Published in Proc Natl Acad Sci U S A on January 21, 2010
Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell (2012) 2.81
Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog (2010) 1.90
C. elegans detects pathogen-induced translational inhibition to activate immune signaling. Cell Host Microbe (2012) 1.79
Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans. Cell Host Microbe (2012) 1.73
Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature (2014) 1.59
A comprehensive analysis of gene expression changes provoked by bacterial and fungal infection in C. elegans. PLoS One (2011) 1.46
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature (2014) 1.40
Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Curr Opin Immunol (2012) 1.33
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2015) 1.10
Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS Genet (2012) 1.09
System wide analysis of the evolution of innate immunity in the nematode model species Caenorhabditis elegans and Pristionchus pacificus. PLoS One (2012) 0.97
Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens. Nat Rev Microbiol (2013) 0.95
Microbial pathogenesis and host defense in the nematode C. elegans. Curr Opin Microbiol (2014) 0.92
Caenorhabditis elegans responses to bacteria from its natural habitats. Proc Natl Acad Sci U S A (2016) 0.90
Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genet (2012) 0.86
Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor. Proc Natl Acad Sci U S A (2013) 0.86
UnZIPping mechanisms of effector-triggered immunity in animals. Cell Host Microbe (2012) 0.85
The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification. PLoS Pathog (2014) 0.84
s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways. Cell Metab (2015) 0.84
Components of the cultivated red seaweed Chondrus crispus enhance the immune response of Caenorhabditis elegans to Pseudomonas aeruginosa through the pmk-1, daf-2/daf-16, and skn-1 pathways. Appl Environ Microbiol (2013) 0.83
Strength in numbers: "Omics" studies of C. elegans innate immunity. Virulence (2012) 0.83
It takes nerves to fight infections: insights on neuro-immune interactions from C. elegans. Dis Model Mech (2010) 0.82
The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity. Cell Rep (2016) 0.78
A functional genomic screen for evolutionarily conserved genes required for lifespan and immunity in germline-deficient C. elegans. PLoS One (2014) 0.78
A MicroRNA-Mediated Insulin Signaling Pathway Regulates the Toxicity of Multi-Walled Carbon Nanotubes in Nematode Caenorhabditis elegans. Sci Rep (2016) 0.77
Characterization of microsporidia-induced developmental arrest and a transmembrane leucine-rich repeat protein in Caenorhabditis elegans. PLoS One (2015) 0.77
The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans. PLoS Pathog (2016) 0.77
DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet (2016) 0.76
Host detection of pathogen-induced translational inhibition: a new pathogen-specific branch of the innate immune system? Future Microbiol (2012) 0.75
An evolutionarily conserved transcriptional response to viral infection in Caenorhabditis nematodes. BMC Genomics (2017) 0.75
Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host. G3 (Bethesda) (2016) 0.75
Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. BMC Biol (2016) 0.75
Detection of Burkholderia pseudomallei toxin-mediated inhibition of protein synthesis using a Caenorhabditis elegans ugt-29 biosensor. Sci Rep (2016) 0.75
Selenite enhances immune response against Pseudomonas aeruginosa PA14 via SKN-1 in Caenorhabditis elegans. PLoS One (2014) 0.75
HandKAchip - Hands-free killing assay on a chip. Sci Rep (2016) 0.75
Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling. EMBO J (2017) 0.75
Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans. Genetics (2016) 0.75
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa. PLoS Genet (2017) 0.75
Pathogen recognition and innate immunity. Cell (2006) 44.14
Unravelling the pathogenesis of inflammatory bowel disease. Nature (2007) 18.52
Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99
Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proc Natl Acad Sci U S A (1999) 7.04
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science (2002) 5.97
Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science (2008) 5.14
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol (2003) 5.07
Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem (2007) 4.56
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet (2006) 4.47
Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe (2008) 4.14
Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe (2009) 3.86
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol (2006) 3.75
A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks. Genome Biol (2005) 3.24
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc Natl Acad Sci U S A (2004) 2.93
A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A (2006) 2.91
Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors. Cell (2006) 2.66
Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med (2002) 2.53
Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans. PLoS Biol (2008) 2.14
Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa. FEMS Microbiol Rev (2009) 1.91
Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans. Curr Opin Immunol (2005) 1.89
Caenorhabditis elegans as a model for innate immunity to pathogens. Cell Microbiol (2005) 1.86
Evolution of the innate immune system: the worm perspective. Immunol Rev (2004) 1.83
Models of Caenorhabditis elegans infection by bacterial and fungal pathogens. Methods Mol Biol (2008) 1.74
Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway. Pulm Pharmacol Ther (2008) 1.72
Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity. Proc Natl Acad Sci U S A (2006) 1.68
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response. Proc Natl Acad Sci U S A (2009) 1.58
Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. Nat Immunol (2008) 1.54
One billion years of bZIP transcription factor evolution: conservation and change in dimerization and DNA-binding site specificity. Mol Biol Evol (2006) 1.30
MAP kinase signalling cascade in Arabidopsis innate immunity. Nature (2002) 11.40
An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants. Proc Natl Acad Sci U S A (2006) 7.62
Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature (2002) 7.08
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science (2002) 5.97
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science (2003) 4.91
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet (2006) 4.47
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence. Proc Natl Acad Sci U S A (2006) 4.33
Glucosinolate metabolites required for an Arabidopsis innate immune response. Science (2008) 4.21
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol (2006) 3.75
The worm has turned--microbial virulence modeled in Caenorhabditis elegans. Trends Microbiol (2005) 3.34
Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect Immun (2005) 3.13
Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis. Proc Natl Acad Sci U S A (2003) 2.71
Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis. Infect Immun (2003) 2.70
Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infect Immun (2003) 2.59
Arabidopsis local resistance to Botrytis cinerea involves salicylic acid and camalexin and requires EDS4 and PAD2, but not SID2, EDS5 or PAD4. Plant J (2003) 2.56
BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14. J Bacteriol (2007) 2.49
Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nat Rev Immunol (2010) 2.45
Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. Proc Natl Acad Sci U S A (2002) 2.29
Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns. Plant Cell (2010) 2.28
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A (2004) 2.23
Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance. Plant J (2006) 2.18
Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans. PLoS Biol (2008) 2.14
Resistance to Botrytis cinerea induced in Arabidopsis by elicitors is independent of salicylic acid, ethylene, or jasmonate signaling but requires PHYTOALEXIN DEFICIENT3. Plant Physiol (2007) 2.10
The apoplastic oxidative burst peroxidase in Arabidopsis is a major component of pattern-triggered immunity. Plant Cell (2012) 2.09
Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings. Mol Plant (2008) 2.06
Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS Pathog (2007) 2.05
Pseudomonas syringae manipulates systemic plant defenses against pathogens and herbivores. Proc Natl Acad Sci U S A (2005) 2.00
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc Natl Acad Sci U S A (2004) 1.99
High-throughput screen for novel antimicrobials using a whole animal infection model. ACS Chem Biol (2009) 1.99
Identification of novel antimicrobials using a live-animal infection model. Proc Natl Acad Sci U S A (2006) 1.98
Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice. Infect Immun (2002) 1.96
Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. Curr Biol (2003) 1.94
A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae. Proc Natl Acad Sci U S A (2005) 1.90
Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog (2010) 1.90
Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans. Curr Opin Immunol (2005) 1.89
C. elegans detects pathogen-induced translational inhibition to activate immune signaling. Cell Host Microbe (2012) 1.79
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J (2004) 1.76
GCAT-SEEKquence: genome consortium for active teaching of undergraduates through increased faculty access to next-generation sequencing data. CBE Life Sci Educ (2011) 1.76
Caenorhabditis elegans as a host for the study of host-pathogen interactions. Curr Opin Microbiol (2002) 1.75
Models of Caenorhabditis elegans infection by bacterial and fungal pathogens. Methods Mol Biol (2008) 1.74
Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans. Cell Host Microbe (2012) 1.73
Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions. Curr Biol (2004) 1.71
VPEgamma exhibits a caspase-like activity that contributes to defense against pathogens. Curr Biol (2004) 1.70
Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms. J Bacteriol (2002) 1.68
Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth. Genome Res (2012) 1.65
Construction of an Enterococcus faecalis Tn917-mediated-gene-disruption library offers insight into Tn917 insertion patterns. J Bacteriol (2004) 1.65
