Published in World J Gastroenterol on February 14, 2010
Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest (2012) 1.45
Iron deprivation in cancer--potential therapeutic implications. Nutrients (2013) 0.98
Intestinal iron homeostasis and colon tumorigenesis. Nutrients (2013) 0.88
Gastrins, iron homeostasis and colorectal cancer. Biochim Biophys Acta (2011) 0.86
Iron and cancer: recent insights. Ann N Y Acad Sci (2016) 0.86
Contribution of meat to vitamin B₁₂, iron and zinc intakes in five ethnic groups in the USA: implications for developing food-based dietary guidelines. J Hum Nutr Diet (2013) 0.84
Systemic and tumor level iron regulation in men with colorectal cancer: a case control study. Nutr Metab (Lond) (2014) 0.76
Distribution and inhibition effect of Seleno-L-Methionine on 4T1 mouse mammary carcinoma. Int J Physiol Pathophysiol Pharmacol (2015) 0.75
A novel test for gene-ancestry interactions in genome-wide association data. PLoS One (2012) 0.75
Improved Serum Alpha-Fetoprotein Levels after Iron Reduction Therapy in HCV Patients. ISRN Hepatol (2014) 0.75
Inflammation and cancer: back to Virchow? Lancet (2001) 27.40
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Lessons from hereditary colorectal cancer. Cell (1996) 25.73
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34
The global health burden of infection-associated cancers in the year 2002. Int J Cancer (2006) 13.57
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell (2009) 11.52
Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact (2006) 10.64
Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature (1987) 10.21
The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut (2001) 10.07
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology (1994) 8.79
A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest (2007) 8.54
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (1994) 8.04
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest (2002) 7.90
Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med (1990) 6.87
Cancer mortality among the foreign-born in the United States. J Natl Cancer Inst (1961) 6.27
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst (1997) 5.68
Iron withholding: a defense against infection and neoplasia. Physiol Rev (1984) 5.54
The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol (2004) 5.14
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A (2002) 4.64
Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A (1997) 4.63
NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev (2008) 4.61
The gene for familial polyposis coli maps to the long arm of chromosome 5. Science (1987) 4.48
Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst (2005) 4.45
Colorectal cancer: molecules and populations. J Natl Cancer Inst (1999) 4.39
Oxidative stress and cancer: have we moved forward? Biochem J (2007) 4.20
Persistent oxidative stress in cancer. FEBS Lett (1995) 3.85
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med (1985) 3.73
Induction of sarcoma in the rat by iron-dextran complex. Br Med J (1959) 3.56
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet (2003) 3.53
Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci U S A (1987) 3.35
Roles of nitric oxide in tumor growth. Proc Natl Acad Sci U S A (1995) 3.28
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene (2005) 3.17
Cancer Incidence in Five Continents. Comparability and quality of data. IARC Sci Publ (1992) 2.99
Meat consumption and colorectal cancer risk: dose-response meta-analysis of epidemiological studies. Int J Cancer (2002) 2.60
Iron and colorectal cancer risk: human studies. Nutr Rev (2001) 2.56
Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev (2003) 2.52
Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology (1996) 2.51
Pro-oxidant and cytotoxic effects of circulating heme. Blood (2002) 2.45
Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat. Cancer Res (2003) 2.30
Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health Study. J Natl Cancer Inst (2004) 2.17
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res (1998) 2.15
Why cancer and inflammation? Yale J Biol Med (2006) 2.13
Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst (2008) 2.11
Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog (2009) 2.06
Pathogenesis and treatment of anaemia of chronic disease. Blood Rev (2002) 1.98
Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis (2003) 1.98
Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls. Hepatology (2007) 1.94
Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med (2005) 1.90
The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta (2002) 1.86
Iron sequestration and anemia of inflammation. Semin Hematol (2009) 1.85
Cancer morbidity in ulcerative colitis. Gut (1982) 1.82
Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci (2008) 1.81
Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer. J Natl Cancer Inst (2003) 1.80
Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme. Cancer Res (1999) 1.79
HFE C282Y homozygotes are at increased risk of breast and colorectal cancer. Hepatology (2010) 1.76
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci (2004) 1.75
Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment. Blood (2004) 1.67
Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. Gastroenterology (2001) 1.56
Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma. Arch Biochem Biophys (1998) 1.54
Role of reactive oxygen metabolites in experimental colitis. Gut (1990) 1.51
Oxygen radicals in ulcerative colitis. Free Radic Biol Med (1992) 1.50
Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res (2001) 1.49
