Published in PLoS Comput Biol on January 29, 2010
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev (2014) 1.96
Mitochondria in the diabetic heart. Cardiovasc Res (2010) 1.50
Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes. Cardiovasc Res (2015) 1.39
Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J (2011) 1.33
Mitochondrial network determines intracellular ROS dynamics and sensitivity to oxidative stress through switching inter-mitochondrial messengers. PLoS One (2011) 1.16
Biophysical properties and functional consequences of reactive oxygen species (ROS)-induced ROS release in intact myocardium. J Physiol (2011) 1.12
Mitochondrial redox signaling: Interaction of mitochondrial reactive oxygen species with other sources of oxidative stress. Antioxid Redox Signal (2012) 1.10
Mitochondrial energetics, pH regulation, and ion dynamics: a computational-experimental approach. Biophys J (2011) 1.05
Computational approaches to understand cardiac electrophysiology and arrhythmias. Am J Physiol Heart Circ Physiol (2012) 1.05
Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death Dis (2014) 1.04
Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model. Biophys J (2013) 1.04
New roles for mitochondria in cell death in the reperfused myocardium. Cardiovasc Res (2011) 1.03
Calcium signaling in cardiac mitochondria. J Mol Cell Cardiol (2013) 1.01
Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress. J Mol Cell Cardiol (2011) 0.98
Emergence of the mitochondrial reticulum from fission and fusion dynamics. PLoS Comput Biol (2012) 0.93
Mitochondria are sources of metabolic sink and arrhythmias. Pharmacol Ther (2011) 0.92
Modeling the TNFα-induced apoptosis pathway in hepatocytes. PLoS One (2011) 0.92
Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radic Biol Med (2012) 0.90
Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide. Free Radic Biol Med (2014) 0.90
The cardiac acetyl-lysine proteome. PLoS One (2013) 0.90
Intracellular signaling by diffusion: can waves of hydrogen peroxide transmit intracellular information in plant cells? Front Plant Sci (2012) 0.88
Multistationary and oscillatory modes of free radicals generation by the mitochondrial respiratory chain revealed by a bifurcation analysis. PLoS Comput Biol (2012) 0.87
Cardiac mitochondrial network excitability: insights from computational analysis. Am J Physiol Heart Circ Physiol (2012) 0.86
Mitochondrial signaling: forwards, backwards, and in between. Oxid Med Cell Longev (2013) 0.86
Mitochondrial networks in cardiac myocytes reveal dynamic coupling behavior. Biophys J (2015) 0.86
Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis. Circ Arrhythm Electrophysiol (2014) 0.85
From isolated to networked: a paradigmatic shift in mitochondrial physiology. Front Physiol (2010) 0.85
Targeting the redox balance in inflammatory skin conditions. Int J Mol Sci (2013) 0.84
Integrative modeling of the cardiac ventricular myocyte. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84
Mitochondrial network energetics in the heart. Wiley Interdiscip Rev Syst Biol Med (2012) 0.84
A biophysically based mathematical model for the catalytic mechanism of glutathione reductase. Free Radic Biol Med (2013) 0.83
Wavelet analysis reveals heterogeneous time-dependent oscillations of individual mitochondria. Am J Physiol Heart Circ Physiol (2010) 0.82
Mitochondria-derived ROS bursts disturb Ca²⁺ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: a theoretical study. Am J Physiol Heart Circ Physiol (2014) 0.81
Cardiac mitochondria exhibit dynamic functional clustering. Front Physiol (2014) 0.81
A mechanistic mathematical model for the catalytic action of glutathione peroxidase. Free Radic Res (2014) 0.81
Linking flickering to waves and whole-cell oscillations in a mitochondrial network model. Biophys J (2011) 0.81
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function. Front Physiol (2014) 0.80
Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton. Sci Rep (2015) 0.79
Mitochondrial instability during regional ischemia-reperfusion underlies arrhythmias in monolayers of cardiomyocytes. J Mol Cell Cardiol (2014) 0.79
Protective mechanisms of mitochondria and heart function in diabetes. Antioxid Redox Signal (2015) 0.78
Computational modeling of mitochondrial energy transduction. Crit Rev Biomed Eng (2011) 0.78
Mitochondrial health, the epigenome and healthspan. Clin Sci (Lond) (2016) 0.76
Contribution of mitochondrial network dynamics to intracellular ROS signaling. Commun Integr Biol (2012) 0.76
Computational strategies for a system-level understanding of metabolism. Metabolites (2014) 0.76
Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis. Theor Biol Med Model (2016) 0.76
