Published in J Antibiot (Tokyo) on May 12, 2010
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J Am Chem Soc (2002) 1.82
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. J Biol Chem (2006) 1.74
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res (2009) 1.53
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. J Am Chem Soc (2005) 1.40
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc Natl Acad Sci U S A (2007) 1.29
Interaction of telomestatin with the telomeric single-strand overhang. J Biol Chem (2004) 1.27
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene (2003) 1.26
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J (2013) 1.25
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. J Am Chem Soc (2007) 1.10
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products. Environ Microbiol (2010) 0.95
Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format. J Biomol Screen (2009) 0.94
Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neurosci Res (2009) 0.92
Anti-influenza virus compound from Streptomyces sp. RI18. Org Lett (2010) 0.92
Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. J Cell Physiol (2010) 0.91
Streptomyces tateyamensis sp. nov., Streptomyces marinus sp. nov. and Streptomyces haliclonae sp. nov., isolated from the marine sponge Haliclona sp. Int J Syst Evol Microbiol (2010) 0.90
Methanolic extracts of Plocamium telfairiae induce cytotoxicity and caspase-dependent apoptosis in HT-29 human colon carcinoma cells. J Med Food (2007) 0.90
JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75. J Antibiot (Tokyo) (2012) 0.90
Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria. FEMS Microbiol Lett (2009) 0.89
Isolation of 2 new naphthablin analogs, JBIR-79 and JBIR-80, from Streptomyces sp. RI24. J Antibiot (Tokyo) (2010) 0.89
Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator. Toxicology (2006) 0.89
Structure of tyroscherin, an antitumor antibiotic against IGF-1-dependent cells from Pseudallescheria sp. J Antibiot (Tokyo) (2004) 0.89
Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway. J Nat Prod (2011) 0.88
JBIR-83 and JBIR-84, new promothiocin derivatives, isolated from Streptomyces sp. RI19. J Antibiot (Tokyo) (2010) 0.88
Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. I. Fermentation, isolation and biological activities. J Antibiot (Tokyo) (2007) 0.88
Relative and absolute configuration of versipelostatin, a down-regulator of molecular chaperone GRP78 expression. Org Lett (2007) 0.87
New angucycline C-glycosides from Streptomyces sp. RI33. J Antibiot (Tokyo) (2011) 0.87
Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26. J Nat Prod (2010) 0.86
JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge. J Antibiot (Tokyo) (2009) 0.86
Structure of aspochalasin H, a new member of the aspochalasin family. J Antibiot (Tokyo) (2002) 0.85
Three new depsipeptides, JBIR-113, JBIR-114 and JBIR-115, isolated from a marine sponge-derived Penicillium sp. fS36. J Antibiot (Tokyo) (2011) 0.85
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78. Biol Pharm Bull (2006) 0.84
New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1. J Antibiot (Tokyo) (2009) 0.84
Oximidines I and II: Novel Antitumor Macrolides from Pseudomonas sp. J Org Chem (1999) 0.84
Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571. J Antibiot (Tokyo) (2009) 0.83
JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3. J Nat Prod (2010) 0.83
Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph. FEMS Yeast Res (2012) 0.83
JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27. Org Lett (2009) 0.83
Identification and biosynthesis of new acyloins from the thermophilic bacterium Thermosporothrix hazakensis SK20-1(T). Chembiochem (2014) 0.83
JBIR-52, a new antimycin-like compound, from Streptomyces sp. ML55. J Antibiot (Tokyo) (2009) 0.81
Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase. Cancer Res (2003) 0.81
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator. J Cell Physiol (2008) 0.81
Isolation of a novel macrocyclic dilactone-JBIR-101-from Promicromonospora sp. RL26. J Antibiot (Tokyo) (2011) 0.80
Isolation of 2 new metabolites, JBIR-74 and JBIR-75, from the sponge-derived Aspergillus sp. fS14. J Antibiot (Tokyo) (2010) 0.79
A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6. J Antibiot (Tokyo) (2008) 0.79
Neuroprotective effects of SG-168 against oxidative stress-induced apoptosis in PC12 cells. J Med Food (2010) 0.79
