Published in Int J Pharm on February 01, 2010
Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol (2010) 1.82
Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochem Pharmacol (2010) 1.05
Synergic effect of eicosapentaenoic acid and lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells. Lipids Health Dis (2010) 0.86
The nasal delivery of nanoencapsulated statins - an approach for brain delivery. Int J Nanomedicine (2016) 0.77
Tocotrienol Nanoemulsion Platform of Curcumin Elicit Elevated Apoptosis and Augmentation of Anticancer Efficacy against Breast and Ovarian Carcinomas. Int J Mol Sci (2016) 0.75
A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. PLoS One (2009) 1.11
Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. Exp Biol Med (Maywood) (2005) 1.06
(-)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers. Planta Med (2011) 0.97
Hydrophilic matrices: application of Placket-Burman screening design to model the effect of POLYOX-carbopol blends on drug release. Int J Pharm (2006) 0.94
Paclitaxel loaded PEG(5000)-DSPE micelles as pulmonary delivery platform: formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation. Eur J Pharm Biopharm (2011) 0.93
Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. Apoptosis (2009) 0.91
Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells. Exp Biol Med (Maywood) (2004) 0.91
Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells. Nutr Cancer (2003) 0.91
D-optimal mixture design: optimization of ternary matrix blends for controlled zero-order drug release from oral dosage forms. Drug Dev Ind Pharm (2006) 0.91
Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS). Int J Pharm (2008) 0.91
Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines. Eur J Pharm Sci (2012) 0.90
Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. Lipids (2007) 0.90
Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells. BMC Cancer (2010) 0.90
Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. Biomed Pharmacother (2009) 0.90
The value of tocotrienols in the prevention and treatment of cancer. J Am Coll Nutr (2010) 0.89
Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. Anticancer Res (2010) 0.86
Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling. Org Biomol Chem (2014) 0.85
Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in vitro, in situ and in vivo studies. Biopharm Drug Dispos (2012) 0.85
Development and validation of a reversed-phase HPLC method for the determination of γ-tocotrienol in rat and human plasma. Biomed Chromatogr (2010) 0.84
Measurement of surface color as an expedient QC method for the detection of deviations in tablet hardness. Int J Pharm (2007) 0.84
Oral ingestion of silver nanoparticles induces genomic instability and DNA damage in multiple tissues. Nanotoxicology (2014) 0.83
Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproduction, and toxicology. Toxicol Appl Pharmacol (2004) 0.83
PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication. J Drug Target (2014) 0.83
Novel use of Eudragit NE 30D/Eudragit L 30D-55 blends as functional coating materials in time-delayed drug release applications. Int J Pharm (2008) 0.83
Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy ((1)H NMR). Colloids Surf B Biointerfaces (2010) 0.83
Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies. Drug Metab Dispos (2010) 0.82
Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. Biochem Cell Biol (2005) 0.82
Bioactive rearranged and halogenated semisynthetic derivatives of the marine natural product sarcophine. J Nat Prod (2004) 0.82
Molecular modelling and multisimplex optimization of tocotrienol-rich self emulsified drug delivery systems. Int J Pharm (2012) 0.82
Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors. J Nat Prod (2009) 0.82
Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. Lipids (2009) 0.81
Sesamin synergistically potentiates the anticancer effects of γ-tocotrienol in mammary cancer cell lines. Fitoterapia (2012) 0.81
Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products. Food Chem Toxicol (2011) 0.81
Nonlinear absorption kinetics of self-emulsifying drug delivery systems (SEDDS) containing tocotrienols as lipophilic molecules: in vivo and in vitro studies. AAPS J (2013) 0.81
Antiproliferative triterpenes from Melaleuca ericifolia. J Nat Prod (2008) 0.80
Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors. Bioorg Med Chem (2010) 0.80
Enhanced solubility and oral bioavailability of γ-tocotrienol using a self-emulsifying drug delivery system (SEDDS). Lipids (2014) 0.80
Mechanisms Mediating the Synergistic Anticancer Effects of Combined γ-Tocotrienol and Celecoxib Treatment. J Bioanal Biomed (2011) 0.80
Stability and in vitro antiproliferative activity of bioactive "Vitamin E" fortified parenteral lipid emulsions. Colloids Surf B Biointerfaces (2012) 0.80
