Published in Drug Metab Dispos on March 05, 2010
Mechanisms for the prevention of vitamin E excess. J Lipid Res (2013) 1.11
Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation. Nutr J (2012) 0.87
Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity. Toxicol Sci (2011) 0.84
Nonlinear absorption kinetics of self-emulsifying drug delivery systems (SEDDS) containing tocotrienols as lipophilic molecules: in vivo and in vitro studies. AAPS J (2013) 0.81
Drug Delivery Innovations for Enhancing the Anticancer Potential of Vitamin E Isoforms and Their Derivatives. Biomed Res Int (2015) 0.75
Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K. J Atheroscler Thromb (2017) 0.75
Vitamin E transporters in cancer therapy. AAPS J (2014) 0.75
Profiling gene expression in human placentae of different gestational ages: an OPRU Network and UW SCOR Study. Reprod Sci (2008) 1.25
Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models. Cancer Lett (2012) 1.16
A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. PLoS One (2009) 1.11
Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. Exp Biol Med (Maywood) (2005) 1.06
Enhanced brain amyloid-β clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease. J Alzheimers Dis (2012) 1.04
Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies. ACS Chem Neurosci (2013) 0.98
(-)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers. Planta Med (2011) 0.97
Paclitaxel loaded PEG(5000)-DSPE micelles as pulmonary delivery platform: formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation. Eur J Pharm Biopharm (2011) 0.93
Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. Apoptosis (2009) 0.91
Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate. J Nucl Med (2009) 0.91
Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells. Exp Biol Med (Maywood) (2004) 0.91
Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells. Nutr Cancer (2003) 0.91
Role of ABC transporters in the pathogenesis of Alzheimer's disease. ACS Chem Neurosci (2012) 0.90
Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines. Eur J Pharm Sci (2012) 0.90
Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. Lipids (2007) 0.90
Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells. BMC Cancer (2010) 0.90
Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. Biomed Pharmacother (2009) 0.90
Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study. Mol Cancer Ther (2014) 0.89
The value of tocotrienols in the prevention and treatment of cancer. J Am Coll Nutr (2010) 0.89
Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J Med Chem (2010) 0.87
Up-regulation of P-glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P-glycoprotein as a novel therapeutic target for Alzheimer's disease. J Pharm Pharmacol (2011) 0.86
Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. Anticancer Res (2010) 0.86
Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in vitro, in situ and in vivo studies. Biopharm Drug Dispos (2012) 0.85
Development and validation of a reversed-phase HPLC method for the determination of γ-tocotrienol in rat and human plasma. Biomed Chromatogr (2010) 0.84
Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproduction, and toxicology. Toxicol Appl Pharmacol (2004) 0.83
PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication. J Drug Target (2014) 0.83
Genomics and pharmacogenomics of breast cancer: current knowledge and trends. Asian Pac J Cancer Prev (2011) 0.83
Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy ((1)H NMR). Colloids Surf B Biointerfaces (2010) 0.83
Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. Biochem Cell Biol (2005) 0.82
The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. Bioorg Med Chem (2009) 0.82
Molecular modelling and multisimplex optimization of tocotrienol-rich self emulsified drug delivery systems. Int J Pharm (2012) 0.82
Bioactive rearranged and halogenated semisynthetic derivatives of the marine natural product sarcophine. J Nat Prod (2004) 0.82
Preparation, characterization, and anticancer effects of simvastatin-tocotrienol lipid nanoparticles. Int J Pharm (2010) 0.82
Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors. J Nat Prod (2009) 0.82
Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products. Food Chem Toxicol (2011) 0.81
Sesamin synergistically potentiates the anticancer effects of γ-tocotrienol in mammary cancer cell lines. Fitoterapia (2012) 0.81
Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. Lipids (2009) 0.81
Nonlinear absorption kinetics of self-emulsifying drug delivery systems (SEDDS) containing tocotrienols as lipophilic molecules: in vivo and in vitro studies. AAPS J (2013) 0.81
Mechanisms Mediating the Synergistic Anticancer Effects of Combined γ-Tocotrienol and Celecoxib Treatment. J Bioanal Biomed (2011) 0.80
Enhanced solubility and oral bioavailability of γ-tocotrienol using a self-emulsifying drug delivery system (SEDDS). Lipids (2014) 0.80
Experimental models for predicting drug absorption and metabolism. Expert Opin Drug Metab Toxicol (2013) 0.80
Antiproliferative triterpenes from Melaleuca ericifolia. J Nat Prod (2008) 0.80
Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors. Bioorg Med Chem (2010) 0.80
Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1. Exp Biol Med (Maywood) (2009) 0.80
Stability and in vitro antiproliferative activity of bioactive "Vitamin E" fortified parenteral lipid emulsions. Colloids Surf B Biointerfaces (2012) 0.80
Sinulodurins A and B, antiproliferative and anti-invasive diterpenes from the soft coral Sinularia dura. J Nat Prod (2008) 0.80
"Vitamin E" fortified parenteral lipid emulsions: Plackett-Burman screening of primary process and composition parameters. Drug Dev Ind Pharm (2012) 0.80
Mechanisms mediating the synergistic anticancer effects of combined γ-tocotrienol and sesamin treatment. Planta Med (2012) 0.79
Determination of methamphetamine and amphetamine in abusers' plasma and hair samples with HPLC-FL. Biomed Chromatogr (2003) 0.79
Entrapment into nanoemulsions potentiates the anticancer activity of tocotrienols against the highly malignant (+SA) mouse mammary epithelial cells. J Nanosci Nanotechnol (2014) 0.79
Exposure of LS-180 cells to drugs of diverse physicochemical and therapeutic properties up-regulates P-glycoprotein expression and activity. J Pharm Pharm Sci (2011) 0.79
In silico modeling for the nonlinear absorption kinetics of UK-343,664: a P-gp and CYP3A4 substrate. Mol Pharm (2012) 0.79
In vitro investigation of amyloid-β hepatobiliary disposition in sandwich-cultured primary rat hepatocytes. Drug Metab Dispos (2013) 0.78
HPLC determination of phenylpropanolamine in pharmaceutical OTC preparations. Biomed Chromatogr (2002) 0.78
Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability. Lipids (2012) 0.78
Effect of PEG surface conformation on anticancer activity and blood circulation of nanoemulsions loaded with tocotrienol-rich fraction of palm oil. AAPS J (2013) 0.77
Semisynthetic and biotransformation studies of (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol. J Nat Prod (2008) 0.77
Caudal hindbrain glucoprivation enhances gamma-aminobutyric acid release in discrete septopreoptic structures in the steroid-primed ovariectomized rat brain: role of mu opioid receptors. Neuroendocrinology (2004) 0.76
Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids. Expert Opin Investig Drugs (2007) 0.76
Repeated cocaine decreases the avoidance response to a novel aversive stimulus in rats. Psychopharmacology (Berl) (2002) 0.76
Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion. Bioorg Med Chem (2009) 0.76
γ-Tocotrienol-induced autophagy in malignant mammary cancer cells. Exp Biol Med (Maywood) (2013) 0.76
Optimization of tocotrienols as antiproliferative and antimigratory leads. Eur J Med Chem (2012) 0.76
Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells. Int J Breast Cancer (2013) 0.76
Biocatalysis of the anticancer sipholane triterpenoids. Planta Med (2007) 0.75
Vitamin E transporters in cancer therapy. AAPS J (2014) 0.75
Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. Bioorg Med Chem (2009) 0.75
Synthesis and P-glycoprotein induction activity of colupulone analogs. Org Biomol Chem (2015) 0.75
Synthesis of fluorescent analogues of the anticancer natural products 4-hydroxyphenylmethylene hydantoin and delta-tocotrienol. Nat Prod Commun (2010) 0.75
Effect of lipid viscosity and high-pressure homogenization on the physical stability of "Vitamin E" enriched emulsion. Pharm Dev Technol (2014) 0.75
Pentazocine monitoring in rat hair and plasma by HPLC-fluorescence detection with DIB-Cl as a labelling reagent. Luminescence (2007) 0.75
Semi-micro column HPLC of triazolam in rat plasma and brain microdialysate and its application to drug interaction study with itraconazole. J Pharm Biomed Anal (2003) 0.75