Published in EMBO J on May 01, 1993
Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J (1994) 1.94
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol (1998) 1.60
Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells. Mol Cell Biol (1995) 1.48
Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol Cell Biol (1997) 1.43
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases. Biochim Biophys Acta (2012) 1.39
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol Cell Biol (1997) 1.33
Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. Biochem J (1997) 1.16
Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. J Exp Med (1996) 1.11
Arabidopsis COP1 protein specifically interacts in vitro with a cytoskeleton-associated protein, CIP1. Proc Natl Acad Sci U S A (1995) 1.11
The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J Exp Med (1995) 1.06
Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders. Oncotarget (2011) 1.01
The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner. Mol Cell Biol (1996) 0.99
c-Cbl, a ubiquitin E3 ligase that targets active β-catenin: a novel layer of Wnt signaling regulation. J Biol Chem (2013) 0.92
Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages. Biochem J (1996) 0.82
Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement. Biochem J (2002) 0.79
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (1988) 52.71
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. Cell (1990) 9.37
Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24
Myristylation site in Pr65gag is essential for virus particle formation by Moloney murine leukemia virus. Proc Natl Acad Sci U S A (1986) 7.02
Molecular themes in oncogenesis. Cell (1991) 6.73
Sequence requirements for synthetic peptide-mediated translocation to the nucleus. Mol Cell Biol (1989) 4.57
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit. Cell (1992) 3.73
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature (1991) 3.68
Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway. Nature (1991) 3.26
I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family. Cell (1992) 3.25
Fluorescence microphotolysis to measure nucleocytoplasmic transport and intracellular mobility. Biochim Biophys Acta (1986) 3.12
Association of charge clusters with functional domains of cellular transcription factors. Proc Natl Acad Sci U S A (1989) 2.58
Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus. EMBO J (1991) 2.39
Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature (1992) 2.39
v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc Natl Acad Sci U S A (1989) 2.34
Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome. Proc Natl Acad Sci U S A (1990) 2.29
The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50. EMBO J (1992) 2.19
DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism. EMBO J (1992) 2.15
A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor. EMBO J (1989) 2.13
The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene (1991) 1.98
Nuclear localization of c-Fos, but not v-Fos proteins, is controlled by extracellular signals. Cell (1990) 1.59
Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity. Cancer Cells (1991) 1.45
Nuclear translocation of viral Jun but not of cellular Jun is cell cycle dependent. Proc Natl Acad Sci U S A (1992) 1.41
Posttranslational processing of the Epstein-Barr virus-encoded p63/LMP protein. J Virol (1987) 1.33
A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein. Oncogene (1992) 0.98
Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23. Blood (1989) 0.96
CD3G is within 200 kb of the leukemic t(4;11) translocation breakpoint. Genes Chromosomes Cancer (1991) 0.96
A physical linkage group in human chromosome band 11q23 covering a region implicated in leukocyte neoplasia. Genomics (1990) 0.91
Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints. Cytogenet Cell Genet (1991) 0.89
Identification of two murine loci homologous to the v-cbl oncogene. J Virol (1989) 0.87
Gene mapping by microdissection and enzymatic amplification: heterogeneity in leukaemia associated breakpoints on chromosome 11. Genes Chromosomes Cancer (1991) 0.80
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev (1998) 5.31
Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol (2001) 4.11
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med (1988) 3.80
The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell (1986) 3.72
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol (1998) 2.69
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell (2001) 2.26
The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene (1991) 1.98
Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J (1994) 1.94
RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. Mol Cell (2001) 1.91
The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol Chem (1994) 1.72
c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages. J Biol Chem (1996) 1.69