Fluid bed coating: the utility of dual programmable pumps for controlled gradient drug deposition on pellets. Int J Pharm (2007) 0.80
Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1. Exp Biol Med (Maywood) (2009) 0.80
"Vitamin E" fortified parenteral lipid emulsions: Plackett-Burman screening of primary process and composition parameters. Drug Dev Ind Pharm (2012) 0.80
Sinulodurins A and B, antiproliferative and anti-invasive diterpenes from the soft coral Sinularia dura. J Nat Prod (2008) 0.80
Entrapment into nanoemulsions potentiates the anticancer activity of tocotrienols against the highly malignant (+SA) mouse mammary epithelial cells. J Nanosci Nanotechnol (2014) 0.79
Hard gelatin and hypromellose (HPMC) capsules: estimation of rupture time by real-time dissolution spectroscopy. Drug Dev Ind Pharm (2007) 0.79
Mechanisms mediating the synergistic anticancer effects of combined γ-tocotrienol and sesamin treatment. Planta Med (2012) 0.79
Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability. Lipids (2012) 0.78
Tocotrienol combination therapy results in synergistic anticancer response. Front Biosci (Landmark Ed) (2011) 0.78
Thermoresponsive fluconazole gels for topical delivery: rheological and mechanical properties, in vitro drug release and anti-fungal efficacy. Pharm Dev Technol (2013) 0.78
Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells. Int J Pharm (2010) 0.78
Modeling the effect of sonication parameters on size and dispersion temperature of solid lipid nanoparticles (SLNs) by response surface methodology (RSM). Pharm Dev Technol (2013) 0.78
Effect of gel composition and phonophoresis on the transdermal delivery of ibuprofen: in vitro and in vivo evaluation. Pharm Dev Technol (2010) 0.78
Doxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES). Int J Pharm (2012) 0.77
Semisynthetic and biotransformation studies of (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol. J Nat Prod (2008) 0.77
Effect of Eudragit RS 30D and talc powder on verapamil hydrochloride release from beads coated with drug layered matrices. AAPS PharmSciTech (2008) 0.77
Effect of PEG surface conformation on anticancer activity and blood circulation of nanoemulsions loaded with tocotrienol-rich fraction of palm oil. AAPS J (2013) 0.77
Development and validation of a reversed-phase HPLC method for the simultaneous analysis of simvastatin and tocotrienols in combined dosage forms. J Pharm Biomed Anal (2009) 0.76
Optimization of tocotrienols as antiproliferative and antimigratory leads. Eur J Med Chem (2012) 0.76
Repeated cocaine decreases the avoidance response to a novel aversive stimulus in rats. Psychopharmacology (Berl) (2002) 0.76
Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids. Expert Opin Investig Drugs (2007) 0.76
Comparison between lipolysis and compendial dissolution as alternative techniques for the in vitro characterization of alpha-tocopherol self-emulsified drug delivery systems (SEDDS). Int J Pharm (2007) 0.76
Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells. Int J Breast Cancer (2013) 0.76
γ-Tocotrienol-induced autophagy in malignant mammary cancer cells. Exp Biol Med (Maywood) (2013) 0.76
Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion. Bioorg Med Chem (2009) 0.76
Preparation and characterization of cosmeceutical liposomes loaded with avobenzone and arbutin. J Cosmet Sci (2013) 0.76
Caudal hindbrain glucoprivation enhances gamma-aminobutyric acid release in discrete septopreoptic structures in the steroid-primed ovariectomized rat brain: role of mu opioid receptors. Neuroendocrinology (2004) 0.76
Biocatalysis of the anticancer sipholane triterpenoids. Planta Med (2007) 0.75
The effect of emulsifying wax on the physical properties of CTAB-based solid lipid nanoparticles (SLN). Pharm Dev Technol (2013) 0.75
Optimization and in vivo evaluation of an oral dual controlled-release tablet dosage form of insulin and duck ovomucoid. Pharm Dev Technol (2008) 0.75
"Real-time" disintegration analysis and D-optimal experimental design for the optimization of diclofenac sodium fast-dissolving films. Pharm Dev Technol (2012) 0.75
Effect of lipid viscosity and high-pressure homogenization on the physical stability of "Vitamin E" enriched emulsion. Pharm Dev Technol (2014) 0.75
Preparation of delayed release tablet dosage forms by compression coating: effect of coating material on theophylline release. Pharm Dev Technol (2010) 0.75
Synthesis of fluorescent analogues of the anticancer natural products 4-hydroxyphenylmethylene hydantoin and delta-tocotrienol. Nat Prod Commun (2010) 0.75
Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. Bioorg Med Chem (2009) 0.75
Powdered self-emulsified lipid formulations of meloxicam as solid dosage forms for oral administration. Drug Dev Ind Pharm (2012) 0.75