Terpenoids produced by actinomycetes: isolation, structural elucidation and biosynthesis of new diterpenes, gifhornenolones A and B from Verrucosispora gifhornensis YM28-088. J Antibiot (Tokyo) (2010) 0.79
New aureothin derivative, alloaureothin, from Streptomyces sp. MM23. J Antibiot (Tokyo) (2007) 0.79
Napyradiomycin A1, an inhibitor of mitochondrial complexes I and II. J Antibiot (Tokyo) (2012) 0.79
Glycerol affects the acyl moieties of teicoplanin components produced by Actinoplanes teichomyceticus MSl2210. Microbiol Res (2007) 0.78
JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea. J Antibiot (Tokyo) (2009) 0.78
New species of actinomycetes do not always produce new compounds with high frequency. J Antibiot (Tokyo) (2011) 0.78
Tetrapeptides possessing a unique skeleton, JBIR-34 and JBIR-35, isolated from a sponge-derived actinomycete, Streptomyces sp. Sp080513GE-23. J Nat Prod (2010) 0.78
JBIR-107, a new metabolite from the marine-sponge-derived actinomycete, Streptomyces tateyamensis NBRC 105047. Biosci Biotechnol Biochem (2013) 0.78
Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole. Org Biomol Chem (2010) 0.78
Antioxidant activity of propofol and related monomeric and dimeric compounds. Chem Pharm Bull (Tokyo) (2005) 0.77
A novel antimycin-like compound, JBIR-06, from Streptomyces sp. ML55. J Antibiot (Tokyo) (2008) 0.77
A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55. J Antibiot (Tokyo) (2007) 0.77
Cation involvement in telomestatin binding to g-quadruplex DNA. J Nucleic Acids (2010) 0.77
Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis. Angew Chem Int Ed Engl (2015) 0.77
Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A. Eur J Med Chem (2013) 0.77
Two novel benzastatin derivatives, JBIR-67 and JBIR-73, isolated from Streptomyces sp. RI18. J Antibiot (Tokyo) (2011) 0.77
Novel 24-membered macrolides, JBIR-19 and -20 isolated from Metarhizium sp. fE61. J Antibiot (Tokyo) (2009) 0.77
Construction of a natural product library containing secondary metabolites produced by actinomycetes. J Antibiot (Tokyo) (2012) 0.76
JBIR-65, a new diterpene, isolated from a sponge-derived Actinomadura sp. SpB081030SC-15. J Antibiot (Tokyo) (2010) 0.76
Studies on terpenoids produced by actinomycetes. Isolation and structural elucidation of antioxidative agents, naphterpins B and C. J Antibiot (Tokyo) (2005) 0.76
JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. J Antibiot (Tokyo) (2009) 0.76
JBIR-12, a novel antioxidative agent from Penicillium sp. NBRC 103941. J Antibiot (Tokyo) (2009) 0.75
Trapping effect of eugenol on hydroxyl radicals induced by L-DOPA in vitro. Chem Pharm Bull (Tokyo) (2005) 0.75
Stereochemical Assignment of the Protein-Protein Interaction Inhibitor JBIR-22 by Total Synthesis. Angew Chem Weinheim Bergstr Ger (2015) 0.75
Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties. J Nucleic Acids (2010) 0.75
Mithramycin inhibits etoposide resistance in glucose-deprived HT-29 human colon carcinoma cells. J Microbiol Biotechnol (2007) 0.75
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer. Nucleic Acids Symp Ser (Oxf) (2009) 0.75
A novel neuronal cell protecting substance, halxazone, produced by Streptomyces halstedii. J Antibiot (Tokyo) (2002) 0.75
JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin. J Nat Prod (2012) 0.75
Screening and evaluation of new inhibitors of hepatic glucose production. J Antibiot (Tokyo) (2009) 0.75
JBIR-54, a new 4-pyridinone derivative isolated from Penicillium daleae Zaleski fE50. J Antibiot (Tokyo) (2009) 0.75
JBIR-66, a new metabolite isolated from tunicate-derived Saccharopolyspora sp. SS081219JE-28. Biosci Biotechnol Biochem (2010) 0.75
JBIR-78 and JBIR-95: phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56. J Nat Prod (2012) 0.75
New acylated anthocyanins from purple yam and their antioxidant activity. Biosci Biotechnol Biochem (2015) 0.75
A new furaquinocin derivative, JBIR-136, from Streptomyces sp. 4963H2. J Antibiot (Tokyo) (2012) 0.75
Flaviogeranin, a new neuroprotective compound from Streptomyces sp. J Antibiot (Tokyo) (2010) 0.75
Burkholone, a new cytotoxic antibiotic against IGF-I dependent cells from Burkholderia sp. J Antibiot (Tokyo) (2007) 0.75
JBIR-37 and -38, novel glycosyl benzenediols, isolated from the sponge-derived fungus, Acremonium sp. SpF080624G1f01. Biosci Biotechnol Biochem (2009) 0.75
Two novel decanedienamide derivatives, JBIR-07 and -08, from Streptomyces versipellis 4083-SVS6. Nat Prod Res (2009) 0.75
JBIR-69, a new metabolite from Streptomyces sp. OG05. J Antibiot (Tokyo) (2010) 0.75
Tyrosyl-DNA phosphodiesterase 1 inhibitor from an anamorphic fungus. J Nat Prod (2012) 0.75