The regulation of hepcidin and its effects on systemic and cellular iron metabolism. Hematology Am Soc Hematol Educ Program (2008) 1.46
Iron intake and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev (1996) 1.45
Molecular genetic profiles of colitis-associated neoplasms. Gastroenterology (1994) 1.41
Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane. Carcinogenesis (2000) 1.39
Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice. Dig Dis Sci (2002) 1.34
Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives. Gastroenterology (2003) 1.34
Heme and chlorophyll intake and risk of colorectal cancer in the Netherlands cohort study. Cancer Epidemiol Biomarkers Prev (2006) 1.33
Effect of hepcidin on intestinal iron absorption in mice. Blood (2004) 1.31
Body iron stores and risk of cancer. Int J Cancer (1994) 1.31
Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem (2003) 1.30
Iron intake, body iron stores and colorectal cancer risk in women: a nested case-control study. Int J Cancer (1999) 1.24
Modulation of iron transport proteins in human colorectal carcinogenesis. Gut (2006) 1.23
Iron homeostasis: recently identified proteins provide insight into novel control mechanisms. J Biol Chem (2008) 1.22
The regulation of cellular iron metabolism. Crit Rev Clin Lab Sci (2007) 1.21
Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res (2001) 1.21
Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis. Aliment Pharmacol Ther (2001) 1.21
Cancer in migrants to Australia: extending the descriptive epidemiological data. Cancer Res (1988) 1.20
A role for iron in Wnt signalling. Oncogene (2007) 1.19
STUDIES ON IRON ABSORPTION. INTESTINAL REGULATORY MECHANISMS. J Clin Invest (1964) 1.19
Hepcidin, the iron watcher. Biochimie (2009) 1.19
Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins. Am J Physiol Gastrointest Liver Physiol (2001) 1.18
Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons. J Nutr (2004) 1.13
Body iron stores and risk of colonic neoplasia. J Natl Cancer Inst (1994) 1.11
The mechanism of heme oxygenase. Curr Opin Chem Biol (2000) 1.11
Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats. Carcinogenesis (2003) 1.11
Redox signaling and cancer: the role of "labile" iron. Cancer Lett (2008) 1.10
Molecular mechanisms of oxidative stress-induced carcinogenesis: from epidemiology to oxygenomics. IUBMB Life (2008) 1.10
Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol (2002) 1.10
Free radicals and the etiology of colon cancer. Free Radic Biol Med (1990) 1.09
Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res (1987) 1.05
High dietary iron and copper and risk of colorectal cancer: a case-control study in Burgundy, France. Nutr Cancer (2004) 1.05
Red meat and colon cancer: dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium. Carcinogenesis (2000) 1.03
Interaction between haemochromatosis and transferrin receptor genes in different neoplastic disorders. Carcinogenesis (1999) 1.01
Intestinal absorption of hemoglobin iron-heme cleavage by mucosal heme oxygenase. J Clin Invest (1974) 1.01
Systemic iron supplementation replenishes iron stores without enhancing colon carcinogenesis in murine models of ulcerative colitis: comparison with iron-enriched diet. Dig Dis Sci (2005) 1.01
Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women. J Natl Cancer Inst (2005) 1.01
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med (2008) 5.43
Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med (2005) 5.36
Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med (2007) 4.56
Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood (2004) 4.40
Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology (2004) 3.00
Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells. Hepatology (2010) 2.23
NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am J Gastroenterol (2009) 2.19
The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial. Hepatology (2015) 2.04
Lower fructose intake may help protect against development of nonalcoholic fatty liver in adolescents with obesity. J Pediatr Gastroenterol Nutr (2014) 2.00
Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease. Hepatology (2011) 1.94
Diagnosis and management of iron deficiency anaemia: a clinical update. Med J Aust (2010) 1.78
The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis. Gastroenterology (2008) 1.78
HFE C282Y homozygotes are at increased risk of breast and colorectal cancer. Hepatology (2010) 1.76
The Western dietary pattern is prospectively associated with nonalcoholic fatty liver disease in adolescence. Am J Gastroenterol (2013) 1.71
Predictors of fibrostenotic Crohn's disease. Inflamm Bowel Dis (2011) 1.64
Cost-effectiveness of colorectal cancer screening: comparison of community-based flexible sigmoidoscopy with fecal occult blood testing and colonoscopy. J Gastroenterol Hepatol (2004) 1.63
Hepatic iron loading in mice increases cholesterol biosynthesis. Hepatology (2010) 1.53
Oval cell-mediated liver regeneration: Role of cytokines and growth factors. J Gastroenterol Hepatol (2003) 1.51
Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations. Mayo Clin Proc (2008) 1.49
Making sense of differing bowel cancer screening guidelines. Med J Aust (2009) 1.47
Screening for coeliac disease using anti-tissue transglutaminase antibody assays, and prevalence of the disease in an Australian community. Med J Aust (2009) 1.46
Efficacy of adalimumab for the management of inflammatory bowel disease in the clinical setting. J Gastroenterol Hepatol (2009) 1.45
Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice. J Hepatol (2006) 1.45
