Published in Science on March 29, 1991
Mechanisms of neuropathic pain. Neuron (2006) 4.03
Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci (2011) 2.12
Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia. Arthritis Res Ther (2007) 1.73
Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc Natl Acad Sci U S A (1999) 1.69
A peripheral adrenoceptor-mediated sympathetic mechanism can transform stress-induced analgesia into hyperalgesia. Anesthesiology (2011) 1.65
A search for activation of C nociceptors by sympathetic fibers in complex regional pain syndrome. Clin Neurophysiol (2010) 1.42
Preclinical and early clinical investigations related to monoaminergic pain modulation. Neurotherapeutics (2009) 1.26
Arthritis and pain. Future targets to control osteoarthritis pain. Arthritis Res Ther (2007) 1.17
Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation. J Physiol (1999) 1.11
Norepinephrine-induced nociception and vasoconstrictor hypersensitivity in rats with chronic post-ischemia pain. Pain (2008) 1.07
Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation. J Radiat Res (2013) 0.94
Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun (2006) 0.92
Sympathetic vasoconstrictor antagonism and vasodilatation relieve mechanical allodynia in rats with chronic postischemia pain. J Pain (2008) 0.92
Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. Br J Pharmacol (2001) 0.91
Weather change and pain: a behavioral animal study of the influences of simulated meteorological changes on chronic pain. Int J Biometeorol (2003) 0.90
Sympathetic block with botulinum toxin to treat complex regional pain syndrome. Ann Neurol (2009) 0.90
Activity-dependent slowing of conduction velocity in uninjured L4 C fibers increases after an L5 spinal nerve injury in the rat. Pain (2006) 0.88
Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalities. CNS Neurol Disord Drug Targets (2012) 0.87
The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin. Exp Neurol (2009) 0.86
Causalgia, pathological pain, and adrenergic receptors. Proc Natl Acad Sci U S A (1999) 0.85
The inhibitory effects of alpha(2)-adrenoceptor agonists on gastrointestinal transit during croton oil-induced intestinal inflammation. Br J Pharmacol (1996) 0.85
Skin temperature in the dorsal hand of office workers and severity of upper extremity musculoskeletal disorders. Int Arch Occup Environ Health (2009) 0.84
Differential transcriptional profiling of damaged and intact adjacent dorsal root ganglia neurons in neuropathic pain. PLoS One (2015) 0.82
What lies above and beyond the concept of "sympathetically maintained pain"? Clin Auton Res (2001) 0.82
A comparative study of clonidine and dexmedetomidine as an adjunct to bupivacaine in supraclavicular brachial plexus block. J Anaesthesiol Clin Pharmacol (2016) 0.81
No adrenergic sensitization of afferent neurons in painful sensory polyneuropathy. J Neurol (2005) 0.80
Transient allodynia pain models in mice for early assessment of analgesic activity. Br J Pharmacol (2007) 0.80
Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain. Mol Pain (2015) 0.78
Persistence of pain induced by startle and forehead cooling after sympathetic blockade in patients with complex regional pain syndrome. J Neurol Neurosurg Psychiatry (2004) 0.78
Review of overlap between thermoregulation and pain modulation in fibromyalgia. Clin J Pain (2014) 0.78
Baroreceptor reflex is suppressed in rats that develop hyperalgesia behavior after nerve injury. Pain (2009) 0.78
Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats. Mol Pain (2013) 0.77
Weather and headache onset: a large-scale study of headache medicine purchases. Int J Biometeorol (2014) 0.77
Meningeal norepinephrine produces headache behaviors in rats via actions both on dural afferents and fibroblasts. Cephalalgia (2015) 0.77
Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats. Clinics (Sao Paulo) (2011) 0.77
Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis. J Biomed Sci (2012) 0.76
Evaluation of clonidine as an adjuvant to bupivacaine in wound infiltration for providing postoperative analgesia after abdominal hysterectomy. Anesth Essays Res (2016) 0.75
Involvement of selective alpha-2 adrenoreceptor in sympathetically maintained pain. J Korean Neurosurg Soc (2010) 0.75
Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats. Acta Pharmacol Sin (2009) 0.75
Chronic pain in society--a case for chronic pain as a dysfunctional state? Qual Life Res (1994) 0.75
[Prolonged-release tapentadol for phantom pain. A case series]. Schmerz (2013) 0.75
Dexmedetomidine as an Adjuvant for Intravenous Regional Anesthesia in Upper Limb Surgeries. Anesth Essays Res (2017) 0.75
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol (1969) 4.68
Myelinated afferent fibres responding specifically to noxious stimulation of the skin. J Physiol (1967) 3.09
Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn. J Physiol (2002) 2.49
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn. J Neurophysiol (1970) 2.26
Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers. J Comp Neurol (1979) 2.15
Dynamic properties of mechanoreceptors with unmyelinated (C) fibers. J Neurophysiol (1971) 2.04
Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig. J Physiol (1997) 2.01
Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science (1986) 1.99
Primate cutaneous sensory units with unmyelinated (C) afferent fibers. J Neurophysiol (1977) 1.95
Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers. J Comp Neurol (1979) 1.80
Amovement receptor of the small intestine. J Physiol (1966) 1.75
Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal horn. J Comp Neurol (1979) 1.74
Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: indications of their place in dorsal horn functional organization. J Comp Neurol (1978) 1.67
Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli. J Physiol (1968) 1.48
