Published in PLoS Comput Biol on February 05, 2010
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats. PLoS One (2013) 0.87
BF02, a recombinant TNFR2 fusion protein, alleviates adjuvant arthritis by regulating T lymphocytes in rats. Acta Pharmacol Sin (2013) 0.77
T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα. PLoS One (2017) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene (1989) 23.74
Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. Arthritis Rheum (2004) 6.22
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol (2001) 5.59
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell (1993) 5.37
TNF-mediated inflammatory disease. J Pathol (2008) 5.00
Computational redesign of protein-protein interaction specificity. Nat Struct Mol Biol (2004) 3.66
Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J Immunol (1993) 3.03
Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology (2001) 2.69
Binding and functional comparisons of two types of tumor necrosis factor antagonists. J Pharmacol Exp Ther (2002) 2.58
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut (2002) 2.26
p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease. J Immunol (2002) 2.14
Computer-aided design of a PDZ domain to recognize new target sequences. Nat Struct Biol (2002) 1.89
Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem (1997) 1.83
Rapid onset of cutaneous squamous cell carcinoma in patients with rheumatoid arthritis after starting tumor necrosis factor alpha receptor IgG1-Fc fusion complex therapy. J Am Acad Dermatol (2001) 1.70
Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety. BMC Musculoskelet Disord (2008) 1.63
Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue. PLoS Comput Biol (2007) 1.29
Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling. J Immunol (1998) 1.18
Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin Ther (1999) 1.02
Aspartic acid 50 and tyrosine 108 are essential for receptor binding and cytotoxic activity of tumour necrosis factor beta (lymphotoxin). Protein Eng (1991) 1.01
Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen-induced arthritis. Arthritis Rheum (2005) 0.99
Changing paradigms in dermatology: tumor necrosis factor alpha (TNF-alpha) blockade in psoriasis and psoriatic arthritis. Clin Dermatol (2003) 0.96
Animal models of rheumatoid arthritis and related inflammation. Curr Rheumatol Rep (1999) 0.95
Anti-TNF agents for rheumatoid arthritis. Br J Clin Pharmacol (2001) 0.88
Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2. Protein Eng (1997) 0.88
Model complexes of tumor necrosis factor-alpha with receptors R1 and R2. Protein Eng (1995) 0.82
Structure-expression relationship of tumor necrosis factor receptor mutants that increase expression. J Biol Chem (2003) 0.81
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Reconstructing the early evolution of Fungi using a six-gene phylogeny. Nature (2006) 8.94
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell (2003) 8.11
A higher-level phylogenetic classification of the Fungi. Mycol Res (2007) 7.93
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell (2005) 7.29
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol (2009) 6.43
The genome of the protist parasite Entamoeba histolytica. Nature (2005) 5.33
A large-scale evaluation of computational protein function prediction. Nat Methods (2013) 4.61
A polymer tandem solar cell with 10.6% power conversion efficiency. Nat Commun (2013) 4.48
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res (2003) 4.03
Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol (2011) 3.80
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab (2009) 3.51
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev (2010) 3.49
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell (2012) 3.30
For the bright future-bulk heterojunction polymer solar cells with power conversion efficiency of 7.4%. Adv Mater (2010) 3.24
Differential regulation of cell motility and invasion by FAK. J Cell Biol (2003) 3.15
Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study. Ophthalmology (2004) 3.14
Osteopontin expression correlates with melanoma invasion. J Invest Dermatol (2005) 3.13
The Ascomycota tree of life: a phylum-wide phylogeny clarifies the origin and evolution of fundamental reproductive and ecological traits. Syst Biol (2009) 2.93
Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes. Blood (2009) 2.88
Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease. Am J Respir Crit Care Med (2007) 2.86
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82
Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res (2011) 2.73
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
Four novel frameworks built by imidazole-based dicarboxylate ligands: hydro(solvo)thermal synthesis, crystal structures, and properties. Inorg Chem (2010) 2.60
A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat Med (2012) 2.53
Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Nature (2009) 2.53
Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy (2011) 2.47
Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med (2006) 2.37
Planar heterojunction perovskite solar cells via vapor-assisted solution process. J Am Chem Soc (2013) 2.32
Empirical likelihood analysis of the Buckley-James estimator. J Multivar Anal (2008) 2.28
Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am J Hum Genet (2011) 2.27
Clinical value of monitoring plasma octreotide levels during chronic octreotide long-acting repeatable therapy in carcinoid patients. Pancreas (2008) 2.24
Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays. Genome Res (2006) 2.11
Advanced imaging technologies increase detection of dysplasia and neoplasia in patients with Barrett's esophagus: a meta-analysis and systematic review. Clin Gastroenterol Hepatol (2013) 2.10
Prevalence and factors associated with CKD: a population study from Beijing. Am J Kidney Dis (2008) 2.09
Uncoupling and turnover in a Cl-/H+ exchange transporter. J Gen Physiol (2007) 2.09
Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. Dev Cell (2009) 2.03
