The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

PubWeight™: 1.98‹?› | Rank: Top 2%

🔗 View Article (PMID 2030914)

Published in Oncogene on April 01, 1991

Authors

T J Blake1, M Shapiro, H C Morse, W Y Langdon

Author Affiliations

1: Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, Australia.

Articles citing this

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J Virol (1993) 5.15

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature (2009) 3.80

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J (1996) 3.57

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol (1998) 2.69

Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci U S A (1993) 2.55

The ubiquitin-proteasome pathway and proteasome inhibitors. Med Res Rev (2001) 2.18

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet (2010) 2.03

Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. J Clin Oncol (2009) 2.03

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J (1994) 1.94

Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors. Proc Natl Acad Sci U S A (2000) 1.82

Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Mol Biol Cell (2003) 1.72

A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol (1998) 1.60

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol (2002) 1.52

Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells. Mol Cell Biol (1995) 1.48

Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol Cell Biol (1997) 1.43

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl. Nat Struct Mol Biol (2012) 1.40

Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases. Biochim Biophys Acta (2012) 1.39

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation. Mol Cell Biol (2000) 1.34

Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol Cell Biol (1997) 1.33

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes. J Exp Med (1996) 1.32

Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells. J Exp Med (2006) 1.29

Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling. J Exp Med (1996) 1.25

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. Biochem J (1997) 1.16

c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells. J Biol Chem (2010) 1.15

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. J Exp Med (1996) 1.11

The Drosophila neuralized gene encodes a C3HC4 zinc finger. EMBO J (1993) 1.11

The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J (1993) 1.10

Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding. J Exp Med (2000) 1.05

The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme. J Biol Chem (2010) 1.02

The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner. Mol Cell Biol (1996) 0.99

Recent advances in the understanding of interleukin-2 signal transduction. J Clin Immunol (1998) 0.91

Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism. J Biol Chem (2010) 0.90

Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment. Clin Cancer Res (2014) 0.90

A CSF-1 receptor phosphotyrosine 559 signaling pathway regulates receptor ubiquitination and tyrosine phosphorylation. J Biol Chem (2010) 0.88

Metformin regulates glucose transporter 4 (GLUT4) translocation through AMP-activated protein kinase (AMPK)-mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells. J Biol Chem (2012) 0.88

Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights. Protein Sci (2008) 0.86

Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation. J Biol Chem (2010) 0.85

The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells. Mol Cell Biol (1999) 0.85

Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins. Biochem Anal Biochem (2012) 0.85

Detailed deletion mapping at chromosome 11q23 in colorectal carcinoma. Br J Cancer (2000) 0.83

The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. Proc Natl Acad Sci U S A (2000) 0.82

Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages. Biochem J (1996) 0.82

Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk. Biochem J (2000) 0.81

Modulation of Immune Cell Functions by the E3 Ligase Cbl-b. Front Oncol (2015) 0.81

Development of a fluorescence polarization based high-throughput assay to identify Casitas B-lineage lymphoma RING domain regulators. PLoS One (2013) 0.77

Articles by these authors

Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiatry (2001) 7.30

Viral clearance without destruction of infected cells during acute HBV infection. Science (1999) 6.78

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev (1998) 5.31

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci U S A (1996) 4.82

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell (1996) 4.74

The hippocampus, memory, and place cells: is it spatial memory or a memory space? Neuron (1999) 4.36

Control of fatty acid metabolism. I. Induction of the enzymes of fatty acid oxidation in Escherichia coli. J Bacteriol (1969) 4.12

Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol (2001) 4.11

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med (1988) 3.80

The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell (1986) 3.72

Diagnosing small bowel Crohn's disease with wireless capsule endoscopy. Gut (2003) 3.69

Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci U S A (1994) 3.56

Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol Rev (1992) 3.30

Access of vulnerable groups to antiretroviral therapy among persons in care for HIV disease in the United States. HCSUS Consortium. HIV Cost and Services Utilization Study. Health Serv Res (2000) 3.09

Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J Exp Med (1985) 2.87

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset. J Immunol (1982) 2.78

Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo. Virology (1998) 2.76

Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease--where next? Aliment Pharmacol Ther (2005) 2.75

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol (1998) 2.69

Determining the size of non-A, non-B hepatitis virus by filtration. J Infect Dis (1987) 2.68

Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome. Proc Natl Acad Sci U S A (1989) 2.63

Two modes of c-myb activation in virus-induced mouse myeloid tumors. Mol Cell Biol (1986) 2.57

Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice. J Immunol (1986) 2.51

Epidural steroids for treating "failed back surgery syndrome": is fluoroscopy really necessary? Anesth Analg (1999) 2.48

Hepatitis B virus produced by transfected Hep G2 cells causes hepatitis in chimpanzees. Proc Natl Acad Sci U S A (1987) 2.46

Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells. Nature (1987) 2.45

Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. Science (1987) 2.44

Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J Virol (1989) 2.41

Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of CD4+ T cells. J Virol (1992) 2.35

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc Natl Acad Sci U S A (1989) 2.34

Vitamin A deficiency in mice causes a systemic expansion of myeloid cells. Blood (2000) 2.30

Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10. J Virol (1994) 2.29

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell (2001) 2.26

Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade. Science (1998) 2.25

A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. J Exp Med (1983) 2.08

CD4+ T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS). J Exp Med (1988) 2.06

Early events in hepatitis C virus infection of chimpanzees. Proc Natl Acad Sci U S A (1990) 2.04

Evolution of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome, MAIDS. J Immunol (1988) 2.04

Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med (1989) 2.02

XenCSA: cell surface antigens related to the major glycoproteins (gp70) of xenotropic murine leukemia viruses. J Immunol (1979) 2.02

Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS). J Exp Med (1987) 2.00

Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS (1992) 1.97

Burkitt lymphoma in the mouse. J Exp Med (2000) 1.96

Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors. Mol Cell Biol (1988) 1.95

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J (1994) 1.94

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. Mol Cell (2001) 1.91

A unique series of lymphomas related to the Ly-1+ lineage of B lymphocyte differentiation. J Immunol (1984) 1.89

Murine hematopoietic cells with pre-B or pre-B/myeloid characteristics are generated by in vitro transformation with retroviruses containing fes, ras, abl, and src oncogenes. J Exp Med (1986) 1.88

A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice. Science (1991) 1.80

Triple approach in the diagnosis of dominant breast masses: combined physical examination, mammography, and fine-needle aspiration. J Surg Oncol (1994) 1.79

Use of the ED as a regular source of care: associated factors beyond lack of health insurance. Ann Emerg Med (1997) 1.75

3D time-resolved MR angiography (MRA) of the carotid arteries with time-resolved imaging with stochastic trajectories: comparison with 3D contrast-enhanced Bolus-Chase MRA and 3D time-of-flight MRA. AJNR Am J Neuroradiol (2008) 1.74

Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J Exp Med (1997) 1.73

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol Chem (1994) 1.72

Abrogation of resistance to severe mousepox in C57BL/6 mice infected with LP-BM5 murine leukemia viruses. J Virol (1987) 1.72

Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice. J Virol (1991) 1.70

c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages. J Biol Chem (1996) 1.69

Phenotypic characteristics of cell lines requiring interleukin 3 for growth. J Immunol (1982) 1.67

A multiscale random field model for Bayesian image segmentation. IEEE Trans Image Process (1994) 1.66

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J Biol Chem (1995) 1.65

Experimental hepatitis E in pregnant rhesus monkeys: failure to transmit hepatitis E virus (HEV) to offspring and evidence of naturally acquired antibodies to HEV. J Infect Dis (1995) 1.65

CD4+ subset regulation in viral infection. Preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice. J Immunol (1992) 1.62

Characteristics of B cell proliferation and activation in murine AIDS. J Immunol (1989) 1.61

Correlation of cell-surface phenotype with the establishment of interleukin 3-dependent cell lines from wild-mouse murine leukemia virus-induced neoplasms. Proc Natl Acad Sci U S A (1985) 1.61

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts. J Immunol (1986) 1.58

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nat Genet (1997) 1.55

Pneumothorax. A complication of fine needle aspiration of breast tumors. Acta Cytol (1994) 1.53

Biologic properties of rat antibodies. II. Time-course of appearance of antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (SRS-A rat); association of this activity with rat IgGa. J Immunol (1968) 1.52

Multidrug-resistant Trichosporon asahii infection of nongranulocytopenic patients in three intensive care units. J Clin Microbiol (2001) 1.52

Variation in course of hepatitis E in experimentally infected cynomolgus monkeys. J Infect Dis (1993) 1.52

A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J Biol Chem (1996) 1.50

Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene. Blood (2001) 1.50

Biologic properties of rat antibodies. I. Antigen-binding by four classes of anti-DNP antibodies. J Immunol (1968) 1.50

Biologic properties of rat antibodies. 3. Histamine release mediated by two classes of antibodies. J Immunol (1969) 1.49

Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci U S A (1997) 1.48

Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF. Mol Cell Biol (2001) 1.48

Differential expression of two distinct xenotropic viruses in NZB mice. Clin Immunol Immunopathol (1980) 1.48

The cytolytic activity of pulmonary CD8+ lymphocytes, induced by infection with a vaccinia virus recombinant expressing the M2 protein of respiratory syncytial virus (RSV), correlates with resistance to RSV infection in mice. J Virol (1993) 1.48

Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cells. J Virol (1993) 1.47

Risk factors for infection at the operative site after abdominal or vaginal hysterectomy. N Engl J Med (1982) 1.44

Cellular motor protein KIF-4 associates with retroviral Gag. J Virol (1999) 1.43

Cell growth inhibition by the multifunctional multivalent zinc-finger factor CTCF. Cancer Res (2001) 1.42

Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41

B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome. J Exp Med (1990) 1.41

Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. EMBO J (1989) 1.40

Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7  TeV. Phys Rev Lett (2011) 1.39

Molecular phylogeny of Fv1. Mamm Genome (1998) 1.38

Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2. Nature (1995) 1.38

Successful passive and active immunization of cynomolgus monkeys against hepatitis E. Proc Natl Acad Sci U S A (1994) 1.38

Wild mouse ecotropic murine leukemia virus infection of inbred mice: dual-tropic virus expression precedes the onset of paralysis and lymphoma. J Virol (1981) 1.35

Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus. J Virol (1985) 1.35

Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation. Mol Cell Biol (2000) 1.34

Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi]. Eur J Pharmacol (1995) 1.34

Increased susceptibility to HIV-1 infection of peripheral blood mononuclear cells from chronically immune-activated individuals. AIDS (1998) 1.33

cDNA clone of hepatitis A virus encoding a virulent virus: induction of viral hepatitis by direct nucleic acid transfection of marmosets. J Virol (1992) 1.33

Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol Cell Biol (1997) 1.33

Murine plasma cells secreting more than one class of immunoglobulin heavy chain. II. SAMM 368--a plasmacytoma secreting IgG2b-kappa and IgA-kappa immunoglobulins which do not share idiotypic determinants. J Immunol (1977) 1.32