Published in Cell Cycle on September 01, 2010
Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease. J Neurosci (2013) 1.55
Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol (2015) 1.39
Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems. Hum Mol Genet (2012) 1.24
HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation. Brain (2014) 1.13
The incredible ULKs. Cell Commun Signal (2012) 1.12
Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proc Natl Acad Sci U S A (2014) 1.05
Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin. Hum Mol Genet (2014) 0.99
The role of chaperone-mediated autophagy in huntingtin degradation. PLoS One (2012) 0.99
The Function of Autophagy in Neurodegenerative Diseases. Int J Mol Sci (2015) 0.95
The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov Today (2014) 0.92
Attenuation of Rhes activity significantly delays the appearance of behavioral symptoms in a mouse model of Huntington's disease. PLoS One (2013) 0.88
SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. Cell Rep (2013) 0.88
A novel multiplex cell viability assay for high-throughput RNAi screening. PLoS One (2011) 0.87
Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration. Front Oncol (2012) 0.85
Huntington's disease: the past, present, and future search for disease modifiers. Yale J Biol Med (2013) 0.85
Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin. Aging (Albany NY) (2015) 0.84
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Rhes suppression enhances disease phenotypes in Huntington's disease mice. J Huntingtons Dis (2014) 0.76
Serine 421 regulates mutant huntingtin toxicity and clearance in mice. J Clin Invest (2016) 0.76
Huntingtin facilitates selective autophagy. Nat Cell Biol (2015) 0.75
Is Huntingtin Dispensable in the Adult Brain? J Huntingtons Dis (2017) 0.75
A cause for childhood ataxia. Elife (2016) 0.75
Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion. J Huntingtons Dis (2017) 0.75
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Signaling to NF-kappaB. Genes Dev (2004) 19.78
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
The genetic landscape of a cell. Science (2010) 16.52
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Autophagosome formation: core machinery and adaptations. Nat Cell Biol (2007) 13.59
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
mTOR signaling at a glance. J Cell Sci (2009) 8.66
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab (2007) 8.05
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature (2001) 6.76
The molecular machinery of autophagy: unanswered questions. J Cell Sci (2005) 6.67
mTOR regulation of autophagy. FEBS Lett (2010) 6.59
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J (2008) 6.32
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell (2004) 6.13
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol (2006) 5.25
Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol (2005) 5.21
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet (2003) 4.76
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science (2002) 4.72
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol (2008) 4.68
Autophagy and aging: the importance of maintaining "clean" cells. Autophagy (2005) 4.61
Mutations of optineurin in amyotrophic lateral sclerosis. Nature (2010) 4.54
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol (2008) 4.47
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc Natl Acad Sci U S A (2003) 4.44
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science (2006) 4.23
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci (2010) 4.22
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19
A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J Cell Biol (1997) 4.16
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci U S A (2000) 4.01
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol (2004) 3.98
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
SUMO modification of Huntingtin and Huntington's disease pathology. Science (2004) 3.85
Comparison of ARM and HEAT protein repeats. J Mol Biol (2001) 3.78
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet (2005) 3.75
The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modification. J Biol Chem (2001) 3.64
Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell (2007) 3.42
Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells (2008) 3.23
Age-related decline in chaperone-mediated autophagy. J Biol Chem (2000) 3.22
Peptide sequences that target cytosolic proteins for lysosomal proteolysis. Trends Biochem Sci (1990) 3.21
Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol (2007) 3.18
The hunt for huntingtin function: interaction partners tell many different stories. Trends Biochem Sci (2003) 3.15
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron (2005) 3.13
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A (2003) 3.03
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev (2008) 2.89
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell (2009) 2.87
Physiological significance of selective degradation of p62 by autophagy. FEBS Lett (2010) 2.83
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy (2009) 2.78
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med (2008) 2.78
Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell (2005) 2.73
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72
Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron (2005) 2.68
Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ (2006) 2.67
ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy (2007) 2.67
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell (2004) 2.65
The molecular mechanism of autophagy. Mol Med (2003) 2.63
Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell (2009) 2.57
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. Dev Cell (2002) 2.56
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity. Hum Mol Genet (2007) 2.51
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell (2003) 2.50
Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol (2010) 2.45
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron (2009) 2.43
Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2007) 2.43
The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science (2009) 2.39
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice. Neuron (2003) 2.39
Altered lipid content inhibits autophagic vesicular fusion. FASEB J (2010) 2.35
Proteolytic and lipolytic responses to starvation. Nutrition (2006) 2.33
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum Mol Genet (1997) 2.28
Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Neuron (2009) 2.26
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci (2006) 2.19
Interaction of Huntington disease protein with transcriptional activator Sp1. Mol Cell Biol (2002) 2.19
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol (2009) 2.16
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science (2009) 2.13
Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. J Cell Biol (1998) 2.13
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10
A SIM-ultaneous role for SUMO and ubiquitin. Trends Biochem Sci (2008) 2.05
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet (2008) 2.05
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J (2008) 2.03
Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res (2010) 2.02
Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr Biol (2007) 1.98
The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis. Hum Mol Genet (2006) 1.96
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.94
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. Nat Genet (2000) 1.92
Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions. Biochem J (2003) 1.89
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci (2008) 1.88
FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Curr Biol (2001) 1.84
Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease. Hum Mol Genet (2001) 1.81
Current knowledge of the pre-autophagosomal structure (PAS). FEBS Lett (2010) 1.72
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol (2008) 1.69
Regulation of autophagy by the p300 acetyltransferase. J Biol Chem (2009) 1.69
Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J Biol Chem (2008) 1.65