PubRank

Hirotatsu Kojima

Author PubWeight™ 46.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe. J Am Chem Soc 2004 2.12
2 Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs. J Am Chem Soc 2005 1.41
3 Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. J Virol 2010 1.40
4 Development of a ratiometric fluorescent zinc ion probe in near-infrared region, based on tricarbocyanine chromophore. J Am Chem Soc 2006 1.36
5 Rational principles for modulating fluorescence properties of fluorescein. J Am Chem Soc 2004 1.26
6 Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes. J Am Chem Soc 2010 1.18
7 Mechanism-based molecular design of highly selective fluorescence probes for nitrative stress. J Am Chem Soc 2006 1.18
8 Development of a highly specific rhodamine-based fluorescence probe for hypochlorous acid and its application to real-time imaging of phagocytosis. J Am Chem Soc 2007 1.16
9 Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics and regional distribution of synaptically released Zn2+ in hippocampal slices. J Am Chem Soc 2005 1.15
10 Design and synthesis of fluorescent probes for selective detection of highly reactive oxygen species in mitochondria of living cells. J Am Chem Soc 2007 1.14
11 Development of an iminocoumarin-based zinc sensor suitable for ratiometric fluorescence imaging of neuronal zinc. J Am Chem Soc 2007 1.14
12 Highly activatable and rapidly releasable caged fluorescein derivatives. J Am Chem Soc 2007 1.12
13 Design and synthesis of a library of BODIPY-based environmental polarity sensors utilizing photoinduced electron-transfer-controlled fluorescence ON/OFF switching. J Am Chem Soc 2007 1.08
14 Tunable design strategy for fluorescence probes based on 4-substituted BODIPY chromophore: improvement of highly sensitive fluorescence probe for nitric oxide. Anal Bioanal Chem 2006 1.07
15 Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production. Eur J Neurosci 2003 1.01
16 Rational design of ratiometric near-infrared fluorescent pH probes with various pKa values, based on aminocyanine. J Am Chem Soc 2011 0.97
17 Development of a zinc ion-selective luminescent lanthanide chemosensor for biological applications. J Am Chem Soc 2004 0.94
18 Molecular design strategies for near-infrared ratiometric fluorescent probes based on the unique spectral properties of aminocyanines. Chemistry 2009 0.93
19 Oxysterol-binding protein family I is the target of minor enviroxime-like compounds. J Virol 2013 0.93
20 Orthogonality of calcium concentration and ability of 4,5-diaminofluorescein to detect NO. J Biol Chem 2001 0.91
21 A dual inhibitor against prolyl isomerase Pin1 and cyclophilin discovered by a novel real-time fluorescence detection method. Biochem Biophys Res Commun 2011 0.90
22 A novel design method of ratiometric fluorescent probes based on fluorescence resonance energy transfer switching by spectral overlap integral. Chemistry 2003 0.90
23 Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells. J Am Chem Soc 2008 0.90
24 Design and synthesis of zinc-selective chelators for extracellular applications. J Am Chem Soc 2005 0.88
25 A thiol-reactive fluorescence probe based on donor-excited photoinduced electron transfer: key role of ortho substitution. Org Lett 2007 0.87
26 Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe. ACS Chem Biol 2013 0.86
27 Development of selective, visible light-excitable, fluorescent magnesium ion probes with a novel fluorescence switching mechanism. Analyst 2003 0.85
28 Creation of superior carboxyfluorescein dyes by blocking donor-excited photoinduced electron transfer. Org Lett 2006 0.83
29 Structural basis for specific recognition of substrates by sapovirus protease. Front Microbiol 2012 0.83
30 Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. Biochem Pharmacol 2013 0.82
31 Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures. Bioorg Med Chem 2012 0.82
32 A practical strategy to create near-infrared luminescent probes: conversion from fluorescein-based sensors. Chem Commun (Camb) 2012 0.82
33 Fluorescence probe for lysophospholipase C/NPP6 activity and a potent NPP6 inhibitor. J Am Chem Soc 2011 0.82
34 Identification of novel ASK1 inhibitors using virtual screening. Bioorg Med Chem 2010 0.81
35 Establishment of an indicator cell system for hepatitis C virus. Microbiol Immunol 2010 0.81
36 A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide. J Mol Biol 2012 0.81
37 Nitric oxide (NO) synthase mRNA expression and NO production via muscarinic acetylcholine receptor-mediated pathways in the CEM, human leukemic T-cell line. Life Sci 2003 0.80
38 Development of 2,6-carboxy-substituted boron dipyrromethene (BODIPY) as a novel scaffold of ratiometric fluorescent probes for live cell imaging. Chem Commun (Camb) 2009 0.80
39 Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound. J Med Chem 2012 0.79
40 Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors. Bioorg Med Chem Lett 2008 0.79
41 Virtual screening and further development of novel ALK inhibitors. Bioorg Med Chem 2011 0.79
42 A fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53. J Biomol Screen 2012 0.78
43 High-throughput screening system to identify small molecules that induce internalization and degradation of HER2. ACS Chem Biol 2014 0.77
44 Practical fluorescence detection of acrolein in human plasma via a two-step tethering approach. Chem Commun (Camb) 2014 0.77
45 A long-lived luminescent probe to sensitively detect arylamine N-acetyltransferase (NAT) activity of cells. Chem Commun (Camb) 2012 0.76
46 Sensitive detection of acrolein in serum using time-resolved luminescence. Org Lett 2010 0.76
47 Selective detection of zinc ions with novel luminescent lanthanide probes. Angew Chem Int Ed Engl 2003 0.76
48 Near-infrared fluorescence probes for enzymes based on binding affinity modulation of squarylium dye scaffold. Anal Chem 2012 0.76
49 A novel fluorescent probe for zinc ion based on boron dipyrromethene (BODIPY) chromophore. Chem Pharm Bull (Tokyo) 2004 0.75
50 [Open innovation center for drug discovery: a research-supporting network for drug discovery]. Nihon Yakurigaku Zasshi 2013 0.75
51 A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening. Chemistry 2010 0.75
52 A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein-peptide interaction inhibitors. Anal Biochem 2010 0.75
53 A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors. Chem Commun (Camb) 2015 0.75