Published in Mol Cell Biol on May 01, 2006
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Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol Cell Biol (2007) 1.08
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p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell (2011) 2.54
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An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci U S A (2005) 2.18
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CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol (2009) 1.75
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell Metab (2011) 1.74
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Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. J Biol Chem (2005) 1.50
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Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J (2003) 1.47
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Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Mol Cell Biol (2005) 1.37
Blue light-induced autophosphorylation of phototropin is a primary step for signaling. Proc Natl Acad Sci U S A (2008) 1.37
p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res (2009) 1.37
Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation. Cancer Sci (2006) 1.34
Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway. J Biol Chem (2003) 1.34
Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. J Biol Chem (2004) 1.32
Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res (2006) 1.31
Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. Biochem Biophys Res Commun (2003) 1.28
Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol (2009) 1.28
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell (2013) 1.27
A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev (2008) 1.27
Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway. Mol Cell Biol (2011) 1.27
KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev (2010) 1.26
The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase. J Virol (2004) 1.25
Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res (2004) 1.24
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HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells. FASEB J (2006) 1.21
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DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J Clin Invest (2012) 1.18
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest (2010) 1.17
Mammalian E4 is required for cardiac development and maintenance of the nervous system. Mol Cell Biol (2005) 1.17
Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol Cell Biol (2012) 1.17
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J Biol Chem (2011) 1.17
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease. Blood (2008) 1.17
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PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2006) 1.16
Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. FASEB J (2006) 1.15
Geminin is essential for the development of preimplantation mouse embryos. Genes Cells (2006) 1.14
Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev (2004) 1.14
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Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. J Biol Chem (2005) 1.12
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Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage. J Biol Chem (2002) 1.11
Fbxw7 in cell cycle exit and stem cell maintenance: insight from gene-targeted mice. Cell Cycle (2008) 1.11
Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem (2006) 1.10
Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Cancer Res (2006) 1.10
Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production. J Immunol (2007) 1.10