Profile of specific antibodies to the SARS-associated coronavirus. N Engl J Med (2003) 2.02
Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases. J Clin Oncol (2005) 2.01
The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci (2005) 2.00
ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy (2010) 1.97
Activation of remote meta-C-H bonds assisted by an end-on template. Nature (2012) 1.96
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci (2010) 1.93
G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci U S A (2002) 1.87
The rice HIGH-TILLERING DWARF1 encoding an ortholog of Arabidopsis MAX3 is required for negative regulation of the outgrowth of axillary buds. Plant J (2006) 1.85
The national program for deceased organ donation in China. Transplantation (2013) 1.83
Mesenchymal stem cells in immunoregulation. Immunol Cell Biol (2006) 1.82
Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med (2006) 1.81
Control of petal shape and floral zygomorphy in Lotus japonicus. Proc Natl Acad Sci U S A (2006) 1.78
An approach to joint analysis of longitudinal measurements and competing risks failure time data. Stat Med (2007) 1.78
Robot-assisted endoscopic submucosal dissection is effective in treating patients with early-stage gastric neoplasia. Clin Gastroenterol Hepatol (2012) 1.76
Cytoreductive nephrectomy for kidney cancer with sarcomatoid histology--is up-front resection indicated and, if not, is it avoidable? J Urol (2009) 1.75
Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock. Mol Cell (2011) 1.75
The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4. Mol Pharmacol (2005) 1.75
Tailorable stimulated Brillouin scattering in nanoscale silicon waveguides. Nat Commun (2013) 1.73
Direct, nonoxidative conversion of methane to ethylene, aromatics, and hydrogen. Science (2014) 1.71
Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal (2013) 1.71
Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones. J Bone Miner Res (2011) 1.70
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci U S A (2007) 1.69
Dynamic visualization of a joint-specific autoimmune response through positron emission tomography. Nat Immunol (2002) 1.68
HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination. Nat Neurosci (2011) 1.67
Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger. Proc Natl Acad Sci U S A (2008) 1.67
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res (2006) 1.67
Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature (2013) 1.66
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66
Regenerative adsorption and removal of H2S from hot fuel gas streams by rare earth oxides. Science (2006) 1.66
Isolation and characterization of multipotent rat tendon-derived stem cells. Tissue Eng Part A (2010) 1.65
High genetic diversity of HIV-1 was found in men who have sex with men in Shijiazhuang, China. Infect Genet Evol (2011) 1.65
Genetic background controls tumor development in PTEN-deficient mice. Cancer Res (2006) 1.63
Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions. Kidney Int (2008) 1.63
Histologic evaluation of metastases in renal cell carcinoma with sarcomatoid transformation and its implications for systemic therapy. Cancer (2010) 1.61
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold. Bioorg Med Chem (2008) 1.61
Phosphatized polar lobe-forming embryos from the Precambrian of southwest China. Science (2006) 1.61
Concise review: multipotent mesenchymal stromal cells in blood. Stem Cells (2006) 1.60
Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. Clin Cancer Res (2006) 1.57
Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer. Clin Cancer Res (2009) 1.56
MicroRNA-218 inhibits glioma invasion, migration, proliferation, and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1. Cancer Res (2013) 1.54
Novel pb and zn coordination polymers: synthesis, molecular structures, and third-order nonlinear optical properties. Inorg Chem (2003) 1.54
Marchantin C: a potential anti-invasion agent in glioma cells. Cancer Biol Ther (2010) 1.54
Baerveldt-350 implant versus Ahmed valve for refractory glaucoma: a case-controlled comparison. J Glaucoma (2004) 1.52
Salvage-targeted kidney cancer therapy in patients progressing on high-dose interleukin-2 immunotherapy: the UCLA experience. Cancer J (2013) 1.52
Measurement of vertebral kinematics using noninvasive image matching method-validation and application. Spine (Phila Pa 1976) (2008) 1.52
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab (2012) 1.51
Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions. Proc Natl Acad Sci U S A (2011) 1.51
A simple, tunable, and highly sensitive radio-frequency sensor. Appl Phys Lett (2013) 1.50
Comparisons of LIPOXYGENASE3- and JASMONATE-RESISTANT4/6-silenced plants reveal that jasmonic acid and jasmonic acid-amino acid conjugates play different roles in herbivore resistance of Nicotiana attenuata. Plant Physiol (2007) 1.50
An efficient titanium catalyst for enantioselective cyanation of aldehydes: cooperative catalysis. Angew Chem Int Ed Engl (2010) 1.50
Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem (2006) 1.50
A joint model for longitudinal measurements and survival data in the presence of multiple failure types. Biometrics (2007) 1.49
Catalytic asymmetric synthesis of aromatic spiroketals by spinphox/iridium(I)-catalyzed hydrogenation and spiroketalization of α,α'-bis(2-hydroxyarylidene) ketones. Angew Chem Int Ed Engl (2011) 1.48
Does normothermic normokalemic simultaneous antegrade/retrograde perfusion improve myocardial oxygenation and energy metabolism for hypertrophied hearts? Ann Thorac Surg (2007) 1.48
Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes. J Immunol (2004) 1.48
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res (2013) 1.48
Phytochrome signaling mechanisms. Arabidopsis Book (2011) 1.47
Superposition of episodic memories: overdistribution and quantum models. Top Cogn Sci (2013) 1.47
A method to estimate treatment efficacy among latent subgroups of a randomized clinical trial. Stat Med (2010) 1.46
Prediction of global and local quality of CASP8 models by MULTICOM series. Proteins (2009) 1.46