PubRank

W Y Langdon

Author PubWeight™ 74.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 1998 5.31
2 Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2001 4.11
3 The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med 1988 3.80
4 The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell 1986 3.72
5 Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol 1998 2.69
6 Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell 2001 2.26
7 The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 1991 1.98
8 Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J 1994 1.94
9 RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. Mol Cell 2001 1.91
10 The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol Chem 1994 1.72
11 c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages. J Biol Chem 1996 1.69
12 Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J Biol Chem 1995 1.65
13 Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts. J Immunol 1986 1.58
14 A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J Biol Chem 1996 1.50
15 Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2. Nature 1995 1.38
16 The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation. Mol Cell Biol 2000 1.34
17 Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol Cell Biol 1997 1.33
18 Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J Biol Chem 1998 1.28
19 Histologic and cell surface antigen studies of hematopoietic tumors induced by Cas-Br-M murine leukemia virus. J Natl Cancer Inst 1984 1.27
20 Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes. J Immunol 1999 1.17
21 EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene. Oncogene 1997 1.17
22 Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem 1996 1.17
23 The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation. Oncogene 1995 1.14
24 The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J 1993 1.10
25 The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J Biol Chem 2000 1.08
26 Physical linkage of the fragile site FRA11B and a Jacobsen syndrome chromosome deletion breakpoint in 11q23.3. Hum Mol Genet 1994 1.07
27 The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain. Oncogene 1996 1.07
28 Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl. Oncogene 1997 1.02
29 A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein. Oncogene 1992 0.98
30 Regulation of the association of p120cbl with Grb2 in Jurkat T cells. J Biol Chem 1996 0.96
31 Abnormalities induced by the mutant gene, lpr. Patterns of disease and expression of murine leukemia viruses in SJL/J mice homozygous and heterozygous for lpr. J Exp Med 1985 0.95
32 c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology. J Cell Sci 2000 0.94
33 c-Cbl: a regulator of T cell receptor-mediated signalling. Immunol Cell Biol 1998 0.93
34 Transgenic mouse models for hematopoietic tumorigenesis. Curr Top Microbiol Immunol 1988 0.92
35 Relationship between a retroviral germ line reintegration and a new mutation at the ashen locus in B10.F mice. Retroviral integration and an ashen mutation. Virology 1984 0.92
36 TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. Biochem Biophys Res Commun 1995 0.90
37 Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl. J Biol Chem 2000 0.89
38 Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells. J Biol Chem 1997 0.89
39 Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints. Cytogenet Cell Genet 1991 0.89
40 Identification of two murine loci homologous to the v-cbl oncogene. J Virol 1989 0.87
41 Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase. Oncogene 1997 0.86
42 Identification of a spleen focus-forming virus in erythroleukemic mice infected with a wild-mouse ecotropic murine leukemia virus. J Virol 1983 0.85
43 c-myc-induced lymphomagenesis in transgenic mice and the role of the Pvt-1 locus in lymphoid neoplasia. Curr Top Microbiol Immunol 1986 0.85
44 The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. Proc Natl Acad Sci U S A 2000 0.82
45 A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components. Biochem Biophys Res Commun 1997 0.82
46 Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc. J Exp Med 1987 0.81
47 Antigen-pulsed macrophage monolayers as specific immunoabsorbents: selective absorption of murine T cells committed to soluble protein antigen. Immunology 1981 0.81
48 The myc oncogene and lymphoid neoplasia: from translocations to transgenic mice. Haematol Blood Transfus 1987 0.81
49 Identification of a transforming virus from a lymphoma of a mouse infected with a wild mouse retrovirus. Curr Top Microbiol Immunol 1984 0.80
50 Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferation. Oncogene 1998 0.80
51 Cas spleen focus-forming virus. II. Further biological and biochemical characterization. J Virol 1983 0.78
52 Characterization of ecotropic murine leukemia viruses in SJL/J mice. Virology 1985 0.77
53 Expression of c-cbl proto-oncogene is modulated during differentiation but not during induction of proliferation. Oncogene 1994 0.76
54 Molecular characterization of a transforming retrovirus involved in pre-B cell lymphomas. Curr Top Microbiol Immunol 1988 0.76
55 Oncogene cooperation and B-lymphoid tumorigenesis in Emu-myc transgenic mice. Haematol Blood Transfus 1989 0.75
56 Inhibition of antigen-induced T-cell proliferation by antibodies to endogenous AKR-MuLV. Cell Immunol 1981 0.75
57 Lymphoid neoplasia and the control of haemopoietic differentiation. Ciba Found Symp 1989 0.75
58 High titres of antibody to murine leukaemia virus in lymphocyte (Ly) alloantisera. Immunogenetics 1980 0.75
59 Ly- and ecotropic MuLV antigens are separate entities. J Immunogenet 1982 0.75
60 Five sequence tagged sites for human chromosome band 11q23. Hum Mol Genet 1993 0.75