Published in Cancer Sci on February 03, 2010
Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication. J Biol Chem (2012) 1.18
An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PLoS One (2012) 1.01
Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome. Hum Mol Genet (2012) 0.94
The role of epigenetics in resistance to Cisplatin chemotherapy in lung cancer. Cancers (Basel) (2011) 0.86
Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis (2014) 0.85
Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. PLoS Genet (2015) 0.85
α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73. Breast Cancer Res (2011) 0.84
Predictive factors of the response of rectal cancer to neoadjuvant radiochemotherapy. Cancers (Basel) (2011) 0.83
Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53. Int J Oncol (2014) 0.81
Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes. Carcinogenesis (2014) 0.80
Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis. Clin Exp Gastroenterol (2011) 0.80
Biodegradable double nanocapsule as a novel multifunctional carrier for drug delivery and cell imaging. Int J Nanomedicine (2015) 0.78
Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB. J Cancer (2016) 0.78
The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain. Oncogene (2015) 0.78
Modulation of cyclins, p53 and mitogen-activated protein kinases signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. Int J Mol Sci (2014) 0.76
New insights into the link between DNA damage and apoptosis. Antioxid Redox Signal (2012) 0.76
Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme. Sci Rep (2016) 0.75
Compound A398, a novel podophyllotoxin analogue: cytotoxicity and induction of apoptosis in human leukemia cells. PLoS One (2014) 0.75
The muscle regulatory transcription factor MyoD participates with p53 to directly increase the expression of the pro-apoptotic Bcl2 family member PUMA. Apoptosis (2017) 0.75
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol (2005) 2.56
Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage. Cancer Sci (2004) 2.33
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell (2007) 2.18
Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol Cell (2010) 2.09
C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Mol Cancer Ther (2002) 1.95
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. J Biol Chem (2005) 1.50
Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection. Arch Surg (2002) 1.49
Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res (2011) 1.47
Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J (2003) 1.47
Reduced levels of ATF-2 predispose mice to mammary tumors. Mol Cell Biol (2006) 1.22
Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis. Int J Oncol (2004) 1.20
DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J Clin Invest (2012) 1.18
Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage. J Biol Chem (2002) 1.11
The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha). J Biol Chem (2007) 1.09
Identification of novel deletion polymorphisms in breast cancer. Int J Oncol (2008) 1.08
Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol Cell Biol (2007) 1.08
Transforming mutations of RAC guanosine triphosphatases in human cancers. Proc Natl Acad Sci U S A (2013) 1.07
Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest (2012) 1.02
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J Biol Chem (2009) 1.02
Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division. Biochem Biophys Res Commun (2007) 1.01
Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma. Cancer Sci (2007) 1.00
Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. J Biol Chem (2001) 1.00
IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis. Clin Cancer Res (2008) 0.99
Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells. Am J Pathol (2009) 0.99
Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform. Genomics (2002) 0.99
Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis. Histopathology (2011) 0.98
DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter. Biochem J (2009) 0.98
A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese. J Hum Genet (2012) 0.94
DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail. Cancer Lett (2013) 0.94
Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha. Cancer Res (2009) 0.93
Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer. Cancer Sci (2008) 0.93
BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization. Cancer Sci (2009) 0.93
Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress. Cell Signal (2007) 0.93
Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. Mol Cell Biol (2006) 0.92
High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas. Breast Cancer Res Treat (2011) 0.90
A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress. Nucleic Acids Res (2008) 0.89
Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies. Histol Histopathol (2012) 0.89
Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer. J Hum Genet (2007) 0.88
Expression profiling to predict postoperative prognosis for estrogen receptor-negative breast cancers by analysis of 25,344 genes on a cDNA microarray. Cancer Sci (2004) 0.88