Modeling mitochondrial ROS: a great balancing act. Biophys J (2013) 0.75
PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis. Int J Mol Sci (2017) 0.75
Identical mitochondrial somatic mutations unique to chronic periodontitis and coronary artery disease. J Indian Soc Periodontol (2016) 0.75
Function of metabolic and organelle networks in crowded and organized media. Front Physiol (2015) 0.75
Decoding of cytosolic calcium oscillations in the mitochondria. Cell (1995) 7.31
Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med (2000) 5.90
Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol (2006) 5.37
Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem (2003) 3.93
Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell (1997) 3.71
Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta (2006) 3.57
The mitochondrial origin of postischemic arrhythmias. J Clin Invest (2005) 3.08
Subcellular metabolic transients and mitochondrial redox waves in heart cells. Proc Natl Acad Sci U S A (1998) 2.42
Coupling membranes as energy-transmitting cables. I. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes. J Cell Biol (1988) 2.38
Percolation and criticality in a mitochondrial network. Proc Natl Acad Sci U S A (2004) 2.17
A mitochondrial oscillator dependent on reactive oxygen species. Biophys J (2004) 1.99
The role of the mitochondrial permeability transition pore in heart disease. Biochim Biophys Acta (2009) 1.92
Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem (2007) 1.92
Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole. Cardiovasc Res (2006) 1.85
The fundamental organization of cardiac mitochondria as a network of coupled oscillators. Biophys J (2006) 1.55
Intracellular energetic units in red muscle cells. Biochem J (2001) 1.53
Regulation of mitochondrial respiration in heart cells analyzed by reaction-diffusion model of energy transfer. Am J Physiol Cell Physiol (2000) 1.48
Systems biology approaches to metabolic and cardiovascular disorders: network perspectives of cardiovascular metabolism. J Lipid Res (2006) 1.46
Coordinated behavior of mitochondria in both space and time: a reactive oxygen species-activated wave of mitochondrial depolarization. Biophys J (2004) 1.40
Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart. Cardiovasc Res (2008) 1.35
Mitochondrial oscillations in physiology and pathophysiology. Adv Exp Med Biol (2008) 1.31
The fractal architecture of cytoplasmic organization: scaling, kinetics and emergence in metabolic networks. Mol Cell Biochem (2004) 1.11
Spatial patterns in a photobiochemical system. Proc Natl Acad Sci U S A (1989) 0.86
Distributed computing for membrane-based modeling of action potential propagation. IEEE Trans Biomed Eng (2000) 0.83
Pattern formation in an immobilized bienzyme system. A morphogenetic model. Biochem J (1990) 0.80
Smoke-free legislation and hospitalizations for acute coronary syndrome. N Engl J Med (2008) 4.57
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell (2003) 4.55
Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem (2003) 3.93
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature (2002) 3.92
Classifying gene expression profiles from pairwise mRNA comparisons. Stat Appl Genet Mol Biol (2004) 3.45
Simple decision rules for classifying human cancers from gene expression profiles. Bioinformatics (2005) 3.24
The mitochondrial origin of postischemic arrhythmias. J Clin Invest (2005) 3.08
Evidence of structural remodeling in the dyssynchronous failing heart. Circ Res (2005) 3.05
Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res (2006) 3.03
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation (2010) 2.94
Dosimetric and technical considerations for interstitial adenoviral gene therapy as applied to prostate cancer. Int J Radiat Oncol Biol Phys (2003) 2.67
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J (2003) 2.52
Measuring and mapping cardiac fiber and laminar architecture using diffusion tensor MR imaging. Ann N Y Acad Sci (2005) 2.35
Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science (2002) 2.23
Percolation and criticality in a mitochondrial network. Proc Natl Acad Sci U S A (2004) 2.17
Identification and characterization of a functional mitochondrial angiotensin system. Proc Natl Acad Sci U S A (2011) 2.16
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation (2009) 2.09
Large deformation diffeomorphic metric mapping of vector fields. IEEE Trans Med Imaging (2005) 2.09
From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales. Philos Trans A Math Phys Eng Sci (2008) 2.05
A mitochondrial oscillator dependent on reactive oxygen species. Biophys J (2004) 1.99
