Published in Mol Cell on April 01, 2003
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev (2003) 3.32
A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell (2009) 3.27
A gateway-compatible yeast one-hybrid system. Genome Res (2004) 3.23
MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes. BMC Bioinformatics (2005) 3.23
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression. Proc Natl Acad Sci U S A (2009) 2.98
P-Match: transcription factor binding site search by combining patterns and weight matrices. Nucleic Acids Res (2005) 2.87
Defining the mammalian CArGome. Genome Res (2005) 2.59
Clustering of DNA sequences in human promoters. Genome Res (2004) 2.30
CREB binds to multiple loci on human chromosome 22. Mol Cell Biol (2004) 2.28
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem (2006) 2.11
Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci U S A (2005) 1.96
The MAPPER database: a multi-genome catalog of putative transcription factor binding sites. Nucleic Acids Res (2005) 1.80
Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci U S A (2004) 1.77
Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity. PLoS Genet (2009) 1.72
CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem (2010) 1.58
Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation. Cell (2013) 1.55
Discovering functional transcription-factor combinations in the human cell cycle. Genome Res (2005) 1.53
Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A (2005) 1.52
Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences. Nucleic Acids Res (2004) 1.52
Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension. Am J Physiol Renal Physiol (2012) 1.47
Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation. Ann Rheum Dis (2015) 1.42
Knock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity. PLoS One (2016) 1.40
A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway. Proc Natl Acad Sci U S A (2007) 1.34
Differential regulation of NF-kappaB by elongation factors is determined by core promoter type. Mol Cell Biol (2007) 1.33
CisOrtho: a program pipeline for genome-wide identification of transcription factor target genes using phylogenetic footprinting. BMC Bioinformatics (2004) 1.30
The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol (2013) 1.30
Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed) (2012) 1.24
The coactivator CRTC1 promotes cell proliferation and transformation via AP-1. Proc Natl Acad Sci U S A (2009) 1.20
Identification of novel light-induced genes in the suprachiasmatic nucleus. BMC Neurosci (2007) 1.17
Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. J Immunol (2009) 1.15
Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction. J Biol Chem (2009) 1.15
Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in quiescent cells. J Biol Chem (2007) 1.12
Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells. BMC Genomics (2010) 1.12
Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. PLoS One (2010) 1.09
Identification of regulatory targets of tissue-specific transcription factors: application to retina-specific gene regulation. Nucleic Acids Res (2005) 1.07
Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci U S A (2004) 1.07
CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis. BMB Rep (2013) 1.07
Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway. Mol Cell Biol (2007) 1.06
RGS13 acts as a nuclear repressor of CREB. Mol Cell (2008) 1.02
Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J Immunol (2011) 1.02
Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock. Proc Natl Acad Sci U S A (2008) 1.02
Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites. Nucleic Acids Res (2008) 1.01
A comparative genomics approach to identifying the plasticity transcriptome. BMC Neurosci (2007) 1.00
A functional analysis of the CREB signaling pathway using HaloCHIP-chip and high throughput reporter assays. BMC Genomics (2009) 0.98
G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia. Oncogene (2005) 0.98
Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. BMC Genomics (2013) 0.97
CREB is activated by muscle injury and promotes muscle regeneration. PLoS One (2011) 0.96
Evolution of motif variants and positional bias of the cyclic-AMP response element. BMC Evol Biol (2007) 0.92
E2F8 as a Novel Therapeutic Target for Lung Cancer. J Natl Cancer Inst (2015) 0.91
Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line. Antioxid Redox Signal (2008) 0.91
Renal proximal tubule Na,K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1. Cell Signal (2015) 0.91
Creb coactivators direct anabolic responses and enhance performance of skeletal muscle. EMBO J (2014) 0.91
Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology (2011) 0.91
Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation. BMC Cancer (2014) 0.90
Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors. J Immunol (2009) 0.90
Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. J Biol Chem (2009) 0.89
The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure. Am J Physiol Heart Circ Physiol (2007) 0.88
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nat Commun (2016) 0.87
The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors. Nucleic Acids Res (2006) 0.87
Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology (Berl) (2012) 0.87
Senescent-induced dysregulation of cAMP/CREB signaling and correlations with cognitive decline. Brain Res (2013) 0.85
The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis. Neuroscience (2008) 0.84
Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death Dis (2011) 0.84
Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission. PLoS Pathog (2014) 0.84
The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. Genetics (2006) 0.83
OHMM: a Hidden Markov Model accurately predicting the occupancy of a transcription factor with a self-overlapping binding motif. BMC Bioinformatics (2009) 0.82
FSH modulates PKAI and GPR3 activities in mouse oocyte of COC in a gap junctional communication (GJC)-dependent manner to initiate meiotic resumption. PLoS One (2012) 0.82
A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity. PLoS One (2014) 0.82
Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation. EMBO J (2009) 0.81
CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement. Proc Natl Acad Sci U S A (2014) 0.81
Ca2+, CREB and krüppel: a novel KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB-dependent transcription. Mol Cell Neurosci (2007) 0.81
GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer. PLoS One (2016) 0.81
NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells. PLoS One (2013) 0.80
A Role of CREB in BRCA1 Constitutive Promoter Activity and Aromatase Basal Expression. Int J Biomed Sci (2008) 0.80
Basic leucine zipper (bZIP) domain transcription factor MBZ1 regulates cell wall integrity, spore adherence, and virulence in Metarhizium robertsii. J Biol Chem (2015) 0.79
RCAN1 is an important mediator of glucocorticoid-induced apoptosis in human leukemic cells. PLoS One (2012) 0.79
Microarray and proteomics analyses of human intestinal epithelial cells treated with the Aeromonas hydrophila cytotoxic enterotoxin. Infect Immun (2005) 0.79
Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget (2016) 0.79
A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic Acids Res (2010) 0.78
CRTC2 Is a Coactivator of GR and Couples GR and CREB in the Regulation of Hepatic Gluconeogenesis. Mol Endocrinol (2015) 0.78
A GSK-3-mediated transcriptional network maintains repression of immediate early genes in quiescent cells. Cell Cycle (2011) 0.78
cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS One (2013) 0.78
Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription. J Neurosci (2009) 0.78
Real-time monitoring of functional interactions between upstream and core promoter sequences in living cells of sea urchin embryos. Nucleic Acids Res (2007) 0.77
Unique reporter-based sensor platforms to monitor signalling in cells. PLoS One (2012) 0.77
D-MATRIX: a web tool for constructing weight matrix of conserved DNA motifs. Bioinformation (2009) 0.77
Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in Middle-Aged Mice. Front Behav Neurosci (2016) 0.77
CCAAT/enhancer-binding proteins are key regulators of human type two deiodinase expression in a placenta cell line. Endocrinology (2012) 0.76
Single-Molecule Imaging Reveals Dynamics of CREB Transcription Factor Bound to Its Target Sequence. Sci Rep (2015) 0.76
Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism. J Biol Chem (2011) 0.76
MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3. Cell Death Dis (2016) 0.75
Human SNF2L gene is regulated constitutively and inducibly in neural cells via a cAMP-response element. Yonsei Med J (2013) 0.75
CREB is required for cAMP/PKA signals upregulating neuropathy target esterase expression. DNA Cell Biol (2013) 0.75
Decompensation of β-cells in diabetes: when pancreatic β-cells are on ICE(R). J Diabetes Res (2014) 0.75
Integrated microfluidic approach for quantitative high-throughput measurements of transcription factor binding affinities. Nucleic Acids Res (2015) 0.75
Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdale. Neuropsychopharmacology (2016) 0.75
Porcine SOX9 Gene Expression Is Influenced by an 18bp Indel in the 5'-Untranslated Region. PLoS One (2015) 0.75
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (2005) 12.35
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol (2009) 11.17
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature (2005) 7.14
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet (2005) 6.91
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol (2004) 6.72
A gene wiki for community annotation of gene function. PLoS Biol (2008) 6.60
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM). Bioinformatics (2011) 6.20
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron (2004) 5.71
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science (2003) 5.25
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell (2009) 5.03
Harmonics of circadian gene transcription in mammals. PLoS Genet (2009) 4.97
Circadian rhythms from flies to human. Nature (2002) 4.95
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med (2004) 4.64
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature (2007) 4.54
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
TORCs: transducers of regulated CREB activity. Mol Cell (2003) 4.42
Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science (2002) 4.24
Melanopsin is required for non-image-forming photic responses in blind mice. Science (2003) 4.22
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol (2011) 4.12
Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol (2004) 4.08
Hepatic glucose sensing via the CREB coactivator CRTC2. Science (2008) 4.05
A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64
Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res (2008) 3.54
The Gene Wiki: community intelligence applied to human gene annotation. Nucleic Acids Res (2009) 3.51
JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J Biol Rhythms (2010) 3.42
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem (2006) 3.35
Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci (2002) 3.34
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature (2011) 3.32
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev (2003) 3.32
A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell (2009) 3.27
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science (2006) 3.26
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A (2007) 3.06
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell (2003) 2.85
Extensive variation in chromatin states across humans. Science (2013) 2.83
Feedback repression is required for mammalian circadian clock function. Nat Genet (2006) 2.73
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med (2010) 2.65
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
Network features of the mammalian circadian clock. PLoS Biol (2009) 2.59
Illumination of the melanopsin signaling pathway. Science (2005) 2.58
BioGPS and MyGene.info: organizing online, gene-centric information. Nucleic Acids Res (2012) 2.57
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity (2005) 2.56
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest (2004) 2.56
An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A (2006) 2.51
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature (2009) 2.48
Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A (2003) 2.45
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet (2008) 2.32
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nat Struct Biol (2003) 2.32
The Gene Wiki in 2011: community intelligence applied to human gene annotation. Nucleic Acids Res (2011) 2.31
c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell (2005) 2.30
A hormone-dependent module regulating energy balance. Cell (2011) 2.30
The imprinted gene Magel2 regulates normal circadian output. Nat Genet (2007) 2.18
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med (2007) 2.17
The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab (2008) 2.09
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J (2007) 2.07
The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis. Bioessays (2012) 2.07
Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol Genomics (2007) 2.06
Universality and flexibility in gene expression from bacteria to human. Proc Natl Acad Sci U S A (2004) 2.03
Applications of a rat multiple tissue gene expression data set. Genome Res (2004) 2.01
Genomewide association analysis in diverse inbred mice: power and population structure. Genetics (2007) 2.01
Small-molecule inhibitors of microrna miR-21 function. Angew Chem Int Ed Engl (2008) 2.00
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature (2003) 1.98
The circadian clock interacts with metabolic physiology to influence reproductive fitness. Cell Metab (2011) 1.96
Mammalian Per-Arnt-Sim proteins in environmental adaptation. Annu Rev Physiol (2010) 1.94
Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol (2002) 1.94
Crowdsourcing for bioinformatics. Bioinformatics (2013) 1.92
Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. Chem Biol (2012) 1.91
The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med (2008) 1.87
Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Rep (2013) 1.87
Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci U S A (2004) 1.77
Adipocyte CREB promotes insulin resistance in obesity. Cell Metab (2009) 1.72
CREB: the unindicted cancer co-conspirator. Trends Cell Biol (2005) 1.70
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A (2010) 1.63
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A (2010) 1.60
Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis. Genome Res (2005) 1.59
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest (2013) 1.57
CRTC3 links catecholamine signalling to energy balance. Nature (2010) 1.55
Comparative analysis of haplotype association mapping algorithms. BMC Bioinformatics (2006) 1.55
WAVECLOCK: wavelet analysis of circadian oscillation. Bioinformatics (2008) 1.52
Large-scale profiling of Rab GTPase trafficking networks: the membrome. Mol Biol Cell (2005) 1.49
CircaDB: a database of mammalian circadian gene expression profiles. Nucleic Acids Res (2012) 1.47
Games with a scientific purpose. Genome Biol (2011) 1.45
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior. PLoS One (2009) 1.44
Gene expression evolves faster in narrowly than in broadly expressed mammalian genes. Mol Biol Evol (2005) 1.44
Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab (2005) 1.43