Genome-wide association study of breast cancer in the Japanese population. PLoS One (2013) 0.87
BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2. Cancer Res (2010) 0.87
Enabling death by the Abl tyrosine kinase: mechanisms for nuclear shuttling of c-Abl in response to DNA damage. Cell Cycle (2005) 0.87
Conserved domains in the chicken homologue of BRCA2. Oncogene (2002) 0.87
Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Sci (2009) 0.87
Programmed cell death 6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer Sci (2012) 0.86
Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Int J Cancer (2010) 0.86
Microsatellite instability caused by hMLH1 promoter methylation increases with tumor progression in right-sided sporadic colorectal cancer. Oncology (2005) 0.85
Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosis. J Dermatol Sci (2009) 0.85
Molecular prediction of the therapeutic response to neoadjuvant chemotherapy in breast cancer. Breast Cancer (2008) 0.85
BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC. Cancer Res (2014) 0.85
A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene. Int J Clin Oncol (2008) 0.84
Prevalence and differentiation of hereditary breast and ovarian cancers in Japan. Breast Cancer (2013) 0.84
BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress. Antioxid Redox Signal (2008) 0.84
Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC. Int J Exp Pathol (2006) 0.83
Gene expression profiling of breast cancer. Breast Cancer (2006) 0.82
Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines. Breast Cancer (2002) 0.80
Gene-expression phenotypes for vascular invasiveness of hepatocellular carcinomas. Surgery (2009) 0.80
Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis. Clin Cancer Res (2008) 0.79
The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage. Apoptosis (2010) 0.79
Histological features of breast cancer, highly sensitive to chemotherapy. Breast Cancer (2007) 0.79
Gene expression patterns as marker for 5-year postoperative prognosis of primary breast cancers. J Cancer Res Clin Oncol (2004) 0.79
Prognostic value of matrix Gla protein in breast cancer. Mol Med Rep (2011) 0.79
D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage. Exp Cell Res (2010) 0.79
Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage. Cancer Sci (2008) 0.79
Relatively common mutations of the Bloom syndrome gene in the Japanese population. Int J Mol Med (2004) 0.78
[Gene expression profiling for prediction of response to chemotherapy]. Gan To Kagaku Ryoho (2006) 0.77
Postoperative prognosis of node-negative breast cancers predicted by gene-expression profiling on a cDNA microarray of 25,344 genes. Breast Cancer (2005) 0.77
Development of detection method for novel fusion gene using GeneChip exon array. J Clin Bioinforma (2014) 0.77
PKCδ regulates Mdm2 independently of p53 in the apoptotic response to DNA damage. Mol Carcinog (2011) 0.77
Immunohistochemical study of β-catenin and functionally related molecular markers in tongue squamous cell carcinoma and its correlation with cellular proliferation. Oncol Lett (2010) 0.77
Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan. Dis Colon Rectum (2006) 0.77
Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage. Biochim Biophys Acta (2011) 0.77
Common peak approach using mass spectrometry data sets for predicting the effects of anticancer drugs on breast cancer. Cancer Inform (2007) 0.75
Introduction and characterization of a polymerase-dead point mutation into the POLK gene in vertebrates. FEBS Lett (2009) 0.75
[Problem of the hereditary breast cancer screening; including the genetic diagnosis]. Nihon Rinsho (2012) 0.75
[SNPs associated with adverse effects]. Gan To Kagaku Ryoho (2005) 0.75
[PARP (poly(ADP-ribose) polymerase) family]. Nihon Rinsho (2012) 0.75
[Gene expression profiling studies in breast cancer]. Nihon Rinsho (2012) 0.75
Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer. Cancer Sci (2010) 0.75
[PARP inhibitors for cancer therapy]. Gan To Kagaku Ryoho (2011) 0.75
Recurrence pattern and rapid intraoperative detection of carcinoembryonic antigen (CEA) mRNA in pleural lavage in patients with non-small cell lung cancer (NSCLC). Rinsho Byori (2008) 0.75
Familial breast and ovarian cancers. Int J Clin Oncol (2004) 0.75
[Clinical genetics for hereditary cancers: from the viewpoint of physicians working at a hospital specialized in cancer]. Gan To Kagaku Ryoho (2005) 0.75
[Genomic based approach to individualized cancer therapy]. Nihon Rinsho (2010) 0.75
[Gene testing of hereditary cancer on comprehensive gene medical examination support system]. Gan To Kagaku Ryoho (2005) 0.75
Clinical impact of intraoperative detection of carcinoembryonic antigen mRNA in pleural lavage specimens from nonsmall cell lung cancer patients. Thorac Cardiovasc Surg (2012) 0.75
[Prospects for genetic diagnosis]. Nihon Rinsho (2007) 0.75
Identifying haplotype block structure using an ancestor-derived model. J Hum Genet (2007) 0.75
[Mechanisms of human breast cancer tumorigenesis: outline (including the molecular mechanism and multi-step of breast carcinogenesis)]. Nihon Rinsho (2012) 0.75