An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophys J (2002) 1.97
Mitochondrial ion channels: gatekeepers of life and death. Physiology (Bethesda) (2005) 1.94
Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem (2007) 1.92
Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data. Bioinformatics (2005) 1.91
A computational model of the human left-ventricular epicardial myocyte. Biophys J (2004) 1.88
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res (2009) 1.88
Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A (2012) 1.80
The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophys J (2004) 1.78
Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure. Circ Res (2004) 1.77
Large-scale integration of cancer microarray data identifies a robust common cancer signature. BMC Bioinformatics (2007) 1.74
Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol (2007) 1.74
A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte. Biophys J (2006) 1.69
Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure. Magn Reson Med (2005) 1.68
Mitochondrial criticality: a new concept at the turning point of life or death. Biochim Biophys Acta (2005) 1.68
Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes. Circulation (2010) 1.61
Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching. Circ Res (2008) 1.60
Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness. J Appl Physiol (1985) (2006) 1.59
Beta-adrenergic stimulation of L-type Ca2+ channels in cardiac myocytes requires the distal carboxyl terminus of alpha1C but not serine 1928. Circ Res (2006) 1.57
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res (2006) 1.56
The fundamental organization of cardiac mitochondria as a network of coupled oscillators. Biophys J (2006) 1.55
Cytosolic free magnesium modulates Na/Ca exchange currents in pig myocytes. Cardiovasc Res (2002) 1.54
Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failure. J Mol Cell Cardiol (2005) 1.54
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. J Cell Biol (2011) 1.52
Mitochondrial ROMK channel is a molecular component of mitoK(ATP). Circ Res (2012) 1.51
Transport of Relational Structures in Groups of Diffeomorphisms. J Math Imaging Vis (2008) 1.51
Deranged sodium to sudden death. J Physiol (2015) 1.51
Merging microarray data from separate breast cancer studies provides a robust prognostic test. BMC Bioinformatics (2008) 1.48
Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes. Cell Signal (2008) 1.44
Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophys J (2005) 1.42
Molecular correlates of altered expression of potassium currents in failing rabbit myocardium. Am J Physiol Heart Circ Physiol (2005) 1.39
Mitochondrial K(ATP) channels in cell survival and death. J Mol Cell Cardiol (2005) 1.38
Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart. Cardiovasc Res (2008) 1.35
Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res (2003) 1.35
Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria. J Biol Chem (2011) 1.35
Redox regulation of mitochondrial ATP synthase: implications for cardiac resynchronization therapy. Circ Res (2011) 1.32
Mitochondrial oscillations in physiology and pathophysiology. Adv Exp Med Biol (2008) 1.31
Cardiac mitochondria and arrhythmias. Cardiovasc Res (2010) 1.29
Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts. J Mol Cell Cardiol (2008) 1.27
Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes. Circ Res (2003) 1.26
Computational cardiac anatomy using MRI. Magn Reson Med (2004) 1.23
Diffeomorphic Matching of Diffusion Tensor Images. Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit (2006) 1.23
Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes. Genomics (2004) 1.22
Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte function. Biophys J (2009) 1.20
Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization. J Mol Cell Cardiol (2009) 1.19
Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart. J Bioenerg Biomembr (2009) 1.17
Cardioprotective role of the mitochondrial ATP-binding cassette protein 1. Circ Res (2005) 1.17
Discovering robust protein biomarkers for disease from relative expression reversals in 2-D DIGE data. Proteomics (2007) 1.15
Differential actions of cardioprotective agents on the mitochondrial death pathway. Circ Res (2003) 1.14
Role of mitochondrial dysfunction in cardiac glycoside toxicity. J Mol Cell Cardiol (2010) 1.14
Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release. Biophys J (2007) 1.14
Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip. Mol Cell Proteomics (2009) 1.14
Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes. Biophys J (2009) 1.13