Published in Stem Cells Int on April 11, 2016
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
RNA-guided genetic silencing systems in bacteria and archaea. Nature (2012) 17.12
Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res (2009) 7.09
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science (1995) 6.03
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol (2002) 5.91
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (2009) 5.69
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (2010) 5.50
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res (2009) 3.44
The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryot Gene Expr (2008) 3.06
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat Biotechnol (2006) 3.02
Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet (2001) 2.79
VEGF targets the tumour cell. Nat Rev Cancer (2013) 2.71
The roles of TGFβ in the tumour microenvironment. Nat Rev Cancer (2013) 2.35
Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol (1996) 2.22
Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A (2000) 2.22
Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta (2003) 2.16
Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells. Stem Cell Rev (2010) 1.98
Mammalian Per-Arnt-Sim proteins in environmental adaptation. Annu Rev Physiol (2010) 1.94
Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat Med (2006) 1.90
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells (2008) 1.83
Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. Proc Natl Acad Sci U S A (2010) 1.67
Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells. Blood (2010) 1.66
Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target. Toxicol Sci (2013) 1.53
Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro. FASEB J (2009) 1.52
A cut above the rest: targeted genome editing technologies in human pluripotent stem cells. J Biol Chem (2013) 1.47
Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. Arch Biochem Biophys (1998) 1.46
Aryl hydrocarbon receptor ligands in cancer: friend and foe. Nat Rev Cancer (2014) 1.46
Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. Toxicol Appl Pharmacol (1999) 1.44
Isolation and characterization of the human cytochrome P450 CYP1B1 gene. J Biol Chem (1996) 1.44
Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells. J Cell Mol Med (2011) 1.43
The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation. Chem Biol Interact (2002) 1.42
Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide. J Biol Chem (2001) 1.35
Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction. Mol Cell Biol (2005) 1.35
The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry (2010) 1.32
Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix. J Clin Invest (2013) 1.31
DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation. Chem Biol Interact (2002) 1.28
Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. Biofactors (2004) 1.27
Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole. Chem Biol Interact (1998) 1.24
Off-target Effects in CRISPR/Cas9-mediated Genome Engineering. Mol Ther Nucleic Acids (2015) 1.23
Hematopoietic development from human induced pluripotent stem cells. Ann N Y Acad Sci (2009) 1.22
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis (2002) 1.21
Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells. PLoS One (2011) 1.19
Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art. Curr Drug Metab (2011) 1.14
Activation of the Ah receptor signaling pathway by prostaglandins. J Biochem Mol Toxicol (2001) 1.12
Generation of human induced pluripotent stem cells from peripheral blood using the STEMCCA lentiviral vector. J Vis Exp (2012) 1.11
Genome engineering using CRISPR-Cas9 system. Methods Mol Biol (2015) 1.07
Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia. Cardiovasc Toxicol (2002) 1.07
The immune phenotype of AhR null mouse mutants: not a simple mirror of xenobiotic receptor over-activation. Biochem Pharmacol (2008) 1.06
The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood (2013) 1.06
Human induced pluripotent stem cells are capable of B-cell lymphopoiesis. Blood (2011) 1.04
Structure and drug inducibility of the human cytochrome P-450c gene. Eur J Biochem (1986) 1.03
Functional analysis of the human cytochrome P4501A1 (CYP1A1) gene enhancer. Eur J Biochem (1998) 0.99
A role for the aryl hydrocarbon receptor in cardiac physiology and function as demonstrated by AhR knockout mice. Cardiovasc Toxicol (2003) 0.98
Dioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene transcription. Mol Cell Biol (1995) 0.97
The role of endogenous aryl hydrocarbon receptor signaling in cardiovascular physiology. J Cardiovasc Dis Res (2011) 0.96
Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders. Nutr Rev (2013) 0.95
Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling. J Clin Invest (2013) 0.91
Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies. Adv Drug Deliv Rev (2015) 0.91
Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity. Pharmacol Ther (2010) 0.90
Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A. Breast Cancer Res (2006) 0.90
Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. Cell Rep (2015) 0.90
Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem Cell Reports (2013) 0.89
Pluripotent stem cells and gene therapy. Transl Res (2013) 0.88
Binding of polychlorinated biphenyls to the aryl hydrocarbon receptor. Environ Health Perspect (1993) 0.88
Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix. Ann Thorac Surg (2014) 0.87
The Ah receptor in stem cell cycling, regulation, and quiescence. Ann N Y Acad Sci (2014) 0.87
Induction of human UGT1A1 by bilirubin through AhR dependent pathway. Drug Metab Lett (2008) 0.86
Cytochrome P450 1 family and cancers. J Steroid Biochem Mol Biol (2014) 0.86
Aryl hydrocarbon receptor: Linking environment to immunity. Semin Immunol (2015) 0.86
Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes. Toxicol Sci (1999) 0.85
In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells. Methods Mol Biol (2012) 0.85
Activation of aryl hydrocarbon receptor (ahr) by tranilast, an anti-allergy drug, promotes miR-302 expression and cell reprogramming. J Biol Chem (2013) 0.83
Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports (2015) 0.81
Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases. N Biotechnol (2014) 0.81
Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychlorinated biphenyls. Toxicol In Vitro (2002) 0.81
Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors. Stem Cells Transl Med (2013) 0.80
Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery. Neurol Sci (2014) 0.80
Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges. Int J Mol Sci (2015) 0.79
Fate of Ah receptor agonists during biological treatment of an industrial sludge containing explosives and pharmaceutical residues. Environ Sci Pollut Res Int (2004) 0.79
Transplantation of induced pluripotent stem cell-derived renal stem cells improved acute kidney injury. Cell Biosci (2015) 0.78
Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol (2014) 0.78
Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress. J Neurosci Res (2015) 0.77
Ligand binding and functional selectivity of L-tryptophan metabolites at the mouse aryl hydrocarbon receptor (mAhR). J Chem Inf Model (2014) 0.77
iPSC-based drug screening for Huntington׳s disease. Brain Res (2015) 0.77
Inducing pluripotency for disease modeling, drug development and craniofacial applications. Expert Opin Biol Ther (2014) 0.77
Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor:ARNT complex is unaffected by ligand structure. Toxicol Sci (2013) 0.76
Multisystemic Disease Modeling of Liver-Derived Protein Folding Disorders Using Induced Pluripotent Stem Cells (iPSCs). Methods Mol Biol (2016) 0.75