Published in FEBS Lett on February 12, 2010
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells (2010) 2.91
Autophagy and p62 in cardiac proteinopathy. Circ Res (2011) 2.24
Mitochondrial dysfunction in ataxia-telangiectasia. Blood (2011) 1.93
Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice. J Neurosci (2010) 1.92
DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell (2011) 1.85
A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med (2012) 1.74
The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. Front Oncol (2012) 1.64
Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. Mol Cell (2014) 1.58
Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control study. PLoS One (2012) 1.43
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis (2014) 1.30
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade. EMBO Rep (2012) 1.25
Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation. FASEB J (2010) 1.24
Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One (2011) 1.22
Does Huntingtin play a role in selective macroautophagy? Cell Cycle (2010) 1.20
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest (2013) 1.17
TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation. Cell Death Differ (2012) 1.17
Relationship between the proteasomal system and autophagy. Int J Biochem Mol Biol (2013) 1.16
Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseases. Autophagy (2012) 1.16
AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia. Cell Signal (2011) 1.14
Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes Dev (2012) 1.13
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nat Med (2013) 1.13
zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function. Am J Physiol Renal Physiol (2012) 1.12
HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus. Ann Rheum Dis (2010) 1.10
Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors. Autophagy (2011) 1.09
Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions. Cell Death Differ (2010) 1.07
Selective autophagy and viruses. Autophagy (2011) 1.07
Curvature of double-membrane organelles generated by changes in membrane size and composition. PLoS One (2012) 1.06
Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin. J Biol Chem (2011) 1.04
Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells. J Biol Chem (2011) 1.03
Selective autophagy: talking with the UPS. Cell Biochem Biophys (2013) 1.02
Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction. Autophagy (2014) 1.02
Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20. Cell Mol Life Sci (2011) 1.01
Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology. J Biol Chem (2013) 1.00
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. Cancer Cell (2014) 0.99
p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions. PLoS One (2012) 0.99
Role of p62/SQSTM1 in liver physiology and pathogenesis. Exp Biol Med (Maywood) (2013) 0.96
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. Eur J Histochem (2015) 0.96
bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway. Sci Rep (2015) 0.95
Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice. Hum Mol Genet (2014) 0.94
NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nat Commun (2014) 0.94
Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells. Autophagy (2011) 0.93
Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo. Cancer Chemother Pharmacol (2013) 0.92
Cell loss and autophagy in the extra-adrenal chromaffin organ of Zuckerkandl are regulated by glucocorticoid signalling. J Neuroendocrinol (2013) 0.91
Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. J Gastroenterol Hepatol (2012) 0.91
Salinomycin activates AMP-activated protein kinase-dependent autophagy in cultured osteoblastoma cells: a negative regulator against cell apoptosis. PLoS One (2013) 0.91
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis. Autophagy (2014) 0.90
Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery. J Biol Chem (2012) 0.90
Instructive roles of extracellular matrix on autophagy. Am J Pathol (2014) 0.90
Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function. Proc Natl Acad Sci U S A (2012) 0.90
The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS One (2012) 0.90
Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation. Antioxid Redox Signal (2015) 0.89
The Acinetobacter baumannii Omp33-36 porin is a virulence factor that induces apoptosis and modulates autophagy in human cells. Infect Immun (2014) 0.89
Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Neuroscience (2012) 0.88
Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth. Neoplasia (2013) 0.87
Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms. Front Cell Infect Microbiol (2013) 0.87
Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition. Autophagy (2012) 0.87
Endorepellin evokes autophagy in endothelial cells. J Biol Chem (2014) 0.86
Ubiquitination, intracellular trafficking, and degradation of connexins. Arch Biochem Biophys (2012) 0.86
Prognostic impact of p62 expression in cutaneous malignant melanoma. J Invest Dermatol (2013) 0.86
Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin. PLoS One (2014) 0.85
Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. PLoS One (2013) 0.84
Selenium induces a multi-targeted cell death process in addition to ROS formation. J Cell Mol Med (2014) 0.84
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy (2015) 0.84
Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases. Neurol Res Int (2012) 0.84
p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines. Prostate (2013) 0.83
Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy. Mol Neurodegener (2015) 0.82
Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons. J Virol (2016) 0.82
The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition. J Biol Chem (2014) 0.82
Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression. Autophagy (2014) 0.82
ISG15 deregulates autophagy in genotoxin-treated ataxia telangiectasia cells. J Biol Chem (2012) 0.82
Autophagy is involved in nanoalumina-induced cerebrovascular toxicity. Nanomedicine (2012) 0.82
A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy (2015) 0.82
β-Hydroxy-β-methylbutyrate (HMB) normalizes dexamethasone-induced autophagy-lysosomal pathway in skeletal muscle. PLoS One (2015) 0.81
Aggresome-Autophagy Involvement in a Sarcopenic Patient with Rigid Spine Syndrome and a p.C150R Mutation in FHL1 Gene. Front Aging Neurosci (2014) 0.80
Endosome-mediated autophagy: an unconventional MIIC-driven autophagic pathway operational in dendritic cells. Autophagy (2013) 0.80
Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury. PLoS One (2015) 0.80
Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. Redox Biol (2016) 0.79
High ω3-polyunsaturated fatty acids in fat-1 mice prevent streptozotocin-induced Purkinje cell degeneration through BDNF-mediated autophagy. Sci Rep (2015) 0.79
Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney. Cell Death Dis (2016) 0.79
Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling. BMC Cancer (2015) 0.79
Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration. Oncotarget (2015) 0.79
Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells. PLoS One (2016) 0.78
Characterization of growth suppressive functions of a splice variant of cyclin D2. PLoS One (2013) 0.78
Changes of lysosomes in the earliest stages of the development of atherosclerosis. J Cell Mol Med (2013) 0.78
A balancing act for autophagin. J Clin Invest (2010) 0.78
Optineurin: The autophagy connection. Exp Eye Res (2015) 0.78
Oncosuppressive functions of decorin. Mol Cell Oncol (2015) 0.78
Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. Am J Pathol (2016) 0.78
Atg8 is involved in endosomal and phagosomal acidification in the parasitic protist Entamoeba histolytica. Cell Microbiol (2015) 0.77
Regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: implications for health, fitness, and fertility. Biomed Res Int (2014) 0.77
Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis. Antioxid Redox Signal (2015) 0.77
Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy. PLoS One (2016) 0.77
Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. Protein Cell (2016) 0.77
Protein recycling pathways in neurodegenerative diseases. Alzheimers Res Ther (2014) 0.77
Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy. Toxicol Rep (2017) 0.77
p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation. Cell Mol Biol Lett (2016) 0.76
Morphine potentiates LPS-induced autophagy initiation but inhibits autophagosomal maturation through distinct TLR4-dependent and independent pathways. Acta Physiol (Oxf) (2015) 0.76
Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury. World J Gastroenterol (2015) 0.76
Autophagy and ubiquitin-proteasome system contribute to sperm mitophagy after mammalian fertilization. Proc Natl Acad Sci U S A (2016) 0.76
Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis. Sci Signal (2016) 0.76
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell (2007) 7.11
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem (2007) 6.28
p62/SQSTM1/A170: physiology and pathology. Pharmacol Res (2012) 1.74
Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy. EMBO Rep (2006) 1.72
Selective autophagy regulates various cellular functions. Genes Cells (2010) 1.58
The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation. J Biol Chem (2007) 1.55
Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol (2011) 1.23
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures. EMBO Rep (2014) 0.90
Annexin II, a novel HSP27-interacted protein, is involved in resistance to UVC-induced cell death in human APr-1 cells. Photochem Photobiol (2008) 0.78
Crystallization and preliminary X-ray analysis of Atg3. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.77
Down-regulation of molecular chaperone 78-kd glucose-regulated protein/immunoglobulin-binding protein expression involved in enhancement of human RS cell mutability. Pancreas (2008) 0.76
[Involvement of ubiquitin system in mammalian autophagy]. Seikagaku (2012) 0.75
Anti-proliferative and apoptosis-inducible activity of Sarcodonin G from Sarcodon scabrosus in HeLa cells. Int J Oncol (2009) 0.75
[Neuronal autophagy, its defects and neurodegenerative diseases]. Tanpakushitsu Kakusan Koso (2008) 0.75