Is ATP a central synaptic mediator for certain primary afferent fibers from mammalian skin? Proc Natl Acad Sci U S A (1984) 1.47
Sensitization of high threshold receptors with unmyelinated (C) afferent fibers. Prog Brain Res (1976) 1.37
Differences in Ca2+ channels governing generation of miniature and evoked excitatory synaptic currents in spinal laminae I and II. J Neurosci (1998) 1.30
Sensory fibers of the pelvic nerve innervating the Rat's urinary bladder. J Neurophysiol (2000) 1.26
Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn. J Neurosci (1988) 1.20
Calcitonin gene-related peptide immunoreactivity and afferent receptive properties of dorsal root ganglion neurones in guinea-pigs. J Physiol (2002) 1.15
Sympathetic activity and the systemic circulation in the spinal cat. J Physiol (1965) 1.14
Characteristics of viscerosympathetic reflexes in the spinal cat. Am J Physiol (1966) 1.14
Sensory receptors with unmyelinated (C) fibers innervating the skin of the rabbit's ear. J Neurophysiol (1985) 1.11
Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation. J Physiol (1999) 1.11
Antidromically evoked responses from sympathetic preganglionic neurones. J Physiol (1965) 1.09
Adenosine inhibition of synaptic transmission in the substantia gelatinosa. J Neurophysiol (1994) 1.09
ATP modulation of synaptic transmission in the spinal substantia gelatinosa. J Neurosci (1995) 1.04
Fine structure of myelinated mechanical nociceptor endings in cat hairy skin. J Comp Neurol (1981) 0.99
A comparison of four tests for assessing the pain sensitivity of different subjects and test areas. Pain (1977) 0.95
Synaptic ultrastructure of functionally and morphologically characterized neurons of the superficial spinal dorsal horn of cat. J Neurosci (1989) 0.93
Synaptic complexes formed by functionally defined primary afferent units with fine myelinated fibers. J Comp Neurol (1982) 0.90
Regeneration of cutaneous afferent unmyelinated (C) fibers after transection. J Neurophysiol (1985) 0.89
Selective excitation of neurons in the mammalian spinal dorsal horn by aspartate and glutamate in vitro: correlation with location and excitatory input. Brain Res (1985) 0.89
Morphology and synaptic relationships of physiologically identified low-threshold dorsal root axons stained with intra-axonal horseradish peroxidase in the cat and monkey. J Neurophysiol (1984) 0.88
Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonists. Brain Res (1997) 0.87
Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors. J Neurophysiol (1990) 0.86
Pain. Curr Opin Genet Dev (1999) 0.86
The Use of Change in Capacity to Record Cardiac Volume in Human Subjects. Science (1949) 0.86
Functional and morphological features of neurons in the midline region of the caudal spinal cord of the cat. Brain Res (1985) 0.84
Primate cutaneous receptors with unmyelinated (C) fibres and their projection to the substantia gelatinosa. J Physiol (Paris) (1977) 0.84
In situ hybridization using 32P labelled oligodeoxyribonucleotides for the cellular localisation of mRNA in neuronal and endocrine tissue. An analysis of procedural variables. Histochemistry (1988) 0.83
Sensory experiences in man evoked by intraneural electrical stimulation of intact cutaneous afferent fibers. Exp Brain Res (1981) 0.82
Differential termination of large-diameter and small-diameter primary afferent fibers in the spinal dorsal gray matter as indicated by labeling with horseradish peroxidase. Neurosci Lett (1977) 0.82
Effects of nerve injury on sympathetic excitation of A delta mechanical nociceptors. J Neurophysiol (1995) 0.82
Synaptic mediation from cutaneous mechanical nociceptors. J Neurophysiol (1994) 0.82
Sympathectomy induces adrenergic excitability of cutaneous C-fiber nociceptors. J Neurophysiol (1996) 0.79
Cutaneous sensory receptors. J Clin Neurophysiol (1994) 0.79
Reorganization of primary afferent nerve terminals in the spinal dorsal horn of the primate caudal to anterolateral chordotomy. J Comp Neurol (1988) 0.79
Microelectrode arrays for stimulation of neural slice preparations. J Neurosci Methods (1997) 0.79
Chemical factors in the sensitization of cutaneous nociceptors. Prog Brain Res (1988) 0.78
Species-specific expression of cholecystokinin messenger RNA in rodent dorsal root ganglia. Brain Res Mol Brain Res (1990) 0.78
Neurons in ventrobasal region of cat thalamus selectively responsive to noxious mechanical stimulation. J Neurophysiol (1983) 0.78
Criteria for evaluating spinal cord regeneration experiments. Exp Neurol (1980) 0.77
Is pain a specific sensation? J Psychiatr Res (1971) 0.77
Criteria for evaluating spinal cord regeneration experiments. Surg Neurol (1980) 0.77
Getting a line on pain: is it mediated by dedicated pathways? Nat Neurosci (1998) 0.76
Somatic sensation: transfer and processing of information. 1. Peripheral receptors. Electroencephalogr Clin Neurophysiol (1969) 0.76
Failure of acupuncture to produce localized analgesia. Pain (1977) 0.75
Failure of sympathetic stimulation to affect responsiveness of rabbit polymodal nociceptors. J Neurophysiol (1985) 0.75
N-methyl-D-aspartate (NMDA) depolarizes glutamate-insensitive neurones in the superficial dorsal horn. Acta Physiol Scand (1992) 0.75
Neuronal geometry. Science (1982) 0.75
Distribution of primary afferent fibers within the sacrococcygeal dorsal horn: an autoradiographic study. J Comp Neurol (1979) 0.75
Afferent basis of nociception and pain: evidence from the characteristics of sensory receptors and their projections to the spinal dorsal horn. Res Publ Assoc Res Nerv Ment Dis (1980) 0.75
Acupuncture analgesia of the skin in relation to the traditional meridian map. J Physiol (1975) 0.75
[Study on sympathetic medullary reflexes]. Actual Neurophysiol (Paris) (1968) 0.75
Differential L-glutamate responsiveness among superficial dorsal horn neurons. J Neurophysiol (1994) 0.75