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J Biol Chem (1995) 1.65
Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts. J Immunol (1986) 1.58
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J Biol Chem (1996) 1.50
Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2. Nature (1995) 1.38
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation. Mol Cell Biol (2000) 1.34
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol Cell Biol (1997) 1.33
Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J Biol Chem (1998) 1.28
Histologic and cell surface antigen studies of hematopoietic tumors induced by Cas-Br-M murine leukemia virus. J Natl Cancer Inst (1984) 1.27
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes. J Immunol (1999) 1.17
EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene. Oncogene (1997) 1.17
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem (1996) 1.17
The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation. Oncogene (1995) 1.14
The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J Biol Chem (2000) 1.08
Physical linkage of the fragile site FRA11B and a Jacobsen syndrome chromosome deletion breakpoint in 11q23.3. Hum Mol Genet (1994) 1.07
The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain. Oncogene (1996) 1.07
Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl. Oncogene (1997) 1.02
A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein. Oncogene (1992) 0.98
Regulation of the association of p120cbl with Grb2 in Jurkat T cells. J Biol Chem (1996) 0.96
Abnormalities induced by the mutant gene, lpr. Patterns of disease and expression of murine leukemia viruses in SJL/J mice homozygous and heterozygous for lpr. J Exp Med (1985) 0.95
c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology. J Cell Sci (2000) 0.94
c-Cbl: a regulator of T cell receptor-mediated signalling. Immunol Cell Biol (1998) 0.93
Transgenic mouse models for hematopoietic tumorigenesis. Curr Top Microbiol Immunol (1988) 0.92
Relationship between a retroviral germ line reintegration and a new mutation at the ashen locus in B10.F mice. Retroviral integration and an ashen mutation. Virology (1984) 0.92
TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. Biochem Biophys Res Commun (1995) 0.90
Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells. J Biol Chem (1997) 0.89
Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints. Cytogenet Cell Genet (1991) 0.89
Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl. J Biol Chem (2000) 0.89
Identification of two murine loci homologous to the v-cbl oncogene. J Virol (1989) 0.87
Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase. Oncogene (1997) 0.86
c-myc-induced lymphomagenesis in transgenic mice and the role of the Pvt-1 locus in lymphoid neoplasia. Curr Top Microbiol Immunol (1986) 0.85
Identification of a spleen focus-forming virus in erythroleukemic mice infected with a wild-mouse ecotropic murine leukemia virus. J Virol (1983) 0.85
A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components. Biochem Biophys Res Commun (1997) 0.82
The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. Proc Natl Acad Sci U S A (2000) 0.82
The myc oncogene and lymphoid neoplasia: from translocations to transgenic mice. Haematol Blood Transfus (1987) 0.81
Antigen-pulsed macrophage monolayers as specific immunoabsorbents: selective absorption of murine T cells committed to soluble protein antigen. Immunology (1981) 0.81
Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc. J Exp Med (1987) 0.81
Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferation. Oncogene (1998) 0.80
Identification of a transforming virus from a lymphoma of a mouse infected with a wild mouse retrovirus. Curr Top Microbiol Immunol (1984) 0.80
Cas spleen focus-forming virus. II. Further biological and biochemical characterization. J Virol (1983) 0.78
Characterization of ecotropic murine leukemia viruses in SJL/J mice. Virology (1985) 0.77
Expression of c-cbl proto-oncogene is modulated during differentiation but not during induction of proliferation. Oncogene (1994) 0.76
Molecular characterization of a transforming retrovirus involved in pre-B cell lymphomas. Curr Top Microbiol Immunol (1988) 0.76
Oncogene cooperation and B-lymphoid tumorigenesis in Emu-myc transgenic mice. Haematol Blood Transfus (1989) 0.75
Five sequence tagged sites for human chromosome band 11q23. Hum Mol Genet (1993) 0.75
Lymphoid neoplasia and the control of haemopoietic differentiation. Ciba Found Symp (1989) 0.75
Inhibition of antigen-induced T-cell proliferation by antibodies to endogenous AKR-MuLV. Cell Immunol (1981) 0.75
Ly- and ecotropic MuLV antigens are separate entities. J Immunogenet (1982) 0.75
High titres of antibody to murine leukaemia virus in lymphocyte (Ly) alloantisera. Immunogenetics (1980) 0.75
The localization of the products of the c-cbl and v-cbl oncogenes during mitosis and transformation. Curr Top Microbiol Immunol (1992) 0.75