PubRank

Paul A M Michels

Author PubWeight™ 90.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
2 Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei. J Biol Chem 2005 1.60
3 Plant-like traits associated with metabolism of Trypanosoma parasites. Proc Natl Acad Sci U S A 2003 1.59
4 Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes. Proc Natl Acad Sci U S A 2008 1.37
5 Autophagy in protists. Autophagy 2011 1.29
6 Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei. Mol Biochem Parasitol 2007 1.26
7 Turnover of glycosomes during life-cycle differentiation of Trypanosoma brucei. Autophagy 2008 1.25
8 Autophagy in parasitic protists: unique features and drug targets. Mol Biochem Parasitol 2011 1.19
9 ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation. J Biol Chem 2003 1.15
10 When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle. Int J Parasitol 2011 1.08
11 Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model. J Biol Chem 2010 1.06
12 Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. FEMS Microbiol Rev 2004 1.02
13 Complex I of Trypanosomatidae: does it exist? Trends Parasitol 2008 1.01
14 Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites. Bioorg Med Chem 2009 1.01
15 The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J Biol Chem 2011 1.00
16 Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5. J Mol Biol 2008 0.97
17 Rewiring and regulation of cross-compartmentalized metabolism in protists. Philos Trans R Soc Lond B Biol Sci 2010 0.97
18 Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei. Biochim Biophys Acta 2007 0.96
19 Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target. Enzyme Res 2011 0.95
20 Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. J Med Chem 2010 0.95
21 A domino effect in drug action: from metabolic assault towards parasite differentiation. Mol Microbiol 2010 0.95
22 Leishmania mexicana: molecular cloning and characterization of enolase. Exp Parasitol 2007 0.95
23 The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp. Mol Biochem Parasitol 2006 0.94
24 The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis. FEBS Lett 2002 0.93
25 Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state. J Mol Biol 2008 0.93
26 Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins. Eur J Biochem 2003 0.92
27 Horizontal gene transfer in trypanosomatids. Trends Parasitol 2007 0.92
28 Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem 2008 0.91
29 Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids. Curr Opin Microbiol 2014 0.90
30 Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei. Mol Biochem Parasitol 2009 0.90
31 Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi. Mol Biochem Parasitol 2003 0.89
32 Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei. J Med Chem 2006 0.89
33 Glycosomal ABC transporters of Trypanosoma brucei: characterisation of their expression, topology and substrate specificity. Int J Parasitol 2010 0.89
34 Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei. PLoS One 2012 0.89
35 Identification and characterization of three peroxins--PEX6, PEX10 and PEX12--involved in glycosome biogenesis in Trypanosoma brucei. Biochim Biophys Acta 2005 0.89
36 Comparison of the peroxisomal matrix protein import system of different organisms. Exploration of possibilities for developing inhibitors of the import system of trypanosomatids for anti-parasite chemotherapy. Eur J Cell Biol 2010 0.88
37 Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct. J Mol Biol 2003 0.88
38 The first crystal structure of phosphofructokinase from a eukaryote: Trypanosoma brucei. J Mol Biol 2006 0.86
39 The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features. Eur J Biochem 2004 0.86
40 The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases. J Mol Biol 2008 0.86
41 An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.85
42 The silicon trypanosome. Parasitology 2010 0.85
43 Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei. Biochemistry 2003 0.84
44 The crystal structure of Trypanosoma brucei enolase: visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition. J Mol Biol 2003 0.84
45 Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase. Eur J Biochem 2003 0.84
46 Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids. Mol Biochem Parasitol 2010 0.84
47 Structural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase. FEBS J 2012 0.83
48 Fumarate hydratase isoforms of Leishmania major: subcellular localization, structural and kinetic properties. Int J Biol Macromol 2012 0.83
49 An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes. Mol Biochem Parasitol 2010 0.83
50 Identification, characterization and essentiality of the unusual peroxin 13 from Trypanosoma brucei. Biochim Biophys Acta 2009 0.83
51 Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting. Mol Membr Biol 2006 0.82
52 6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis. FEBS J 2005 0.81
53 Trypanosomes contain two highly different isoforms of peroxin PEX13 involved in glycosome biogenesis. FEBS Lett 2012 0.81
54 Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo. Metallomics 2011 0.81
55 The multifunctional isopropyl alcohol dehydrogenase of Phytomonas sp. could be the result of a horizontal gene transfer from a bacterium to the trypanosomatid lineage. J Biol Chem 2003 0.81
56 Leishmania donovani phosphofructokinase. Gene characterization, biochemical properties and structure-modeling studies. Eur J Biochem 2002 0.81
57 Stearoyl-CoA desaturase is an essential enzyme for the parasitic protist Trypanosoma brucei. Biochem Biophys Res Commun 2011 0.81
58 Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target. PLoS One 2010 0.80
59 Molecular and biochemical characterization of novel glucokinases from Trypanosoma cruzi and Leishmania spp. Mol Biochem Parasitol 2007 0.80
60 The characterization and evolutionary relationships of a trypanosomal thiolase. Int J Parasitol 2011 0.80
61 Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification. Eur J Biochem 2004 0.80
62 Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux. J Biol Chem 2013 0.80
63 Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features. Biochim Biophys Acta 2013 0.80
64 `In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase. Acta Crystallogr D Biol Crystallogr 2013 0.80
65 Translocation of solutes and proteins across the glycosomal membrane of trypanosomes; possibilities and limitations for targeting with trypanocidal drugs. Parasitology 2012 0.79
66 Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase. Mol Microbiol 2014 0.79
67 Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. PLoS Negl Trop Dis 2013 0.79
68 The crystal structure of Trypanosoma cruzi glucokinase reveals features determining oligomerization and anomer specificity of hexose-phosphorylating enzymes. J Mol Biol 2007 0.79
69 Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors. J Med Chem 2012 0.78
70 Extra-glycosomal localisation of Trypanosoma brucei hexokinase 2. Int J Parasitol 2012 0.78
71 Leishmania mexicana mexicana glucose-6-phosphate isomerase: crystallization, molecular-replacement solution and inhibition. Acta Crystallogr D Biol Crystallogr 2004 0.78
72 Glucose-6-phosphate dehydrogenase of trypanosomatids: characterization, target validation, and drug discovery. Mol Biol Int 2011 0.78
73 Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass. J Mol Biol 2009 0.78
74 Exploring the active site of Trypanosoma brucei phosphofructokinase by inhibition studies: specific irreversible inhibition. Biochemistry 2002 0.77
75 Studies on the organization of the docking complex involved in matrix protein import into glycosomes of Trypanosoma brucei. Biochem Biophys Res Commun 2012 0.77
76 Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. ChemMedChem 2014 0.77
77 A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase. Biochem J 2012 0.77
78 Pyruvate kinases have an intrinsic and conserved decarboxylase activity. Biochem J 2014 0.76
79 Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.75
80 The evolution of organellar metabolism in unicellular eukaryotes. Philos Trans R Soc Lond B Biol Sci 2010 0.75
81 Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop. Biochem J 2013 0.75
82 Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target. J Biochem 2013 0.75
83 Biochemical effects of riluzole on Leishmania parasites. Exp Parasitol 2012 0.75
84 Processing of the glycosomal matrix-protein import receptor PEX5 of Trypanosoma brucei. Biochem Biophys Res Commun 2012 0.75