Waiting times for colonoscopy and colorectal cancer diagnosis. Med J Aust (2007) 1.45
Careful patient selection may improve response rates to infliximab in inflammatory bowel disease. J Gastroenterol Hepatol (2007) 1.44
Anti-tumour necrosis factor-alpha treatment for perianal Crohn's disease in Australia. Med J Aust (2010) 1.39
Screening sigmoidoscopy for colorectal cancer: further pieces in the jigsaw. Med J Aust (2004) 1.39
Hereditary haemochromatosis: to screen or not to screen? J Hepatol (2005) 1.38
Continuous therapy with certolizumab pegol maintains remission of patients with Crohn's disease for up to 18 months. Clin Gastroenterol Hepatol (2010) 1.30
A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation. Gastroenterology (2002) 1.26
Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet. Int J Biochem Cell Biol (2007) 1.23
The regulation of cellular iron metabolism. Crit Rev Clin Lab Sci (2007) 1.21
Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones. Eur J Appl Physiol (2008) 1.21
Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis. Blood (2004) 1.15
Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury. J Hepatol (2007) 1.12
Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice. J Hepatol (2006) 1.08
Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury. Immunol Cell Biol (2005) 1.08
Liver iron transport. World J Gastroenterol (2007) 1.08
HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity. Hepatology (2009) 1.07
Training surface and intensity: inflammation, hemolysis, and hepcidin expression. Med Sci Sports Exerc (2009) 1.04
Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo. Hepatology (2006) 1.03
C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice. Gastroenterology (2008) 1.03
Serum iron markers are inadequate for guiding iron repletion in chronic kidney disease. Clin J Am Soc Nephrol (2010) 1.03
Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity. Eur J Appl Physiol (2009) 1.03
Identification of nestin-positive putative mammary stem cells in human breastmilk. Cell Tissue Res (2007) 1.03
A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis. Br J Haematol (2009) 1.00
Normal iron metabolism and the pathophysiology of iron overload disorders. Clin Biochem Rev (2006) 0.99
The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels. Eur J Appl Physiol (2011) 0.98
Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents. Hepatology (2013) 0.98
Effects of exercise on hepcidin response and iron metabolism during recovery. Int J Sport Nutr Exerc Metab (2009) 0.98
Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. Hepatology (2009) 0.97
Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice. Hepatology (2012) 0.96
Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumption. J Gastroenterol Hepatol (2008) 0.95
Jekyll and Hyde: evolving perspectives on the function and potential of the adult liver progenitor (oval) cell. Bioessays (2005) 0.95
Differential effects of gadolinium chloride on Kupffer cells in vivo and in vitro. Int J Biochem Cell Biol (2004) 0.95
Effect of exercise modality and intensity on post-exercise interleukin-6 and hepcidin levels. Int J Sport Nutr Exerc Metab (2012) 0.94
Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proc Natl Acad Sci U S A (2002) 0.93
Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor. Carcinogenesis (2006) 0.93
Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta. Carcinogenesis (2005) 0.91
The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells. Am J Physiol Cell Physiol (2009) 0.91
Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. J Gastroenterol Hepatol (2014) 0.90
Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age. Int J Cancer (2009) 0.89
Iron overload. Clin Chim Acta (2005) 0.89
Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn's disease. J Gastroenterol Hepatol (2007) 0.89
HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis. Hepatology (2010) 0.89
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. Hepatology (2013) 0.89
Association of intestinal granulomas with smoking, phenotype, and serology in Chinese patients with Crohn's disease. Am J Gastroenterol (2006) 0.88
Spontaneous hepatic fibrosis in transgenic mice overexpressing PDGF-A. Gene (2008) 0.88
Hereditary hemochromatosis in the post-HFE era. Hepatology (2008) 0.87
A comparison of self-reported and record-linked blood donation history in an Australian cohort. Transfusion (2011) 0.87
Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease. Inflamm Bowel Dis (2013) 0.87
Outcomes after 10 years of a community-based flexible sigmoidoscopy screening program for colorectal carcinoma. Med J Aust (2007) 0.87
SPARC, FOXP3, CD8 and CD45 correlation with disease recurrence and long-term disease-free survival in colorectal cancer. PLoS One (2011) 0.87
Mechanisms of initiation and progression of intestinal fibrosis in IBD. Scand J Gastroenterol (2015) 0.86
HCV, iron, and oxidative stress: the new choreography of hepcidin. Gastroenterology (2008) 0.85
Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity. J Gastroenterol Hepatol (2012) 0.85
Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study. Age Ageing (2012) 0.85
Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study. J Gastroenterol Hepatol (2015) 0.85
Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron. J Hepatol (2007) 0.84
Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease. Nephrology (Carlton) (2010) 0.84
Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice. PLoS One (2013) 0.83
Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading. Brain Res (2012) 0.83