Retracted Mediation of pathogen resistance by exudation of antimicrobials from roots. Nature (2005) 1.59
Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses. PLoS Pathog (2007) 1.58
Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis. J Bacteriol (2002) 1.58
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response. Proc Natl Acad Sci U S A (2009) 1.58
The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea. Plant Physiol (2008) 1.57
RESISTANCE TO FUSARIUM OXYSPORUM 1, a dominant Arabidopsis disease-resistance gene, is not race specific. Genetics (2005) 1.56
Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi. PLoS Pathog (2007) 1.55
An image analysis toolbox for high-throughput C. elegans assays. Nat Methods (2012) 1.48
Prospects for plant-derived antibacterials. Nat Biotechnol (2006) 1.48
Tandemly duplicated Arabidopsis genes that encode polygalacturonase-inhibiting proteins are regulated coordinately by different signal transduction pathways in response to fungal infection. Plant Cell (2003) 1.46
Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. Eukaryot Cell (2004) 1.45
Signals involved in Arabidopsis resistance to Trichoplusia ni caterpillars induced by virulent and avirulent strains of the phytopathogen Pseudomonas syringae. Plant Physiol (2002) 1.41
Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection. Proc Natl Acad Sci U S A (2003) 1.40
Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Mol Microbiol (2004) 1.39
Genome-wide identification of Pseudomonas aeruginosa virulence-related genes using a Caenorhabditis elegans infection model. PLoS Pathog (2012) 1.38
The Arabidopsis flagellin receptor FLS2 mediates the perception of Xanthomonas Ax21 secreted peptides. Proc Natl Acad Sci U S A (2011) 1.37
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics (2008) 1.34
The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model. Infect Immun (2002) 1.33
Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Curr Opin Immunol (2012) 1.33
Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model. Infect Immun (2005) 1.31
Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial. ACS Chem Biol (2006) 1.24
Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLoS Pathog (2011) 1.24
Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe (2013) 1.22
Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay. PLoS One (2009) 1.22
Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis. Infect Immun (2004) 1.21
Ubiquitin-mediated response to microsporidia and virus infection in C. elegans. PLoS Pathog (2014) 1.20
Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc Natl Acad Sci U S A (2008) 1.20
Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. PLoS Pathog (2013) 1.20
A peroxidase-dependent apoplastic oxidative burst in cultured Arabidopsis cells functions in MAMP-elicited defense. Plant Physiol (2012) 1.17
Mining the plant-herbivore interface with a leafmining Drosophila of Arabidopsis. Mol Ecol (2010) 1.15
Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model. Proc Natl Acad Sci U S A (2011) 1.13
RESOLVING CLUSTERED WORMS VIA PROBABILISTIC SHAPE MODELS. Proc IEEE Int Symp Biomed Imaging (2010) 1.13
Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS Genet (2012) 1.09
Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. PLoS Pathog (2011) 1.05
Cytotoxicity of hydrogen peroxide produced by Enterococcus faecium. Infect Immun (2004) 1.00
Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants. PLoS Pathog (2013) 0.98
Genes involved in the evolution of herbivory by a leaf-mining, Drosophilid fly. Genome Biol Evol (2012) 0.97
Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation. Microbiology (2007) 0.95
Changes in external pH rapidly alter plant gene expression and modulate auxin and elicitor responses. Plant Cell Environ (2010) 0.95
"First generation" automated DNA sequencing technology. Curr Protoc Mol Biol (2011) 0.93
Caenorhabditis elegans as a model for intracellular pathogen infection. Cell Microbiol (2013) 0.93
Polymorphic amplified typing sequences provide a novel approach to Escherichia coli O157:H7 strain typing. J Clin Microbiol (2002) 0.92
UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants. Plant Cell (2011) 0.91
The art of serendipity: killing of Caenorhabditis elegans by human pathogens as a model of bacterial and fungal pathogenesis. Expert Rev Anti Infect Ther (2003) 0.90
Temporal global expression data reveal known and novel salicylate-impacted processes and regulators mediating powdery mildew growth and reproduction on Arabidopsis. Plant Physiol (2009) 0.90
Pseudomonas aeruginosa PA14 pathogenesis in Caenorhabditis elegans. Methods Mol Biol (2014) 0.89
High-throughput screening for novel anti-infectives using a C. elegans pathogenesis model. Curr Protoc Chem Biol (2014) 0.89
Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. Antimicrob Agents Chemother (2010) 0.88
Pathogen-triggered ethylene signaling mediates systemic-induced susceptibility to herbivory in Arabidopsis. Plant Cell (2013) 0.87
Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality. Methods Mol Biol (2008) 0.86
Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system. J Med Microbiol (2008) 0.84