PubRank

Gregory D Cuny

Author PubWeight™ 93.78‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005 11.63
2 Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008 9.24
3 BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med 2008 4.20
4 Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 2010 2.08
5 Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab 2008 2.06
6 Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res 2010 1.89
7 Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 2003 1.85
8 Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett 2005 1.72
9 Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 2011 1.61
10 Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg Med Chem Lett 2005 1.38
11 A new class of small molecule inhibitor of BMP signaling. PLoS One 2013 1.36
12 The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. J Am Chem Soc 2010 1.35
13 Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One 2010 1.35
14 Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem 2009 1.33
15 Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem 2007 1.27
16 Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology 2010 1.27
17 Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. J Biomol Screen 2010 1.14
18 Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay. J Biomol Screen 2008 1.13
19 Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol 2006 1.10
20 Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Rep 2015 1.09
21 Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem 2013 1.09
22 Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J Clin Invest 2014 1.06
23 Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. PLoS One 2009 1.03
24 Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrob Agents Chemother 2013 1.03
25 In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesth Analg 2011 1.01
26 Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem 2012 1.01
27 Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg Med Chem Lett 2012 1.00
28 Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther 2013 0.99
29 Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. Biochemistry 2008 0.99
30 Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol 2013 0.99
31 Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol 2005 0.98
32 Biological properties of novel antistaphylococcal quinoline-indole agents. Antimicrob Agents Chemother 2003 0.97
33 Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorg Med Chem Lett 2010 0.97
34 Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett 2007 0.96
35 Identification of novel small molecules that elevate Klotho expression. Biochem J 2012 0.95
36 Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett 2011 0.95
37 Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 2011 0.94
38 Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett 2012 0.94
39 In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol 2009 0.93
40 FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein. J Mol Neurosci 2004 0.92
41 Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. J Med Chem 2014 0.91
42 Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem 2012 0.89
43 RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Curr Alzheimer Res 2006 0.88
44 Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. PLoS One 2013 0.88
45 Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal Biochem 2008 0.87
46 Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. Am J Neurodegener Dis 2012 0.87
47 Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay. J Biomol Screen 2012 0.86
48 Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors. Anal Biochem 2010 0.86
49 Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett 2007 0.86
50 One-pot synthesis of alpha-carbolines via sequential palladium-catalyzed aryl amination and intramolecular arylation. J Org Chem 2009 0.85
51 Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant. Biochemistry 2011 0.85
52 Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. EMBO Mol Med 2013 0.84
53 Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 2012 0.84
54 Syntheses of aporphine and homoaporphine alkaloids by intramolecular ortho-arylation of phenols with aryl halides via SRN1 reactions in liquid ammonia. J Org Chem 2006 0.83
55 Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods. J Med Chem 2010 0.83
56 New approaches to the discovery of cdk5 inhibitors. Curr Alzheimer Res 2007 0.83
57 Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression. Bioorg Med Chem Lett 2005 0.83
58 Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. J Biol Chem 2013 0.83
59 Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorg Med Chem Lett 2008 0.82
60 Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett 2009 0.82
61 Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors. Bioorg Med Chem Lett 2011 0.82
62 A high-throughput screen to identify inhibitors of SOD1 transcription. Front Biosci (Elite Ed) 2012 0.80
63 Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system. Protein Expr Purif 2013 0.80
64 Synthesis of carbolines by photostimulated cyclization of anilinohalopyridines. J Org Chem 2011 0.79
65 Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorg Med Chem Lett 2012 0.79
66 Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S. Biochemistry 2013 0.79
67 Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem 2012 0.78
68 Intramolecular Aldol reaction of N-acylated (2-aminophenyl)-alpha-oxoacetic acids: rapid access to tri- and tetracyclic 1,2-dihydroquinolin-2(1H)-ones. J Org Chem 2010 0.78
69 Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem 2014 0.78
70 Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. J Biomol Screen 2010 0.77
71 A mild, one-pot Stadler-Ziegler synthesis of arylsulfides facilitated by photoredox catalysis in batch and continuous-flow. Angew Chem Int Ed Engl 2013 0.77
72 Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization. J Org Chem 2006 0.77
73 Synthesis, receptor binding and functional studies of mesoridazine stereoisomers. Bioorg Med Chem Lett 2004 0.75
74 Synthesis of fused imidazoles, pyrroles, and indoles with a defined stereocenter α to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. J Org Chem 2011 0.75
75 Synthesis of tetracyclic indoles via intramolecular α-arylation of ketones. J Org Chem 2012 0.75
76 Synthesis of the indolizino[7,6-c]quinoline alkaloid isaindigotidione. Org Lett 2010 0.75
77 Synthetic studies of 7-oxygenated aporphine alkaloids: preparation of (-)-oliveroline, (-)-nornuciferidine, and derivatives. Org Lett 2015 0.75
78 Potent in vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)tetrahydroquinoline derivatives. Bioorg Med Chem Lett 2002 0.75