Published in J Nat Prod on February 26, 2010
Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer. ACS Cent Sci (2016) 0.82
Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications. Mar Drugs (2017) 0.75
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J Am Chem Soc (2002) 1.82
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. J Biol Chem (2006) 1.74
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res (2009) 1.53
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. J Biol Chem (2002) 1.46
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. J Am Chem Soc (2005) 1.40
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A (2007) 1.29
Interaction of telomestatin with the telomeric single-strand overhang. J Biol Chem (2004) 1.27
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene (2003) 1.26
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J (2013) 1.25
Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase. Cancer Sci (2007) 1.23
Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life. J Control Release (2007) 1.11
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. J Am Chem Soc (2007) 1.10
Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice. Biomaterials (2006) 1.07
Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models. Cancer Sci (2008) 1.06
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nat Chem Biol (2012) 0.97
Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products. Environ Microbiol (2010) 0.95
Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes. ChemMedChem (2007) 0.94
Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway. J Nat Prod (2010) 0.94
Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format. J Biomol Screen (2009) 0.94
Total synthesis of spiruchostatin B aided by an automated synthesizer. Org Biomol Chem (2011) 0.93
Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines. J Antibiot (Tokyo) (2012) 0.93
Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Acta Crystallogr D Biol Crystallogr (2002) 0.92
Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neurosci Res (2009) 0.92
Molecular determinants of microbial resistance to thiopeptide antibiotics. J Am Chem Soc (2010) 0.90
JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75. J Antibiot (Tokyo) (2012) 0.90
Novel GRP78 molecular chaperone expression down-regulators JBIR-04 and -05 isolated from Streptomyces violaceoniger. J Antibiot (Tokyo) (2007) 0.90
Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase. Biol Pharm Bull (2007) 0.90
Streptomyces tateyamensis sp. nov., Streptomyces marinus sp. nov. and Streptomyces haliclonae sp. nov., isolated from the marine sponge Haliclona sp. Int J Syst Evol Microbiol (2010) 0.90
Isolation of 2 new naphthablin analogs, JBIR-79 and JBIR-80, from Streptomyces sp. RI24. J Antibiot (Tokyo) (2010) 0.89
Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator. Toxicology (2006) 0.89
Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria. FEMS Microbiol Lett (2009) 0.89
Structure of tyroscherin, an antitumor antibiotic against IGF-1-dependent cells from Pseudallescheria sp. J Antibiot (Tokyo) (2004) 0.89
Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. ACS Chem Biol (2013) 0.89
A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559. J Antibiot (Tokyo) (2007) 0.88
JBIR-83 and JBIR-84, new promothiocin derivatives, isolated from Streptomyces sp. RI19. J Antibiot (Tokyo) (2010) 0.88
Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. I. Fermentation, isolation and biological activities. J Antibiot (Tokyo) (2007) 0.88
Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway. J Nat Prod (2011) 0.88
Aminocaprophenone- and pyrrolidine-type alkaloids from the leaves of Ficus septica. J Nat Prod (2009) 0.87
Relative and absolute configuration of versipelostatin, a down-regulator of molecular chaperone GRP78 expression. Org Lett (2007) 0.87
New angucycline C-glycosides from Streptomyces sp. RI33. J Antibiot (Tokyo) (2011) 0.87
New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6. Org Biomol Chem (2009) 0.87
Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26. J Nat Prod (2010) 0.86
JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge. J Antibiot (Tokyo) (2009) 0.86
Structure of aspochalasin H, a new member of the aspochalasin family. J Antibiot (Tokyo) (2002) 0.85
Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36. J Antibiot (Tokyo) (2011) 0.85
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78. Biol Pharm Bull (2006) 0.84
Oximidines I and II: Novel Antitumor Macrolides from Pseudomonas sp. J Org Chem (1999) 0.84
New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1. J Antibiot (Tokyo) (2009) 0.84
Combinatorial synthesis of deoxyhexasaccharides related to the landomycin A sugar moiety, based on an orthogonal deprotection strategy. Chem Asian J (2010) 0.83
Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin. Toxicon (2009) 0.83
JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3. J Nat Prod (2010) 0.83
Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571. J Antibiot (Tokyo) (2009) 0.83
JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27. Org Lett (2009) 0.83
Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph. FEMS Yeast Res (2012) 0.83
Identification and biosynthesis of new acyloins from the thermophilic bacterium Thermosporothrix hazakensis SK20-1(T). Chembiochem (2014) 0.83
JBIR-15, a new aspochracin derivative, isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. Biosci Biotechnol Biochem (2009) 0.82
JBIR-56 and JBIR-57, 2(1H)-pyrazinones from a marine sponge-derived Streptomyces sp. SpD081030SC-03. J Nat Prod (2011) 0.82
New tensidols, JBIR-86 and JBIR-87, isolated from Aspergillus sp. fJ80. J Antibiot (Tokyo) (2010) 0.82
Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator. Org Lett (2007) 0.82
A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil. J Antibiot (Tokyo) (2011) 0.82
Solid-phase total synthesis of (-)-apratoxin A and its analogues and their biological evaluation. Chem Asian J (2011) 0.81
JBIR-52, a new antimycin-like compound, from Streptomyces sp. ML55. J Antibiot (Tokyo) (2009) 0.81
Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase. Cancer Res (2003) 0.81
A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. Mol Cancer Ther (2010) 0.81
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator. J Cell Physiol (2008) 0.81
Novel siderophore, JBIR-16, isolated from Nocardia tenerifensis NBRC 101015. J Antibiot (Tokyo) (2009) 0.80
Isolation of a novel macrocyclic dilactone-JBIR-101-from Promicromonospora sp. RL26. J Antibiot (Tokyo) (2011) 0.80
JBIR-59, a new sorbicillinoid, from a marine-derived fungus Penicillium citrinum SpI080624G1f01. J Antibiot (Tokyo) (2010) 0.79
New aureothin derivative, alloaureothin, from Streptomyces sp. MM23. J Antibiot (Tokyo) (2007) 0.79
A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp. J Antibiot (Tokyo) (2010) 0.79
JBIR-58, a new salicylamide derivative, isolated from a marine sponge-derived Streptomyces sp. SpD081030ME-02. J Antibiot (Tokyo) (2010) 0.79
JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07. J Nat Prod (2012) 0.79
A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6. J Antibiot (Tokyo) (2008) 0.79
Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. J Nat Prod (2012) 0.78
Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex binders. Angew Chem Int Ed Engl (2008) 0.78
Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole. Org Biomol Chem (2010) 0.78
JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea. J Antibiot (Tokyo) (2009) 0.78
JBIR-107, a new metabolite from the marine-sponge-derived actinomycete, Streptomyces tateyamensis NBRC 105047. Biosci Biotechnol Biochem (2013) 0.78
New species of actinomycetes do not always produce new compounds with high frequency. J Antibiot (Tokyo) (2011) 0.78
JBIR-25, a novel antioxidative agent from Hyphomycetes sp. CR28109. J Antibiot (Tokyo) (2009) 0.77
Paraoerskovia marina gen. nov., sp. nov., an actinobacterium isolated from marine sediment. Int J Syst Evol Microbiol (2009) 0.77
Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis. Angew Chem Int Ed Engl (2015) 0.77
Synthesis, structure determination, and biological evaluation of destruxin E. Org Lett (2010) 0.77
Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A. Eur J Med Chem (2013) 0.77
A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55. J Antibiot (Tokyo) (2007) 0.77