1.22
Kindlin-2 is required for myocyte elongation and is essential for myogenesis. BMC Cell Biol (2008) 1.22
The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish. Blood (2011) 1.14
Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes. Am J Pathol (2009) 1.09
Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1). J Biol Chem (2012) 1.09
Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord. J Neurosci (2016) 1.06
Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis. J Am Soc Nephrol (2013) 1.05
Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tails. J Biol Chem (2012) 1.04
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. Elife (2016) 1.04
Cell-matrix adhesion of podocytes in physiology and disease. Nat Rev Nephrol (2013) 1.02
A mouse model of generalized non-Herlitz junctional epidermolysis bullosa. J Invest Dermatol (2010) 0.99
A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation. J Biol Chem (2012) 0.97
Immunopathologies linked to integrin signalling. Semin Immunopathol (2010) 0.94
Integrins are the necessary links to hypertrophic growth in cardiomyocytes. J Signal Transduct (2011) 0.93
Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification. Am J Pathol (2011) 0.92
Structural and functional characterization of the kindlin-1 pleckstrin homology domain. J Biol Chem (2012) 0.91
Kindler syndrome and periodontal disease: review of the literature and a 12-year follow-up case. J Periodontol (2008) 0.91
Biophysical analysis of Kindlin-3 reveals an elongated conformation and maps integrin binding to the membrane-distal β-subunit NPXY motif. J Biol Chem (2012) 0.90
Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice. PLoS Genet (2014) 0.89
IL-1β enhances cell adhesion to degraded fibronectin. FASEB J (2012) 0.89
Kindlin-2 expression in arsenite- and cadmium-transformed bladder cancer cell lines and in archival specimens of human bladder cancer. Urology (2011) 0.88
Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation. J Cell Sci (2014) 0.87
Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice. Arterioscler Thromb Vasc Biol (2014) 0.86
Localization and potential function of kindlin-1 in periodontal tissues. Eur J Oral Sci (2009) 0.86
Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Proc Natl Acad Sci U S A (2013) 0.85
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. J Biol Chem (2013) 0.84
Kindlin 2 regulates myogenic related factor myogenin via a canonical Wnt signaling in myogenic differentiation. PLoS One (2013) 0.83
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Mol Cell Proteomics (2013) 0.83
Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation. Am J Pathol (2009) 0.82
Kindlin-1 regulates integrin dynamics and adhesion turnover. PLoS One (2013) 0.82
FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. Oncotarget (2016) 0.82
Kindlin-2 directly binds actin and regulates integrin outside-in signaling. J Cell Biol (2016) 0.81
Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness. Mol Biol Cell (2014) 0.80
Phylogenetic analysis of kindlins suggests subfunctionalization of an ancestral unduplicated kindlin into three paralogs in vertebrates. Evol Bioinform Online (2011) 0.80
Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail (2016) 0.79
Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells. Sci Rep (2015) 0.78
Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence. J Cell Biol (2016) 0.77
Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D. Biomed Microdevices (2015) 0.77
Podosomes and Invadopodia: Related structures with Common Protein Components that May Promote Breast Cancer Cellular Invasion. Breast Cancer (Auckl) (2008) 0.77
Increased expression of kindlin-2 is correlated with hematogenous metastasis and poor prognosis in patients with clear cell renal cell carcinoma. FEBS Open Bio (2016) 0.77
Diverse functions of kindlin/fermitin proteins during embryonic development in Xenopus laevis. Mech Dev (2014) 0.76
Cooperative Stimulation of Megakaryocytic Differentiation by Gfi1b Gene Targets Kindlin3 and Talin1. PLoS One (2016) 0.76
Site-specific phosphorylation of kindlin-3 protein regulates its capacity to control cellular responses mediated by integrin αIIbβ3. J Biol Chem (2015) 0.76
Recent advances in the understanding of the molecular mechanisms regulating platelet integrin αIIbβ3 activation. Protein Cell (2010) 0.75
Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity. Mol Cell Biol (2016) 0.75
NMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain. PLoS One (2016) 0.75
Peripheral blood mononuclear cell proteome changes in patients with myelodysplastic syndrome. Biomed Res Int (2015) 0.75
Structure and lipid binding properties of the kindlin-3 pleckstrin homology domain. Biochem J (2016) 0.75
Of Kindlins and Cancer. Discoveries (Craiova) (2016) 0.75
Efficient production and purification of recombinant murine kindlin-3 from insect cells for biophysical studies. J Vis Exp (2014) 0.75
Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing. Int J Mol Med (2017) 0.75
Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells. Stem Cells Int (2017) 0.75
Kindlin-3 Is Essential for the Resting α4β1 Integrin-mediated Firm Cell Adhesion under Shear Flow Conditions. J Biol Chem (2016) 0.75
Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease. J Am Soc Nephrol (2017) 0.75
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell (2008) 5.02
ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol (2006) 4.64
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Stable isotope labeling by amino acids in cell culture (SILAC) and proteome quantitation of mouse embryonic stem cells to a depth of 5,111 proteins. Mol Cell Proteomics (2007) 3.60
Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev (2009) 3.57
Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol (2008) 3.26
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med (2009) 2.85
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev (2003) 2.68
Covered versus uncovered self-expandable nitinol stents in the palliative treatment of malignant distal biliary obstruction: results from a randomized, multicenter study. Gastrointest Endosc (2010) 2.67
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat Med (2009) 2.51
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol (2008) 2.46
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med (2007) 2.43
Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy. Nat Genet (2005) 2.38
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci (2009) 2.29
The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26
LAD-1/variant syndrome is caused by mutations in FERMT3. Blood (2008) 2.22
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev (2003) 2.21
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
Covered metal versus plastic stents for malignant common bile duct stenosis: a prospective, randomized, controlled trial. Gastrointest Endosc (2006) 2.11
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol (2005) 2.10
The role of laminin in embryonic cell polarization and tissue organization. Dev Cell (2003) 2.05
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood (2010) 2.04
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell (2008) 1.98
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res (2002) 1.96
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Integrins in invasive growth. J Clin Invest (2002) 1.96
The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol (2008) 1.89
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet (2008) 1.78
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med (2006) 1.75
Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A (2003) 1.74
Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol (2006) 1.73
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood (2004) 1.70
Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD/PKHD1). J Am Soc Nephrol (2003) 1.70
Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Dev Cell (2008) 1.70
Laminin: the crux of basement membrane assembly. J Cell Biol (2004) 1.69
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res (2008) 1.68
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy. J Clin Invest (2008) 1.67
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep (2003) 1.63
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J (2005) 1.61
Effects of a perioperative smoking cessation intervention on postoperative complications: a randomized trial. Ann Surg (2008) 1.60
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med (2009) 1.59
The Kindlin protein family: new members to the club of focal adhesion proteins. Trends Cell Biol (2009) 1.57
Cylindroma as tumor of hair follicle origin. J Invest Dermatol (2006) 1.56
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration. Cancer Res (2005) 1.49
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol (2012) 1.48
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol (2002) 1.48
Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol (2011) 1.46
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature (2009) 1.45
Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability. Circ Res (2008) 1.43
Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene. J Am Soc Nephrol (2002) 1.41
Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J Neurosci (2005) 1.40
PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD). Hum Mutat (2004) 1.40
KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages. Blood (2010) 1.39
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity (2002) 1.38
Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape. J Cell Sci (2008) 1.38
Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev Biol (2006) 1.37
Regulation of neural progenitor proliferation and survival by beta1 integrins. J Cell Sci (2005) 1.34
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. J Cell Sci (2005) 1.34
Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila. J Neurosci (2005) 1.33
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol (2009) 1.33
Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function. EMBO J (2007) 1.32
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol (2011) 1.32
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol (2002) 1.31
Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology. Blood (2004) 1.30
Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev Dyn (2008) 1.30
The molecular basis of leukocyte recruitment and its deficiencies. Mol Immunol (2012) 1.30